Chilichonse chokhudzana ndi ufa wa J147

1.Chiani J147?
2.Kodi J147 Yapangidwa Kuchokera?
3. Kodi J147 Zimagwira Ntchito Bwanji?
4.J147 Rearch?
5. Zopindulitsa za J147
6.J147 mtengo
7. Kumene mungapeze J147


J 147 powder video


I.Raw J 147 powder Mfundo zofunikira:

Name: J 147 ufa
CAS: 1146963-51-0
Makhalidwe a Maselo: C18H17F3N2O2
Kulemera kwa maselo: 350.3349896
Melt Point: 177-178 ° C
Kusungirako nyengo: 4 ° C
mtundu; Yeretsani kapena yang'anireni ufa wonyezimira


1. Kodi J147 N'chiyani?aasraw

Mankhwala osokoneza bongo J147 (1146963-51-0), ndi njira yabwino kwambiri yothandizira khunyu komanso khunyu. J147 imateteza matenda a neurotoxicity mu cortical neurons mu vitro (EC50 = 25 - 200 nM). J147. J147 imasintha kukhumudwa kwa chidziwitso ku matenda a Alzheimer's disease. J147 ndi gulu latsopano losangalatsa lomwe liri labwino kwambiri, lotetezeka mu maphunziro a nyama komanso pamaganizo. J147 ndizovuta zothandizira AD chifukwa chotha kupereka chithandizo chadzidzidzi mwamsanga, komanso zimatha kuimitsa komanso mwinamwake kusintha kwa matenda m'zinyama zozizwitsa monga momwe zasonyezedwera mu maphunzirowa.

J147 Technical Data
dzina J147, J-147
CAS 1146963-51-0
Mafananidwe N- (2,4-dimethylphenyl) -2,2,2-trifluoro-N - [(E) - (3-methoxyphenyl) methylideneamino] acetamide; J-147; 1146963-51-0; N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N '- (3-methoxybenzylidene) acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1- (2,4-dimethylphenyl) -2 - [(3-methoxyphenyl) methylene] hydrazide; J 147 | 2,2,2-Trifluoroacetic acid 1- (2,4-Dimethylphenyl) -2 - [(3-methoxyphenyl) methylene] hydrazide
Kufotokozera J147, Pulogalamu yapamwamba ya neuroprotective ndi neurotrophic, pansi pa IUPAC dzina N- (2,4-dimethylphenyl) -2,2,2-trifluoro-N - [(E) - (3-methoxyphenyl) methylideneamino] acetamide, phenyl hydrazide compound yomwe yawonetsedwa Pewani kukumbukira kukumbukira matenda a Alzheimer's disease. in vitro: Kachilombo kake kamene kamakhala ndi mpweya wotchedwa neuroprotective ndi neurotrophic (EC50 = 25 - 200 nM) mu vivo: Amachepetsa kusungunuka kwa asidi Aβ40 ndi Aβ42 ndipo kumawonjezera ma BDNF mu hippocampus
ntchito Amakhudzidwa ndi matenda a Alzheimer's
Molecular Formula C18H17F3N2O2
J147


Kulemera kwa maselo 350.3349896
Melt Point 177-178 ° C
Maonekedwe Wonyezimira kapena woyera-woyera, wakuda wonyezimira
Kutupa Kusungunuka kwa 100 mM ku DMSO ndi ku 100 mM mu mowa
yosungirako Sungani malo ozizira ndi owuma komanso 0 - 4 ℃ kwa nthawi yochepa (masiku ndi masabata) kapena -37 ℃ kwa nthawi yaitali (miyezi mpaka zaka).
Mwachidule www.aasraw.com
Chiyeretso > = 99.8%
MSDS Funsani
phukusi Zosintha


2. Kodi J147 Yapangidwa Chiyani?aasraw

J147 ndilo gawo latsopano losangalatsa lomwe liri lolimba kwambiri, lotetezeka mu maphunziro a zinyama ndi pamagwira ntchito. J147 ndizovuta zothandizira AD chifukwa cha kuthekera kwake kupereka zopindulitsa zadzidzidzi, komanso zimatha kuimitsa komanso mwinamwake kusintha kwa matenda m'zinyama zozizwitsa. Mosiyana ndi mankhwala omwe akuvomerezedwa ku matenda a Alzheimer's, J147 si acetylcholinesterase inhibitor kapena phosphodiesterase inhibitor, komabe imapangitsa kuti adziwitsidwe ndi mankhwala achidule. Kotero, kodi j147 imapangidwa kuchokera ku chiyani?

