Chilichonse chokhudza Cetilistat powder

1. Dzina la Zamalonda: Cetilistat
2. Zakudya Zamakono Zamagetsi
3. Kulongosola Kwachidule kwa Cetilistat ufa
4. Njira Yogwira Ntchito ya Cetilistat ufa
5. Ntchito ya Cetilistat
6. Mlingo wa ufa wothira
7. Zotsatira zoyipa za Cetilistat
8. Zilonda za Cetilistat
Malangizo a 8.1 yosungirako
8.2 Zomwe mungachite Muzochitika Mukusowa Mliri
8.3 N'chiyani Chimachitika Mukamapitirira Kuwonjezera pa Mafuta a Cetilistat?
Kugwiritsira ntchito 8.4 Kugwiritsira ntchito mankhwalawa kwa ana

1. Name mankhwala: Cetilistataasraw

Dzina la IUPAC: 2-hexadecoxy-6-methyl-3,1-benzoxazin-4-imodzi

Mafunso a 8 kuti mudzifunse musanatenge ufa wa Cetilistat

2. Zakudya Zamakono Zamagetsiaasraw

Dzina la Malo Phindu la katundu
Chokhazikika-Chokhazikika Unit Unit 1
Isotope Atomu Namba 0
Chiwerengero Chosavomerezeka Chotsatira Chigwirizano 0
Ndondomeko Yowonjezera Bondere Yowonjezera 0
Nambala yosawerengeka ya Atomu 0
Nambala yosawerengeka ya Atomu yofotokozedwa 0
Kuchuluka kwa Atomu Yambiri 29
Kulipira Kwachibadwa 0
Chimanga ndi Canonicalized N'zoona
XLogP3-AA 9.8
Misa Yeniyeni 401.293 g / mol
Misa ya Monoisotopic 401.293 g / mol
Malo otchedwa Topological Polar Area 47.9 A ^ 2
Kuvuta 477
Chiwerengero Chogwirizana Chogwirizana 16
Chiwerengero Chovomerezeka cha Hydrogeni 4
Hydrogen Bond Donor Count 0
Kulemera kwa maselo 401.591 Mol

3. Ndemanga Yosavuta Tsamba la ufaaasraw

Cetilistat ndi mankhwala ovomerezeka omwe amapangidwa kuti athandize anthu olemera kukhala olemera. Amagwiritsidwa ntchito ndi benzozaxines, omwe ali ndi mankhwala omwe ali ndi benzene kuphatikizapo mphete ya oxizine. Mzere wa oxizine kwenikweni ndi mzere wa XMUMX wa aliphatic ring ndi 6 nayitrogeni atomu, atomu ya 1 oksijeni, ndi ma atomu a carbon 1.

Zofufuza zokhudzana ndi mayesero a anthu zakhazikitsa kuti cetilistat imagwira ntchito mofananamo ndi Orlistat (Xenical). Izi kuwonda Mankhwalawa amachepetsanso pancreatic lipase, yomwe imayambitsa triglycerides m'matumbo. Kupezeka kwa mavitaminiwa kumathandiza kuti hydrolization ya triglycerides ikhale yopanda mafuta. Izi zimathandiza kuti triglycerides ikhale yosakanizidwa.

4. Njira Yogwira Ntchito ya Cetilistat ufaaasraw

Monga ngati Orlistat, Cetilistat ndi lipase inhibitor, zomwe zikutanthauza kuti zimagwira ntchito m'mimba kuti zichepetsedwe, zomwe ndizo zowonongeka kwa mafuta odya. Kutha kumathandiza kuchepetsa kuwonongeka ndi kuyamwa kwa mafuta odya m'matumbo, mankhwalawa amathandiza kuchepetsa zakudya ndi mafuta, motero amathandiza kulemera.

5. Ntchito ya Cetilistat aasraw

Mndandanda wa mayesero a Phase II watsimikizira kuti Cetilistat ndi yothandiza ndi chitetezo. Mu mayesero amodzi omwe amatha masabata a 12 komanso odwala matenda a shuga a 612, ofufuza adapeza kuti odwala omwe amagwiritsa ntchito ma XMUMX milligrams ndi 80 milligrams a Cetilistat anali olemera kwambiri, omwe amatha kutaya makilogalamu a 120 ndi ma 3.85 kilogalamuyi. Izi ndi poyerekeza ndi makilogalamu a 4.32 omwe anatayika ndi odwala omwe anatenga placebo.

