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17-Hydroxyprogesterone caproate powder

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
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AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kuti ikhale yaikulu ya 17-Hydroxyprogesterone caproate powder (630-56-8), pansi pa lamulo la CGMP ndi dongosolo loyendetsa khalidwe labwino.

17-Hydroxyprogesterone caproate powder, Pafupi ana a 500,000 amabadwira ku United States chaka chilichonse. Kubadwa kwapakati (PTB), kapena kubadwa kwapang'ono kuposa masabata a 37, kumapangitsa ana kukhala pachiopsezo chachikulu cha imfa ndipo amachititsa ana kukhala ndi ubongo wautali kwa nthawi yaitali. Kuwonjezera apo, ndalama zokhudzana ndi umoyo wa PTB zokhudzana ndi zaumoyo zimapangitsa ndalama za US zaumoyo zoposa ndalama zoposa $ 26 biliyoni chaka chilichonse. Kulepheretsa PTB kukhala kofunika kwambiri pofuna kulimbitsa thanzi lakale ndi chitukuko cha makanda m'dziko lonse lapansi.

Mafotokozedwe Akatundu

17-Hydroxyprogesterone caproate powder video


I.17-Hydroxyprogesterone caproate powder Mfundo zofunikira:

Name: 17-Hydroxyprogesterone caproate powder
CAS: 630-56-8
Makhalidwe a Maselo: C27H40O4
Kulemera kwa maselo: 428.6
Melt Point: 119 ° C
Kusungirako nyengo: Kutentha kwa Chipinda
mtundu; Yoyera mpaka wofiira


II. 17-Hydroxyprogesterone yowonjezeretsa ufa

1. Mayina:

Mayina a Mankhwala: 17-Hydroxyprogesterone
Maina Ena: 17-OHPC, 17P, hexanoate

2. Ntchito ya 17-Hydroxyprogesterone.

Mankhwalawa 17-alpha hydroxyprogesterone caproate ndi injini yopanga mankhwala. Izi zatsimikiziridwa kuti zathandiza kupewa kapena kuchepetsa kubadwa kwa amayi omwe ali ndi mimba ya singleton. Amayi omwe ali ndi mbiri yowonongeka mofulumira .1 Kawirikawiri ngati mankhwala osakwera mtengo, tsopano ali ndi maina (Makena; AMAG Pharmaceuticals) omwe amawononga pafupifupi 100 nthawi zambiri kuposa zoyambirira. Pa February 4, 2011, KV Dokotala wa Zamankhwala (amene anadzatchedwanso Lumara) analandira chivomerezo kuchokera ku US Food and Drug Administration kuti apange ndi kugulitsa Makena, yomwe ili ndi zofanana zomwe zimagwiritsidwa ntchito monga momwe zinakhazikitsidwa poyamba. Chivomerezocho chinaphatikizapo dzina la mankhwala osungirako ana amasiye ndipo anapatsa KV Kampani Yogulitsa Mankhwala ufulu woyenerera kupanga Makena, zomwe zingapangitsepo mtengo wake wotchulidwa pamwamba. Phunziro ili, tinagwiritsa ntchito deta ya inshuwalansi yokhudza inshuwalansi kuti tikambirane za 17-alpha hydroxyprogesterone caproate pakati pa akazi omwe ali ndi pakati pa 4000 (osati Medicaid). Cholinga chathu chinali kumvetsa kugwiritsa ntchito, ndondomeko, ndi zotsatira za mawonekedwe ndi zolemetsa za mankhwala.

3.Kodi mlingo wa 17-Hydroxyprogesterone uli ndi ufa wochuluka bwanji?

250 mg kamodzi pamlungu (tsiku lililonse la 7); kuyamba mankhwala pakati pa masabata a 16, masiku a 0 ndi masabata a 20, masiku a 6 of pregnancy; Pitirizani mpaka sabata la 37 (kupyolera mu masabata a 36, masiku a 6) a mimba kapena yobereka, chirichonse chimene chimachitika poyamba.

Tinachita mayesero awiri omwe ali okhudzidwa, omwe ali ndi abambo oyembekezera omwe ali ndi mbiri yakale ya kubereka kwachangu. Akazi amalembedwa kuzipatala za 19 pa 16 mpaka masabata a 20 omwe ali ndi chiwalo chokhalira limodzi komanso omwe amagawira pakati pa deta, pakati pa 2: chiwerengero cha 1, kulandira majekeseni a mlungu uliwonse wa 250 mg wa 17P kapena jekeseni wa mlungu umodzi wa placebo mafuta placebo; jekeseni anapitilira mpaka kubereka kapena kwa masabata a 36 of pregnancy. Chotsatira chachikulu chinali kutanganidwa kusanayambe masabata a 37 asanakwatirane. Kufufuza kunkachitika molingana ndi cholinga chofuna kuchiza.

Makhalidwe apansi a amayi a 310 mu gulu la progesterone ndi akazi a 153 mu gulu la placebo anali ofanana. Kuchiza ndi 17P kunachepetsera chiopsezo chotenga maselo osachepera masabata osachepera 37 (chiwerengero, chiwerengero cha 36.3 mu gulu la progesterone vs. 54.9 peresenti mu gulu la placebo; chiopsezo chokwanira, 0.66 [95 peresenti yogwirizana, 0.54 kwa 0.81]), Kupereka mavoti osachepera masabata osachepera 35 a chiwopsezo (chivundikiro, chiwerengero cha 20.6 vs.% ya 30.7; chiwopsezo chachiyanjano, 0.67 [95 peresenti yogwira mtima, 0.48 kwa 0.93]), ndi kubereka osachepera masabata osachepera 32 (pakati pa 11.4 vs. 19.6 peresenti ; chiwopsezo chachilendo, 0.58 [95 peresenti yogwirizana, 0.37 kwa 0.91]). Ana azimayi omwe amachiritsidwa ndi 17P anali ndi chiwerengero chochepa cha mankhwala osokoneza bongo, omwe amalowa m'mimba, komanso osowa owonjezera.

