Chilichonse chokhudza Cortexolone 17A-propionate ufa

1.Chifukwa Chotani Chosowa Kwachisoni?
2.Kodi mankhwala osowa Khungu?
3.Kodi Cortexolone 17A-propionate ndi yotani?
4.ndi kusiyana kotani pakati pa RU58841 ndi CB-03-01?
5.Kodi Mungagule Kortexolone 17A-propionate powder?
Wopatsa 6.17α-propionate wophika ufa



Cortexolone 17α-propionate ufa Anthu oyambirira:

Name: Cortexolone 17α-propionate ufa
CAS: 19608-29-8
Makhalidwe a Maselo: C24H34O5
Kulemera kwa maselo: 402.52
Melt Point:
Kusungirako nyengo: Kutentha kwa Chipinda
mtundu; Yoyera mpaka woyera-ufa ufa


1.Chifukwa Chotani Chosowa Kwachisoni?aasraw

Mimba ya amuna, yotchedwa alorogenic androgenic alopecia, imakhudza kwambiri chiwerengero cha amuna komanso akazi ambiri. Mkhalidwe umenewu, zomwe zimayambitsa mitundu ya majeremusi zimapangitsa kuti tsitsi lopweteka pamutu likhale lodziwika bwino ndi kukhalapo kwa hormone yotchedwa dihydrotestosterone (DHT). An enzyme yotchedwa 5-alpha-reductase imatembenuza testosterone kukhala DHT. DHT kenako imamangiriza ndi androgen receptors mu follicles tsitsi. Pambuyo pake, tsitsi la DHT limapangitsa kuti tsitsili likhale ndi nthawi yambiri yopuma m'malo molima tsitsi, ndipo patapita nthaŵi, follicle imayamba kuyenda pang'ono pang'onopang'ono, ndipo pamapeto pake imabweretsa tsitsi lochepa chabe lotchedwa vellum.

Ofufuzira ambiri apeza kuti mavitaminiwa a androgen ali ndi zolinga zabwino pochiza alopecia androgenic. Ngati atrogen obwera m'matumbo amatha kutsekedwa kapena olumala, ndiye kuti DHT sichikhoza kuwonetsa tsitsi la tsitsi. Komabe, kayendedwe kake ka mankhwala a androgen receptor blockers, monga mankhwala ogwiritsira ntchito kansa ya prostate, amachititsa mavuto aakulu kwambiri. Popeza kutayirira kumakhudza khungu, lomwe limapezeka mosavuta, limakhala lopangidwa ndi mavitamini ovomerezeka ndi atrogen receptor blocker. Akatswiri ofufuza kale atulukira mamolekyu omwe amachititsa chimodzimodzi.

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2.Kodi mankhwala osowa Khungu?aasraw

Sitikukayikira kuti antiandrojeni ndi imodzi mwa mankhwala othandiza kwambiri kwa amuna amphongo (androgenetic alopecia, AGA) m'chaka chino. Antiandrogens monga opaleshoni yamakono komanso osowa mankhwala otsekemera m'munsi mwa anthu ambiri omwe amagwiritsira ntchito komanso ngakhale kuwonjezera mphamvu. Komabe samathandiza aliyense ndi zotsatira zake (kusagonana, kupanikizika, ndi zina zotero) kuchepetsa ntchito yawo yofala kufalikira. Mankhwala otetezeka otetezeka, ngati atagwira ntchito bwino, angakhale owonjezera ku mankhwala omwe tikugwiritsa ntchito panopa.

Tawonapo chidwi chowonjezeka cha anti androgens zamakono m'zaka zaposachedwapa, kuphatikizapo othandizira monga opaleshoni yamakono, topical Fluridil, mitu yapamwamba RU 54481 ndi ena.

Pakadali pano palibe mankhwala otchedwa torojeni omwe amavomerezedwa ndi FDA kuti agwiritsidwe ntchito mu mwamuna wamwamuna wa AGA. Malingaliro abwino a atrojeni okwera pamwamba ayenera kukhala ndi ntchito zabwino zomwe zimangokhala khungu, osakhala ndi zotsatira zoyenerera komanso kukhala ololera.


