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Nicotinamide Mononucleotide NMN

 

  1. Kodi ufa wa NMN ndi chiyani?
  2. Kodi NAD + Zikugwirizana Bwanji Ndi NMN?
  3. Kodi NMN Powder Safe Supplements?
  4. Kodi Phindu La NMN Lingabweretse Thupi Langa Ndi Chiyani?
  5. Kodi Ndingapeze NMN Yokwanira Kuchokera Pazakudya Kupita Kukalamba?
  6. Kodi Mungatenge Bwanji Ufa wa NMN?
  7. Kodi ndiyenera kutenga zowonjezera zina ndi NMN limodzi?
  8. Kodi NMN Yothandiza Potsutsana ndi COVID-2019?
  9. NMN motsutsana. NR: Ndi uti wabwino?
  10. Kodi Ndingapeze Bwanji Ufa Wabwino Kwambiri wa NMN?
  11. Kodi Mungasunge Bwanji ufa wa NMN?
  12. Kodi Pali Zowona Zenizeni pa Powder ya NMN?
  13. Chidule

 

Monga tonse tikudziwa, Zinthu zotsutsana ndi ukalamba ndi mutu wokhazikika ndipo anthu ambiri amaphunzira za malowa kwanthawi yayitali, Ku 2018, pali mankhwala atsopano olimbana ndi ukalamba ndipo zidapangitsa chidwi pazinthu zotsutsana ndi ukalamba, izi zatsopano zomwe zimatchedwa " NMN ”. NMN (β-Nicotinamide Mononucleotide) monga mtundu watsopano wazowonjezera zotsutsana ndi ukalamba ndiwotchuka kwambiri. Kutenga mankhwala a NMN kapena kuwonjezera ufa wa NMN pachakudya cham'mawa ndizodziwika bwino kuyambira 2020. Zomwe tingadziwe zokhudza NMN ndi momwe tingagulire ufa wa NMN pa intaneti, mafunso onse amakhudzidwa ndi anthu ambiri omwe ali okonzeka kugwiritsa ntchito ufa wa NMN kapena zowonjezera. Lero, tasonkhanitsa mitu yomwe takambirana kwambiri pa intaneti kuchokera ku reddit ndi quora pa NMN, ndikuyembekeza mayankho awa atha kukuthandizani kudziwa NMN ndikugula ufa wa NMN weniweni pa intaneti.

 

Kodi ufa wa NMN ndi chiyani? 

NMN ndiyachidule kwa nicotinamide mononucleotide (CAS: 1094-61-7), molekyulu yachilengedwe yomwe imapezeka m'mitundu yonse. Pamlingo wa maselo, ndi ribonucleotide, gawo loyambira la nucleic acid RNA. Mu mawonekedwe amapangidwa ndi gulu la nicotinamide, ribose ndi gulu la phosphate. NMN ndi Vitamini B3 (niacin) chochokera. Zimachitika mwachilengedwe ndipo zimatha kupangidwa kuchokera kuzakudya monga zipatso, mkaka, ndi ndiwo zamasamba. Thupi, NMN imagwiritsidwa ntchito kupanga nicotinamide adenine dinucleotide (NAD +), molekyulu yamphamvu komanso yofunikira yomwe imapezeka m'selo iliyonse ya thupi. Chifukwa chake, Kutenga ufa wa NMN ndi njira imodzi momwe milingo ya NAD + imathandizira, kenako kukwaniritsa cholinga chotsutsa ukalamba.

Pakadali pano, pali njira zingapo zopangira zopangira za NMN mufakitole, yotchedwanso ufa wa NMN. Momwe ndikudziwira, ndadziwa njira ziwiri kuchokera ku fakitale yomwe imapanga ufa wa NMN:

Njira 1 yopangira ufa wa NMN: Njira yothandizira (Industrial grade)

Izi zimapangidwa kokha kuti zigwiritsidwe ntchito ndi mafakitale a Industrial, osayenera anthu, sadzafunika kudziwa chitsulo cholemera, chizindikiro cha microbiological mkati mwa ufa, ndizowopsa.

Njira 2 yopangira ufa wa NMN: Njira ya Enzymatic (Gulu la Zakudya)

Mwa njirayi, ufa wa NMN ndiwotetezeka kuti anthu azigwiritsa ntchito, ndipo palibe zotsalira za Reagent, ngakhale kugwiritsa ntchito njira zakunja kuyesa mtunduwo, zotsatirazo sizotsika 98%. (pali mankhwala ena osavuta owumitsa madzi amadzimadzi kuti atenge ufa, ndikugwiritsa ntchito njira ya HPLC kuyesa kuyera, ilinso osachepera 98%, koma ikagwiritsa ntchito njira zakunja kuyeza, ndiye kusiyana kudzaonekera .

AASraw ndi fakitole wopanga kuti apange ufa wa NMN ku China ndipo ndi njira iti yomwe tidagwiritsa ntchito ndi njira ya enzymatic, ufa uliwonse wa NMN uyesedwa usanagulitsidwe ndipo chiyero chikuwonetsa 99% min, mtunduwo ndiwokhazikika. Tapanga mgwirizano ndi kampani yayikulu yowonjezerapo zowonjezera ndikuwapatsa ufa wa NMN kwa nthawi yayitali. Palibe kukayika kuti njira ya Enzymatic ndiyabwino kwamafakitale ambiri. Chifukwa chake, chonde tsimikizirani izi ndi omwe amakupatsirani ufa wa NMN musanachitike gulani kuchuluka kwa NMN ufa.

 

Kodi NAD + Zikugwirizana Bwanji Ndi NMN?

NAD imayimira nicotinamide adenine dinucleotide. Kuyambira mabakiteriya mpaka anyani, ndi amodzi mwamolekyulu ambiri komanso ofunikira kwambiri pama cell metabolism. Mwanjira ina, thupi lililonse lili ndi mankhwala a NAD, titha kufa m'masekondi 30 popanda NAD + kukhalapo. Zomwe zikutiuza NAD + ndizofunikira kwambiri mthupi lathu, zitha kuthandizira thupi lathu kugwira ntchito tsiku lililonse.

