Zambiri Zotsogoza Pa Lenvatinib Za Khansa - AASraw
AASraw imapanga ufa wa Cannabidiol (CBD) ndi Hemp Mafuta Ofunika ambiri!

Lenvatinib

 

  1. Mbiri Ya Lenvatinib
  2. Kodi Lenvatinib ndi Chiyani?
  3. Njira yogwirira ntchito ya Lenvatinib
  4. Kodi Lenvatinib Amagwiritsidwira Ntchito Chiyani?
  5. Kodi Ndi Zoyipa Ziti Zomwe Ndingazindikire Mukamagwiritsa Ntchito Lenvatinib?
  6. Zotsatira Zachipatala za Lenvatinib (Kuvomerezeka kwa FDA)
  7. Kodi ndingasunge kuti Lenvatinib?
  8. Mankhwala Osokonekera: Lenvatinib Mesylate (CAS: 857890-39-2)
  9. Kodi Tingagule Kuti Lenvatinib pa intaneti?

 

Mbiri Ya Lenvatinib

Gawo lakuyesa kwachipatala kwa odwala khansa lidachitika mu 2006. [8] Kuyesedwa kwa gawo lachitatu lothandizira odwala khansa ya chithokomiro kudayamba mu Marichi 2011.

Lenvatinib adapatsidwa mankhwala amasiye kuti amuthandize mitundu yosiyanasiyana ya khansa ya chithokomiro yomwe siyankha ma radioiodine ku US ndi Japan ku 2012 komanso ku Europe ku 2013.

Mu February 2015, US FDA idavomereza lenvatinib yothandizira khansa yopita patsogolo ya radioiodine. Mu Meyi 2015, European Medicines Agency (EMA) idavomereza mankhwalawa kuti awonetsenso.

Mu Meyi 2016, a FDA adavomereza (kuphatikiza ma everolimus) kuti athe kuchiza matenda a renal cell carcinoma kutsatira mankhwala am'mbuyomu a anti-angiogenic.

Mu Ogasiti 2018, a FDA adavomereza lenvatinib kuchiza mzere woyamba wa anthu omwe ali ndi hepatocellular carcinoma (HCC) yosawerengeka.

 

Kodi N'chiyani? Lenvatinib?

Lenvatinib (CAS:417716-92-8) ndi receptor tyrosine kinase (RTK) inhibitor yomwe imalepheretsa zochitika za kinase zamavuto endothelial grow factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), ndi VEGFR3 (FLT4). Lenvatinib imaletsanso ma RTK ena omwe adakhudzidwa ndi angiogenesis ya tizilombo toyambitsa matenda, kukula kwa chotupa, komanso kupita patsogolo kwa khansa kuphatikiza magwiridwe antchito apakompyuta, kuphatikiza ma fibroblast growth factor (FGF) receptors FGFR1, 2, 3, ndi 4; platelet yotengedwa kukula factor receptor alpha (PDGFRcy), KIT, ndi RET. Ma receptor tyrosine kinases (RTKs) omwe amakhala pakhungu la cell amatenga gawo lalikulu pakukhazikitsa njira zosinthira ma siginolo zomwe zimakhudzana ndi kayendedwe kabwino ka ma cell, monga kuchuluka kwa ma cell, kusamuka, apoptosis ndi kusiyanitsa, komanso angiogenesis ya pathogenic, lymphogenesis, kukula kwa chotupa komanso kukula kwa khansa. Makamaka, VEGF yadziwika kuti ndi yofunikira pakuwongolera ma physiologic ndi pathologic angiogenesis komanso kuwonjezeka kwamawonedwe a VEGF kumalumikizidwa ndi kufooka koyipa m'mitundu yambiri ya khansa.

