USA Kutumiza Kwawo Kumudzi, Canada Kutumiza Kwawo, Kunyumba kwa ku Ulaya

Fosaprepitant dimeglumine (EMEND) powder

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 265121-04-8. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga mphamvu kuchokera ku gramu mpaka kulemera kwa Fosaprepitant dimeglumine (EMEND) powder (265121-04-8), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Fosaprepitant Dimeglumine ufa ndi mtundu wa mchere wa dimeglumine wa fosaprepitant, wosungunuka madzi, N-phosphorylated prodrug ya aprepitant, ndi ntchito ya antiemetic. Pa ma intravenous administration ndi kutembenuka mofulumira kwa aprepitant, wothandizira uyu amamanga mosankhidwa ku chinthu chaumunthu P / neurokinin 1 (NK1) cholandira mkatikatikati mwa zamanjenje (CNS). Izi zimalepheretsa kulandira cholowa cha mankhwala osakanikirana P ndi kuteteza mankhwala P-emduced emesis.

Mafotokozedwe Akatundu

Fosaprepitant dimeglumine (EMEND) pakompyuta


Fosaprepitant dimeglumine (EMEND) powder Anthu oyambirira

Name: Fosaprepitant dimeglumine (EMEND) powder
CAS: 265121-04-8
Makhalidwe a Maselo: C23H22F7N4O6P.2C7H17NO5
Kulemera kwa maselo: 1004.83
Melt Point: 242-247 ° C
Kusungirako nyengo: -20 ° C Freezer
mtundu; zoyera ndi zoyera zofiira


Fosaprepitant dimeglumine (EMEND) Kugwiritsa ntchito poda

dzina

Fosaprepitant dimeglumine powder (CAS 265121-04-8)

TUMIZANI powder

Fosaprepitant dimeglumine Kugwiritsa ntchito Powder

Kuphatikizana ndi othandizira ena oletsa antimetic, pofuna kupewa kwambiri komanso kuchepetsa kunyoza ndi kusanza komwe kumakhala koyamba ndi kubwereza maphunziro omwe ali ndi khansa yapamwamba kwambiri komanso yapamwamba kwambiri, kuphatikizapo mlingo waukulu wa cisplatin.

Chenjezo pa EMEND powder (CAS 265121-04-8)

  • Fosaprepitant iyenera kugwiritsidwa ntchito mosamala kwa odwala omwe akulandira mankhwala othandizira kuti ayambe kugwiritsa ntchito mankhwala a CYP3A4.
  • Zomwe zimachitika pamtunduwu zimatha kuchitika panthawi yopuma. Odwala kawirikawiri amavomereza kuti achoke. Sichikulimbikitsidwa kubwezeretsanso kulowetsedwa. (B)
  • Kutsogoleredwa kwa fosaprepitant kapena aprepitant ndi warfarin (CYP2C9 substrate) kungawononge kuchepa kwakukulu mu International Normalized Ratio (INR) ya nthawi ya prothrombin. (C)
  • Kugwiritsa ntchito njira za kulera kwa mahomoni nthawi ndi masiku 28 pambuyo pa mlingo womaliza wa fosaprepitant kapena aprepitant kungachepetse. Njira zina zothandizira kubereka zimayenera kugwiritsidwa ntchito. (D)

A: CYP3A4 Interactions Fosaprepitant imasinthidwa mofulumira kupita ku aprepitant, yomwe imakhala yoletsa kwambiri ya CYP3A4 pamene imayendetsedwa ngati regimen ya XINUMX day antimetic dosing ya CINV. Fosaprepitant iyenera kugwiritsidwa ntchito mwaluso kwa odwala omwe akulandira mankhwala othandizana ndi mankhwala omwe amapangidwa ndi CYP3A3. Kuletsedwa kwa CYP4A3 ndi aprepitant kapena fosaprepitant kungabweretse mitsempha yapamwamba ya mankhwala a mankhwalawa. Pamene fosaprepitant imagwiritsidwa ntchito mogwirizanitsa ndi yina CYP4A3 inhibitor, aprepitant maphalama a plasma akhoza kukwezedwa. Pamene aprepitant imagwiritsidwa ntchito moyenera ndi mankhwala omwe amachititsa CYP4A3 ntchito, aprepitant maphalamu a plasma akhoza kuchepetsedwa, ndipo izi zingachititse kuchepa kwa aprepitant. Mankhwala otchedwa Chemotherapy omwe amadziwika kuti ayambitsidwa ndi CYP4A3 amatchedwa docetaxel, paclitaxel, etoposide, irinotecan, ifosfamide, imatinib, vinorelbine, vinblastine ndi vincristine. M'maphunziro azachipatala, regimen ya pamlomo inkagwiritsidwa ntchito mofanana ndi etoposide, vinorelbine, kapena paclitaxel. Mlingo wa othandizirawo sunasinthidwe ku akaunti chifukwa chotsutsana ndi mankhwala. Mu maphunziro apadera a mankhwala, palibe kusintha kwakukulu kwa docetaxel kapena vinorelbine pharmacokinetics kunawonedwa pamene lipatimenti ya mouth aprepitant inaliyendetsedwa. Chifukwa cha owerengeka odwala omwe amaphunzira ku chipatala omwe analandira CYP4A3 substrates vinblastine, vincristine, kapena ifosfamide, chenjezo ndi kuyang'anitsitsa mosamala zimalangizidwa ndi odwala omwe amalandira awa kapena othandizira mankhwala omwe amagwiritsidwa ntchito kwambiri ndi CYP4A3 omwe sanaphunzire.
B: Kuyankha kwa Hypensensitivity Kufotokozedwa kwapadera mauthenga omwe amachititsa kuti munthu asamawonongeke, kuphatikizapo kupweteka, erythema, dyspnea, ndi anaphylaxis zakhala zikuchitika panthawi yopuma kwa fosaprepitant. Maganizo amenewa amachititsa kuti asiye kusamalidwa ndi kuyang'anira njira zoyenera. Kubwezeretsedwa kwa kulowetsedwa sikuvomerezedwa kwa odwala omwe amawona zizindikirozi panthawi yoyamba.
C: Utsogoleri ndi Warfarin Udindo wa fosaprepitant kapena aprepitant ndi warfarin ukhoza kuwonetsa kuchepa kwakukulu mu International Normalized Ratio (INR) ya nthawi ya prothrombin. Odwala omwe ali ndi matenda aakulu a anti-warfarin, a INR ayenera kuyang'aniridwa mosamala pa nthawi ya masabata a 2, makamaka pa 7 mpaka masiku a 10, pambuyo pa kuyamba kwa fosaprepitant ndi mankhwala enaake.
D. Kuchita Zochita ndi Kugonana kwa Amuna Omwe Amagwiritsira Ntchito Mankhwala Osamalidwa Pogonana Pogwiritsa ntchito fosaprepitant kapena aprepitant, mphamvu yowononga mimba ikhoza kuchepetsedwa pa masiku a 28 pambuyo pa mlingo womaliza wa fosaprepitant kapena aprepitant. Njira zina zothandizira kubereka zimayenera kugwiritsidwa ntchito panthawi ya mankhwala ndi mwezi wa 1 pambuyo pa mlingo womaliza wa fosaprepitant kapena aprepitant [onani Drug Interactions]. 5.5 Yopitirira Ntchito Yopitirira Kusagwiritsidwa ntchito mosalekeza kwa EMEND powder kwa Kujambulira kupewa kupewa kunyoza ndi kusanza sikukondweretsedwa chifukwa sikunaphunzire; komanso chifukwa chakuti machitidwe oyanjana nawo mankhwala angasinthe pamene akugwiritsa ntchito mosalekeza.

