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Canrenone ufa (976-71-6)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 976-71-6. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kake kuchokera ku gramu mpaka kulemera kwa Canrenone ufa (976-71-6), pansi pa lamulo la CGMP ndi dongosolo loyendetsa khalidwe labwino.

Canrenone ufa Ankapatsidwa mlingo wa 2 × 82 mg ndi 2 × 164 mg pa tsiku pa masiku a 10 kwa odwala matenda a shuga popanda kugwira nawo mtima, chiwindi kapena impso. Aldosterone excretion ndi plasma aldosterone inangowonjezera pang'ono panthawi ya maulamuliro onsewa.

Mafotokozedwe Akatundu

Video ya Canrenone ya ufa


Canrenone ufa Anthu oyambirira

Name: Canrenone ufa
CAS: 4642-95-9
Makhalidwe a Maselo: C18H20O2
Kulemera kwa maselo: 258.36
Melt Point: 138-141 ℃
Kusungirako nyengo: Kutentha kwa Chipinda
mtundu; Mphuno yonyezimira kapena yonyezimira ya Crystalline


Dongosolo la ufa wa Canrenone

Mayina

ZOKHUDZA (S): Canrenone ufa
DZINA LENIWENI (S): Contaren, Luvion, Phanurane, Spiroletan

Mankhwala a Canrenone

Mafuta a Plasma a Canrenone ufa ndi 'metabolites' onse pambuyo poyambira hydrolysis amafaniziridwa mu maphunziro achichepere ndi achikulire omwe amatsatira miyeso imodzi komanso yambiri ya spironolactone. Pambuyo pa mlingo woyamba pa Tsiku 1, mazira a plasma a Canrenone ufa wofiira ndi 'metabolites' onse anali apamwamba kwambiri kuposa achinyamata okalamba, ndipo kusiyana kwakukulu kunapezeka pakati pa magulu awiri a AUC onse a Canrenone ufa ndi ' metabolites '. Komabe, kusiyana kwakukulu pakati pa magulu awiriwa kunachepetsedwa pambuyo pa zochitika zambiri pa Tsiku 8, ndipo mazira a pulasitiki omwe analipo asanafikepo angrenone ndi 'metabolite' onse anali oposa kwambiri pa maphunziro okalamba. Kuwonjezeka kwa mgwirizano wa Canrenone ufa ndi 'metabolites' onse anali okwera kwambiri kuposa okalamba. Zonse ziwiri za Canrenone zopangidwa ndi ufa ndi canrenoic acid zinali zowonjezereka kwa mapuloteni a pulasitiki, koma palibe kusiyana komwe kunapezeka pakati pa magulu a zaka ziwiri mu mapuloteni omangiriza. Kuwona kusiyana pakati pa magulu a m'magazi pambuyo pokhala limodzi ndi angapo pakamwa pakati pa achinyamata ndi achikulire angakhale zotsatira za zinthu zambiri monga kusintha kwa chiwerengero cha kagayidwe ka maselo ndi zaka; Kusokonezeka kwa m'kamwa kwa kholo limodzi; ndi / kapena kusintha mavoti a kufalitsa mankhwala.

Kodi mlingo wa Canrenone ndi chiani?

Mwamwayi, nthawi zambiri, 50-200 mg pa tsiku ngati mlingo umodzi kapena m'madera ambiri ndi okwanira.
Pa milandu yoopsa kwambiri, mlingo woyambirira ukhoza kuwonjezeka kufika kwa 300 mg kapena zambiri, ndiye mlingo umasinthidwa ku mayendedwe a kachipatala ndi mayina a labotale.

Kodi Canrenone ufa amagwira ntchito bwanji?

Kukula kwa njira ya HPLC yowonongeka kwa maselo kunkachitika pa TQ4 Quantum Discovery katatu quadrupole mass spectrometer ndi dongosolo la Aria CTC HPLC autosampler. Pogwiritsa ntchito electrospray ionisation, ionisoni yaikulu yomwe imazindikira kuti inali yonyamulira ion (M + H) + m / z 341 ya Canrenone powder. Alfaxalone (chotsatira m / z 333; 1 μg) chinagwiritsidwa ntchito monga muyezo wamkati. Pogwiritsidwa ntchito pang'onopang'ono, zidutswa zazikuluzikulu zinkakhala m / z 107.1 ndi 91.1 ya Canrenone yaiwisi yaiwisi ndi m / z 297.3 ndi 315.3 ya alfaxalone. Ion igawanika imagwiritsidwa ntchito monga quantifier ndi qualifier ions motsatira kuti kuwonjezera pa yeseso. Kupatukana koyenera kwa steroids kunapindula pogwiritsa ntchito ammonium acetate (5 mM) / methanol pa (60: 40, 0.3 ml / min) pa Madzi C18 T3 Atlantis HPLC chingwe (3 μm; 100 × 2.1 mm) pa 25 ° C. Chida chochokera ku 40 kufika ku 90% methanol chinagwiritsidwa ntchito, ndi nthawi yonse ya 8 maminiti.