jxNUMX curcumin

Malinga ndi kafukufuku wa salk Institute J147, J147 ndi chochokera ku curcumin (jxNUMX curcumin), J147 ndi kusintha kwa ma molekyulu (curcumin) yomwe imapezeka mu mchere wonyezimira. Curcumin ndi zonunkhira zamagetsi zomwe zimagwira ntchito zambiri zomwe zimagwiritsidwa ntchito m'thupi la AD mouse. Pofuna kupititsa patsogolo potency ndi pharmacokinetic zamtundu wa curcumin, olembawo anapanga mitundu yambiri ya ma selolekiti pakati pa curcumin ndi cyclohexyl-bisphenol A (CBA), kamodzi komwe kamakhala ndi ntchito ya neurotrophic yomwe imalephera. Chomera chabwino kwambiri kuchokera pachiyambi cha kaphatikizidwe ndi CNB-001, molekyulu yomwe yakhala ikulimba pa curcumin (j147 curcumin) ndipo ndiyo njira yothandizira kuti munthu asagwiritse ntchito mankhwalawa. Kenaka, olembawo anapanga chiwerengero chochulukira cha CNB-001 ndipo anasankhidwa bwino kwambiri pamagwiridwe a ntchito m'mayesero athu ambiri a poizoni. Zotsatira zake zinali molekyu yochuluka kwambiri yotchedwa J147. Kuyesera kwina kunapeza kuti J147 inali yotetezeka kwambiri yokhudzana ndi ntchito yowonjezera kukumbukira kukumbukira makoswe akale komanso AD kusintha kwa mbewa.

Zochitika za neurotrophic ndi kukumbutsa kukumbukira za J147 zinapezeka kuti zikugwirizana ndi kuwonjezeka kwa ubongo wotengedwa ndi ubongo wa neurotrophic factor (BDNF) ndi mafotokozedwe a mapuloteni omvera a BDNF, kupititsa patsogolo LTP, kusungidwa kwa mapuloteni a synaptic, kuchepetsa kwa zizindikiro za kupsyinjika kwa okosijeni ndi kutupa, kuchepetsedwa kwa miyala ya amyloid, komanso kuchepa kwa Aβ1-42 ndi Aβ1-40. Choncho, mitundu yambiri ya zamoyo za J147 zokhudzana ndi AD zaumunthu zimakhalanso zochulukirapo kusiyana ndi mankhwala ena omwe alephereka m'mayesero a zachipatala. Kuwonjezera apo, J147 ndiyamphamvu kwambiri, imakhala ndi mankhwala abwino a CNS mankhwala, mwachiwonekere ndi otetezeka, ndipo imakhala yogwira ntchito pamlomo. Choncho, J147 ndi gawo latsopano losangalatsa lomwe lingathe kukhala lachipatala cha AD mwa kuchepetsa matenda opatsirana pogwiritsa ntchito njira zothandizira kuteteza matendawa komanso kupereka phindu lodziwika bwino.


3. Kodi J147 Zimagwira Ntchito Bwanji?aasraw

Mankhwala osokoneza bongo a Alzheimer J147 anayamba kukonzedwa mu 2011, ndipo ofufuza achita kafukufuku angapo omwe amasonyeza kuti ikhoza kusinthira kutayika kwa kukumbukira ndi kuchepetsa kapenanso kusinthira Alzheimer mu mbewa. Koma mpaka phunziro ili, iwo sankadziwa momwe mlingo J147 amagwirira ntchito mu maselo. Iwo anatha kusonyeza kuti J147 imagwira ntchito pogwiritsa ntchito ATP, mapuloteni mitochondria ndi magetsi a thupi. Pamene J147 inalipo, neurons anatetezedwa ku poizoni okhudzana ndi ukalamba. Zowonjezera zowonjezera zasonyeza kuti J147 imachulukitsa magulu a ATP ndipo imalimbikitsa mitochondria yathanzi kwambiri.


4. J147 Rearchaasraw

Mu pepala lofalitsidwa pa January 7, 2018 m'nyuzipepala ya Aging Cell, ofufuza a Salk Institute J147 kwa Biological Studies anafotokoza mwatsatanetsatane tsatanetsatane wa momwe mankhwalawa, opangidwa kuchokera ku kusintha kwa molekyu komwe amapezeka mu curcumin, amagwira ntchito mu ubongo. Iwo anapeza kuti imamangiriza mapuloteni mu mitochondria, maselo omwe amapanga mphamvu. Pochita zimenezi, zimapangitsa maselo kuoneka ngati osachepera kwambiri m'magulu omwe mankhwalawa ayesedwa mpaka pano.J147 ndi chinthu chamoyo chamakono; Awonetseredwa kuti amachiza matenda a Alzheimer ndi kubwezeretsa ukalamba m'magulu ndipo ali pafupi Mayesero a J147 mwa anthu (j147 mayesero aumunthu).

Kafukufuku wa J147

Tikudziwa kuti matenda a Alzheimer ndi omwe akugwirizana ndi ukalamba, popeza okalamba ali ndi vuto loyambitsa matendawa, koma kodi maubwenziwa ndi otani?

Kafukufuku watsopano mwa ofufuza ku US akufotokozera zambiri za ubale pakati pa ukalamba ndi Alzheimer, ndi kuyesedwa koyesedwa kwa munthu woyesera mankhwala omwe amamutcha J147 kufotokoza zopindulitsa zomwe sizinayembekezedwe mwa kufufuza kwatsopano. Poyesera pa makoswe, mankhwalawa anadabwitsa ofufuza powonetsa zotsatira zosayembekezereka zokhudzana ndi kukalamba pa mbewa.