Maumboni ena

Fosaprepitant dimeglumine ufa wa jekeseni 150 mg tsopano ikuwonetsedwa kwa akuluakulu kuphatikizapo othandizira ena oletsa antimetic pofuna kupewa kuchepetsa kunyoza ndi kusanza komwe kumakhala koyamba ndi kubwereza maphunziro a MEC. Mankhwala ovomerezeka achikulire ndi 150-mg yokha (IV) yomwe imaphatikizapo 20 kwa 30 maminiti pafupifupi 30 maminiti asanafike chemotherapy pa Tsiku 1. Chidziwitso cha FDA chachiwonetsero chatsopanocho chinachokera ku zomwe anapeza kuchokera ku kafukufuku wowongolera, wofanana, wowerengeka, wogwira ntchito wowerengera omwe anayeza fosaprepitant kwa jekeseni monga kulowetsedwa m'modzi mofanana ndi ondansetron ndi dexamethasone (yotchedwa EMEND powder regimen ) (N = 502) poyerekezera ndi ondansetron ndi dexamethasone okha (kulamulira regimen) (N = 498) odwala omwe amalandira MEC. Poyambira mapeto anali yankho lathunthu (losatanthauzidwa ngati palibe kusanza ndi kugwiritsa ntchito mankhwala opulumutsa) mu nthawi yochedwa (25 kwa ma 120 maola pambuyo poyambitsa mankhwala a chemotherapy) a mankhwala osokoneza bongo ndi mankhwala osokoneza bongo. Chiwerengero cha 78.9% chokwanira chinayankhidwa ndi Fosaprepitant dimeglumine powder regimen poyerekeza ndi 68.5% ndi regimen control (P <0.001). Zomwe zimayambitsa mavuto ambiri omwe amapezeka mu EMEND powder regimen ndi regimen anali otopa (15% vs 13%), kutsekula m'mimba (13% vs 11%), neutropenia (8% vs 7%), asthenia (4% vs 3%) , kuperewera kwa magazi m'thupi (3% vs 2%), phokoso la m'mimba (3% vs 2%), leukopenia (2% vs 1%), dyspepsia (2% vs 1%), matenda oyambitsa mkodzo (2% vs 1%), ndi zowawa pamapeto (2% vs 1%).

Chizindikiro Fosaprepitant dimeglumine ufa wa jekeseni, kuphatikizapo othandizira ena, amasonyeza anthu akuluakulu kuti asamangodzimva ndi kuchepetsa kusambidwa ndi kusanza komwe kumakhala koyamba ndi kubwereza maphunziro a khansa yapamwamba kwambiri ya khansa, kuphatikizapo dose ya cisplatin; komanso kupewa kuchepetsa kunyoza ndi kusanza komwe kumakhala koyamba ndi kubwereza maphunziro ochepa omwe amachititsa khansa yapakhungu.

Fosaprepitant dimeglumine ufa wa jekeseni siinaphunzirepo pochiza chitsimikizo chokhazikika ndi kusanza.

Fosaprepitant Dimeglumine Powder Wowonjezera (CAS 265121-04-8)

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

Fosaprepitant dimeglumine powder Marketing

Kuti aperekedwe m'tsogolomu.


Mungagule bwanji Fosaprepitant dimeglumine powder: Gulani EMEND powder kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


=

COA

COA 265121-04-8 Fosaprepitant dimeglumine (EMEND) ufa AASRAW

HNMR

Ndife Fosaprepitant dimeglumine powder supplie, EMEND powder yogulitsa, Fosaprepitant dimeglumine (EMEND) powder (265121-04-8) ≥98% | AASraw

Maphikidwe

Fosaprepitant dimeglumine Maphikidwe a Mpweya Wowonjezera:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Fosaprepitant Dimeglumine amagwiritsira ntchito mankhwala opatsirana khansa