Cetilistat sikuti imangopeza madigiri olemera enieni monga Orlistat, koma zowawa zonse zolemetsa zasonyezeranso kuti zimapangitsa kuchepa kwapadera kwa HbA1c.

Kumayambiriro kwa phunziro limodzi, odwala anali ndi chiwerengero cha thupi pakati pa 28 ndi 45 ndipo anapatsidwa metformin kuti athetse matenda a shuga. Ngakhale odwala omwe adatenga mcherewo atayika kwambiri ngati omwe adatenga Orlistat, gulu lachilistat linalekerera mankhwalawa bwino kwambiri. Pamapeto pa mayesero, zinakhazikitsidwa kuti zonse zolekerera ndi zotsatira za chitetezo cha mchere zimakhala zogwirizana ndi zomwe zinayesedwa m'mayesero ambuyomu.

Zotsatira za kuchotsedwa mwamsanga chifukwa cha zochitika zovuta zinali 2.5 peresenti, 5.0 peresenti ndi 2.5 peresenti ya cetilistat 120 milligrams, 80 milligrams ndi 40 milligrams motsatira. Izi ndi poyerekeza ndi peresenti ya 11.6 ya% ya Orlistat ndi 6.4 ya placebo. Chifukwa chachikulu cha ntchito zachipatala zochepa za Orlistat ndi zotsatira zovuta za mankhwala m'mimba.

Mafunso a 8 kuti mudzifunse musanatenge ufa wa Cetilistat

6. Tsamba la ufa aasraw

Nthaŵi zambiri, madokotala amapereka mlingo wa cetilistat kuchokera ku 60 milligrams mpaka 100 milligrams. Muyenera kutenga mankhwalawa monga momwe dokotala wanu wakuuzani, ndipo musapitirire mlingo pokhapokha mutapatsidwa uphungu.

Ngati mukugwiritsa ntchito levothyroxine kapena cyclosporine, onetsetsani kuti mumamwa ma ARV 4-5 maola musanayambe kapena mutatenga mankhwalawa.

7. Zotsatira zoyipa za Cetilistataasraw

Monga ndi ambiri (ngati si onse) kuwonda mankhwala, mankhwalawa amakhala ndi zotsatira zina. Zotsatira zofanana zomwe zimakhalapo zimaphatikizapo (koma sizingatheke):

  • kutsekula
  • Flatulence
  • Mphuno ya m'mimba kapena ululu
  • Mafuta muchitetezo
  • Oily spotting
  • Flatus ndi kutaya
  • Kutha kusadziletsa
  • Sopo

Ngati mukumva zotsatira zina mutatha kugwiritsa ntchito cetilistat, ndikofunikira kupeza chithandizo mwamsanga.

8. Zilonda za Cetilistat

Malangizo a 8.1 yosungirakoaasraw

  • Sungani mapiritsi a puloteni kutentha kutentha.
  • Awasunge kutali ndi kuwala kowonekera kapena kutentha.
  • Musati muunditse mapiritsi ophimba.
  • Khalani kutali ndi ziweto ndi ana.
  • Musamatsanulire mapiritsi otsekemera mu ngalande kapena kuwatsitsa pansi pa chimbudzi.

Kuti mudziwe zambiri za momwe mungatulutsire mapiritsi a pulogalamuyi, mutsimikizireni kuti mufunsane ndi wamisiri wanu kapena dokotala.

8.2 Zomwe mungachite Muzochitika Mukusowa Mliriaasraw

Munasowa mlingo? Tengani mwamsanga mukakumbukira. Ngati ili pafupi nthawi yanu yotsatira, yesani mlingo wanu womwe umasowa ndipo mutenge gawo lotsatira. Musatenge mlingo wochulukirapo kuti mupange osowa. Pambuyo pa mlingo wotsatira, tangoyambiraninso mlingo wanu wa mlingo monga mwachizolowezi.

