USA Kutumiza Kwawo Kumudzi, Canada Kutumiza Kwawo, Kunyumba kwa ku Ulaya

IDFP (615250-02-7)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 615250-02-7. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita ku dongosolo la IDFP (615250-02-7), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe.

Mafotokozedwe Akatundu

Video ya IDFP


IDFP Anthu oyambirira:

Name: IDFP
CAS: 615250-02-7
Makhalidwe a Maselo: C15H32FO2P
Kulemera kwa maselo: 294.391
Melt Point:
Kusungirako nyengo: -20 ° C
mtundu;


Pulogalamu ya IDFP (615250-02-7)

Mayina

Mayina a mankhwala: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Mawu ofanana:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

Ntchito ya IDFP (615250-02-7)

IDFP ndi chigawo cha organophosphorus chogwirizana ndi wothandizira mitsempha. Monga sarin, IDFP ndi inhibitor yosasinthika kwa mitundu yambiri yamadzimadzi yomwe imathandiza kuthetsa mazembera amtunduwu, komabe chingwe cha alfine cha IDFP chimapangitsa kuti chikhale chofooka kwambiri ngati chiletso cha acetylcholinesterase (AChE), ndi IC50 ya 6300nM yokha, pomwe ndi woletsa amphamvu michere awiri monoacylglycerol lipase (MAGL), enzyme chachikulu udindo kunyoza endocannabinoid 2-arachidonoylglycerol (2-AG), ndi mafuta asidi amide hydrolase (FAAH), enzyme chachikulu kuti khalidwe la yaikulu endocannabinoid anandamide . IC50 ya IDFP ndi 0.8nM ku MAGL, ndi 3.0nM ku FAAH. Kuletsedwa kwa mavitamini awiriwa kumayambitsa kuchuluka kwa anandamide ndi 2-AG mu ubongo, zomwe zimapangitsa kuti zizindikiro zowonongeka zowonongeka komanso zomwe zimachitika pamaphunziro a nyama, pomwe kusowa kwake kwa AChE kumatanthauza kuti palibe zizindikiro zowonongeka zomwe zimapangidwa. [1 ] [2] [3] [4] Ngakhale kuti mankhwalawa ndi ofanana ndi omwe amaletsedwa, mzere wa alkyl wa IDFP umapangitsa kukhala kunja kwa tanthawuzo la "mankhwala oopsa" pansi pa Msonkhano wa Zida Zachilengedwe, [5] ndipo kuyambira Sichisonyezeranso kuti mphamvu za mtundu wa organophosphorous zotsutsana, IDFP sizitsatiridwa ndi malamulo omwewo.

Kodi mlingo wa IDFP ndi chiani?

Kwa kusungirako kwa nthawi yaitali, tikupempha IDFP kusungidwa monga -20 ℃. Iyenera kukhala yolimba kwa chaka chimodzi.
IDFP imaperekedwa monga njira yothetsera methyl acetate. Kuti musinthe zosungunulira, imwani mchere wa methyl acetate pansi pa madzi osakaniza a nitrogen ndipo nthawi yomweyo yikani zosakaniza zosankha. Mafuta monga ethanol, DMSO, ndi dimethyl formamide otsukidwa ndi mpweya wambiri angagwiritsidwe ntchito. Kutha kwa IDFP mu zotupazi ndi pafupifupi 10mg / ml.
Ngati njira zowonjezera zowonongeka zimayesedwa pa zowonongeka, zimatha kukonzekera bwino pakusungunula zowonongeka zamadzimadzi kapena zamchere zamchere kapena isotonic saline.Zitsimikiziranso kuti kuchepa kwa thupi kumakhala kosafunikira, chifukwa zowonongeka zimakhala ndi zotsatirapo za thupi panthawi yochepa. Osati kulangiza kusunga njira yamadzimadzi kwa tsiku limodzi.