Kutsimikiziridwa kwa magawo ochulukidwe kunkachitidwa pogwiritsa ntchito magawo asanu ndi limodzi omwe amatsutsana. Kupeza bwino kwa Canrenone powder ndi alfaxalone (106.2% (kusemphana kwapadera (RSD) 9.5%) ndi 102.2% (RSD 4.7%)) zinapindula pokhapokha kutulutsa madzi ndi 25 μl plasma ndi ethyl acetate (1: 10). Malire a chidziwitso anali 5 ng / ml ndipo malire ochepa anali 15 ng / ml. Nsoloyi inali yowonjezera (r = 0.9936) pamtundu wosiyanasiyana (5 ng / ml ku 5 μg / ml). Nkhumbayi inakhala yabwino yokwanira Canrenone yaiwisi yaiwisi mu gulu la odwala omwe analandira mlingo wa 400 mg, omwe mkati mwake munali plasma anapezeka kuti ali mu 5-45 μmol / l.

Ubwino wa Canrenone ufa

Canrenone ufa ndi waukulu yogwira metabolite wa spironolactone. Mwachiwonetsero cha chikhalidwe, chimagwira mpikisano ndi aldosterone mwa kuchoka ku malo obwezeretsa pamtunda wa gawo la distal of the renal renal ndi njira yotolera; izi zimapangitsa kuwonjezeka kwa diuresis ndi natriuresis komanso kuchepetsa chimaliyosi. Poyerekeza ndi spironolactone ali ndi ubwino wa nthawi yotsika ya latency. Komabe, monga spironolactone, sichikuchitapo kanthu pazochitika zapadera kapena muzochitika zachilendo zochepetsera.
Pambuyo pa mauthenga ovomerezeka, Canrenone yaiwisi yaiwisi imayambitsidwa kwambiri, mpaka kufika pazigawo zambiri za m'magazi mkati mwa maola awiri oyambirira. Theka la moyo liri pafupi maola a 18 ndipo, mosiyana ndi spironolactone, imasintha mosasintha, mkati mwa maola a 72, ndi mkodzo ndi ntchentche mofanana.
Khansa ya Canrenone imasonyezedwa m'matenda omwe mankhwala owonjezera a aldosterone amachititsa kuti madzi asungidwe komanso sodium komanso kuwonjezeka kwa kaliuria. Ndikofunika pochiza ascites mu chiwindi cha chiwindi, ngakhale ngati mlingowo umasinthidwa kuti uyankhule pamlanduwu.

Canrenone ufa

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

Canrenone yai yowonjezera malonda

Kuti aperekedwe m'tsogolomu.

Canrenone mwachidule potsatira ufa

Canrenone yaiwisi yaiwisi ndi yogwiritsira ntchito metabolite ya spironolactone, canrenoic acid, ndi potaziyamu canrenoate, ndipo imawoneka kuti ili ndi zotsatira zake. Zapezeka kuti zili ndi pafupifupi 10 ku 25% ya potassium-ignaring effect of spironolactone, pamene ina ya metabolite, 7α-thiomethylspironolactone (7α-TMS), imawerengera pafupifupi 80% ya potassium-kutulutsa mankhwala.

Khansa ya Canrenone imakhala yochuluka ngati antimineralocorticoid yokhudzana ndi spironolactone, koma ndi yochepa kwambiri komanso yothandiza ngati antiandrogen. Mofananamo ndi spironolactone, Canrenone ufa wofiira umalepheretsa michere ya steroidogenic monga 11β-hydroxylase, cholesterol-chain chain cleavage, 17α-hydroxylase, 17,20-lyase, ndi 21-hydroxylase, koma kamodzinso, sizingakhale zovuta pochita chotero.


Kodi kugula Canrenone ufa kuchokera ku AASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

HNMR

Maphikidwe

Canrenone yaiwisi ufa Maphikidwe

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

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