Kafukufuku wa matenda a Alzheimer's adakopetsa ena a maganizo abwino kwambiri pa kafukufuku wa zachipatala m'zaka zapitazo za 20. Ngakhale kuti ofufuza aphunzira zambiri zokhudza matenda, matenda ake, ndi zomwe zimayambitsa, pangakhale pang'ono pang'onopang'ono zomwe zasintha polimbana ndi matendawa.

Gulu lotsatira mankhwala oyesera J147 (1146963-51-0) adaganiza zosiyana. Zotsatira zake zakhala zodabwitsa, ndipo ofufuza akupitiriza kuphunzira momwe mankhwala atsopanowa amagwirizanirana ndi maselo osiyanasiyana a thupi.


Kodi J147?

J147 ndi ufa wa nootropics woyamba wopangidwa mu 2011. Ochita kafukufuku apeza kuti mankhwalawa, pamaphunziro angapo osiyanasiyana, amatha kusokoneza kukumbukira kukumbukira ndi kupepuka, kapenanso kusinthika, ku Alzheimer's.

J147 ufa ndi phenyl hydrazide. Icho chimachokera ku curcumin yamagulu a zonunkhira. Ndizochepa poizoni. Ngakhale kuti pali mavuto ena oyambirira, ufa wa J147 sunakhale wosonyeza kuti ndi wakufa. Ochita kafukufuku anayesera kuti izi zitheke pofufuza metabolites a J147 mu microsomes yaumunthu ndi a mouse ndi mouse ya plasma.

Zotsatira zinawonetsa kuti J147 siyiyi yopangidwa ndi minofu yambiri yamadzimadzi kapena hydrazines.


Njira Zolimbana ndi Nkhondo ya Alzheimer's

Mankhwala ambiri omwe amapangidwa m'zaka zapitazi za 20 akhala akugwiritsidwa ntchito pamapangidwe a amyloid m'maganizo a odwala a Alzheimers. Njira imeneyi imapanga nzeru chifukwa izi ndizo zimapangitsa maselo a mitsempha kuti afe.

Komabe, patapita zaka 20 sipanakhalepo phindu lalikulu mu mayesero a zamankhwala ndi mankhwala alionse omwe akugwiritsira ntchito chipikacho.

Njira yowonjezereka yakhala ikuyesera kulumikiza amyloid isanayambe kupanga mapepala. Nyama yamadzi ija imapha maselo asanagwiritsidwe ntchito. Komabe, ngakhale kuyimilira koyambirira kumeneku sikungakhale kogwira ntchito.

Mpaka chitukuko cha J147 (1146963-51-0), chithandizo chenichenicho cha Alzheimer chinali choyimira. Panalibe njira iliyonse yoyenera kutsogolo ndi mankhwala alionse amene anapangidwa m'zaka zapitazi za 20 ndipo matenda a matendawa sanagwiritse ntchito njira zina zoonekera.


Momwe J147 (1146963-51-0) Imagwira Ntchito Yotsutsa Alzheimer's

Gulu lotsatira J147 linasankha kuchita zinthu mwanzeru polimbana ndi Alzheimer's. M'malo mowonjezeranso mankhwala ena omwe amamenyana ndi amyloid, gululo linaganiza zoganizira za chiopsezo chachikulu cha Alzheimer's. Chinthu chachikulu chomwe chimayambitsa matenda ndi ukalamba-choncho gululo linayesayesa njira zotsutsa ukalamba.

Gulu linapanga J147 pogwiritsira ntchito selo-based screens motsutsana ndi toxicities zakale za ubongo. Kuchokera pawotchiyi, iwo amapanga ufa wa J147.

J147 ufa umagwira ntchito pochepetsa ntchito ya ATP synthase mu mitochondria. Izi zimatetezera maselo a neuronal kuchokera ku ziwalo zambiri zolimbana ndi ubongo. Kafukufuku wasonyeza chifukwa chake mankhwalawa amapanga zotsatirazi zokhudzana ndi ubongo chifukwa cha zomwe zimachititsa kuti maselo ena asokonezeke.

Neuroni amaonongeka ndipo amafa ndi kuwonjezereka kwa obvomerezeka kwa opatsa mphamvu ya neurotransmitter glutamate. J147 kwenikweni imachepetsa njira zomwe ubongo wina wokalamba wautali umayendera. Izi zimasungira neurons ndipo, mochititsa chidwi kwambiri, zingayambitsenso kusinthidwa kwa zina zotchuka za Alzheimer's.