Mwina mukudabwa - chimachitika ndi chiyani ngati ndikusowa mlingo? Chabwino, kusowa kwa mlingo kungachepetse mphamvu ya mankhwala ndikulepheretsa kulemera kwa kulemera kwanu. Kupanda mlingo panthawi ya kuchipatala kumachepetsa mphamvu ya mankhwala. Odwala ena amatha kusonyeza zizindikiro zoyambirira ngati akusowa nthawi zambiri.

Zotsatirazi ndi zothandiza zomwe zingakuthandizeni kuti musasowe mlingo wanu:

  • Konzani ndondomeko, mwachitsanzo, sankhani nthawi yeniyeni yomwe mutenga mlingo wanu. Onetsetsani kuti musinthe ndondomeko yanu ya mlingo kuti mukhale osangalala.
  • Ngati mukuvutika kukumbukira kutenga mlingo wanu, khalani ndi alamu kapena chikumbutso pafoni yanu kapena penyani.
  • Funsani mamembala anu kuti akukumbutseni.

8.3 N'chiyani Chimachitika Mukamangogonjetsa? Tsamba la ufaaasraw

Ngati simukukwaniritsa zotsatira zomwe mukuziyembekezera, musaganize za kumwa mankhwala ochulukirapo kuti muthamangitse ndondomekoyi. Izi ziri choncho, ngakhale mutatenga mankhwalawa mochulukirapo kapena mufupikitsa kusiyana ndi momwe mwauzidwira, simungataye kulemera kwambiri, kapena kutaya thupi mwamsanga. M'malo mwake, mungadye mopitirira muyeso pa mankhwala ndikukumana ndi zovuta zina zomwe zingayambitse imfa.

Ngati mutagwiritsa ntchito mankhwala owonjezera, funsani kuchipatala chapafupi kapena kuchipatala. Ndikofunikira kuti mubweretse chizindikiro, chidebe, kapena bokosi limodzi ndi inu kuti madotolo athe kupeza zambiri zofunika zokhudza mankhwalawa.

Musanagwiritse ntchito Cetilistat, ndibwino kuti mufunsane ndi wamankhwala wanu kapena dokotala za mankhwalawa ndi momwe mungatetezere. Mofanana ndi mankhwala ena ambiri, Cetilistat sayenera kugawidwa. Izi zikutanthauza kuti musapereke mapiritsi anu oyenera kuti mukhale nawo, ngakhale ngati ali ndi vuto lomweli. Ichi ndi chifukwa chakuti mlingo woyenera ukhoza kukhala wotetezeka kwa iwe, koma ukhoza kukhala mopitirira muyeso kwa wina.

Kugwiritsira ntchito 8.4 anaaasraw

Izi siziyenera kutengedwa ndi ana chifukwa zingathe kuchepetsa kukula kwawo. Choncho, ndibwino kuchepetsa mankhwala mpaka zaka 18 kapena mpaka kukula kukutha.

  • Gwiritsani ntchito pa ana

Ana, makamaka pa nthawi ya kutha msinkhu, samalimbikitsidwa kugwiritsa ntchito mankhwalawa chifukwa akhoza kukhala ndi zotsatirapo pa msinkhu wawo ndi kukula. Chithandizo, ngati sichikutulutsa zotsatira, chingachedweke kufikira kukula kwatha. [

  • Kutsiliza

Kafukufuku wasonyeza kuti Cetilistat ufa ndi wolimba kwambiri popanga chiwerengero chokwanira komanso kuchipatala kuwonda mu olemera kwambiri komanso olemera kwambiri. Kuwonjezera pa kuchepetsa kulemera, odwala omwe ali ndi matenda ena obwera chifukwa cha kunenepa kwamtundu wa mimba amakhalanso ndi kusintha kwakukulu.

  • Zothandizira

Yamada Y, Kato T, Ogino H, Ashina S, Kato K: Cetilistat powder (ATL-962), buku la pancreatic lipase inhibitor, limapangitsa kuti thupi likhale lolemera komanso limapangitsa kuti phokoso likhale lopweteka. Horm Metab Res. 2008 Aug; 40 (8): 539-43. yesani: 10.1055 / s-2008-1076699. Epub 2008 May 21.

P Kopelman, Bryson, R Hickling, A Rissanen, S Rossner, S Toubro & P Valensi Magazini Yadziko Lonse Okhutira buku 31, masamba 494-499 (2007


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