NAD + imagwira ntchito ngati basi yoyenda, kusamutsa ma elekitironi kupita ku ma molekyulu amodzi kupita kwina. Imathandizira kusintha michere kukhala mphamvu ngati chofunikira pakudya ndipo imagwira ntchito ngati ma molekyulu othandizira mapuloteni omwe amayang'anira ntchito zina zamagetsi. Ntchito zina za NAD + zimaphatikizapo kukhazikitsa kayendedwe ka kugona / kudzuka. NAD + imayendetsa ma sirtuins kuti aziwongolera kagayidwe kake ndikukhala ndi ma chromosomes okhazikika. Molekyu imathandizanso pakukonza DNA yomwe yawonongeka.

Nicotinamide Mononucleotide 04

 

Chifukwa chake, ndikofunikira kwambiri kuti tisunge thupi la NAD +. Izi zinatiuzanso kuti timakhala achichepere powonjezera mulingo wa NAD +, tithandizeni kulimbana ndi ukalamba. Ndiye zomwe tiyenera kuwonjezera mulingo wathu wa NAD +?

Monga asayansi anenera, pali njira zitatu zowonjezera NAD + mulingo:

Zakudya zosintha. Zakudya zamafuta ambiri komanso zopatsa mphamvu m'thupi, monga keto kapena zakudya za Atkins, zimalimbikitsa ketosis. Thupi lanu likakhala mu ketosis, mumagwiritsa ntchito mafuta mphamvu m'malo mwa shuga. Njira imeneyi imakulitsa kuchuluka kwa NAD + ndi NADH, potero amateteza thupi lanu ku oxidation.

Zowonjezera za NAD +. Thupi lanu limatha kutulutsa NAD +, chifukwa chake kupeza chowonjezera kuchokera kwa wopanga mbiri yemwe amapereka chitsimikizo cha kuyera ndi njira yopanda ululu yolimbikitsira milingo iyi m'thupi lanu. Zowonjezera izi ndi nicotinamide, nicotinic acid, nicotinamide mononucleotide (NMN), ndi nicotinamide riboside (NR). 【Nicotinic acid amatembenukira ku NAD + kudzera munjira zitatu. Pachigawo choyamba, NAPRT ya enzyme imasintha asidi wa nicotinic kukhala nicotinic acid mononucleotide (NAMN). Gawo lachiwiri, ma enzyme, NMNAT, amasintha NAMN kukhala nicotinic acid adenine dinucleotide (NAAD). Enzyme, NAD + synthetase (NADS) imasintha NAAD kukhala NAD +. NAD + biosynthesis mu njira yopulumutsa imakhudza kusintha kwa nicotinamide kukhala NMN kudzera mu enzyme, phosphoribosyltransferase, NMNAT. Enzyme imasintha NMN kukhala NAD +.】

Kusala kudya kwakanthawi. Ngakhale kuletsa kwambiri ma calorie kapena kusala kwakanthawi sikulimbikitsidwa kwa achikulire ambiri, kusala kwakanthawi kapena kwakanthawi kumatha kuwonetsa zomwezo. Kusala kudya kosalekeza ndi njira yodalirika yodziwitsa thupi lanu nthawi yayitali osadya, kukweza magawo anu a NAD + mofanana ndi ketosis.

Tsoka ilo, zakudya zamafuta ambiri sizingakhale bwino ngati muli ndi matenda ashuga, matenda amtima, kapena kuchuluka kwa cholesterol ya LDL. Momwemonso, kusala kudya sikungakhale koyenera kwa iwo omwe ali ndi matenda ndipo nthawi zambiri kumakhala kovuta kupitiliza pakapita nthawi. Chifukwa chake, kuwonjezera ndi ufa wa NMN kapena zina Zowonjezera za NAD Nthawi zambiri ndiyo njira yabwino kwambiri komanso yabwino kwambiri yolimbikitsira kuchuluka kwa NAD.

Tikadziwa NAD + ndi momwe imagwirira ntchito, ndikuganiza kuti muyenera kudziwa chifukwa chake tikufunika kutenga ufa wa NMN? Zimagwira bwanji ntchito ngati ufa wa NMN mthupi lathu. Mwanjira yosavuta, NMN ndiyomwe idatsogolera NAD + isanalowe m'thupi lathu. Kutenga ufa wa NMN kumatha kuwonjezera mulingo wa NAD + ndikutithandiza kugonjetsa liwiro la ukalamba.

 

Kodi NMN Powder Safe Supplements? 

Zambiri mpaka pano zachokera ku nyama, zomwe sizinawonetse zovuta zilizonse. Kafukufuku wa mbewa yayitali sanawonetsenso poizoni, zovuta zoyipa, kapena kuchuluka kwa anthu akufa m'miyezi yonse ya 12 yolowererapo. Monga momwe tikudziwira, Kuyesedwa kwa anthu posachedwa kunachitika kuchokera ku Japan. Cholinga cha mayeserowa chinali kudziwa ngati ufa wa NMN ndiwotheka kutenga. NMN idaperekedwa kwa amuna 10 athanzi. Mlingo wa 100, 250, ndi 500 mg NMN adapatsidwa. Kuwongolera pakamwa kamodzi kwa NMN sikunayambitse zizindikiritso zamatenda akulu kapena kusintha kwa zotengera zazikulu monga kugunda kwa mtima, kuthamanga kwa magazi, kukwaniritsidwa kwa oxygen, ndi kutentha kwa thupi. Mlanduwu umathandiza kutsimikizira kuti, mwapadera, ufa wa NMN ndiwotetezeka komanso wololera bwino; kuti akwaniritse izi, mayeserowa angawoneke ngati opambana. Kafukufukuyu adayesanso kugona mokwanira, ndipo sanapeze kusiyana kulikonse asanadye komanso atagwiritsa ntchito NMN.

Chifukwa chakuchepa kwamayesero amunthu, asayansi akupitilizabe kuwunika zoyipa za NMN, kuyesetsa kuti apeze zambiri zamankhwala kuchokera kumayeso amunthu, kuti awonetsetse kuti mankhwala atsopanowa okalamba ayambitsidwa mwalamulo.

