Chilichonse chokhudza Mibolerone (Fufuzani madontho)

  1.Chiani IDFP (615250-02-7)
  2.Kodi IDFP (615250-02-7) imagwira ntchito bwanji?
  3.IDFP (615250-02-7) zotsatira
  Mlingo wa 4.IDFP (615250-02-7)
  5. Chenjezo la IDFP (615250-02-7)
  6.IDFP (615250-02-7) ndemanga


Video ya IDFP


I.IDFP Anthu oyambirira:

Name: IDFP
CAS: 615250-02-7
Makhalidwe a Maselo: C15H32FO2P
Kulemera kwa maselo: 294.391
Melt Point:
Kusungirako nyengo: -20 ° C
mtundu;


1. Kodi IDFP (615250-02-7) ndi chiyani?aasraw

IDFP(615250-02-7), ndi gulu la organophosphorus lokhudzana ndi wothandizira mitsempha. Dzina la mankhwalawa ndi: IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID; 1- [fluoro (propan-2-yloxy) phosphoryl] dodecane.

IDFP (615250-02-7) Kufotokozera Zachilengedwe
dzina IDPF, ISOPROPYL DODECYLFLUOROPHOSPHONATE
CAS 615250-02-7
Molecular Formula C15H32FO2PIDFP (615250-02-7)
Kulemera kwa maselo 294.391
yosungirako aganyu -20 ° C
Kusankha IDFP ndi chigawo cha organophosphorus chogwirizana ndi wothandizira mitsempha. Mofanana ndi sarin, IDFP ndi inhibitor yosasinthika kwa michere yambiri yosiyanasiyana yomwe imathandiza kuthetsa ziwalo za m'mimba
Maonekedwe Mphala wambiri
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2. Kodi IDFP (615250-02-7) imagwira ntchito bwanji?aasraw

Matendawa, 2-arachidonoyl glycerol (2-AG) ndi arachidonoyl ethanolamide (AEA), amakhala ndi lipids omwe amachititsa kuti mitundu yambiri yambiri imagwiritsidwe ntchito poyambitsa matendawa. Monoacylglycerol lipase (MAGL) ndi mafuta a asidi amide hydrolase (FAAH) hydrolyze 1-AG ndi AEA, motero amathetsa chilengedwe chawo. IDFP (2-2-615250) ndi mbali ya organophosphorus yomwe imalepheretsa MAGL ndi FAAH kukhala ndi IC02 mikhalidwe ya 7 ndi 50 nM, motero.0.8 Pa 3 mg / kg, IDFP imapanga ubongo wa 1-AG ndi AEA kuposa 10- khola, ndipo amachepetse chiwerengero cha arakidonic acid ndi kukula kwake.

Chakudya cha IDFP chakuda (615250-02-7) hplc≥98% | Nkhosa yowonjezera


3. Zotsatira za IDFP (615250-02-7)aasraw

Zotsatira za CB1 zokhudzana ndi khalidwe lachiwerewere

Kodi ndi chiyani? IDFP (615250-02-7)zotsatira? Pakati pa 5 min mutatha kuchipatala ndi IDFP (10 mg kg-1, ip), mbewa zinasintha ndipo zinkakhalabe maso. Chikhalidwe ichi chosasunthika chinali chikumbumtima cha mayankho omwe adafunsidwa ndi a CB1 agonist, omwe adatipangitsa kuti tiwone nyama za mtundu wa IDFP m'mayesero a tetrad chifukwa cha khalidwe lopweteka. IDFP inapezedwa kuti iwononge zotsatira zake zonse zoyipa zomwe zimayembekezeka kuchoka ku CB1-hypomotility, analgesia, catalepsy ndi hypothermia. Zotsatira za makhalidwewa zinali zotsekedwa ndi pretreatment ndi CB1 antpistist AM25120 ndipo analibe mu CB1 (- / -) mice21. Zotsatira izi zinkasonyeza kuti kutsekedwa kwa matenda a endocannabinoid kagayidwe ndiko kunayambitsa zotsatira za zotsatira za IDFP. Kukula kwa zotsatira zomwe zinkachitika ndi IDFP zinali zofanana ndi zomwe zimagwirizana ndi CB1 agonist, WIN55212-2 (10 mg kg-1, ip). Pogwiritsira ntchito njira yofanana ndi ubongo wong'onong'onong'ono, IDFP imapangitsa CB1 kugonist kukhazikika mkati mwa IC50 ya 2 nM17, yofanana ndi IC50 ya MAGL (0.8 nM) ndi FAAH (3 nM), ngakhale ngakhale pa 30 nM sizinayambe kwambiri (5 ± 9%, n = 6, p> 0.05) imalimbikitsa guanosine triphosphate kumangirira. Izi zikusonyeza kuti zotsatira za IDFP sizichita monga olandila molandirira agonist pazofunikira.

Zotsatira za IDFP

Kusokonezeka kwa matenda a endocannabinoid mu vivo

Zochitika za Endocannabinoid-hydrolyzing zinayesedwa m'zigawo za ubongo kuchokera ku IDFP- (10 mg kg-1, ip) ndi mbewa zothandizira galimoto. Mlingo wa mankhwalawa wa IDFP unasankhidwa kuchokera ku chiyanjano cha mayendedwe pofuna kupanga khalidwe lopanda matenda. Mayi anayi asanalandire chithandizo, hydrolysis ya 2-AG ndi anandamide inaletsedwa ndi 86 ± 1% ndi 94 ± 1%, motero, mu ziwalo za ubongo kuchokera ku nyama zochitira IDFP. Mosiyana ndi zimenezi, palibe chidziwitso cha AChE chomwe chinayanjanitsidwa ndi IDFP moyesera, mofanana ndi kusowa kwa poizoni. IDFP ndi analoji wautali wa sarin ndi dodecyl m'malo mwa methyl, kusintha komwe kumakhala kochepa kwa AChE pothibititsa potency.