Majekeseni a masabata onse a 17P amachititsa kuti kuchepetsedwa kwakukulu kwa chiwerengero cha kubwereka kwa amayi oyambirira kwa amayi omwe anali pachiopsezo chachikulu chobwezeretsa kubereka komanso kuchepetsa mwayi wa mavuto ambiri kwa ana awo.

4.Kodi Cortexolone 17-Hydroxyprogesterone ikugwira ntchito yotani?

17α-hydroxyprogesterone caproate (17-OHPC) ndi progestogen yokha. Thupi laumunthu silimapangitsa kuti caproateyo imange. Dzina lina loti caproate ndi "hexanoate," limene ndi ester lochokera ku hexanoic (kapena caproic) acid. Fomu ya 17-OHPC ikuwonetsedwa mu Chithunzi. Madokotala ena adanena kuti 17-OHPC imapezeka mbuzi. Izi zikuwoneka ngati zachikhalidwe, chifukwa kudziwika kwa molekyulu iyi kuchokera kumadzipipipipipipipipi a thupi, matenda a mbuzi, kapena ziwalo zina zamoyo sizikanakhoza kutsimikiziridwa mu kufufuza kwa mabuku.

Zotsatira za 17-OHPC pa kutalika kwa chiberekero kwa odwala omwe ali ndi mbiri ya ≥ 1 obadwa kumene asanabadwe omwe adapatsidwa kuti alandire 17-OHPC ndi gulu losatetezedwa. Palibe kusiyana pakati pa kutalika kwa chiberekero kwa nthawi yomwe adawonetsedwa mwa amayi omwe analandira 17-OHPC. Mosiyana ndi zimenezi, progesterone ya m'mimba inachepetsera kuchulukitsa kwa chiberekero kwa odwala omwe ali ndi mbiri ya kubadwa msinkhu kapena kuchepa kwa chiberekero.

17 alpha-hydroxyprogesterone caproate (17P) ndi mawonekedwe a progesterone omwe awonetsedwa kuchepetsa kubwereza kwa PTB kwa amayi omwe ali ndi masewera a singleton omwe ali ndi mbiri yakale. Akazi omwe ali ndi mbiri yakale ya PTB ali ndi mwayi wambiri woti akakhale ndi mwana wakhanda poyerekeza ndi amayi omwe alibe. Kawirikawiri olembedwa ndi madokotala, 17P imayendetsedwa kudzera mu jekeseni mlungu ndi mlungu kuyambira masabata a 16-24 mpaka kubereka. Kafukufuku akusonyeza kuti kupereka 17P kwa mkazi woyenera kumachepetsa mwayi wokhala ndi PTB ndi 33 peresenti. Chaka chilichonse, pafupifupi, azimayi oyembekezera a 30,000 amakumana ndi ziyeneretsozo ndipo amaonedwa kuti ndi oyenerera ku 17P.

5.Zindikirani:

Kuchepetsa chiopsezo cha kubadwa msanga kwa amayi omwe ali ndi mimba ya singleton yomwe ili ndi mbiri ya singleton nthawi yoyamba kubadwa (yosankha mankhwala amasiye ndi FDA pa ntchitoyi).

Kuchita bwino kumatsimikiziridwa malinga ndi kusintha kwa chiwerengero cha amayi omwe amapereka pa <masabata a 37 of pregnancy; kulandira chithandizo chamankhwala (mwachitsanzo, kusintha kwa matenda osokoneza bongo ndi kufa) osakhazikitsidwe.

Chitetezo ndi zogwira mtima zimawonetsedwa mwa amayi okha omwe ali ndi chithunzithunzi chobadwa cha singleton; osati cholinga chogwiritsidwa ntchito kwa amayi omwe ali ndi zibwenzi zambiri kapena zifukwa zina zoopseza kubereka.

ACOG ikuyamikira kupatsa progesterone supplementation pofuna kupewa kubereka koyambirira kwa amayi omwe ali ndi mimba ya singleton komanso kubadwa kwapakati pa msinkhu wa masabata osakanikirana ndi masabata.

6.17-Hydroxyprogesterone caproate powder:

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

7.17-Hydroxyprogesterone caproate ufa Maphikidwe:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

8.17-Hydroxyprogesterone yowonjezera Powulitsa:

Kuti aperekedwe m'tsogolomu.

9.Does 17-Hydroxyprogesterone yapamadzi yowonjezera Ili ndi zotsatirapo zoyipa?

  • Chiwonetsero; yopangidwa ndi esterification ya 17α-hydroxyprogesterone, yomwe imapezeka ndi progesterone, yomwe ili ndi caproic acid.
  • Ali ndi ntchito yayikulu ya progestogenic; zikuwoneka kuti zimapangitsa kuti progesterum iyambe yaitali komanso yamphamvu kwambiri kuposa progesterone.
  • Sizimawoneka kuti ndi androgenic, antiandrogenic, estrogenic, kapena glucocorticoid ntchito.

Njira yogwiritsira ntchito kuchepetsa chiopsezo cha kubereka kusanafike nthawi yodziwika


III. 17-Hydroxyprogesterone kapu ya ufa HNMR

Ndife aprepitant ufa wophimba, ufa wa Aprepitant wogulitsidwa, ufa wochuluka wa Aprepitant (170729-80-3) hplc =98% | Ikani ma Reagents a R &amp; D


IV. Kodi mungagule bwanji 17-Hydroxyprogesterone caproate powder kuchokera ku AASraw?

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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