Mu ntchito yatsopano, motsogoleredwa ndi Schubert ndi Salk Research Associate Josh Goldberg, gululo linagwiritsa ntchito njira zingapo zoti azipita kunyumba zomwe J147 ikuchita. Amadziŵa kuti chilombo cha J147 ndi mapuloteni a mitochondrial otchedwa ATP synthase omwe amathandiza kupanga ATP-selo ya mphamvu ya ndalama-mkati mwa mitochondria. Awonetsetsa kuti mwa kugwiritsa ntchito ntchitoyi, akhoza kuteteza maselo a neuronal ku maizoni ambiri okhudzana ndi ubongo wokalamba. Komanso, ATP synthase yawonetsedwa kale kuti idzalamba mu mphutsi za C. elegans ndi ntchentche.

Zinyama zikagwiritsidwa ntchito ndi J147 zimasonyeza bwino kukumbukira ndi kuzindikira, mitsempha yathanzi ya ubongo, ndi zina zowonjezera zakuthupi.

"Poyambirira, kulimbikitsa mankhwalawa kunali kuyesa mankhwalawa pamtundu watsopano wa nyama zomwe zinali zofanana kwambiri ndi 99 peresenti ya zochitika za Alzheimer," anatero Antonio Currais, wofufuza kafukufuku wa Cellular Neurobiology Laboratory ku Salk Institute for Biological Studies ku California. "Ife sitinaneneratu kuti tidzawona mtundu uwu wotsutsa ukalamba, koma J147 amapanga mbewa zakale zikuwoneka ngati zinali zachinyamata, zochokera pazigawo zambiri za thupi."

J147 imatenga njira zosiyana ndi mankhwala ena ambiri opangidwa kuti athetse matenda a Alzheimers. "Ngakhale kuti mankhwala ambiri akugwiritsidwa ntchito m'zaka zapitazi za 20 zomwe zimapangidwa ndi chipika cha amyloid mu ubongo (chomwe chimadziwika ndi matendawa), palibe chomwe chawonetsetsa kuti chipatala chikugwira bwino ntchito," anatero David Schubert, wolemba mabuku wamkulu. M'malo mwake, chithandizochi chimayang'ana zomwe ochita kafukufuku akunena ndizoopsa kwambiri pa matendawa: ukalamba.

Akatswiri a sayansi akhala akulimbana ndi mapuloteni otchedwa beta-amyloid, omwe amapezeka mu ubongo wa odwala a Alzheimer, koma kuyambira msinkhu ndilo vuto lalikulu lomwe limayambitsa matenda a 'dementia', mankhwala omwe amachititsa kuti akhale akatswiri ofufuza amatsenga. J147 ikhoza kukhala yopambana mu matenda ena opatsirana, komanso, monga Parkinson. "Anthu akhala akuganiza kuti mukusowa mankhwala osokoneza bongo kwa Alzheimer's, Parkinson's and stroke," anatero Schubert. "Koma zikhoza kukhala kuti pakuwongolera ukalamba tingathe kuchitapo kanthu kapena kuchepetsa zinthu zambiri zomwe zimakhala zokalamba zogwirizana."

Gululi likuchita kafukufuku wowonjezera pa mamolekyulu omwe amasinthidwa ndi zotsatira za J147 pa mitochondrial ATP synthase-zomwe zikhoza kukhala zida zatsopano za mankhwala. J147 yatsiriza mayeso oyenerera a FDA-oyenerera kuzilombo, ndipo ndalama zikufunidwa kuyambitsa mayesero a 1 J147 m'zipatala za anthu (j147 mayesero aumunthu).


5. Zopindulitsa za J147aasraw

J147 ndi gulu latsopano losangalatsa lomwe liri labwino kwambiri, lotetezeka mu maphunziro a nyama komanso pamaganizo. J147 ndizovuta zothandizira AD chifukwa cha kuthekera kwake kupereka zopindulitsa zadzidzidzi, komanso zimatha kuimitsa komanso mwinamwake kusintha kwa matenda m'zinyama zozizwitsa. Zopindulitsa za J147 zingaphatikizepo:

-Kuletsa Matenda a Alzheimer

J147 imasintha kuwonongeka kwa chidziwitso muchitsanzo cha mbewa cha matenda a Alzheimer's (AD).

J147 ikhoza kupangitsa kuti thupi la Amyloid-Beta (Aβ) likhazikike komanso kuchepetsa ubongo mu ubongo pochepetsa mapuloteni a β-Secretase (BACE).

Mu zinyama za AD, J147 ikhoza kuteteza BBB permeability homeostasis ndikuthandizira kusintha kwa ubongo.

J147 imathandizanso kwambiri kukula kwa Docosahexaenoic Acid (DHA) mu ubongo.

Ikhozanso kubwezeretsanso magutamate (omwe amachokera ku TCA yapakati-ketoglutarate) mu ubongo.

Mankhwala a Alzheimer's J147

-Magulu Ubongo

J147 ikhoza kusintha mapuloteni a syntaptic mu ubongo ndikupangitsa kukula kwake.