Nthawi yomweyo, tikuyenera kukambirana za Dr. David Sinclair yemwe ndi m'modzi mwa anthu 100 odziwika kwambiri padziko lapansi ndi Time Magazine, yemwe amatenga zowonjezera za NMN kwazaka zambiri ndi abwenzi mumsika wokalamba. Anatiuza zomwe adakumana nazo atatenga ufa wa NMN kwa nthawi yayitali. Anati: "Nthawi zonse ndimatenga gramu imodzi ya NMN tsiku lililonse, komanso zowonjezera zina kuphatikiza resveratrol, metformin, ndi aspirin. Sindinakumaneko ndi china chilichonse kupatula kukhumudwa m'mimba mpaka pano. ” Anakumbukiranso kuti tiyenera kusunga ufa wa NMN pamalo ozizira kapena mufiriji, chifukwa NMN imasokoneza Nicotinamide poizoni m'thupi lanu NMN ikasungidwa kutentha kapena kotentha.

 

Kodi Phindu La NMN Lingabweretse Thupi Langa Ndi Chiyani? 

NMN (Nicotinamide Mononuleotide) ndiyomwe imayambitsa NAD +. Kuonjezera kwa NMN kumakweza DAN + kuti akhale ndi thanzi labwino & kukhala ndi moyo wautali pakati pa kupereka zina zaumoyo.NMN ufa uli mgawo loyambirira la mayesero aumunthu ndipo madandaulidwe apano apitilira maphunziro a nyama. Mpaka pano, palibe umboni wazovuta zilizonse, ngakhale pamlingo waukulu kwa nthawi yayitali. Iwonetsanso maubwino azaumoyo panjira ya matenda a shuga amtundu wachiwiri komanso Matenda a AlzheimerPansipa pali zabwino 10 za ufa wa NMN:

♦ Anti-okalamba kwenikweni

♦ Kuchulukitsa chonde kwa amayi

♦ Zimasintha kuona & kuwona

♦ Mphamvu zowonjezera

Imathandizira kukonzanso zingwe za DNA zosweka

♦ Zimasintha kugwira ntchito kwa impso ndi kuthamanga kwa magazi

♦ Amachepetsa cholesterol & triglycerides

♦ Kupititsa patsogolo chitetezo cha chitetezo cha mthupi

Zimalimbikitsa thanzi la mtima & ntchito

♦ Kupititsa patsogolo ntchito ya mitochondrial pochepetsa kufooka kwa ubongo

 

Kodi Ndingapeze NMN Yokwanira Kuchokera Pazakudya Kupita Kukalamba? 

Yankho ndi "ayi ayi". Chifukwa NMN imapezeka mwachilengedwe muzakudya zambiri ndipo mutha kuzipeza m'moyo wathu.

▪ Broccoli

▪ Kabichi

▪ Nkhaka

▪ Edamame

▪ Peyala

▪ Matimati

 

Nicotinamide Mononucleotide

Tsopano, mukuganiza kuti: "Ngati NMN ipezeka mchakudya, sindingathe kuwonjezera milingo yanga ya NAD + ndikamadya zochulukirapo?" Limenelo ndi funso labwino. Komabe, ndiyenera kunena kuti ngati mukufuna kuthana ndi ukalamba ndi NMN, muyenera kudya chilichonse mwazakudya izi. Zachisoni, NMN mu zimayambira zochepa za broccoli ndiyokwanira kuti ingayambitse mphamvu za NMN. Mwanjira ina, kuti mupeze pafupifupi 1mg ya NMN, muyenera kudya pafupifupi 1kg ya broccoli! Izi ndizokwera kwambiri kuposa zomwe titha kutenga kuchokera pazakudya zathu, ngakhale titadya broccoli wochuluka motani. Chifukwa chake, tiyenera kuganizira zakumwa kwa ufa wa NMN ngati zowonjezera kuti tithandizire kukalamba m'moyo wathu, zitha kuthandiza thupi lathu kukulitsa NAD + yambiri, kulimbana ndi ukalamba.

 

Kodi Mungatenge Bwanji Ufa wa NMN? 

Funso lomaliza, tidatchula Dr. David Sinclair yemwe amatenga 1g NMN tsiku lililonse. Ndiye 1g akhale mulingo wothandiza kwambiri kuti tilandire zabwino za NMN, sichoncho? Ayi, sichoncho! ” Mukamafufuza kuchuluka komwe mukufuna kutenga, ndikofunikira kulingalira momwe NMN imayendetsedwera komanso kupezeka kwake. Kuphatikiza apo, thupi losiyanasiyana mosiyanasiyana. Tiyenera kudziwa nthawi yabwino kumwa NMN, momwe tingamwere komanso kuchuluka kwa mlingo womwe tingatenge mukakonzeka kumwa ufa wa NMN.

 

Tiyeni tikambirane funso loyamba: Kodi tingamwe bwanji ufa wa NMN? 

NMN imayendetsedwa m'njira zinayi zomwe zingakhudze kuchuluka kwa momwe NMN imapangidwira m'magazi anu: ufa, ufa wochulukirapo, makapisozi oyenera, ndi makapisozi osagwira m'mimba.

Kuti mumvetsetse kupezeka kwa bioavailability, munthu ayenera kumvetsetsa Mphamvu Yoyambirira Yoyambira (zimatanthawuza kuchuluka kwa zinthu zomwe zawonongeka kapena kusinthidwa ndi chiwindi zisanalowe m'magazi). Ili ndiye lingaliro lovuta, ndikuganiza kanemayu atha kutithandiza kumvetsetsa momwe zimagwirira ntchito komanso chifukwa chake ndikofunikira kuti tizidziwe tisanatenge ufa wa NMN. Chifukwa cha kagayidwe kake koyambirira, kumwa m'kamwa kwa NMN sikothandiza kwenikweni kuposa makapisozi ang'onoang'ono kapena osagwiritsa ntchito m'mimba. Phulusa la NMN likamamwa pakamwa (mwina akamadya kapena kusakaniza ndi madzi) ambiri amawonongeka ndi asidi m'mimba. NMN yotsalayo imapukusidwa ndi chiwindi. Momwe chiwindi chimagwiritsira ntchito NMN kumatha kukhala ndi gawo lalikulu pakupezeka kwa bioavailability. Zitha kukhala kuti kachigawo kokha ka NMN kamene kamakupangitsani kukhala kachitidwe kanu. Komanso kuti mukwaniritse milingo yanu ya NAD +, mutha kutenga makapisozi a NMN otulutsidwa mochedwa ndi Sirtuin Activator monga Resveratrol ndi mafuta yogurt omwe amathandiza kupezeka kwa Resveratrol.

