N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder ndi piperazinyl phenyl urea yomwe maonekedwe ake ndi osiyana ndi alkyl carbamates ndi mankhwala a alpha-keto heterocyclic ndipo ndi mankhwala othandiza kwambiri a mafuta a amide hydrolase (FAAH) (IC50s = 34 ndi 33 nM mu khola ndi anthu, motero) omwe angathe kuthana ndi vuto la ubongo wa ubongo.1 Pa 20 mg / kg, imamangiriza ku FAAH mwachangu pogwiritsa ntchito ntchito ya urea yopanga aniline ndi FAAH-poperazinyl carbamate.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

 

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Chiyero: ≥99% (HPLC)
Mafanowo: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Makhalidwe a Maselo: C19H19N5OS
Kulemera kwa maselo: 365.459
Mfundo yosungunula: 240.48
Mfundo yophika: 559.69 ° C pa 760 mmHg
Kusakanikirana: ~ 1.3 g / cm3
Kusungirako nyengo: Sungani ku + 4 ° C
Kutupa: DMSO: ≥28mg / mL
Chizindikiro cha refractive: N20D 1.68
mtundu; Kristalline olimba
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Kugwiritsa ntchito Powder pozungulira:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ufa, JNJ 166101 Poda

2.Kodi ntchito ya N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ntchito ya Powder ndi yotani?

FAAH yomwe imayambitsidwa ndi JNJ-1661010 imasonyeza kuti pang'onopang'ono, kugwirizanitsa pakati pa JNJ1661010 ndi malo ogwira ntchito, omwe amachepetsedwa pa kutentha kwambiri. JNJ-1661010 ndi njira yowonongeka yogwiritsidwa ntchito, yomwe imayang'aniridwa ndi LC-ESI-MS. JNJ-1661010 docks ndi phenylthidiadiale mu mpweya wa hydrophobic ndi phenylurea mu hydrophilic mthumba wa FAAH, JNJ-1661010 (20 mg / kg ip) imalepheretsa FAAH ndi 85% pokhapokha mpaka 4 h pambuyo pa mankhwala, ethanolamides mu ubongo wamphongo. Dongosolo la JNJ-1661010 limadodometsanso tactile allodynia ndi mphamvu yaikulu ya pafupifupi 90% pa 30 min pambuyo ponse mu maulendo ofatsa ndi owopsa. JNJ-1661010 (20 mg / kg) imasintha zowonongeka ndi 60.8% pa 30 min mu ndondomeko yovulaza mitsempha ya msana. JNJ-1661010 (50 mg / kg ip) amasonyeza kuonongeka kwakukulu kwa hyperalgesia ku 30 min pambuyo poyerekeza ndi katoto carrageenan yopweteka kwambiri.
Makoswe omwe anagwidwa ndi JNJ-1661010 (20 mg / kg ip) ali ndi Plasma Cmax ya 26.9 μM pa Tmax ya 0.75 h ndi Cmax mu ubongo wa 6.04 μM pa Tmax ya 2 h. JNJ-1661010 (20 mg / kg ip) imaletsa ubongo wa FAAH ndikukweza AEA mlingo m'magulu a ubongo.

3.Zindikirani pa N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ufa

4.Inanso malangizo:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder Maphikidwe:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ufa Malonda:

Kuti aperekedwe m'tsogolomu.

 


 

III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide ufa HNMR

 

Ndife aprepitant ufa wophimba, ufa wa Aprepitant wogulitsidwa, ufa wochuluka wa Aprepitant (170729-80-3) hplc =98% | Ikani ma Reagents a R & D

 


 

IV. Kodi kugula N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide ufa kuchokera ku AASraw?

 

1.Kutiwuza ife ndi imelo yathukafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.

 


 

Tangoganizirani zomwe mumakonda kwambiri blog:

 

 Mkazi Wachikazi? Chilichonse chokhudza kugwirizanitsa kugonana kwa Flibanserin powder Mmene mungagwiritsire ntchito Clenbuterol kuti muwonongeke Kodi ufa wa nandrolone umagwiritsidwa ntchito bwanji / nandrolone phindu?

 


 

Zambiri mwatsatanetsatane zamagetsi,kulandila apa.


Kuti mufunse mafunso, chonde lemberani imelo , Timakonda kuyankha mkati mwa maola 8.
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