J147 imapanga chipangizo cha syntaptic plastiki mwa kukhalabe ndi Synaptophysin (mapuloteni otchedwa synaptic vesicle omwe amachepetsedwa ku ukalamba ndi AD ndipo amawonedwa kuti ndi chinthu chofunika kwambiri cha synapse).

J147 imakula ubongo mwa kuchulukitsa mbali zonse za Nerve Growth Factor (NGF) ndi Brain-Derived Neurotrophic Factor (BDNF).

Zotsatira zochokera kwa J147, T-006 (zomwe zinakambidwa pansipa pa momwe zingapangidwire), zingathandizenso kutuluka kwa neurite poyendetsa njira ya PI3K / AKT ndi kuonjezera mayendedwe a NGF.

-Imagwira Ntchito ya Mitochondrial Ndi Zaka Zambiri

J147 imathandiza kwambiri kuteteza kupanikizika kwa okosijeni ndi kusintha ntchito ya mitochondrial.

Mwachitsanzo, J147 imapangitsa ntchito ya mitochondrial kupititsa patsogolo ma ATP (kuletsa ATP synthase, makamaka ATP5A).

Zopindulitsa za J147

Mwa kuletsa ATP synthase, J147 ikhoza kuchepetsa metabolites owopsa omwe amachititsa excitotoxicity.

Izi zimathandiza kuti mitochondria yambiri yathanzi / yachinyamatayi (pamtundu wa maselo muyendetse njira ya AMPK / mTOR).

Mwachitsanzo, ntchentche zomwe zidapatsidwa J147 zinali ndi moyo wautali (9.5-12.8%) chifukwa cha zotsatira za mitochondria.

J147 ikhozanso kuchepetsa ukalamba wa ubongo pogwiritsa ntchito γ-glutamyl amino acid ndi BCAAs.

-Kukumbukira Memory

Zimapangitsa kukumbukira ming'onoting'ono ya AD ndi zinyama zokalamba zachilendo.

Ngakhalenso zitsanzo zamakono zakale, J147 ikhoza kuthetseratu zoperewera zazikulu zamaganizo.

J147 ingathandizenso kukumbukira malo osungirako zinthu komanso kupititsa patsogolo nthawi yaitali (Potentiation).

-Matenda a Neurons

J147 sinafunike mwachindunji BDNF kukhala neuroprotective.

J147 imapulumutsanso kutentha kwa Glutathione (GSH).

J147 imathandizanso kuti munthu asatenge njala.

M'kati mwa AD ubongo, Heme Oxygenase 1 (HO-1) monga anti-oxidant, m'malo mwa antioxidant, pamene 5-Lipoxygenase (5-LOX) imagwiritsa ntchito maselo ena am'thupi kumatenda kuti ayankhe.

Mankhwala osokoneza bongo


J147 imatha kuchepetsa ma level HO-1 ndikuletsa 5-LOX.

T-006 panthawi yochepa kwambiri imatha kupulumutsa mphutsi ku imfa (imateteza mitundu yambiri ya zowonjezera / zitsamba zamadzimadzi zomwe zimawopsya mu ubongo ndi excutotoxicity).

T-006 imalepheretsanso kusokoneza NMDA, kupangitsa nthawi 100 kukhala yochuluka kuposa Memantine.

-May Kulimbitsa Nkhawa

J147 ikhoza kukhala ndi zina zomwe zingathandize kuthetsa nkhawa.

Mu zitsanzo zamtundu wa AD, J147 inatha kuthetsa nkhawa m'kati mwa mayesero a Maze.


6. Mtengo wa J147aasraw

J147 ingagulidwe pa intaneti (J147 kugula) kuchokera kwa ogulitsa ena, ngati mukufuna kugwiritsa ntchito $$$ pa J147, ikupita kuzungulira 10 mg / $ 165.


7. Kumene mungapeze J147aasraw

Aasraw Biochemical Technology Company Limited yatangoyamba kumene kupanga kapangidwe kake ka J147 (1146963-51-0). Pamene idakonzedwa koyamba mu 2011, kampaniyo inayamba kupanga malonda a ufa posachedwa. Aasraw Biochemical Technology Company Limited ingathe kubweretsa mankhwala osakaniza komanso othandizira mankhwala m'zovuta zamakono. Choncho, ofalitsa angathe tsopano kufuna kuchuluka kwa phulusa kapena pakufunika, ndipo ndi zabwino Mtengo wa J147 kumene.

Malingana ndi ochita kafukufuku, ufa wa J147 (1146963-51-0) siwowoneka kuti umatsitsa madzi hydrazine kapena amadzi odzola. "Kwenikweni, ufawu umachokera ku zinthu zomwe zimagwiritsidwa ntchito nthawi zonse zotsalira za curry zotchedwa 'curcumin', zomwe zimadziwika kuti ndizochepa poizoni. Puloteni ndi ATP synthase. Ofufuza athu anasonyeza bwino kuti ngati ntchito ya ATP synthase inachepetsedwa, maselo a neuronal angatetezedwe ku mayendedwe angapo okhudzana ndi ukalamba wa ubongo, "anatero mmodzi mwa akatswiri ofufuza a Aasraw Biochemical Technology Company Limited.