Koma NMN (kapena mankhwala aliwonse kapena chowonjezera) akamamwedwa pang'ono, amadzilowetsa m'mimbamo (pansi pa lilime) ndikudutsa molunjika m'magazi. Kuchokera pamenepo imapita molunjika ku ubongo ndi ziwalo zina, kudutsa "choyamba chodutsa" kuchokera pachiwindi. Ndi chifukwa chake, tikukhulupirira kuti kugwiritsa ntchito NMN yazing'ono kapena mu kapisozi wosagwiritsa ntchito chapamimba ndiko kothandiza kwambiri komanso kothandiza. Zitha kukhala ndi zotsika zochepa kuposa kumwa ufa wa NMN pakamwa kapena mu kapisozi wamba.

  1. Kodi ufa wa NMN ndi chiyani?
  2. Kodi NAD + Zikugwirizana Bwanji Ndi NMN?
  3. Kodi NMN Powder Safe Supplements?
  4. Kodi Phindu La NMN Lingabweretse Thupi Langa Ndi Chiyani?
  5. Kodi Ndingapeze NMN Yokwanira Kuchokera Pazakudya Kupita Kukalamba?
  6. Kodi Mungatenge Bwanji Ufa wa NMN?
  7. Kodi ndiyenera kutenga zowonjezera zina ndi NMN limodzi?
  8. Kodi NMN Yothandiza Potsutsana ndi COVID-2019?
  9. NMN motsutsana. NR: Ndi uti wabwino?
  10. Kodi Ndingapeze Bwanji Ufa Wabwino Kwambiri wa NMN?
  11. Kodi Mungasunge Bwanji ufa wa NMN?
  12. Kodi Pali Zowona Zenizeni pa Powder ya NMN?
  13. Chidule

 

Funso lotsatira: Ndi nthawi iti yabwino yoti mutenge ufa wa NMN? 

Kukalamba ndi matenda omwe amatha kumenyedwa ndi zowonjezera zowonjezera ndi machitidwe, malinga ndi kafukufuku watsopano kuchokera ku University of Waterloo. Pogwiritsa ntchito masamu onse, ofufuzawo apezanso kuti nthawi yabwino tsiku kuti munthu atenge zowonjezera izi zimadalira pa msinkhu wawo. Mankhwala ena okalamba okhudzana ndi ukalamba ayenera kumwa usiku, pomwe achikulire akuyenera kumwa mankhwalawa masana kuti agwire bwino ntchito. zimakhudza thupi lanu, msinkhu wanu komanso momwe mumakhalira, "wofufuza Layton adatero. "Anthu ayenera kukumbukira nthawi yomwe amadya ndikuonetsetsa kuti ikugwirizana ndi zinthu zina mdera lawo zomwe zimakhudza kugona kwawo / nthawi yodzuka kapena nthawi yathupi.

Chifukwa chake, nthawi yabwino kutenga NMN ufa ndi iti? zaka ndizofunikira kwambiri musanasankhe kuchuluka kwa ufa wa NMN. Mwachitsanzo, zidaphunziridwa kuti zowonjezera za NMN ndizopindulitsa kwambiri kwa achinyamata kutenga maola asanu ndi limodzi atadzuka. M'malo mwake, kafukufuku akuwonetsa kuti Resveratrol supplements amagwira ntchito bwino ngati achinyamata amawamwa masana. Kwa achikulire, ndikofunikira kumwa mankhwalawa masana.

 

Funso lotsiriza: Kodi titenge kuchuluka kwa ufa wa NMN motani? 

Titawerenga mafunso omwe ali pamwambapa, tiyenera kudziwa kuti aliyense amafunika kupeza mlingo wake wa ufa wa NMN, osati mlingo weniweni monga umboni. Ndiye tingadziwe bwanji miyezo ya NMN tokha? Monga maphunziro aposachedwa, zimakhudzana ndi kulemera kwathu. Kuchokera pa kafukufukuyu: "Popeza kuti 100 mg / kg / tsiku la NMN lidatha kuchepetsa kuchepa kwa thupi kwa mbewa, gawo lofananira la anthu limakhala ~ 8 mg / kg / tsiku, kupereka chiyembekezo kumasulira kupeza kwa anthu. ” Malinga ndi omwe adalemba kafukufuku waposachedwa, ndikutenga osachepera 8 mg ya NMN pa kg ya kulemera kwa thupi patsiku. Ngati kafukufukuyu ndi wolondola, ndiye kuti mupeze kuchuluka kwa NMN yomwe mukusowa, muyenera kupeza kulemera kwanu mu kg, ndikuchulukitsa ndi 8. Mwachitsanzo, ngati kulemera kwanu kuli 50kg, mulingo woyenera uli pafupifupi 400mg.

Ngati mutenga chowonjezera chapamwamba kwambiri ndi bioavailability, monga AASraw's NMN ufa, ndiye timalangiza miyezo yotsatirayi yotsata malingaliro amakasitomala:

 

Kunenepa Mlingo Wotchulidwa (tsiku lililonse)
45kg 45kg * 8mg = 360mg
50kg 50kg * 8mg = 400mg
60kg 60kg * 8mg = 480mg
70kg 70kg * 8mg = 560mg
90kg 90kg * 8mg = 720mg
Mlingowu umangokhala ngati refence. Muyenera kutenga zochuluka motani? Zili ndi inu. Koma ngati mungaone kuti kuphunzira kumeneku ndi kotsimikizika, mutha kuyamba kuwerengera kwanu pa 8 mg pa kg ya kulemera kwa thupi patsiku.

 

Kodi ndiyenera kutenga zowonjezera zina ndi NMN limodzi? 

