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Lapatinib ufa (231277-92-2)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 231277-92-2. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga zopangidwa kuchokera ku gramu mpaka kulemera kwa Lapatinib powder (231277-92-2), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Mafotokozedwe Akatundu

Vuto la phala la Lapatinib


Lapatinib ufa Anthu oyambirira

Name: Lapatinib ufa
CAS: 231277-92-2
Makhalidwe a Maselo: C29H26ClFN4O4S
Kulemera kwa maselo: 581.05
Melt Point: 136-140 ° C
Kusungirako nyengo: Firiji
mtundu; Yoyera kapena kuchotsa nyemba yakuyera ya Crystalline


Yaikulu Lapatinib ufa mu Antineoplastic Agent ulendo

Mayina

Dzina lachibadwa: Lapatinib ufa (la PA tin ib)
Dzina lajambula: Tykerb

Mafuta akuluakulu a Lapatinib

Mafuta a lapatinib ndi mankhwala omwe amagwiritsidwa ntchito ndi mankhwala ena (capcitabine) kuti athetse khansa ya m'mawere yomwe imafalikira kumadera ena a thupi lomwe ndi HER2 zabwino (zotupa zomwe zimatulutsa mapuloteni ambiri otchedwa epidermal growth factor receptor-2) , komanso omwe ali kale ndi mankhwala ena a khansa ya m'mawere.

Mafuta a lapatinib amagwiritsidwanso ntchito ndi mankhwala omwe amatchedwa letrozole kuti azitsatira akazi a postmenopausal omwe ali ndi kachilombo kabwino ka HIV, kansalu ka HER2 yabwino yamatenda omwe amachititsa kuti mankhwalawa aziwonetsedwa.

Mafuta a lapatinib ndi mankhwala ochizira khansa ya m'mawere. Amagwiritsidwa ntchito kuphatikiza ndi mankhwala ena kuti athetse khansa ya m'mawere ya mtundu wina yomwe yafalikira kumbali zina za thupi ndi zomwe sizinachitepo ndi mankhwala ena a khansa.

Lapatinib ufa ndi gulu la mankhwala otchedwa kinase inhibitors omwe amagwira ntchito poletsa kugwira ntchito ya mapuloteni ena omwe amasonyeza kuti maselo a khansa akuchuluka.

Mankhwalawa amabwera mu mawonekedwe apiritsi ndipo amatengedwa kamodzi tsiku lililonse m'mimba yopanda kanthu.

Zotsatira zoyipa za Lapatinib ufa zimaphatikizapo zofiira, manja opweteka ndi mapazi, kutsegula m'mimba, kuthamanga, ndi nseru.

Kodi mlingo wa Lapatinib ufa ndi wotani?

Kawirikawiri Mankhwala akuluakulu a khansa ya m'mawere

-HER2-POSITIVE METASTATIC BREAST CANCER (kuphatikizapo capecitabine): 1250 mg pamlomo kamodzi pa tsiku pa masiku 1 mpaka 21 nthawi zonse pobwerezabwereza masiku a 21 mpaka kupitirira kwa matenda kapena poizoni.

-HORMONE MLEMEKEZO WOKHALA, WOKHALA WA HER2-POSITIVE METASTATIC BREAST CANCER (kuphatikizapo letrozole): 1500 mg mlomo kamodzi patsiku.

Comments:
-Consult opanga mankhwala mankhwalawa capecitabine ndi letrozole dosing zoyamikira.
-Adwala odwala khansa ya m'mawere a HER2 ayenera kukhala ndi matenda opatsirana pa trastuzumab asanayambe kumwa mankhwala ndi mankhwalawa kuphatikizapo capecitabine.

Amagwiritsa ntchito:
-kuphatikizana ndi capecitabine kuchiza odwala ali ndi khansa yapamwamba kapena yamatenda omwe matumbo amadzipweteka kwambiri HER2 ndipo adalandira chithandizo cham'mbuyomo monga anthracycline, taxane, ndi trastuzumab.
-kuphatikizana ndi letrozole kuchipatala kwa amayi omwe amatha kutuluka m'magazi omwe ali ndi khansa ya m'mawere yomwe imalandira mahomoni omwe amachititsa chidwi kwambiri ndi HER2 receptor omwe amachititsa kuti mankhwala a mahomoni asonyezedwe.

Zosintha Zosamba za Renal
Deta siilipo pokhudzana ndi kusintha kwa mlingo; Komabe, pharmacokinetics ya mankhwala awa sangawonongeke kuti apatsidwa kuti osachepera 2% ya mlingo woyenera amachotsedwa ndi impso.

Dzira la Chiwindi Kusintha
MALANGIZO OYERA OYERA KUTI AZITHANDIZE NTCHITO YOPHUNZIRA (CHILA-PUGH A / B): Deta palibe.