Mkulu wamkulu ndi mkulu wa Aasraw Biochemical Technology adati, "Timayang'ana kupereka mankhwala omwe ali ndipamwamba kwambiri komanso opanda mtengo. Ochita kafukufuku wathu amayesetsa kupanga mapulasitiki osakaniza ndi othandiza ndipo tiyenera kuvomereza kuti popanda thandizo kuchokera ku studio zingapo, makoleji ndi makampani, sitikanatha kukonza makina opanga makina.

Kotero, ngati mutayesa kupeza J147 (J147 kugula) pa Intaneti, AASraw sizolakwika. Amatha kupereka zolemba zonse za J147, COA, HPLC, HNMR, MSDS ... ndi zina. Ananena mokwanira kuti AASRAW ndi katswiri, ndipo ndiyo yokhayo yopezera J147 ku China.


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Mayankho a 56 Comments

  • Mariel09 / 25 / 2018 pa 5: 53 am

    Ichi ndi mankhwala abwino kwambiri atsopano. Ngati pali mayesero aumunthu pa izi ndipo zakhala zogwira mtima, sindikuwona chifukwa chomwe J147 iyi imadziwika bwino.

  • Dongmin Lee09 / 25 / 2018 pa 5: 47 am

    Kodi mankhwala osokoneza bongo amenewa a J147 amavomerezedwa ndi FDA? Ngati atero, kodi pali mankhwala enieni osokoneza bongo, zovomerezeka, ndi zoletsedwa?

  • Dede09 / 25 / 2018 pa 2: 30 am

    Kukumbukira kwapakati kungapangidwe ndi mankhwala a J147 kotero ngati wina angathe kutero, ndikuganiza kuti wina akhoza kutenga mankhwalawa kuti agwiritse ntchito.

  • dora09 / 25 / 2018 pa 2: 27 am

    Zimaphunzitsa kwenikweni munthu wothandizira kapena banja la wodwalayo, tsopano amvetsetsa mankhwala omwe adzapereke kufunika kwake ndikuonetsetsa kuti akupereka pa nthawi yoyenera, mlingo woyenera ndi munthu woyenera kumuthandiza wodwala ndi mankhwala a Alzheimer J147 akadakali zopindulitsa pa moyo wawo wa tsiku ndi tsiku

  • Barney09 / 25 / 2018 pa 1: 59 am

    Zopindulitsa za mankhwala a J147 zimangokhala zokondweretsa kuziwerenga zikusonyeza kuti pali chiyembekezo kwa wina aliyense yemwe alibe malingaliro abwino kwambiri. Ndikoyenera kuyesera.

  • Vikram Parmar09 / 24 / 2018 pa 10: 44 pm

    Ndikudziwa mankhwala osokoneza bongo J147 omwe angathe kukweza zizindikiro. Ndi zabwino kuti zili ndi chilengedwe.

  • Dan Carson09 / 24 / 2018 pa 2: 57 pm

    Zodabwitsa kuti mankhwala othandizirawa a Alzheimer J147 a mankhwala amapezeka mu curry. Ndi bwino kuti atenge nthawi yawo ndi mayeso a zachipatala ndi kafukufuku wawo asanawamasulire anthu.

  • John Herman09 / 24 / 2018 pa 2: 54 pm

    Ngati mankhwalawa a J147 ali amphamvu monga momwe maphunzirowa amasonyezera ndiye ndikuwona kuti ali ndi msika waukulu. Ndibwino kuti ndizochepa poizoni ndipo ndizovuta kwambiri. Zikomo pogawana!

  • Edwin Kamau09 / 24 / 2018 pa 11: 06 am

    Zosangalatsa kwambiri kuona mtundu uwu wa mankhwala J147. Mitengo ndi kupezeka ndizobwino.

  • David Mureithi09 / 24 / 2018 pa 10: 58 am

    Pali sayansi yayikulu yomwe ikupita ku cub kuwonjezeka kwa mankhwala a Alzheimer's J147. Ambiri amagwera ku matendawa ndikuganiza kuti mankhwalawa ndiwabwino.

  • Pam09 / 24 / 2018 pa 9: 11 am

    Zolembazi zingathandize ngakhale ophunzira a sayansi kupanga kafukufuku wabwino wa mankhwala osokoneza bongo. Ndikudziwa kuti anthu nthawi zonse amafuna kudziwa zambiri zokhudza J147

  • Raf09 / 24 / 2018 pa 9: 05 am

    Ndimakonda mankhwala osokoneza bongo omwe angathandize anthu, amathandiza kuthetsa mavuto aumunthu kwambiri. Kukhala wochenjera n'kofunika kwambiri ndi anthu.