Lenvatinib imawonetsedwa kuti imathandizira odwala omwe ali ndi khansa ya chithokomiro yomwe imasinthidwa mobwerezabwereza kapena metastatic, progressive, radioactive iodine (RAI). Odwala ambiri omwe ali ndi khansa ya chithokomiro amakhala ndi chiyembekezo chokwanira chamankhwala (98% ya zaka 5 kupulumuka) pokhudzana ndi opaleshoni ndi mankhwala a mahomoni. Komabe, kwa odwala omwe ali ndi khansa ya chithokomiro ya RAI, zosankha zamankhwala ndizochepa ndipo matendawa samakhala bwino, zomwe zimapangitsa kuti pakhale njira zothandizirana kwambiri monga lenvatinib.

 

Lenvatinib Njira yogwirira ntchito

Lenvatinib ndi receptor tyrosine kinase (RTK) choletsa zomwe zimalepheretsa zochitika za kinase zamavuto endothelial grow factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), ndi VEGFR3 (FLT4). Lenvatinib imaletsanso ma RTK ena omwe adakhudzidwa ndi angiogenesis ya tizilombo toyambitsa matenda, kukula kwa chotupa, komanso kupita patsogolo kwa khansa kuphatikiza magwiridwe antchito apakompyuta, kuphatikiza ma fibroblast growth factor (FGF) receptors FGFR1, 2, 3, ndi 4; platelet yotengedwa kukula factor receptor alpha (PDGFRcy), KIT, ndi RET.

AASraw ndiye katswiri wopanga Lenvatinib.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Kodi N'chiyani? Lenvatinib Zogwiritsidwa Ntchito? 

❶ Lenvatinib imagwiritsidwa ntchito pochizira mtundu wina wa chithokomiro khansa yomwe yabwerera kapena yomwe yafalikira mbali zina za thupi ndipo singathe kulandira mankhwala a ayodini.

❷ Lenvatinib imagwiritsidwanso ntchito limodzi ndi everolimus (Afinitor, Zortress) kuchiza renal cell carcinoma (RCC, mtundu wa khansa womwe umayamba mu impso) mwa anthu omwe adalandirapo chithandizo ndi mankhwala ena a chemotherapy.

❸ Lenvatinib imagwiritsidwanso ntchito pochiza hepatocellular carcinoma (HCC; mtundu wa khansa ya chiwindi) yomwe singachiritsidwe ndi opaleshoni.

❹ Lenvatinib imagwiritsidwanso ntchito limodzi ndi pembrolizumab (Keytruda) kuchitira mtundu wina wa khansa ya endometrium (kuyala kwa chiberekero) komwe kwafalikira mbali zina za thupi kapena kukuipiraipira mukamalandira kapena mutalandira mankhwala a chemotherapy kapena omwe sangachiritsidwe ndi opareshoni kapena ma radiation.

Lenvatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

 

Chani Spano Ezimayambitsa May ine Nnsonga Wnkhuku Mumagwiritsa Ntchito Lenvatinib?

Zotsatira zoyipa zomwe muyenera kufotokozera dokotala wanu kapena katswiri wazachipatala posachedwa:

▪ Matupi awo sagwirizana ndi totupa pakhungu, kuyabwa kapena ming'oma, kutupa kwa nkhope, milomo, kapena lilime

▪ mavuto a kupuma

▪ kupweteka pachifuwa kapena kugundagunda

▪ chizungulire

▪ Kumva kukomoka kapena kumutu pang'ono, kugwa

▪ mutu

▪ kuthamanga kwa magazi

▪ khunyu

▪ Zizindikiro zakutuluka kwa magazi monga magazi kapena akuda, zotayira; mkodzo wofiira kapena wofiirira; kulavulira magazi kapena zinthu zofiirira zomwe zimawoneka ngati malo a khofi; mawanga ofiira pakhungu; kuvulaza kapena kutuluka mwachilendo m'diso, m'kamwa, kapena mphuno

▪ Zizindikiro zosintha kwa kugunda kwa mtima kapena kugunda kwamtima ngati kupweteka pachifuwa; chizungulire; kuthamanga kapena kusakhazikika kwamtima; kugunda; kumva kukomoka kapena mutu wopepuka, kugwa; mavuto opuma