Ngati ndinu wowonera bwino, muyenera kuti mwawona kuti Dr. David Sinclair amatenga zowonjezera zowonjezera tsiku ndi tsiku, osati ufa wa NMN wokha, komanso ena, monga resveratrol, metformin, ndi aspirin ... Kodi ndizofunika kutenga zina zowonjezera ndi ufa wa NMN limodzi? Chifukwa chiyani?

Pazoyambira pamaphunziro a Dr. David Sinclair ndi gulu lake, kutenga ufa wa NMN zowonjezera zowonjezera ndizothandiza kwambiri pakulimbana ndi ukalamba. Pakadali pano, ndigawana zowonjezera 3 tikamamwa ufa wa NMN. Zowonjezera za 2 ndi resveratrol ndi pterostilbene. Resveratrol ndi stilbenoid yomwe imapezeka pakhungu la mphesa pamtengo wotsika. Kafukufuku wasonyeza kuti resveratrol imachepetsa chiopsezo cha matenda amtima, khansa komanso neurodegeneration. David Sinclair amakhulupirira kuti resveratrol imagwirira ntchito mogwirizana ndi NMN. Resveratrol imafunika kuyambitsa majini a sirtuin (omwe amateteza DNA yathu ndi epigenome), pomwe NMN ikufunika kupangira ma sirtuin. Chifukwa chake, pterostilbene ndi njira yabwinoko. Pterostilbene ndi molekyu yomwe imawoneka yofanana kwambiri ndi resveratrol, koma imalowa bwino kwambiri ndipo imakhazikika m'thupi la munthu.

Chowonjezera china ndi trimethylglycine (TMG), tikamamwa ufa wa NMN kwa nthawi yayitali, NMN imatsitsa magulu amethyl m'matupi athu, monga chenjezo, akuti ndikofunikira kutenga TMG (amino acid yotchedwa betaine) kuti ipereke magulu a methyl. NMN ikasandulika NAD +, nicotinamide (NAM) imapangidwa. Mlingo wokwanira wa nicotinamide siabwino mthupi lathu ndipo kuti matupi athu athe kuchotsa nicotinamide imafunika kupangidwira methylated mu N-methyl nicotinamide yomwe imatuluka mkodzo wathu. Pofuna methylate NAM, thupi limachokera m'mabungwe athu a methyl. Chikhulupiriro ndikuti mukamatenga NMN kwambiri, magulu amethyl akuyenera kuthana ndi NAM.

Podcast yomwe ili pansipa ndi Dr.

Ngakhale zowonjezera zowonjezera zimati ndizabwino komanso zopindulitsa mthupi lathu, nthawi zonse zimakhala bwino kufunsa azachipatala musanayambe kumwa, makamaka ngati muli ndi thanzi labwino komanso mukugwiritsa ntchito mankhwala osachiritsika. Nthawi zonse tsatirani mulingo woyenera.

 

Kodi NMN Yothandiza Potsutsana ndi COVID-2019? 

Kuyankha koyamba kwa thupi pachiwopsezo chofalikira monga COVID-19, chotchedwa immune activate, kumadalira NAD +. Matenda a virus amawononga NAD + chifukwa matenda amayambitsa chitetezo cham'magazi chomwe chimayambitsa kuwonjezeka kwa NAD + kuwononga kachilomboka kuti kasalande selo. Ndende yochepetsedwa kwambiri ya NAD + yawonetsedwa mu COVID-19 ndipo ofufuza ena amaganiza kuti ichi ndi chomwe chimapangitsa kuti vutoli liphe, makamaka kwa iwo omwe asungidwa ndi NAD +. Dr. Zhavoronkov akufuna kuti Kuyesedwa kwa mlingo wochepa wa rapamycin payekhapayekha kapena kuphatikiza ndi metformin, ndi ma NAD + othandizira monga nicotinamide riboside (NR), kapena nicotinamide mononucleotide (NMN) itha kuthandiza kuteteza okalamba kumatenda a gerolavic masiku ano ndipo zithandizanso kuchira pakakhala mliri wapadziko lonse.

Kuphatikiza apo, kafukufuku wasonyeza kuti NAD + imatha kuyambitsa chitetezo chamthupi kuti chiteteze thupi ku coronavirus monga COVID-19. Ndemanga yomwe idasindikizidwa pa Marichi 23, 2020 ndi Isfahan University of Medical Science imapereka umboni kuti milingo yotsika ya NAD + itha kumangirizidwa ku chiwopsezo chachikulu ndi kufooka kwa mliri wa COVID-19. Malinga ndi zoyeserera zamankhwala, NMN imathandizira kuwonjezera NAD + mpaka unyamata. Kupanga molekyulu ya NAD + kupezeka m'mitundu ya SIRT1 kumawonjezera kuthekera kwawo kuteteza thupi kumatenda ndi kuwonongeka. Pamene maphunziro ena akuchitika, ofufuza akuwona kuti NAD + ilinso ndi gawo lofunikira pakuwongolera chitetezo chathu.

Apezanso kuti macrophages (mtundu wamaselo oyera amwazi omwe amadya omwe atha kubowoka monga mabakiteriya, bowa, majeremusi, ndi mavairasi) amagwiritsa ntchito njira yopangidwa ndi NAD + kuonetsetsa kuti maselo apulumuka ndikuthana ndi kutupa. Ponseponse, kafukufuku akuwonetsa kuti NMN komanso kuchuluka kwa NAD + kumatha kugwira ntchito yofunikira pakuthandizira matupi athu kulimbana ndi matenda ndi mabakiteriya. Mwanjira ina, ili ndi mwayi wopititsa patsogolo chitetezo chathu cha mthupi ndikuwathandiza munthawi ya matenda ndi matenda.