Momwe IDFP imagwirira ntchito

IDFP ndi woletsa sizingasinthe kwa chiwerengero cha michere osiyana omwe nthawi zambiri kutumikira kuphwanyaphwanya timene Komabe yaitali alkyl unyolo IDFP zimapangitsa itdramatically ofooka ngati woletsa wa acetylcholinesterase (mukupweteka), pamene ndi woletsa amphamvu michere awiri monoacylglycerol lipase ( MAGL), mavitamini akuluakulu omwe amachititsa kuti thupi la 2-arachidonoylglycerol (2-AG) liwonongeke, komanso mafuta a asidi hydrodese (FAAH), omwe amachititsa kuti mankhwalawa asokonezeke kwambiri. An pawiri organophosphorus kuti dually kumabwezera mmbuyo MAGL ndi FAAH ndi IC50 mfundo za 0.8 ndi 3 NM, respectively.1 Pa 10 MG / kg, IDFP kukweza milingo ubongo 2-AG ndi AEA kuposa 10 khola, ndipo amachepetsa Kuchuluka kwa asidi arachidonic ndi 10.

chenjezo

Chogulitsa chimenechi sichiri cha ntchito ya munthu kapena chowona zanyama, machenjezo ambiri akadali kufufuza. Pewani kugwirizana kwa khungu, maso, kapu, kupuma kulikonse, pitani dokotala mwamsanga.

IDFP (615250-02-7) Mpweya wambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

Kuwonetsa kwa IDFP

Kuti aperekedwe m'tsogolomu.

Kodi IDFP Ili ndi Zovuta Zonse?

The renal medulla, yoona kuti ndi yovuta kwambiri pa kayendedwe ka mchere ndi madzi komanso kuthamanga kwa magazi kwa nthawi yaitali, imapindula mu anandamide komanso mavitamini awiri omwe amagwiritsidwa ntchito kwambiri m'thupi, cyclooxygenase-2 (COX-2) ndi mafuta a acid amide hydrolase (FAAH) . Kulowetsedwa wa anandamide (15, 30, ndi 60 nmol · Mph-1 · makilogalamu-1) mu medulla aimpso wa C57BL / 6J mbewa analimbikitsa diuresis ndi mchere excretion mu Cox-2- koma osati Cox-1 amadalira unsembe. Pofuna kudziwa ngati mapeto a m'mimba mwa renal medulla angapangitse zotsatira zofanana, zotsatira za intramedullary isopropyl dodecyl fluorophosphate (IDFP), yomwe imalepheretsa kuti pakhale magetsi akuluakulu a hydrolases. Chithandizo cha IDFP chinawonjezera kuchuluka kwa mkodzo ndi kupuma kwa sodium mu COX-2-koma osati COX-1. Ngakhalenso antiandamide kapena IDFP sizinakhudze mtundu wa glomerular. Palibe njira yeniyeni (0.625 mg · kg-1 · 30 min-1 iv) kapena intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) IDFP chithandizo choyambirira musanayambe kugwiritsa ntchito anandamide (15-30 nmol · min-1 · kg-1) zowonongeka kwambiri za anandamide, kutanthauza kuti hydrolysis ya anandamide siinali yofunikira pa diuretic yake. Intramedullary IDFP inalibe mphamvu pa kuthamanga kwa magazi koma inachititsa kuti magazi aziyenda bwino. Zotsatira za IDFP pa mlingo woyendetsa mkodzo ndi kuyeretsa kwa magazi kumadalira FAAH-kudalira monga momwe anagwiritsira ntchito FAAH kugwedeza mbewa. Analysis wa woipa mbewa mkodzo PGE2 ndi HPLC-electrospray ionization tandem misa spectrometry anasonyeza kuti IDFP chithandizo utachepa PGE2 mkodzo deta Awa ndi zogwirizana ndi udindo wa FAAH ndipo amkati anandamide akuchita kupyolera metabolite Cox-2 amadalira zonse diuresis ndi mchere excretion mu mousekidney.


Momwe mungagulire ufa wa IDFP (615250-02-7) kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


=

COA

HNMR

Maphikidwe

Maphikidwe a Pakuda Odziwika a IDFP:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

IDFP (615250-02-7): Zotsatira, Mlingo, Zowonetsera