▪ Zizindikiro zovulala ndi impso monga zovuta kudutsa mkodzo kapena kusintha kuchuluka kwa mkodzo

▪ Zizindikiro zovulala pachiwindi monga mkodzo wachikasu kapena wakuda; kudwaladwala kapena matenda onga chimfine; mipando yowala; kusowa chilakolako; nseru; ululu wam'mimba chapamwamba; ofooka kapena otopa modabwitsa; chikasu cha maso kapena khungu

▪ Zizindikiro za potaziyamu wochepa ngati kukokana kwa minofu kapena kupweteka kwa minofu; kupweteka pachifuwa; chizungulire; kumva kukomoka kapena mutu wopepuka, kugwa; kugunda; mavuto a kupuma; kapena kugunda kwamphamvu, kosasinthasintha

▪ Zizindikiro za sitiroko ngati kusintha kwa masomphenya; chisokonezo; kuyankhula molakwika kapena kumvetsetsa; kupweteka mutu; dzanzi mwadzidzidzi kapena kufooka kwa nkhope, mkono kapena mwendo; kuyenda movutikira; chizungulire; kutayika bwino kapena kulumikizana

▪ kupweteka m'mimba

▪ Kutupa kwa miyendo kapena akakolo

▪ ofooka kapena otopa modabwitsa

 

Zotsatira zoyipa zomwe nthawi zambiri sizimafuna chithandizo chamankhwala (fotokozerani dokotala wanu kapena katswiri wazachipatala ngati apitilira kapena akukuvutitsani):

▪ kutsekula m'mimba

▪ kupweteka kwa mafupa

▪ kusowa chilakolako chofuna kudya

▪ zilonda mkamwa

▪ kupweteka kwa minofu

▪ nseru, kusanza

▪ kuonda

Mndandandawu sungathe kufotokoza zovuta zonse zomwe zingachitike. Itanani dokotala wanu kuti akupatseni upangiri wa zamankhwala za zovuta zina. Mutha kunena za FDA ku 1-800-FDA-1088.

 

Lenvatinib

 

Lenvatinib Zotsatira zachipatala(Kuvomerezeka kwa FDA)

The Kuvomerezedwa ndi FDA ya Lenvatinib idayesedwa pamayeso ambiri, osasinthika, akhungu awiri, oyeserera m'malo mwa maphunziro a 392 okhala ndi ziwonetsero zobwezeretsedwera zakomweko chithokomiro khansa ndi maumboni akuwonetsa zakukula kwa matenda mkati mwa miyezi 12 isanachitike mwachisawawa, zatsimikiziridwa ndikuwunika kwawokha kwa ma radiologic. Maphunzirowa adalandira Lenvatinib 24 mg kamodzi tsiku lililonse (n = 261) kapena placebo (n = 131) mpaka matenda atakula. Zotsatira zakusanthula zidawonetsa kuti omwe amathandizidwa ndi Lenvatinib amakhala pakati pa miyezi 18.3 popanda matenda awo kupita patsogolo (kupulumuka kopanda kupita patsogolo), poyerekeza ndi azaka zapakati pa miyezi 3.6 kwaomwe adalandira malowa. Kuphatikiza apo, maphunziro 65% omwe amathandizidwa ndi Lenvatinib adawona kuchepa kwa chotupa, poyerekeza ndi 2% ya omwe adalandira malowa.

AASraw ndiye katswiri wopanga Lenvatinib.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Kodi ndingasunge kuti Lenvatinib?

Pewani ana.

Sungani pakati pa 20 ndi 25 madigiri C (68 ndi 77 madigiri F). Tayani mankhwala aliwonse omwe simunagwiritse ntchito tsiku litatha.

Dziwani: Tsamba ili ndichidule. Sitha kufotokoza zonse zomwe zingachitike. Ngati muli ndi mafunso okhudzana ndi mankhwalawa, lankhulani ndi dokotala, wazamankhwala, kapena wothandizira zaumoyo.