Kafukufuku wina adasindikizidwa pa Epulo 22, 2020 ndi Dr. Robert Huizenga MD ku University of Chicago akufotokozera momwe adayankhira mayi wina wazaka 55 yemwe adagonekedwa mchipatala ndi COVID-19 pa Marichi 16. Matenda ake adapitilira kukulirakulira ndipo patsiku 13 anali ndi chibayo chodziwikiratu, mkuntho wa cytokine komanso hsCRP yokwera kwambiri, chodetsa chopanda tanthauzo. Dr. Huizenga adamuthandiza ndi NMN, betaine ndi NaCl (wodziwika kuti amachepetsa IL-6) ndikupitiliza mankhwala a zinc omwe adapatsidwa kale. Pofika tsiku la 15, malungo ake adachepa ndipo zizindikilo zidakula bwino. Pofika tsiku la 17 anatulutsidwa kuti apite kunyumba. Pofika tsiku la 23, anali atatsimikizika. Odwala ena achikulire awiri amathandizidwa ndi "malo omwera" omwewo ndipo onsewa adalandiranso chimodzimodzi.

 

NMN motsutsana. NR: Ndi uti wabwino? 

Nicotinamide mononucleotide (NMN) ndi nicotinamide riboside (NR) ndi zotsogola za biosynthetic kwa molekyulu yofunikira ya metabolism-nicotinamide adenine dinucleotide (NAD +). Mamolekyulu a NMN ndi NR ali chimodzimodzi, kupatula NMN ili ndi gulu lowonjezera la phosphate. Gulu lowonjezera la phosphate limapangitsa NMN kukhala molekyu yayikulu kuposa NR. NR (nicotinamide riboside) ndi NMN (nicotinamide mononucleotide) zowonjezerazo nthawi zambiri zimakhala ngati zowonjezera zowonjezera zowonjezera kuchepetsa kukalamba.Kutenga ufa wa NR ndi NMN kumawonjezera milingo ya NAD +. Mulingo wapamwamba wa NAD + umateteza epigenome yathu ndi DNA. Kuchulukitsa kwa NAD + kumabweretsa madalitso ambiri azaumoyo pamagulu osiyanasiyana, monga ubongo, dongosolo lamtima, ndi minofu.

Popeza kuti NR ndi NMN zimawonjezera milingo ya NAD +, nthawi zambiri amatchedwa othandizira NAD. Kafukufuku wambiri akuwonetsa kuti NR ndi NMN zitha kusintha zinthu zosiyanasiyana zakukalamba, monga epigenome yolowerera, kuwonongeka kwa DNA, kuchuluka kwa mapuloteni, kutupa (kutukusira kokhudzana ndi ukalamba) ndi njira zina zakukalamba.

Koma funso lalikulu ndilakuti: ndi iti yabwinoko, ufa wa NMN kapena ufa wa NR?

Pakadali pano, palibe maphunziro ofanizira NMN ndi NR moyang'anizana ndi zovuta zaumoyo komanso zotsatira za moyo. Tiyeni tiyerekeze NMN ndi NR:

NMN motsutsana ndi NR

Kodi Ndingapeze Bwanji Ufa Wabwino Kwambiri wa NMN? 

Ndikukhulupirira kuti mwapeza ogulitsa ambiri mukayika "NMN powder" pa Google, kuti musadziwe kuti ndi iti yabwino kapena yoyenera kwa inu nokha. Tiyenera kudziwa zomwe tiyenera kuyang'ana tikamayankhula ndi omwe amapereka ufa wa NMN. Pofuna kuthana ndi vutoli, ndalankhula ndi ogulitsa ambiri a NMN powder pa intaneti ndikusankha mndandanda wazowunikira:

 

(1 Invest Kufufuza Koyambira

Muyenera kuyang'ana tsamba lawo lawebusayiti kapena malo ogulitsira pa intaneti, onetsetsani kuti ndiodalirika, osati achinyengo.Pitani pa intaneti kapena m'masitolo, lankhulani nawo, funsani mafunso chilichonse chomwe mungafune. akayankha mafunso anu, mutha kumva ngati ndi kudalirana, monga tonse tikudziwa, kuwona mtima ndiko maziko a mgwirizano wonse. Mukafunsa mafunso awo, mutha kukambirana izi: Kupanga ufa wa NMM, satifiketi ya ufa wa NMN, kuchuluka kwa ufa wa NMN….

 

(2)Chidziwitso cha Makhalidwe

Phala labwino kwambiri la NMN lidzakhala ndi 99% yoyera kapena kupitilira apo. Sipakhalanso ndi zodzaza kapena zopangira monga ma GMO, mkaka, dzira, soya, giluteni, mankhwala opangira, zitsulo zolemera, kapena zosungunulira zomwe zimagwiritsidwa ntchito pokonza mankhwalawo. Mitundu yambiri yabodza ya NMN imagwiritsa ntchito zonunkhira kapena zopatsa mphamvu kuti apange gawo lalikulu la malonda. Izi zitha kuyika thanzi lanu pachiwopsezo chachikulu chifukwa simudziwa zomwe mukutenga. Ngati mukugula NMN yanu kuchokera ku kampani yomwe imagulitsa ma capsules a NMN okha, zitha kukhala zilizonse.

 

(3)Zolemba Zogwirizana - Malipoti Oyesera

Monga fakitale ya ufa wa NMN, zikalata zogwirizana nazo (COA, HPLC, HNMR, MS) zidzatulutsidwa zitatulutsa zinthu zamagulu, zimafunikira kuwunika kwake, kuzitumiza kumalabu a 3 kuti akayese (izi zikuphatikizapo chiyero, zonyansa, onetsetsani kuti zili pamtengo ndipo zitha kugulitsidwa pamsika. Monga kasitomala, muyenera kufunsa kuti muwone malipoti awa, makamaka a COA ndi HPLC. Mutha kuyang'ana pa tsamba laogulitsa kuti mudziwe zambiri zoyesa anthu ena, kapena kulumikizana ndi makasitomala awo mwachindunji. Kutsimikizira kuyesedwa kwa anthu ena ndi njira yosavuta yotsimikizirira kuti mukugula kuchokera pagwero lodalirika. Kampani iliyonse yomwe ikugwiritsa ntchito kuyesa munthu wina ayenera kukhala osangalala kugawana nanu izi.

