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Apixaban ufa

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 503612-47-3. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kameneka kuchokera ku gramu mpaka kulemera kwa ufa wa Apixaban (503612-47-3), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Mafotokozedwe Akatundu

Video ya Apixaban powder


Apixaban ufa Anthu oyambirira

Name: Apixaban ufa
CAS: 503612-47-3
Makhalidwe a Maselo: C25H25N5O4
Kulemera kwa maselo: 459.50
Melt Point: 238-240 ° C
Kusungirako nyengo: 20 ° C mpaka 25 ° C
mtundu; Mdima woyera mpaka utoto wonyezimira


Apixaban ufa wofiira ufa

Mayina

Apixaban ufa

Apixaban ufa ufa wofiira ufa

Kusintha kwa Mlingo
Kulamulira ndi ma inhibitors awiri a CYP3A4 ndi P-gp

Ngati mutenga> 2.5 PO BID, kuchepetsa mlingo wa 50%
Ngati mutenga 2.5 mg BID, pewani kuyendetsa bwino ndi ziwalo ziwiri zolimba
Mankhwala a antivalvular oopsa

Pewani mlingo ku 2.5 mg PO BID kwa odwala ali ndi 2 iliyonse ya zotsatirazi:
Zaka ≥80 zaka
Kunenepa ≤60 kg
Seramu creatinine ≥1.5 mg / dL

  • Kuchepetsa Pangozi Yopweteka / Kukonzekera Kwambiri mu Nkhalango Zopanda Matenda Osalvular, 5 mg (Okalamba) kawiri tsiku lililonse; 2 iliyonse ya zotsatirazi: zaka ≥80 yr, kulemera ≤60 kg, serum creatinine ≥1.5 mg / dL- 2.5 mg kawiri tsiku lililonse; Kugwiritsiridwa ntchito kwapakati pazitsulo zolimba za CYP3A4 ndi P-gp- 2.5 mg kawiri tsiku lililonse; ngati wodwalayo atenga kale 2.5 mg kawiri tsiku lililonse, pewani kugwiritsa ntchito concomitant.
  • Kuwonongeka kwa Renal, HD- 5 mg (Achikulire) kawiri tsiku lililonse; HD ndi zaka ≥80 yr kapena kulemera ≤60 kg- 2.5 mg kawiri tsiku lililonse.
  • Kupewa Kutsekemera Kwambiri Kupweteka Kwambiri Kumachitika Zopaleshoni, 2.5 mg (Achikulire) kawiri tsiku ndi tsiku, anayambitsa 12-24 hr post-operatively (pamene hemostasis ikukwaniritsidwa) inapitirira kwa masiku 35 pambuyo mchiuno kapena masiku 12 pambuyo pa mawondo.
  • Chithandizo cha DVT kapena PE, 10 mg (Achikulire) kawiri tsiku lililonse kwa masiku 7, kenako 5 mg kawiri tsiku lililonse.
  • Kuchepetsa Kuopsa kwa DVT kapena PE, 2.5 mg (Achikulire) kawiri tsiku lililonse ≥6 mo mankhwala a DVT kapena PE.

Chenjezo pa Apixaban ufa wothira ufa

Zomwe zimawonongeka kwambiri zimakhala ndi magazi ndipo zimatuluka pamtunda, auzeni dokotala wanu kapena pitani kuchipatala mwamsanga ngati muli ndi zizindikiro zotsatirazi zomwe zingagwirizane ndi zotsatira zoyipa kwambiri:

  • Zizindikiro za zomwe zimachitika, monga kutupa; ming'oma; kuyabwa; zofiira, zotupa, kunyezimira, kapena kupukuta khungu kapena popanda malungo; kuwomba; zolimba mu chifuwa kapena mmero; vuto kupuma, kumeza, kapena kuyankhula; chiwonongeko chachilendo; kapena kutupa kwa pakamwa, nkhope, milomo, lilime, kapena mmero.
  • Zizindikiro za kutaya magazi monga kutaya magazi kapena kutaya zomwe zikuwoneka ngati malo a khofi; kukakamira magazi; magazi mu mkodzo; zofiira, zofiira, kapena zitsulo zamatabwa; kutuluka m'magazi; magazi a m'mimba omwe si achilendo; mikwingwirima popanda chifukwa kapena kuti zikhale zazikulu; kapena kutuluka kulikonse komwe kuli koipa kapena kuti simungathe kuima.
  • Chizungulire kapena kutuluka.
  • Kupweteka kumodzi kapena kutupa.
  • Kupweteka pamtima kapena kupanikizika.
  • Kumva kutopa kapena kufooka.
  • Kumverera kusokonezeka.
  • Mutu.
  • Kupuma.