ZOLEMBEDWA ZOCHITIKA ZOKHUDZANA NDI HEPATIC (CHILD-PUGH C): Pezani mlingo:
-HER2-Positive Metastatic Breast Cancer (kuphatikizapo capecitabine): 750 mg / tsiku.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuphatikizapo letrozole): 1000 mg / tsiku

HEPATOTOXICITY ZOTHANDIZA ZOKHUDZA THERA: Kuleka chithandizo kwa nthawi zonse.

Ndemanga: Malingaliro a kusintha kwazitsulo amachokera ku maphunziro a pharmacokinetic; palibe deta yopezekapo.

Kusintha kwa Mitsempha
KUGWIRITSA NTCHITO NDI NTCHITO YA CYP450 3A4 INHIBITORS NDI / KAPENA KWAMBIRI CYP450 3A4 OTHANDIZA: Pewani kugwiritsira ntchito moyenera ngati zingatheke. Malingaliro a kusintha kwazitsulo amachokera ku maphunziro a pharmacokinetic; palibe deta yopezekapo.
KUGWIRITSA NTCHITO NDI CYP450 3A4 INHIBITORI: Pewani mlingo kwa 500 mg / tsiku; Lolani nthawi ya nsomba ya masabata pafupifupi 1 musanayambe kusintha kusintha kwa mankhwalawa kwa mlingo wokhazikika wovomerezeka ngati inhibitor yatha.
KUGWIRITSA NTCHITO NDI CYP450 3A4 INDUCER YAM'MBUYO YOTHANDIZA kuchepetsa dose kubwerera ku chiwerengero chovomerezeka cha mlingo ngati inducer yatha.
-HER2-Positive Metastatic Breast Cancer (kuphatikizapo capecitabine): Kuchulukitsa mlingo mpaka 4500 mg / tsiku.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuphatikiza ndi letrozole): Kuwonjezera mlingo mpaka 5500 mg / tsiku.

GRADE 2 kapena NTCHITO YOPHUNZITSIRA YOPHUNZITSIRA NTCHITO YOPHUNZITSIRA NTCHITO YOPHUNZITSIRA NTCHITO (LVEF) KAPENA KUKHALA KUKHALA KUDZIWA KWAMBIRI KWAKHALIDWE KOPHUNZITSIRA KWA AKULU: Khalani odwala mankhwala; akhoza kuyambiranso pa mlingo wocheperachepera patatha masabata osachepera a 2 ngati LVEF ikubwezeretsanso mwachibadwa ndipo wodwala ali ndi thupi.
Mankhwala Ochepetsedwa:
-HER2-Positive Metastatic Breast Cancer (kuphatikizapo capecitabine): 1000 mg / tsiku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuphatikizapo letrozole): 1250 mg / tsiku

GRADE 3 kapena GRADE 1 kapena 2 DIARRHEA NDI NKHANI ZOCHITIKA (zochepa zochepa mpaka kupweteka kwa m'mimba, Gulu la 2 kapena kupweteka kwambiri kapena kusanza, kuchepa kwa ntchito, kutentha thupi, kuchepa, kutsekemera kwa magazi, kutaya mwazi, kapena kutaya madzi): Mungabwezeretsenso mlingo wotsika pamene kutsekula m'mimba amatsimikiza ku Grade 1 kapena zosachepera.
Mankhwala Ochepetsedwa:
-HER2-Positive Metastatic Breast Cancer Odwala (kuphatikizapo capecitabine): 1000 mg / tsiku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Odwala: 1250mg / tsiku
GRADE 4 DIARRHEA: Osatha mwamsanga mankhwala.

ZOTHANDIZA ZOTHANDIZA, GRADE 2 kapena GREATER: Lingaganize kuleka kapena kusokonezeka kwa dosing; ayambirenso pa mlingo wokhazikika wa mankhwalawa ngati poizoni akukula ku Grade 1 kapena zochepa.
NGATI KUSAKHALA KWA TOXICITY RECURS: kuchepetsa mlingo:
-HER2-Positive Metastatic Breast Cancer (kuphatikizapo capecitabine): 1000 mg / tsiku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Odwala: 1250mg / tsiku

Momwe yaiwisi yakuda la Lapatinib imagwirira ntchito

Mafuta a lapatinib amagwiritsidwa ntchito ndi capecitabine (Xeloda) kuti apeze mtundu wina wa khansa yapakati ya m'mawere kwa anthu omwe akhala akuchiritsidwa ndi mankhwala enaake. Lapatinib ufa uli m'gulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa ntchito ya mapuloteni osadziwika omwe amaonetsa kuti maselo a khansa amachulukira. Izi zimathandiza kuima kapena kuchepetsa kufalikira kwa maselo a khansa.