3.Kodi Cortexolone 17A-propionate ndi yotani?aasraw

Cortexolone 17α-propionate (dzina lachitukuko CB-03-01; mayina odziwika Breezula ufa(kwa acne), Winlevi ufa(kwa androgenic alopecia)), kapena 11-deoxycortisol 17α-propionate, ndi mankhwala otchedwa steroidal antiandrogen - makamaka, omwe amatsutsana ndi a androgen - omwe ali ndi chitukuko cha Cassiopea ndi Therapical Therapeutics kuti agwiritsidwe ntchito ngati mankhwala opatsirana pogwiritsa ntchito mankhwala a torogen kuphatikizapo acne vulgaris ndi alojeni a androgenic (kutayika tsitsi kwa amuna) . Ndi C17A propionate ester ya 11-deoxycortisol (cortexolone); C17α esters ya 11-deoxycortisol anapeza mwadzidzidzi kukhala ndi antiandrogen, ndi cortexolone 17α-propionate CAS 19608-29-8 anasankhidwa kuti apange chitukuko pogwiritsa ntchito mankhwala ake abwino kwambiri.

Mu makoswe, mankhwalawa akupezeka kuti ali ndi ntchito yowonongeka ya antiandrogen, koma osagwiritsidwa ntchito mosagwiritsa ntchito mankhwala ophera antiandrogen pamene akugwiritsidwa ntchito pogwiritsa ntchito jekeseni wa subcutaneous. Kuwonjezera apo, cortexolone 17α-propionate sizowonjezereka, posonyeza kuti imasankha mwachindunji.Pamalo osokoneza bongo, chidziwitso cha mankhwalawa chinali chachikulu kuposa cha progesterone, flutamide, ndi finasteride ndipo chinali chofanana ndi cyproterone acetate.

Mlandu woyendetsa galimoto ku 2011 wa amuna omwe amachititsa khungu la cortexolone 17α-propionate 1% kirimu cha acne anapeza kuti mankhwalawa amalekerera kwambiri ndipo amachepetsa kwambiri zizindikiro za acne. Komanso, mphamvu yake inali yaikulu kwambiri kuposa yowonjezereka, tretinoin 0.05% kirimu. Malingana ndi 2017, mankhwalawa ali mu gawo lachitatu la ma ARV chifukwa cha acne vulgaris ndi mayesero a chigawo chachiwiri cha mankhwala a alogenic androgenic alopecia.

CB-03-01 ndi mankhwala omwe amatsutsana ndi androgen omwe amavomerezedwa ndi Cosmo ndipo amafufuzidwa pansi pa dzina lakuti Breezula. Ndi wotsutsa wa androgen wolandira m'malo molepheretsa 5 alpha reductase. Zili bwino kulowa pakhungu. Kafukufuku akuyang'anitsitsa ngati mankhwalawa ali ndi phindu loyendetsa mamuna kapena ayi. Kwenikweni, phunziro la masabata a 26 ndi Intreprid tsopano likuyesa kuyerekeza 5% CB-03-01 ku 5% minoxidil ndi placebo. Zidzakhalanso zosangalatsa kuona ngati CB-03-01 ili ndi phindu lililonse ndipo ngati likutero, likuyerekezera bwanji ndi minoxidil.

Pakalipano, pali maphunziro awiri okha ofalitsidwa mu mabuku azachipatala a CB-03-01. Kotero ife tiri ndi chidziwitso chochepa pa mankhwala. Zikuwoneka kuti CB-03-01 imagwiritsidwa ntchito mofulumira kwambiri ku cortexolone yomwe ilibe ntchito yotsutsa a androgen. Chachiwiri, zikuwoneka kuti CB-03-01 ili ndi zotsatira zotsutsana ndi zotupa zomwe zingakhale zofunikira pochiza AGA yomwe imadziwika kuti ikuwotcha nthawi zambiri. Kafukufuku wa makoswe ndi akalulu amasonyeza kuti si mutagenic. Zofufuza mwa anthu siziwonetsa zochitika zazikulu zovuta.

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4.Topical hair loss treatments: ndi kusiyana kotani pakati pa RU58841 ndi CB-03-01?aasraw

  • RU58841

RU58841 ndi blokosi la androgen yolandira yomwe idapezeka koyamba mu 1990s oyambirira, ndipo yayiphunziridwa kwambiri mu zinyama. Pogwiritsidwa ntchito pamutu, zimakhala zothandiza kwambiri pakulepheretsa kupititsa patsogolo komanso kumathandizanso kuti tsitsi liwonjezeke. Palibe zotsatira zowonongeka zomwe zapezeka mimbulu zothandizidwa pamutu ndi RU58841. Komabe, chifukwa cha zinthu zosagwirizana ndi RU58841 zokha, sizinayendepo poyesa njira zowonetsera anthu kuti izivomerezedwe ndi FDA ndi mabungwe ena olamulira kuti azigulitsidwa ngati mankhwala oweta. Zilipo kuti zigulitsidwe monga mankhwala ofufuza, ndipo anthu ambiri akhala akugwiritsa ntchito mankhwalawa kuti azisamalira maola makumi angapo apitawo. Zimanenedwa kukhala zothandiza kwambiri kuimitsa tsitsi la tsitsi ndi zotsatira zochepa. Anthu ochepa amavomereza kuti amachititsa kuti tsitsi liwonjezeke.