 

(4)Yerekezerani Mtengo Wapakati pa Ogulitsa Ambiri

Mtengo wa NMN ndi miyala ina yomwe mungagwiritse ntchito poyesa kuyenerera kwa omwe akupereka, poyang'ana angapo omwe amapereka ku NMN ufa ndi makapisozi onse mupeza lingaliro la mtengo wapakati pa gramu iliyonse. Chenjerani ndi ufa wabodza wa NMN, kapena zinthu zotsika kwambiri. Zimakhala zokopa nthawi zonse kufuna kusunga ndalama mwayi uliwonse momwe mungathere, koma ndi NMN makamaka, mumalandira zomwe mumalipira. Mtengo wa NMN wotsika mtengo ukhoza kukhala wowerengera chakudya, osati mankhwala, zomwe zikutanthauza kuti zopindulitsa za NMN sizofanana. M'malo mwake, nthawi zina pamakhala zosakwana 10% NMN mu kalasi ya chakudya NMN. Kuti tidziwe izi, tinali ndi kalasi ya chakudya Zitsanzo za NMN kuyesedwa ndipo idabweranso ndi 8% NMN.Kuwona bajeti yanu ndikofunikira, koma mutha kumalipira ndalama zambiri mukamasankha zotsika mtengo za NMN ngati simukuwona phindu lililonse kuchokera kwa iwo.

 

(5)Ntchito Yabwino Yogulira Makasitomala

Quality NMN imachokera kwa omwe amapereka zabwino, wogulitsa wodalirika ayenera kukhala ndi makasitomala abwino kwambiri. Mukamalankhula ndi omvera makasitomala, tumizani mafunso onse kwa iwo ndipo adzakuyankhani posachedwa. tsatirani nokha. Chonde kumbukirani kuti ntchito yabwino yamakasitomala ndi munthu amene amakhala womasuka kulankhulana nthawi iliyonse.

 

(6)Ndemanga kuchokera kwa Makasitomala Ena

Mwambiri, titha kupeza ndemanga za kampaniyo ngati kampani ikupereka ufa wa NMN kwa nthawi yayitali, kapena atha kukupatsirani mayankho kuchokera kwa makasitomala ena. Kupatula apo, titha kudziwa kuti ndi chowonadi bola atakhala ndi mbiri yogulitsa komanso mayankho enieni amakasitomala. Zachidziwikire, tiyenera kudziwa kuti kuwunika kochokera kwa makasitomala ena kungoti ngati tikufuna kugula ufa wa NMN, zimadalira inu pamapeto pake.

AASraw ndi kampani yomwe yatsimikizira fakitale, imatha kutulutsa ufa wa NMN ndi zina zowonjezera zotsutsana ndi ukalamba, kupezeka kwake kumakhala kolimba. Mumapita patsamba lawo-www.aasraw.com nthawi iliyonse ndikufunsira makasitomala, kufunsa satifiketi yabwino komanso malipoti oyesa mu 3rd-lab, zitsimikizirani kuti ufa wawo wa NMN ndi 99% yoyera pamankhwala ndipo ndipamwamba kwambiri. Momwe ndikudziwira, atha kutumiza zomwe mudalamula m'masiku 1-3 ogwira ntchito, ngakhale maola 12 pambuyo poti dongosolo latsimikizika, magwiridwe antchito ndiokwera kwambiri, ndiyenera kuwapatsa zala zazing'ono kuti achite izi. Mukhala ndi chithunzi cha ufa wa NMN ndi nambala yotsata kuchokera kwa iwo pambuyo pa dongosolo, kenako mutha kugwiritsa ntchito phukusi lapaintaneti ndikudziwa komwe kuli, kutali kwambiri ndi kwanu. Dziwani zambiri za AASraw tsopano

Kodi Mungasunge Bwanji ufa wa NMN? 

Nicotinamide riboside (NR) ndi nicotinamide mononucleotide (NMN), awonetsedwa kuti akukulitsa matenda okhudzana ndi msinkhu wa nyama. Amaloledwa bwino pamlingo waukulu ndipo amakweza bwino milingo ya NAD +. Mamolekyu awa samakhazikika osasunthika kutentha kapena kutentha kwambiri, komabe. Amawotcha msanga nicotinamide, yomwe imalepheretsa ntchito ya ma sirtuins ndi PARP, enzyme yokonza DNA. Ufa wa NMN wosakanizidwa kwa miyezi itatu kapena kupitilira apo ungakhale mufiriji kuti uwonetsetse kuti ali ndi mphamvu zonse. Monga mtsogoleri wapadziko lonse lapansi, AASraw nthawi zonse imapereka NAD + ndi NMN ufa wabwino kwambiri.

 

Kodi Pali Zowona Zenizeni pa Powder ya NMN? 

Tom wochokera ku UK: Ine ndi mkazi wanga tinayamba kumwa ufa wa NMN miyezi ingapo yapitayo ndipo tinadabwa kuti ndinasiya kunong'oneza ndipo mavuto a khungu la mkazi wanga anayamba kuchepa! Timangomva kulongosoka kwamaganizidwe athu komanso mphamvu zambiri, sindinatengeko chowonjezera chomwe ndakhala ndikudziwitsidwa ndikutanthauza kuti mumamwa mavitamini angapo ndi zowonjezera zitsamba koma simukumva zotsatira zake! Ichi ndiye chowonjezera chodabwitsa kwambiri chomwe munthu adachipeza komabe kuthekera kobwezeretsa mamiliyoni amitundu mthupi la munthu ndichinthu chodabwitsa chokhudza ukalamba! Ndikuganiza kuti aliyense adziwa za mapiritsiwa posachedwa ndipo kafukufuku wa khansa azindikiranso, tili mu 50 ndipo sitinganene zokwanira momwe timamvera! Ndani sangafune kukhala wathanzi kuwonjezera izi pazakudya zanu zotsutsana ndi ukalamba zomwe zisinthe moyo wanu kuti mundikhulupirire bwino !!!

liMei wochokera ku China: Ndinasankha ufa wa NMN chifukwa ndimawerenga kuti umathandizira magazi magazi ndikupereka mpweya m'matupi anga. Thupi langa limafuna izi, ndimakhala wotopa ndipo sindingathe kuyang'anitsitsa. Ndakhala kutenga ufa wa NMN kwa masabata awiri tsopano. Ndawona kuwonjezeka kwa mphamvu, ndimatha kutenga nawo gawo pulogalamu yamphamvu yolimbitsa thupi nditagwira ntchito tsiku lonse. Malingaliro anga ali omveka, sindikumva kusinza pamisonkhano. Ndine wokondwa ndi zowonjezera za NMN ndikupeza zotsatira zomwe ndakhala ndikufunafuna. Kuphatikiza apo, ndiyenera kuti: Mtengo wa NMN ndiwokwera pang'ono kwa ine koma ndikufuna kulimbikira, chifukwa ndikufuna kukhala wocheperako, haha…