 

Mankhwala okhudzana: Lenvatinib Mesylate (CAS: 857890-39-2)

Lenvatinib mesylate (CAS: 857890-39-2) ndichopanga, choletsa pakamwa chotupa cha vasot endothelial grow factor receptor 2 (VEGFR2, yotchedwanso KDR / FLK-1) tyrosine kinase yomwe itha kuchititsa antineoplastic. E7080 imatseka kuyambitsa kwa VEGFR2 ndi VEGF, zomwe zimapangitsa kuti njira yoletsa njira yolandirira VEGF, ichepetse kusuntha kwamaselo endothelial cell ndikuchulukirachulukira, komanso ma cell endothelial cell apoptosis.

Lenvatinib mesylate ndi mchere wa methanesulfonate womwe umapezeka chifukwa cha lenvatinib yokhala ndi molar wofanana ndi methanesulfonic acid. Mankhwala ambiri a kinase inhibitor ndi ana amasiye omwe amagwiritsidwa ntchito (monga mesylate salt) pochiza mitundu ingapo ya khansa ya chithokomiro yomwe siyankha radioiodine. Ili ndi gawo ngati EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, fibroblast growth factor receptor antagonist, mankhwala amasiye, chotupa cha endothelial growth factor receptor antagonist ndi antineoplastic agent. Lili ndi lenvatinib (1+).

 

Lenvatinib mesylate imavomerezedwa kuti igwiritsidwe ntchito payokha kapena ndi mankhwala ena kuchiza:

♦ Endometrial carcinoma yomwe yapita patsogolo ndikuwonjezeka pambuyo pothandizira ena. Amagwiritsidwa ntchito ndi pembrolizumab mwa odwala omwe khansa si microsatellite instability-high (MSI-H) kapena vuto losakonzekera bwino (dMMR) ndipo sangachiritsidwe ndi opareshoni kapena ma radiation.

♦ Hepatocellular carcinoma (mtundu wa khansa ya chiwindi). Amagwiritsidwa ntchito ngati chithandizo choyamba cha odwala omwe matenda awo sangachotsedwe ndi opaleshoni.

Al Renal cell carcinoma (mtundu wa khansa ya impso) yomwe yapita patsogolo. Amagwiritsidwa ntchito ndi everolimus mwa odwala omwe alandila kale angiogenesis inhibitor therapy.

Cancer Khansara ya chithokomiro mwa odwala ena omwe ali ndi matenda opita patsogolo, obwereza, kapena a metastatic omwe sagwirizana ndi mankhwala a ayodini.

Kugwiritsa ntchito kumeneku kuvomerezedwa pansi pa Pulogalamu Yowonjezera Yowonjezera ya FDA. Ngati chivomerezo, mayesero ovomerezeka ayenera kuwonetsa kuti lenvatinib mesylate imapereka chithandizo chamankhwala mwa odwalawa. Lenvatinib mesylate ikuwerengedwanso pochiza mitundu ina ya khansa.

 

Kodi Tikagula Kuti? Lenvatinib pa Intaneti?

Pali ogulitsa / opanga ambiri a lenvatinib ufa pamsika, kupeza wowona ndikofunikira kwambiri kwa anthu onse omwe amafunikira izi mwachangu. Tikaganiza zogula lenvatinib powder pamsika, tiyenera kuphunzira zambiri za izo, kudziwa momwe tingagwiritsire ntchito ndi momwe amagwirira ntchito, zoopsa zilizonse tikatenga lenvatinib powder…. Kuphatikiza apo, mtengo ndi mtundu wake ziyenera kukhala nkhawa zathu tisanagule.