  • Cortexolone 17 Alpha-Propionate, kapena "CB-03-01"

CB-03-01 ndi blolo lovomerezeka ndi androgen yoyamba kupezeka mu 2000s. Kuphunzira koyambirira kwa zitsanzo za zinyama zapeza kuti zikhoza kulepheretsa ovomerezeka ndi atrogen pakagwiritsidwe ntchito pamutu koma osaperekedwa. Kulephera kwake ntchito pakagwiritsidwe ntchito kumatanthawuza kuti sikunapangitse zotsatira zowononga ndi androgenic mu makoswe omwe amajambulidwa ndi mankhwala. Kukhoza kwake kutseka ntchito ya torogen yapamwamba inafotokozedwa ndi ofufuza oyambirira ngati pafupifupi katatu kwambiri kuposa flutamide. Chowonadi chakuti chiribe chotsutsana ndi-androgenic ntchito pakagwiritsidwe ntchito ndi mwina chifukwa chakuti mutatha kulowa mthupi, nthawi yomweyo imangokhala ndi mawonekedwe osakanikirana.

  • Kuyerekezera Mphamvu

Kafukufuku oyambirira wa RU588541 nayenso anayerekezera mphamvu zake ndi zina zotchedwa androgen receptor blockers, monga flutamide, nilutamide, ndi bicalutamide. Pogwidwa ndondomeko, RU58841 imakhala ndi zotsatira zoyipa zofanana ndi zonse zam'mimba zotsekemera za orrogen receptor. Kufufuza kwa RU58841, kunapezedwa kwambiri kuchitetezo chokwanira cha mapiritsi a androgen kuposa ochiritsira onse omwe amadziwika kale ndi androgen; Ndipotu, ochita kafukufukuwo adatsimikiza kuti ndi "antiandrogen yamphamvu kwambiri" yomwe idadziwika nthawi imeneyo (1998), mpaka nthawi ya 100 ntchito ya flutamide, yomwe imasonyeza kuti ndizowonjezera kwambiri kuposa CB-03-01.

Ngakhale kuti mabungwe awiriwa sanagwirizane mofanana, onsewa ayesedwa pamayeso ofanana ndi mankhwalawa. Hamsters ali ndi zofiira zamtengo wapatali pakhungu lawo zomwe zimayambira mahomoni amphongo. Kukhoza kwa mankhwala osokoneza bongo ndi a androgenic kuteteza chitukuko cha gland ichi chimagwiritsidwa ntchito mu laboratori. Mu kasitomala ka hamster khungu, peresenti ya 400 micrograms patsiku, CP-03-01 inali yopambana kuposa flutamide (84% vs. 55%, motero) poletsa chitukuko cha liwalo poyankha mahomoni aamuna koma chinali pang'ono zogwira mtima kwambiri kuposa cyproterone acetate (yokha 93% yotseka)

Komabe, pa mlingo wa 10 micrograms patsiku, RU58841 ikhoza kulepheretsa chitukuko cha gland ndi 60%, ndipo inapezeka kuti ndi yokongola kwambiri yowonjezera mchere wa orrogen kusiyana ndi flutamide kapena cyproterone acetate. Kuchokera mosavuta kumasonyeza kuti ndi wothandizira kwambiri kuposa CP-03-01.

  • Acne Treatment

Mosiyana ndi RU58841, yomwe ikuwoneka kuti yanyansidwa ndi makampani ogulitsa mankhwala, CB-03-01 ikuphunzira mwakhama, makamaka ngati chithandizo cha acne. CB-03-01 imapangidwa ndi Cosmo Pharmaceuticals, kampani ya ku Italy. Kampaniyo inavomereza mankhwala ku Medicis ku 2012 kwa chitukuko ku US. Maphunziro oyambirira a mankhwala monga mankhwala osowa tsitsi amasowa njira yapadera yoperekera mankhwala kumapulo a tsitsi pogwiritsa ntchito magetsi (iontophoresis), koma kamodzi kamatulutsidwa, izo zimawoneka kukhala zothandiza kwambiri pakuthana tsitsi. Komabe, odwala ochepa adzakhala okonzeka kuchitidwa kangapo pa sabata kwa iontophoresis.

Kafukufukuyu anafufuza momwe CB-03-01 imathandizira amuna a 40 ndi a androgenetic alopecia grade 1-4 malinga ndi msinkhu wa Hamilton, ndi akazi a 30 omwe amatha kupha amayi omwe ali ndi grade androgenetic alopecia grade 1 malinga ndi chiwerengero cha Ludwig.