Gary wochokera ku Australia: Izi ndizowonjezera zotsutsana ndi ukalamba. Ndikuwona mphamvu yowonjezera, sindinatenge chimfine cha mwana wanga wazaka 4, ndipo sinditopa mosavuta. Mphamvu yomwe ndimamva ndiyosiyana ndi kapeine wambiri. Sindikumva kuda nkhawa kapena kutengeka kwambiri, tcheru komanso kukhala watsopano. Ngakhale kukhala tcheru, kugona kwanga kwasintha. Sindinakhalepo ndi vuto la kugona, koma ndimatha kudzuka kwambiri usiku. Ndi ufa wa NMN ndimagona motalikirapo. Ndikuganiza kuti NMN ikupindulira ine m'njira zambiri ndipo sindingathe kuyankhula mokwanira.

Steven wochokera ku USA: Nditaphunzira za ufa wa NMN komanso zotsatira zake kuchokera ku Harvard Study yochitidwa ndi Dr. David Sinclair, ndidaganiza zoyesa. Kuyambira tsiku loyamba lomwe ndinayesa, ndinawona kusiyana kwa mphamvu yanga. Ndili ndi zaka 57, ndipo kagayidwe kanga kagayidwe kakuwoneka kuti kakusintha kukhala kabwino. Sindinasinthe machitidwe anga azakudya, komabe ndikuchepetsa, 14 lbs in 4 weeks. Nthawi yayitaliyo ikuwonetsa kutayika kwamuyaya. Mkazi wanga wataya mapaundi 9, ndipo ali ndi vuto losowa lotchedwa Erythromelalgia, lomwe limapangitsa kuti matumbo azitentha kwambiri ndi ululu wamitsempha, ndipo chimakhala chimodzimodzi. Gawo la Niacin la kompositi, kuwonjezera pa mankhwala ake, lapangitsa kuti kupweteka kumachepa pang'ono, ndikuthandizira magwiridwe antchito. Nditatha nthawi yoyamba - ndinayesa wina kuchokera kwa omwe amapereka ufa wa NMN. Maofesi ake ndi osiyana, ndipo mphamvu zimatha. Ichi ndichifukwa chake ndidabwerera ku MAAC10, ndipo tsopano ndayambiranso kutsatira njira. Mukudziwa, ndimakhulupirira kuti ena mwa imvi zanga zofala zakhala zopanda mdima. Zimagwira Mukudziwa - sindikuganiza kuti ndikuwonanso 57. Komabe, zikomo chifukwa cha chozizwitsa ichi chowonjezera-ufa wa NMN ndikuthokoza aasraw.

 

Chidule

Pomwe Kasupe wa Achinyamata amakhalabe nthano yongopeka yomwe siyingachitike posachedwa, sayansi ya mankhwala olimbana ndi kukalamba ikupitabe patsogolo. Mwina tsiku lina, mudzatha kumwa mapiritsi ozizwitsa ndikukhala ndi moyo wachinyamata. Kafukufuku wazinyama adawonetsa zinthu zomwe NMN ikulonjeza mu NAD + -kulimbikitsanso komanso kukalamba. Tsopano, ngakhale ofufuzawo akupita patsogolo ndi mayesero azachipatala kuti akafufuze za chitetezo cha molekyulu mwa anthu. Zowonjezera za NAD ndi NMN amapereka zabwino zenizeni zakuchepetsa zovuta zakukalamba kwama cell m'thupi la munthu. Ndikukhulupirira kuti zingakhale zothandiza bola zitakhala zopindulitsa mthupi lathu, Tithandizanenso kukhala achichepere.

 

Reference

[1] Kumpoto, BJ, Rosenberg, MA, Jeganathan, KB, Hafner, AV, Michan, S., Dai, J.,… & van Deursen, JM (2014). SIRT2 imapangitsa kuti cheke kinase BubR1 ichulukitse moyo. Magazini ya EMBO, e201386907.

[2] Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A.,… & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation imalimbikitsa kukonzanso kwa mitsempha mu mbewa zakale: zolemba zotsatsira za SIRT1, chitetezo cha mitochondrial, anti-inflammatory, and anti-apoptotic effects. GeroScience, 1-20.

[3] Grozio, A., Mills, KF, Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K.,… & Imai, SI (2019). Slc12a8 ndi nicotinamide mononucleotide transporter. Kusintha kwa chilengedwe, 1 (1), 47-57.

[4] Li, J., Bonkowski, MS, Moniot, S., Zhang, D., Hubbard, BP, Ling, AJ,… & Sinclair, DA (2017). Thumba lotetezedwa la NAD + lomwe limayang'anira zochitika zamapuloteni-protein pakakalamba. Sayansi, 355 (6331), 1312-1317.

[5] Stipp D. Beyond Resveratrol: Anti-Kukalamba NAD Fad. Scientific American Blog Network. Marichi 11, 2015.

[6] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC. + Chepetsani. Cell kagayidwe. Meyi 2018, 27 (5): 1081-1095.e10. PMC 5935140. PMID 29719225. onetsani: 10.1016 / j.cmet.2018.03.016.

[7] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, ndi nicotinamide riboside: kuwunika kwama molekyulu a mavitamini a NAD + omwe amatsogolera mavitamini a anthu. Kukambirana Kwapachaka pa Zakudya Zabwino. 2008, 28: 115-30. PMID 18429699. (Adasankhidwa)

[8] Fletcher RS, Lavery GG (Okutobala 2018). "Kupezeka kwa nicotinamide riboside kinases pakukhazikitsa NAD + metabolism". Zolemba pa Molecular Endocrinology. 61 (3): R107 – R121. onetsani: 10.1530 / JME-18-0085. PMC 6145238. PMID 30307159.

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