Mankhwalawa amachepetsedwa m'magulu a ubongo a IDFP omwe amagwirizanitsidwa ndi oposa 10 pang'onopang'ono mu ubongo wa 2-AG ndi anandamide. Zina mwazinthu zomwe zimapangidwa m'makina a ubongo zimagwiritsidwanso ntchito muzilombo zamtundu wa IDFP, kuphatikizapo zowonjezera zina za N-acylethanolamines (NAEs) [mwachitsanzo, N-palmitoyl- ndi N-oleoylenanolamines ndi monoacylglycerols [2-na 1-palmitoylglycerol na 2- 1-oleoylglycerol]. Chochititsa chidwi, mazinga a AA adachepetsedwa ndi IDFP mu ndalama zofanana ndi zopambana zomwe zinapezeka kwa 2-AG. Deta izi zimakhazikitsa kuti IDFP ndizowononga kwambiri 2-AG ndi anandamide metabolism mu vivo, zomwe zimapangitsa kuti ubongo wapamwamba kwambiri wa mabungwe a endocannabinoids ndi kuchepa kwapakati pa ma AA omasuka.

Mlingo wa IDFP


4. Mlingo wa IDFP (615250-02-7)aasraw

Kwa nthawi yaitali yosungirako, tikupereka izi Mlingo wa IDFP zisungidwe monga -20 ℃. Iyenera kukhala yolimba kwa chaka chimodzi.
IDFP imaperekedwa monga njira yothetsera methyl acetate. Kuti musinthe zosungunulira, imwani mchere wa methyl acetate pansi pa madzi osakaniza a nitrogen ndipo nthawi yomweyo yikani zosakaniza zosankha. Mafuta monga ethanol, DMSO, ndi dimethyl formamide otsukidwa ndi mpweya wambiri angagwiritsidwe ntchito. Kutha kwa IDFP mu zotupazi ndi pafupifupi 10mg / ml.
Ngati njira zowonjezera zowonongeka zimayesedwa pa zowonongeka, zimatha kukonzekera bwino pakusungunula zowonongeka zamadzimadzi kapena zamchere zamchere kapena isotonic saline.Zitsimikiziranso kuti kuchepa kwa thupi kumakhala kosafunikira, chifukwa zowonongeka zimakhala ndi zotsatirapo za thupi panthawi yochepa. Osati kulangiza kusunga njira yamadzimadzi kwa tsiku limodzi.


5. Chenjezo la IDFP (615250-02-7)aasraw

IDFP (615250-02-7) si yokhudza ntchito za anthu kapena zamatera, machenjezo ambiri akadali kufufuza. Pewani kugwirizana kwa khungu, maso, kapu, kupuma kulikonse, pitani dokotala mwamsanga.


6. IDFP (615250-02-7) ndemangaaasraw

IDFP (615250-02-7) ndi chiwalo cha organophosphorus chogwirizana ndi wothandizira mitsempha. Monga sarin, IDFP ndi inhibitor yosasinthika kwa mitundu yambiri yamadzimadzi yomwe imathandiza kuthetsa mazembera amtunduwu, komabe chingwe cha alfine cha IDFP chimapangitsa kuti chikhale chofooka kwambiri ngati chiletso cha acetylcholinesterase (AChE), ndi IC50 ya 6300nM yokha, pomwe Imeneyi ndi inhibitor yochuluka ya michere iwiri ya monoacylglycerol lipase (MAGL), yomwe imayambitsa kuipitsa matenda a 2-arachidonoylglycerol (2-AG), ndi mafuta a acid amadzi hydrolase (FAAH), yomwe imayambitsa nyamayi yambiri yomwe imayambitsa nyamayi yambiri yam'madzi anandamide . IC50 ya IDFP ndi 0.8nM ku MAGL, ndi 3.0nM ku FAAH. Kuletsedwa kwa mavitamini awiriwa kumayambitsa kuchuluka kwa ziwalo za anandamide ndi 2-AG mu ubongo, zomwe zimapangitsa kuwonjezeka kwa maynabinoid ndikuwonetsa zotsatira za khalidwe la nyama, pomwe kusowa kwa AChE kumatanthauza kuti palibe zizindikiro zowonongeka. Zomwe zimagwiritsidwa ntchito mofanana ndi zida zoletsedwa, maulendo aatali a alangizi a IDFP amachititsa kuti zikhale kunja kwa tanthauzo la "mankhwala oopsa" pansi pa Msonkhano wa Zida Zamadzimadzi, ndipo popeza sichiwonetsanso mphamvu ya AChE yoletsa ziwalo zofanana za organophosphorus, Zizindikiro za IDFP (615250-02-7) sizimayang'aniridwa ndi malamulo omwewo.


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  • mereupregatit07 / 18 / 2018 pa 7: 43 am

    Zikomo !! ndikuyembekeza $$ yanu ikuyenda bwino! 🙂 mankhwala pa Intaneti

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