Kuwonetsedwa kwa Cosmo mu 2013 kumasonyeza kuti mwina athetsa vutoli. Achita mayeso a khungu, ndipo asonyeza kuti 5% yankho la mankhwala mu kirimu chapadera chothandizira amatha kulowa mkati mwazithunzi za tsitsi. Ayeneranso kuchita mayeso oopsa komanso okhumudwitsa nkhumba. Ndemanga ya 2013 inati iwo ayamba kuyamba maphunziro mwa anthu odzipereka. Lipoti laposachedwapa la kampanilo linasonyeza kuti zotsatira za mayesero oyerekeza ndi minodoxil mu odzipereka a 120 adzakhalapo kumapeto kwa 2015.

Ngakhale kuti RU58841 ndi CB-03-01 zilipo kuti zigulitsidwe ngati mankhwala ofufuza ogwiritsira ntchito, zimakhala zovuta kwa wogula yekhayo "kuyesa" CB-03-01 kunyumba. Mosiyana ndi RU58841, yomwe imatha kusungunuka mowa kapena othandizira mosavuta, CB-03-01 imafunika kukonzekera mu kirimu chapadera chothandizira kuti chilowetse minofu ya tsitsi. Chifukwa chake, chifukwa palibe maphunziro a Cosmo onena za tsitsi omwe amafalitsidwa monga amodzi, ndipo palibe amene adatha "kuyesa" CB-03-01 kunyumba, sizikudziwika bwino momwe zilili ndi RU58841 pochizira. CB-03-01 ikuwoneka kuti ili ndi theka laling'ono kwambiri kuposa RU58841, ndipo ikhoza kukhala yochepetsetsa yochepa ya mapulogalamu a androgen. Pogwiritsidwa ntchito pamutu, palibe mankhwala omwe ayenera kusonyeza zotsatira zake.

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5.Kodi Mungagule Kortexolone 17A-propionate powder?aasraw

Ndi zophweka Gulani ufa wa Cortexolone 17α-propionate. Intaneti imadziwika ngati njira yofulumira kwambiri komanso yothetsera kugula zinthu monga CB-03-01 CAS 19608-29-8. Mukupatsidwa zinthu zosiyanasiyana zomwe mungagule. Chowonjezerapo ndicho, mudzapatsidwa mphotho ya galama iliyonse yomwe mumagula. Ngakhale ndalama zowonjezera ndalama zimaperekedwa. Koma kuti muganizire ogulitsa pa intaneti, muyenera kukhala osamala. Ziribe kanthu mtengo wotsika mtengo pa gramu, womwe umasangalatsa maso anu, uyenera kuyang'aniridwa bwino. Kwa ichi, muyenera kudziwa maziko a wogulitsa woyamba musanapereke chikhulupiliro chanu.


6.Phindu la Gulani ufa wa Cortexolone 17α-propionate kuchokera ku AAS Cortexolone 17α-propionate ufa perekani:aasraw

1.Pamwamba kwambiri ndi Mtengo wokakamiza:
1) Chiyero:> 99%
2) Ndife opanga ndipo tingapereke mankhwala apamwamba ndi mtengo wa fakitale.

2.Fast ndi Safe Delivery:
1) Chigawo chingatumizedwe mu maola a 24 mutatha kulipira. Nambala yofufuzira ikupezeka
2) Kutumiza kotetezeka. Njira zosiyanasiyana zoyendetsera zosankha zanu.

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3.Tili ndi Otsatsa Padziko Lonse:
1) Utumiki wamaluso ndi zochitika zamtengo wapatali zimapangitsa makasitomala kumverera momasuka, katundu wokwanira ndi kubweretsa mwamsanga kukumana ndi chikhumbo chawo.
2) Malingaliro a msika ndi katundu wa malonda adzayamikiridwa, kukambirana kwa makasitomala ndi udindo wathu.
3) Makhalidwe apamwamba, mtengo wapikisano, kubwereza kwachangu, utumiki wapamwamba akupeza kukhulupilira ndi kutamanda kuchokera kwa makasitomala.

4.Three Mfundo:
1) Kupereka kosavuta: Chingwe chosiyana, chitetezo chachinsinsi cha makasitomala.Ndipo ngati, onetsetsani kuti mutumize.
2) Sindinasinthe: Zopangidwazo nthawi zonse zimakhalabe zangwiro, sizidzasintha, Mapamwamba ndi chikhalidwe cha kampani yathu.
3) Utumiki wabwino: Mwamsanga kuthetsa mavuto a makasitomala, kotero kuti makasitomala alandire katunduyo bwinobwino.


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