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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 681136-29-8. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kake kuchokera ku gramu kuti ikhale yaikulu ya N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide powder (CAS 681136-29-8), pansi pa lamulo la CGMP ndi mawonekedwe okhwima a khalidwe labwino.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Chiyero: ≥99% (HPLC)
Mafanowo: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Makhalidwe a Maselo: C19H19N5OS
Kulemera kwa maselo: 365.459
Mfundo yosungunula: 240.48
Mfundo yophika: 559.69 ° C pa 760 mmHg
Kusakanikirana: ~ 1.3 g / cm3
Kusungirako nyengo: Sungani ku + 4 ° C
Kutupa: DMSO: ≥28mg / mL
Chizindikiro cha refractive: N20D 1.68
mtundu; Kristalline olimba
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Kugwiritsa ntchito ufa

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N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ufa, JNJ 166101 Poda

Kodi ntchito ya N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ntchito

FAAH yomwe imayambitsidwa ndi JNJ-1661010 imasonyeza kuti pang'onopang'ono, kugwirizanitsa pakati pa JNJ1661010 ndi malo ogwira ntchito, omwe amachepetsedwa pa kutentha kwambiri. JNJ-1661010 ndi njira yowonongeka yogwiritsidwa ntchito, yomwe imayang'aniridwa ndi LC-ESI-MS. JNJ-1661010 docks ndi phenylthidiadiale mu mpweya wa hydrophobic ndi phenylurea mu hydrophilic mthumba wa FAAH, JNJ-1661010 (20 mg / kg ip) imalepheretsa FAAH ndi 85% pokhapokha mpaka 4 h pambuyo pa mankhwala, ethanolamides mu ubongo wamphongo. Dongosolo la JNJ-1661010 limadodometsanso tactile allodynia ndi mphamvu yaikulu ya pafupifupi 90% pa 30 min pambuyo ponse mu maulendo ofatsa ndi owopsa. JNJ-1661010 (20 mg / kg) imasintha zowonongeka ndi 60.8% pa 30 min mu ndondomeko yovulaza mitsempha ya msana. JNJ-1661010 (50 mg / kg ip) amasonyeza kuonongeka kwakukulu kwa hyperalgesia ku 30 min pambuyo poyerekeza ndi katoto carrageenan yopweteka kwambiri.
Makoswe omwe anagwidwa ndi JNJ-1661010 (20 mg / kg ip) ali ndi Plasma Cmax ya 26.9 μM pa Tmax ya 0.75 h ndi Cmax mu ubongo wa 6.04 μM pa Tmax ya 2 h. JNJ-1661010 (20 mg / kg ip) imaletsa ubongo wa FAAH ndikukweza AEA mlingo m'magulu a ubongo.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

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