  • Mikaella Clair09 / 23 / 2018 pa 11: 59 pm

    Ndimakhulupirira mankhwala a Alzheimer's J147 mu ubwino wa thanzi la turmeric ndipo ine ndikuyima kwa izo. Sindinadziwe kuti zingathandize kuthana ndi mavuto amalingaliro, izi zikhale zenizeni.

  • Charlene G09 / 23 / 2018 pa 11: 55 pm

    Ndikuganiza kuti izi ndizodziwika bwino zopezeka ndi mankhwala, izi zingathandize anthu ambiri kunja komwe akukumana ndi mavuto amalingaliro. Ndikukhulupirira kuti izi zatsimikiziridwa ndikuyesedwa.

  • Albeneth09 / 23 / 2018 pa 10: 44 pm

    Mankhwala osokoneza bongo J147 amawoneka okondweretsa kuthandiza anthu omwe ali ndi Alzheimer. Ndimangoganiza kuti ndizotetezeka kwa odwala.

  • Jane09 / 23 / 2018 pa 8: 12 pm

    Ndibwino kuti mudziwe zambiri zokhudza mankhwala osokoneza bongo J147. Kusangalatsa kwambiri kuwerenga. Ndizosangalatsa kudziwa kuti J147 ili ndi ubwino wambiri wathanzi.

  • Doug Brians09 / 23 / 2018 pa 5: 41 pm

    Kupewera matenda kupita patsogolo ndikukula monga AD kuchiritsa ndizokulu zowononga mankhwala awa. Ndikufuna kuwona ziyeso zambiri za umunthu ngakhale ndisanadumphe kuzinthu zirizonse.

  • Hank Nolan09 / 23 / 2018 pa 5: 37 pm

    Momwe mankhwala J147 amachepetsera ukalamba kwa mbewa ndipo mwachidwi amapindula chitukuko chodziwitsidwa chimapangitsa kuti zikhale zomveka kwambiri. Ndani angaganize kuti katundu wa curcumin akhoza kukhala wogwira mtima kwambiri?

  • Paulo09 / 23 / 2018 pa 1: 23 pm

    J147 ndi mankhwala omwe amapereka zotsatira zomveka ngakhale nthawi yayitali yogwiritsiridwa ntchito. Adzathandiza wophunzira kupeza nthawi yomweyo ngati mankhwala akugwira ntchito kapena ayi.

  • Jeremy09 / 23 / 2018 pa 12: 49 pm

    Ndibwino kuti kufufuza kwakukulu kwakhala kochitidwa ndi mankhwala osokoneza bongo a J147 kotero kuti ogwiritsa ntchito sayenera kukayikira mphamvu yake. Zimakhala ngati mankhwala opambana.

  • siyani nsalu09 / 23 / 2018 pa 7: 20 am

    Iyi ndi nkhani yabwino kwambiri. Tiyeni tipitirize kufunafuna mankhwala kuchilombo cha Alzheimer J147.

  • Lisa09 / 23 / 2018 pa 5: 18 am

    Ndiyenera kunena kuti sindinadziwitse kuti anali kale kupanga mankhwala kuti athetse kapena kuchiritsa alzheimers. Ndinadabwa kwambiri ndikuwerenga zonsezi. Ndikukhumba kuti posachedwa mankhwalawa amphamvu a J147 angagwiritsidwe ntchito kuzungulira dziko lonse kuti ukhale wabwino.

  • Chatton09 / 23 / 2018 pa 5: 15 am

    Zikomo kwambiri chifukwa cha nkhani yodabwitsa komanso yodabwitsa! Ndikukhulupirira kuti mankhwala osokoneza bongo awa J147 amagwira ntchito kwambiri kuti tipewe anthu kukhala ndi alzheimers m'tsogolomu. Ndinasangalala kwambiri kuwerenga izi!

  • Mwanza09 / 23 / 2018 pa 5: 13 am

    Omwe sindinadziwe kuti mankhwala awa a Alzheimer J147 alipo kale! Potsiriza chinachake chomwe chingathandize okalamba okondedwa athu kuti ateteze matendawa. Tikuyembekeza kuti maphunziro athu azachipatala amapitanso patsogolo mtsogolo kuti machiritso ambiri abwere!

  • Wendy09 / 23 / 2018 pa 12: 14 am

    Kuwerenga zambiri za mankhwala a J147 kungawononge mantha onse. Kuwerenganso umboni kuchokera kwa ogwiritsa ntchito kale kungachepetse mantha onse a zotsatira zoipa kapena zoipa.

  • patty09 / 23 / 2018 pa 12: 04 am

    Ndi kugulitsa kwa J147, pa intaneti ndi zosiyana zimapatsa ogula mwayi wopita kuchipatala. Kugula izo kwakhala kophweka.

  • Doc Imasowa09 / 22 / 2018 pa 9: 10 pm

    Tidakondwerera tsiku la World Alzheimer ... kotero positiyi ili panthawi yake. Koma sindikutsimikiza zazodalirika za positiyi kwa J147, chifukwa makampani azachipatala achoka ku chitukuko cha mankhwala kwa Alzheimer's.