J147 Ntchito ngati Agwila Okalamba

Mankhwala a J147 sali ofanana ndi mankhwala ena a Alzheimer omwe afikira panthawi yofanana yofufuza. Chifukwa sichimalingalira za matenda a chikhalidwe, koma zimagwira ntchito zochepetsera zoopsa zomwe zimachitika chifukwa cha ukalamba.

J147 imagwira ntchito ngati anti-aging agent. Kuchokera kumagulu awo, ubongo waumunthu umapangika poizoni zina. Ndizoopsa zokhudzana ndi zaka izi zomwe zimapangitsa chilengedwe cha Alzheimer kuti chikule. J147 imabwerera nthawi yowononga poizoni, ndipo izi zimapangitsa kuti Alzheimer azivutika kugwira ntchito yake yowonongeka machitidwe osiyanasiyana.

N'zosakayikitsa kuti njira yochita upainiya ndi J147 idzakhala yopindulitsa kwambiri kuposa kungomenyana ndi Alzheimer's. Otsutsana ndi okalamba omwe amatha kusokoneza matenda ena omwe amachititsa matenda ena ndi matenda omwe ali ndi zaka zambiri. J147 si mankhwala okhaokha a Alzheimers. Ndi mankhwala enieni omwe amathandiza kuchepetsa ukalamba wokha.


J147 chipatala Mayesero

Ngakhale kuti J147 inakhazikitsidwa koyambirira mu 2011, tsopano ikuyandikira kuvomerezedwa kwa mayesero akuluakulu a zachipatala. Pa sitepe iliyonse, J147 yasonyezedwa kuti ikugwira ntchito mopambana, koma inasonyezedwanso kukhala yosasunthika.

Zovuta zoyambirira zokhudzana ndi kuti mwina J147 ndi khansa, kapena kuti poizoni, zasonyezedwa kuti ziribe maziko.

Ochita kafukufuku akufunitsitsa kuti mayesero a chipatala apitirire ndipo pafupifupi aliyense wochita kafukufuku wa Alzheimer akuyembekeza kuti J147 idzakhala yogwira mtima kwa anthu monga momwe zinalili ndi mbewa komanso ma laboratory.


Zotsatira zoyambira J147

Oyambirira kwa ofufuza anapeza kuti J147 (1146963-51-0) amalepheretsa, ndikusintha, kukumbukira kukumbukira m'magulu omwe ali ndi alzheimer's. Komabe, monga chiyembekezo kuti zotsatira zake zinali, mwa anthu, zokhudzana ndi 1% ya odwala a Alzheimer ali ndi maulendo obadwa nawo. Mtundu wambiri wa Alzheimer's sagwirizana ndi mtundu wina wa ma genetic, koma ukalamba wokha.

Gululo kuposa kuphunzira zotsatira za J147 pa gulu la mbewa zomwe zimakula mofulumira ndipo zimakhala ndi mtundu wa matenda a dementia omwe ali ofanana ndi a Alzheimer omwe amapezeka m'badwo.

Zotsatira za phunziro lachiwirili zinalonjezeranso. J147 inatha kupulumutsa zoperewera za chidziwitso, ngakhale pamene zinkaperekedwa kumapeto kwa matendawa. Ikumasunga kukumbukira mu mbewa ndikulepheretsa kuwonongeka kwina.

Anapezanso kuti pamene J147 inagwirizanitsidwa ndi repepezil itagwira ntchito bwino kubwezeretsa chikumbukiro cha mthunzi ndi chithunzithunzi. Koma, J147 yekha ndiye wamkulu pakubwezeretsa kukumbukira malo.


Zimene Zidzakhala M'tsogolo J147 (1146963-51-0)

Padakali msewu wautali pamaso pa J147 (1146963-51-0) adzakhalapo kuti athetse odwala ambiri a Alzheimer. Choyamba mankhwalawa ayenera kumaliza chiyeso choyesa kuchipatala. Pamene mayesero a zachipatala akhala akuyendera ndondomeko, njira yovomerezeka ya FDA idzayamba.

Ochita kafukufuku akumbukira kuti pakufunikira thandizo lachangu la matenda a Alzheimer, komabe akudzipereka kuti asafulumire sayansi. Pakalipano, zotsatira zonse za J147 zili zabwino kwambiri ndipo palibe mankhwala ena a Alzheimer omwe adayang'anapo mpaka pano.


Zambiri zokhudza J147:

Kuyeza Mankhwala Osakaniza J147 Alzheimer Kukalamba | AASraw


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