Titasanthula madata ochokera kumsika, poyerekeza ambiri ogulitsa, AASraw imawoneka ngati njira yabwino kwa anthu omwe akufuna kugula zambiri lenvatinib ufa, kupanga kwawo kumayang'aniridwa mosamalitsa pansi pa cGMP, mtunduwo ukhoza kutsatiridwa nthawi iliyonse ndipo atha kupereka malipoti onse oyesa mukamaitanitsa. Ponena za mtengo wa lenvatinib mtengo / mtengo, ziyenera kukhala zomveka, m'maso mwanga. Chifukwa ndili ndi mitengo yambiri kuchokera kwa ogulitsa osiyanasiyana, poyerekeza ndi mtundu, ndikuganiza kuti aasraw sikhala chisankho choyipa.
Kuti mumve zambiri, takulandirani kuti mukalankhule ndi AASraw!

 

Reference

[1] H. Erdem, C. Gündogdu, ndi S. Üipal, "Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma," Experimental and Molecular Pathology, vol. 90, ayi. 3, masamba 312–317, 2011.

[2] M. Yagi, S. Kato, Y. Kobayashi et al., "Kusankha kosalepheretsa kukula kwa platelet-factor factor (PDGF) receptor autophosphorylation komanso zochitika zama cell za PDGF zomwe zimachokera ku quinoline," Kafukufuku Woyeserera wama cell, vol. 234, ayi. 2, masamba 285–292, 1997.

[3] P. Soares, J. Lima, A. Preto et al., "Kusintha kwa chibadwa m'matenda amtundu wa chithokomiro wosiyanitsidwa bwino," Pakali pano. Chibadwa, vol. 12, ayi. 8, masamba 609-617, 2011.

[4] MM Moura, BM Cavaco, V. Leite. RAS proto-oncogene mu medullary chithokomiro carcinoma. Khansa ya Endocr Relat, 22 (5) (2015), pp. R235-R252.

[5] BR Haugen, SI Sherman Akusintha akuyandikira odwala omwe ali ndi khansa yapamtunda yodziwika bwino. Endocr Rev, 34 (3) (2013), masamba 439-455.

[6] M. Xing, D. Clark, H. Guan, ndi al. Kuyesa kusintha kwa BRAF kwa chithokomiro cha singano chokhala ndi singano yoyeserera yoyeserera poyambitsa chiopsezo cha khansa yapachilombo ya papillary. J Clin Oncol, 27 (18) (2009), masamba 2977-2982.

[7] SR Wedge, DJ Ogilvie, M. Dukes, et al. ZD6474 imalepheretsa kukula kwa mitsempha yam'mimba, angiogenesis, ndi kukula kwa chotupa pambuyo poyang'anira pakamwa. Cancer Res, 62 (16) (2002), masamba 4645-4655.

[8] SI Sherman, EEW Cohen, P. Schoffski, ndi al. Kuchita bwino kwa cabozantinib (Cabo) mu medullary chithokomiro khansa (MTC) odwala omwe ali ndi RAS kapena RET kusintha: Zotsatira za gawo lachitatu la kafukufuku [umboni]. J Clin Oncol, 31 (15 Suppl.) (2013) abstr 6000.

[9] SI Sherman, LJ Wirth, JP Droz, ndi al. Motesanib diphosphate mu khansa yopititsa patsogolo yosiyanitsa khansa. N Engl J Med, 359 (1) (2008), masamba 31-42.

[10] K. Okamoto, K. Kodama, K. Takase, ndi al. Zochita za Antitumor zama multi-tyrosine kinase inhibitor lenvatinib (E7080) motsutsana ndi RET genus fusion-drive tumor models. Khansa Lett, 340 (1) (2013), masamba 97-103.

[11] E. Cabanillas, M. Schlumberger, B. Jarzab, et al. Chiyeso chachiwiri cha lenvatinib (E2) chapamwamba, chopita patsogolo, radioiodine-refractory, chosiyanitsa khansa ya chithokomiro: zotsatira zamankhwala ndi kuyesa kwa khansa Khansa, 7080 (121) ( 16), masamba 2015-2749.

0 Likes
322 Views

Mukhozanso ndimakonda

Comments atsekedwa.