Kusuta
Nkhokwe ya Apixaban ingapangitse chiopsezo chotaya mwazi chomwe chingakhale choopsa komanso chopha. Kugwiritsira ntchito mofanana ndi mankhwala omwe amachititsa hemostasis kungathandizenso kuonjezera ngoziyi. Izi zimaphatikizapo mankhwala monga ma antiticoagulants, heparin, aspirin, antiplatelet mankhwala, serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, komanso mankhwala osakanikirana ndi anti-inflammatory (NSAIDs).

Chodetsa nkhaŵa ndi kugwiritsidwa ntchito kwa ufa wa Apixaban ndi anticoagulants ena atsopano ndi kusowa kovomerezeka bwino kuti asinthe ntchito yawo (palibe mankhwala omwe alipo). Izi ndizovuta kwambiri pokhudzana ndi warfarin pamene vuto lakumwazika likuchitika, kapena pamene anthu akumwa mankhwalawa amafunika opaleshoni yachangu.

Kuthamanga kwa msana
Pamene mliri wamphongo / epidural anesthesia kapena kutsegulidwa ukugwiritsidwa ntchito, odwala omwe akuchiritsidwa ndi anti-thrombotic agents pofuna kupewa vuto la thromboembolic ali pangozi yowonjezera hematoma, yomwe ingayambitse thupi lalitali kapena losatha. Zowopsa za izi zikhoza kuwonjezeka pogwiritsira ntchito catheters apidural kapena intrathecal pambuyo pa opaleshoni kapena ntchito yogwiritsira ntchito yomwe imakhudza hemostasis.

Maumboni ena

Pulogalamu ya Apixaban ndi mankhwala osokoneza bongo komanso okhudza inhibitor ya Factor Xa omwe amagwiritsidwa ntchito kuchepetsa chiopsezo cha mitsempha yowonongeka, kuyambitsa machitidwe ndi kukwapula kwa odwala omwe amagwidwa ndi matenda a atrial, ndipo amachepetsera chiopsezo chachikulu cha mitsempha yothandizira ndi mapulitsi pambuyo pochita opaleshoni . Pulogalamu ya Apixaban yakhala ikugwirizanitsidwa ndi kuchepa kwa mphamvu ya serum aminotransferase panthawi ya mankhwala komanso nthawi zochepa za kuvulala kwa chiwindi.

Ntchito zamankhwala:
Mafuta a Apixaban amasonyezedwa pa zotsatirazi:

Kuchepetsa chiopsezo cha kupwetekedwa ndi kugwidwa ndi odwala omwe alibe nthenda yotchedwa nonvalvular.
Pansi pa mitsempha ya thrombosis (DVT) prophylaxis. DVTs ikhoza kutsogolera ku pulmonary embolism (PE) m'magulu kapena opaleshoni opaleshoni opaleshoni.
Chithandizo cha DVT ndi PE.
Kuchepetsa chiopsezo chobwereza DVT ndi PE pambuyo pa mankhwala oyamba.

Apixaban Mpweya Wofiira

Phala la Apixaban ndi loyera kwambiri. Pachikhalidwe pH (1.2-6.8), ufa wa Apixaban sumadziwika; Madzi ake amadzimadzi a pH ndi ~ 0.04 mg / mL.

Mapiritsi a ELIQUIS amapezeka kuti azitha kupangira mankhwala a 2.5 mg ndi 5 mg wa ufa wa Apixaban ndi zotsatirazi zosagwiritsidwa ntchito: lactose anhydrous, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulphate, ndi magnesium stearate. Kuphimba filimuyi kuli lactose monohydrate, hypromellose, titanium dioxide, triacetin, ndi asidi a zitsulo (2.5 mg mapiritsi) kapena mapiritsi a zitsulo zofiira (5 mg mapiritsi).

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

Apixaban powder Marketing

Kuti aperekedwe m'tsogolomu.


Kodi kugula Apixaban ufa kuchokera ku AASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

HNMR

Pulogalamu ya Apixaban (503612-47-3) hplc≥98% | AASraw HNML

Maphikidwe

Apixaban Maphikidwe a Powder Wofiira:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Apixaban (Eliquis): amagwiritsa ntchito, kuyanjana, zotsatira, machenjezo