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Dolastatin 10 (110417-88-4)

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5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 110417-88-4. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita ku chidziwitso cha Dolastatin 10 (CAS 110417-88-4), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

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Dolastatin 10 kanema


I.Dolastatin 10 zoyambirira Zolemba:

Name: Dolastatin 10
CAS: 110417-88-4
Makhalidwe a Maselo: C42H68N6O6S
Kulemera kwa maselo: 785.09g / mol
Melt Point: 94-95oC
Kusungirako nyengo: Sungani malo ozizira ndi owuma ndi 0 - 4 ℃ kwa nthawi yochepa (masiku ndi masabata) kapena -57 ℃ kwa nthawi yaitali (miyezi ndi zaka)
mtundu; Kuyera mpaka woyera-sollid


II. Dolastatin 10 (110417-88-4) kugwiritsiridwa ntchito m'thupi la antitumor cycle

1. Mayina:

Dzina la mankhwala:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

Ntchito 2.Dolastatin 10:

Cholinga: Wasayansi wa zamankhwala adafufuzira za mphamvu ndi chiopsezo cha buku la anti-microtubule wothandizira dolastatin-10 kwa odwala omwe ali ndi kansa ya m'mawere.

Njira: Odwala makumi awiri ndi mmodzi omwe ali ndi khansa ya m'mawere yowonongeka amathandizidwa ndi dolastatin-10 pa mlingo wa 400 mcg / m2 ndi mankhwala osokoneza bongo kamodzi pa masabata onse a 3.

Zotsatira: Mmodzi mwa odwala 21 (5%; 95% CI: 0-24%) adakhululukidwa pang'ono patsiku la masiku 113. Odwala anayi adakhala ndi matenda osakhazikika kwa masiku apakati a 87. Odwala amalandira pakati pa dolastatin-10. Dokotala wa mankhwalawa anali ochepa kwambiri, ndipo odwala 8 ali ndi chiwerengero cha 4 neutropenia, ndipo 5 ndi kalasi 3 neutropenia; Gulu limodzi la 3 febrile neutropenia linawonedwa. Zochitika izi za kalasi ya 3 ndi 4 neutropenia zakhala zikudziwika pa 36% ya zochitika za mankhwala. Mankhwala osokoneza bongo anali achilendo.

Kutsiliza: Pamene mbiri ya poizoni ya dolastatin-10 inavomerezedwa, idakhala ndi ntchito yochepa mu phunziro la khansa yapitayi.

In Vitro: Dolastatin 10 ndipadera yapadera yomwe ili kutali ndi nyanja ku Dolabella auricularia. Zikupezeka kuti ma data a vitrowa ali ofanana kwambiri ndi a Dolastatin 10 ndi Auristatin PE, iliyonse yomwe ili ndi GI50 chikhalidwe cha 10-5-10-6 μg / mL (10-2-10-3 nM) motsutsa zofanana minipanel ya mizere ya maselo aumunthu. Anti-drug conjugate (ADC) ili ndi anti-CD30 antioconal antibody cAC10 yomwe imagwiritsidwa ntchito ndi cytotoxic wothandizira monomethyl auristatin E (MMAE), chojambula cha tubulin polymerization inhibitor Dolastatin 10 (110417-88-4).

3.Zindikirani pa Dolastatin 10

Chogwiritsira ntchito ndicho kufunafuna kafukufuku kokha, osati kwa anthu kapena zofukula zamagetsi.

Kuti mupeze kutentha kwapadera, chonde muziwotcha chubu pa 37 ℃ ndikugwedezani mu akusamba kwa kanthawi. Njira yothetsera imatha kusungidwa pansipa -20 ℃ kwa miyezi ingapo.

4.Inanso malangizo:

Dolastatin 10 kaphatikizidwe
Chiwerengero cha Dolastatin 10 (110417-88-4) chinatsirizidwa mwa kupanga kaphatikizidwe kabwino ka zigawo zikuluzikulu ziwiri za amino acid, Dil (6) ndi Dap (11), ndi kugawidwa kwa magawo asanu a amino acid kuchokera ku C-terminal Doe .

Kufufuza ndi Kufufuza kwa Dolastatin 10 Analogues Okhudza Heteroatoms pa Amino Acid Side Chains.
Zomwe zimagwirizana ndi chilengedwe zimachita dolastatin 10 ndizochita chidwi kwambiri ndi kansa chifukwa cha ntchito zawo zabwino kwambiri komanso ntchito zawo monga malipiro a anti-drug conjugates (ADCs). Kusinthidwa kwa dolastatin 10 core scaffold yakhala makamaka yokhudza kusintha kwa P1, N-terminus, ndi P5, C-terminus, osasamala kwenikweni pa subunit P2.

M'mayesero am'manja, Dolastatin 10 (110417-88-4) imasonyeza ntchito yotsutsana ndi khansa ya m'magazi, lymphoma ndi maselo olimbitsa thupi (monga OVCAR-3 ndi NSCLC) ndi ma IC50 amtengo wochokera ku 0.1nM mpaka 10nM. Pakali pano ayesedwa m'mayesero am'chipatala.


III. Dolastatin 10 (110417-88-4) HCML

Ndife aprepitant ufa wophimba, ufa wa Aprepitant wogulitsidwa, ufa wochuluka wa Aprepitant (170729-80-3) hplc =98% | Ikani ma Reagents a R & D


IV. Kodi mungagule bwanji Dolastatin 10 kuchokera ku AASRAW?

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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