chenjezo

Awuzeni ogwira ntchito zaumoyo anu onse kuti mupatsidwe ufa wa Lapatinib. Izi zikuphatikizapo madokotala anu, anamwino, asayansi, ndi madokotala a mano.
Ngati mwakhumudwa, kutaya, kutayirira (kutsekula m'mimba), kapena osakhala ndi njala, lankhulani ndi dokotala wanu. Pakhoza kukhala njira zochepetsera zotsatirazi.
Zithunzi zotsekula (kutsegula m'mimba) zakhala zikuchitika ndi phala la Lapatinib. Nthawi zina, kutsegula m'mimba kwakhala koipa kwambiri ndipo imfa yachitika. Lankhulani ndi dokotala wanu.
Ngati muli ndi zotsekula (kutsegula m'mimba), kambiranani ndi dokotala wanu. Musayese kutsekula m'mimba musanayambe kuyang'ana ndi dokotala wanu.
Chitani ntchito yokhudza magazi monga mwauzidwa ndi dokotala. Lankhulani ndi dokotala.
Muyenera kukhala ndi mayesero amtundu wa mtima mukatenga Lapatinib powder. Lankhulani ndi dokotala.
Pewani zipatso zamphesa ndi madzi a mphesa.
Ngati mutenga digoxin, lankhulani ndi dokotala wanu. Mungafunike kuti ntchito yanu ya magazi iwonongeke kwambiri pamene mukuitenga ndi Lapatinib powder.
Mankhwalawa akhoza kuvulaza mwana wosabereka ngati mutatenga pamene muli ndi pakati.
Gwiritsani ntchito njira zothandizira kuti mutha kutenga mimba mukatenga Lapatinib ufa.
Ngati muli ndi mimba kapena mutatenga pathupi pakhomo la Lapatinib, funsani dokotala molondola.

Nkhosa Yaikulu ya Lapatinib

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

Malonda a ufa wa Lapatinib

Kuti aperekedwe m'tsogolomu.

Kodi ufa wa Lapatinib yaiwisi uli ndi zotsatira zoyipa

Malinga ndi zofunikira zake, ufa wa Lapatinib ukhoza kuchititsa zina zosayenera. Ngakhale kuti zovuta zonsezi zingachitike, ngati zikuchitika zimakhala zofunikira kuchipatala.

Yang'anani mwamsanga ndi dokotala ngati zotsatirapo zotsatirazi zikuchitika mukatenga Lapatinib ufa:

Zosagwirizana kwambiri
Kupuma kovuta kapena kupanikizika
kutaya
kulapa kwa mtima kapena kosasinthasintha
kutsekula m'mimba
zolimba mu chifuwa
kutopa kapena zofooka
chosowa

Kupweteka m'mimba kapena m'mimba kapena chifundo
zojambula zadongo
mitsempha yamdima
kuchepetsa chilakolako
malungo
mutu
kuyabwa kapena kutupa khungu
kusowa kwa njala
kunyoza ndi kusanza
kutupa mapazi kapena miyendo yochepa
maso a khungu kapena khungu
Chidziwitso chosadziwika
Kusungunuka, kupukuta, kutsegula khungu
kupweteka pachifuwa
zovuta
chifuwa
kutsekula
zovuta ndi kumeza
chizungulire
kumverera kwakukulu kosautsa kapena matenda
ming'oma
ululu wophatikizana kapena wamisala
kudzikuza kapena kutupa kwa maso kapena nkhope, nkhope, milomo, kapena lirime
zilonda za khungu lofiira, nthawi zambiri ndi malo ofiira
zofiira, zowopsya maso
chikhure
zilonda, zilonda, kapena mawanga oyera m'kamwa kapena pakamwa
kuphulika kwachisokonezo chakuda
Zotsatira zina za Lapatinib ufa zingakhalepo zomwe sizikusowa chithandizo chamankhwala. Zotsatirapozi zingathe kutha panthawi ya mankhwala pamene thupi lanu limasintha mankhwala. Komanso, dokotala wanu wathandi akhoza kukuuzani za njira zothetsera kapena kuchepetsa zina mwa zotsatirazi. Fufuzani ndi katswiri wa zaumoyo ngati zotsatirapo zotsatirazi zikupitirira kapena zikuvutitsa kapena ngati muli ndi mafunso okhudza iwo:

Zowonjezereka kwambiri
Mthendayi kapena m'mimba yowawa
ululu wammbuyo
kumangirira
milomo yosweka
kutsekula m'mimba (wofatsa)
khungu youma
kupweteketsa mtima
kunyoza
ululu mmanja kapena miyendo
zofiira, kutupa, kapena khungu lopweteka
kukulitsa khungu pamanja ndi mapazi
zilonda, zilonda, kapena mawanga oyera pa milomo, lilime, kapena mkati mwa pakamwa
kusokonezeka m'mimba, kukwiya, kapena kupweteka
kutupa kapena kutupa kwa pakamwa
kukwapula kwa manja ndi mapazi
vuto logona


Kodi kugula Lapatinib ufa kuchokera ku AASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

COA 231277-92-2 Lapatinib ufa AASRAW

HNMR

Ndife ufa wa Lapatinib wophimba, Lapatinib ufa wogulitsa, Wofiira Lapatinib ufa (231277-92-2) hplc =98% | Ikani ma Reagents a R & D

Maphikidwe

Maphikidwe a Mpweya wa Lapatinib:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Tykerb (231277-92-2) -Wakupha mkaka wa m'mawere