  • Dr. AM Guy09 / 22 / 2018 pa 9: 06 pm

    Pali anthu 50 miliyoni omwe akukhala ndi Alzheimer. Komabe palibe mankhwala atsopano ochizira matendawa. Sindikutsimikiza za positi yanu pano.

  • Daisy09 / 22 / 2018 pa 5: 13 am

    Ndikufuna kukhulupirira kuti J147 ndi yabwino kwambiri ndipo ndibwino kuti wina ayesere momwe ikugwirira ntchito moyenera. Onlne kugula kungakhale kovuta kwambiri.

  • Nana09 / 22 / 2018 pa 5: 09 am

    Ndikuganiza kuti kugula J147 ku aasraw kudzakhala kopambana chifukwa iwo adzakupatsani chithandizo chonse ponena za kugwiritsa ntchito mankhwala.it kumangoyankhula kokha ndi iwo.

  • Peter09 / 22 / 2018 pa 3: 46 am

    Nthawi zonse ndimakhala wosadandaula chifukwa mwina ndi njira yothetsera nkhawa yanga. Ndiyenera kukambirana ndi dokotala kuti ndipeze yankho lake pa izi.

  • Pascal09 / 22 / 2018 pa 3: 33 am

    Ndikuganiza kuti testimonialsn kuchokera kwa ogwiritsira ntchito apitalo angapite nthawi yaitali kuti athe kugwiritsa ntchito mankhwala osokoneza bongo a Alzheimer J147. Kutaya mtima kukumbukira kwenikweni ndi vuto lalikulu ndipo ndikusowa chithandizo mwamsanga monga chonchi.

  • Vikram Parmar09 / 21 / 2018 pa 10: 17 pm

    Zikuwoneka ngati zodabwitsa mankhwala J147! Zidzakhala zofunitsitsa kuwona zotsatira zake kwa anthu mu gawo la matenda a Alzheimer's.

  • Shanna Beltram09 / 21 / 2018 pa 7: 33 pm

    Nkhaniyi ikudziwitsa kwambiri za mankhwala a Alzheimer's J147! Inde ndi chozizwitsa chowonadi. Izi zikhoza kupulumutsa miyoyo komanso kukumbukira. 🙂

  • Janine Marie Alexandra Bocateja09 / 21 / 2018 pa 7: 29 pm

    Zambiri zabwino! Izi zidzathandiza kwambiri anthu omwe ali ndi Alzheimer. Ndikukhulupirira kuti J147 iyi idzayenda bwino. Zikomo!

  • Mog Arten09 / 21 / 2018 pa 7: 11 pm

    Zimamveka ngati mankhwala amphamvu komanso amphamvu omwe amathandiza kwambiri pa moyo wa anthu. Ndibwino kuti Aasraw Biochemical Technology ndi ochita kafukufuku ambiri athe kuvomereza kuti apangidwe ndi kuti azikhala ndi zochitika zina kuti athetsere zomwe akulankhula.

  • Miles Dubager09 / 21 / 2018 pa 7: 06 pm

    Zikomo chifukwa chophatikizapo kusungunuka ndi kulemera kwake kwa mankhwala J147. Ndikofunika kufufuza mtundu uliwonse wa mankhwala musanagwiritse ntchito tsiku ndi tsiku.

  • Danielle09 / 21 / 2018 pa 10: 10 am

    O, ndikudabwa kuona momwe machiritso akuyendera akukweza moyo, sindinadziwe kuti alzheimer ingalephereke, ndipo moona mtima J147 imalankhula motsimikiza kwambiri kuthandizira njirayi.

  • Lisa Nataliany09 / 21 / 2018 pa 9: 35 am

    Ndinaganiza kuti izi zisanachitike, ufa wa J147 udakali m'kati mwa zinyama, koma nditatha kuwerenga zambiri m'nkhani ino. Zikuoneka kuti ufa wa J147 watsimikiziranso ntchito kwa anthu. Ndipo ngakhale kupezeka pa msika wa pa intaneti, ndizodabwitsa kwambiri ...

  • David Tjoe09 / 21 / 2018 pa 8: 30 am

    Eya, mtengo wake! ... Koma zikuwoneka ngati izi zikhoza kutsimikiziridwa bwino. Ndipo zikuwoneka mozama kwambiri kwa anthu okalamba. Sindinadziwe kanthu za mankhwala osokoneza bongo J147 kale, ndipo chidziwitso ichi chiyenera kugawana ... zikomo!

  • Steve Johnson09 / 21 / 2018 pa 7: 53 am

    J147 zikumveka zowonjezera. Vuto la Alzheimer ndi chimodzi mwa mavuto omwe amachititsa kuti masiku ano azivutika maganizo, ndipo J147 ikuwoneka ngati njira yothetsera vutoli.

  • Frankie Gordon09 / 21 / 2018 pa 7: 49 am

    Ndinataya agogo anga ku Alzheimers. Ndikukhulupirira kuti J147 ikhoza kuthandiza anthu omwe akudwala.

  • Tom Esthber09 / 21 / 2018 pa 6: 48 am

    Zimamveka zovuta kwambiri kwa ine. Koma ine ndikuganiza ngati izo zikugwira ntchito, ndiye ine ndikanadya chipewa! Tidzawona m'zaka zingapo ngati izi zikuwombera.

  • admin, admin09 / 21 / 2018 pa 3: 01 am

    Mankhwala osokoneza bongo J147 amagwiritsanso ntchito kwa anthu pakalipano, ndipo timakhala ndi makasitomala kuti agwiritse ntchito.

  • bella09 / 21 / 2018 pa 1: 21 am

    Mitengo ya J147 ingawoneke bwino. Ndikuganiza kuti mtengowu ndi wofunika kwambiri chifukwa uli wamtengo wapatali ndipo ukhoza kukhala wopindulitsa ngati wagwiritsidwa ntchito.

  • Matt09 / 20 / 2018 pa 11: 22 pm

    Mankhwala osokoneza bongo a Alzheimer J147 ndi mankhwala omwe angakhale othandiza pa mavuto omwe amadziwa ngati matenda a Alzheimer's. Kodi mankhwalawa ndi nyama zokha tsopano?

  • Enyi09 / 20 / 2018 pa 11: 15 pm

    Ndikamba kuwerenga za mankhwala atsopano monga awa. Ndimasangalala nthawi zonse ndi ubwino wa J147.ndi zabwino kwambiri kuti ndidziwe zomwe zingamuthandize kukumbukira makoswe a AD komanso zinyama zina zomwe zimakhala zabwino.

  • Fredrick Isinguard09 / 20 / 2018 pa 11: 12 pm

    Ndikufuna kupeza ndemanga kuchokera kwa anthu omwe agwiritsa ntchito mankhwala osokoneza bongo J147. Kwa ine zikuwoneka kuti zingakhale zothandiza kwa anthu ena omwe ali ndi vuto la kukumbukira kusiyana ndi omwe ali ndi Alzheimer. Zotsatira za kuyesedwa kwa zinyama ndi zabwino kwambiri ndipo mankhwalawa amathandiza anthu ambiri.

  • Mariya09 / 20 / 2018 pa 11: 01 pm

    Ndikukhulupirira kuti nyama za nyama zikuwona izi makamaka kwa iwo omwe ali ndi zinyama. J147 mwina ingakhale mankhwala oyenera kuthetsa izo.

  • kukonda09 / 20 / 2018 pa 10: 54 pm

    Ndaphunzitsidwa za J147 mankhwala omwe sindinayambe ndamvapo. Zidzakhala zothandiza ndi kuzindikira kwa nyama zomwe ndimakhulupirira.

  • Kapita U09 / 20 / 2018 pa 10: 39 pm

    Izi ndi zothandiza kwambiri. Mankhwala osokoneza bongo a Alzheimer J147 amakantha anthu nthawi zonse tsopano. Mwina izi zingathandize kwambiri. Kodi izi zidzatha liti?

  • Machine09 / 20 / 2018 pa 9: 52 pm

    Kuti ndikhale woonamtima, mawuwa akuzungunula mutu wanga pozungulira mankhwala osokoneza bongo J147. Ndikufuna kuwonanso izi ndi dokotala pafupi ndi ine kuti ndipeze izi. Sizoipa ayi.

  • Moz Chesk09 / 20 / 2018 pa 3: 28 pm

    Zotsatira zosangalatsa. Ndikudabwa ngati kudya curry ndibwino kukumbukira kwanu ndi ntchito zamaganizo. Ndibwino kuti J147 imapezeka mosavuta komanso kuti mutha kuijambula pa intaneti. Ndikufuna kuti ndiwone momwe anthu amachitira ndi mankhwala osokoneza bongo ndisanafike kwa anthu ena.

  • Maury Cheskes09 / 20 / 2018 pa 3: 20 pm

    Zikumveka ngati mankhwala ozizwitsa! Ndizodabwitsa zomwe mungapange pogwiritsa ntchito kaphatikizidwe ndi ma test modules. Ndikufuna kudziwa zotsatira zake kwa anthu okha kumayambiriro kwa azheimer komanso ngati zingathetsere syndromes kwathunthu. Zikomo pogawana!

  • AJ09 / 20 / 2018 pa 12: 55 pm

    Ndimadabwa kwambiri ndi mankhwala osokoneza bongo omwe amatanthawuza kuchepetsa zizindikiro kapena zizindikiro zomwe zimayambitsa matenda ena - kumwa mankhwala mochuluka kungathe kuwononga chiwindi ndi impso. Ndibwino kuti ali ndi chigawo chachilengedwe chomwe chimatetezedwa. Kupatulapo, ndizo zotsatira za kufufuza kwakukulu ndi mayesero ambiri omwe adachitidwa. Akhoza kutchula msuweni wanga ku izi, akuyang'ana njira yothetsera vuto la agogo anga omwe adayamba kale kusonyeza mankhwala a Alzheimer's J147, kapena ngati adokotala adzalankhula.

  • Cialisonline06 / 22 / 2018 pa 3: 57 am

    Zikomo kwambiri mfumu !! khalani ndi malo abwino a pa Intaneti

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