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LCZ696 ufa (936623-90-4)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 936623-90-4. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu mpaka kulemera kwa LCZ696 powder (936623-90-4), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

LCZ696 ufa (sacubitril / valsartan powder) ndi membala wa gulu la antchito watsopano lotchedwa angiotensin receptor-neprilysin inhibitors (ARNIs) yomwe imaphatikizapo neprilysin inhibitor ndi blocker ya angiotensin receptor (ARB). LCZ696 powder pakalipano akuwonetsetsa kuti odwala ali ndi vuto la mtima ndi kachigawo kakang'ono ka ejection (HFrEF) m'malo mwa angiotensin kutembenuza mazira (ACE) inhibitor kapena ARB yokha. Dzina la malonda la LCZ696 powder ndi Entresto.

Mafotokozedwe Akatundu

LCZ696 powder video


LCZ696 ufa Anthu oyambirira

Name: LCZ696 ufa
CAS: 936623-90-4
Makhalidwe a Maselo: C24H29N5O3.C24H29NO5.5/2H2O.3Na
Kulemera kwa maselo: 915.98
Melt Point: 137-140 ° C
Kusungirako nyengo: pa -XUMUM ° C Zaka 20 Powder
mtundu; White powder


LCZ696 powder mu chiwopsezo chachikulu cha mtima wa imfa ndi mtima

Mayina

LCZ696 ufa, ufa wa sacubitril, valsartan, LCZ 696, LCZ-696

Mafuta akuluakulu a LCZ696

LCZ696 powder (sacubitril / valsartan powder) ndi membala wa gulu linalake lotchedwa angiotensin receptor-neprilysin inhibitors (ARNIs) lomwe limagwirizanitsa ndi neprilysin inhibitor ndi angiotensin receptor blocker (ARB). LCZ696 powder pakalipano akuwonetsetsa kuti odwala ali ndi vuto la mtima ndi kachigawo kakang'ono ka ejection (HFrEF) m'malo mwa angiotensin kutembenuza mazira (ACE) inhibitor kapena ARB yokha. LCZ696 powder (sacubitril / valsartan powder) inavomerezedwa ndi FDA mu July 2015 kuti achepetse chiopsezo cha imfa kuchokera ku ziwalo za mtima ndi kuchipatala chifukwa cholephera mtima kwa odwala omwe ali ndi mtima wosatha, NYHA yachiwiri II-IV, ndi kachigawo kakang'ono kamene kamakhala kochepa. Kuphatikizidwa kwa neprilysin kutetezera ndi renin-angiotensin aldosterone system (RAAS) zotsatira zawonetsedwa kukhala zopambana kuposa za ACE inhibitor. Dzina la malonda la LCZ696 powder ndi Entresto.

Mlingo woyambira mlingo ndi 49 / 51 mg kawiri tsiku lililonse.
Kuchuluka kwa mlingo woyamba wa LCZ696 ufa (sacubitril / valsartan ufa) 24 / 26 mgwiri tsiku lililonse limalimbikitsa odwala awa:

• ACE Inhibitor kapena ARB ndiive
• Kuchuluka kwa mlingo wa ACE inhibitor kapena mankhwala a ARB: mlingo wochepa wa ACE inhibitor wofanana: enalapril <= 10 mg tsiku ndi tsiku, mlingo wochepa wa ARB wofanana: valsartan <= 160mg tsiku ndi tsiku
• Ntchito yochuluka yamtambo (GFR <30ml / min / 1.73m 2)
• Kuwonongeka kwapadera kwapakati (Child-Pugh gulu B)

Chenjezo pa yaiwisi LCZ696 yaiwisi

LCZ696 powder (sacubitril / valsartan powder) amasonyeza kuti amachepetsa kufala kwa mtima wamtima komanso imfa ya mtima kusamalidwa kwa mtima kwa odwala omwe ali ndi matenda aakulu a HFrEF, NYHA yachiwiri II-IV. LCZ696 ufa wochuluka (sacubitril / valsartan ufa) ayenera kugwiritsidwa ntchito mogwirizana ndi ma GDMTs ena m'malo mwa ACE inhibitor kapena ARB.

Zotsutsa zikuphatikizapo:
• Kutengera mphamvu kwa chinthu chilichonse.
• Kugwiritsira ntchito kogwiritsira ntchito ACE inhibitor: LCZ696 powder (sacubitril / valsartan ufa) sayenera kuperekedwa mkati mwa maola 36 kulandira choletsera cha ACE.
• Kugwiritsa ntchito aliskiren moyenera kwa odwala matenda a shuga.
• Mbiri ya angioedema yokhudzana ndi mankhwala apitalo ndi ACE inhibitor kapena mankhwala a ARB.

Zotsatira zosayenera

(1) Zoopsa za feteleza: Mankhwala onse omwe amagwira ntchito pa RAAS angathe kuvulaza mwanayo ataperekedwa pa nthawi ya mimba. Zingathe kuchepetsa ubongo wa fetal m'kati mwachiwiri ndi chitatu chachitatu cha mimba ndi kuonjezera chiwerewere ndi matenda osokoneza bongo. LCZ696 ufa wochuluka (sacubitril / valsartan ufa) uyenera kuthetsedwa ngati mimba ikupezeka.

(2) Angioedema: Angioedema imadziwika ngati 0.5% ndi LZC696 (sacubitril / valsartan powder) ndi 0.2% ndi mpata wochulukirapo nthawi yomwe imakhala nthawi yayitali mu PARADIGM-HF. Panalinso chiŵerengero chowonjezeka mumtundu wakuda ndi osakhala achimuna ndi omwe ali ndi mbiri yakale ya angioedema. Ngati angioedema ikupezeka, LCZ696 ufa (sacubitril / valsartan powder) iyenera kuthetsedwa ndipo sayenera kuyambiranso. LCZ696 ufa wochuluka (sacubitril / valsartan ufa) sayenera kugwiritsidwa ntchito kwa iwo omwe ali ndi mbiri ya angioedema yokhudzana ndi ACE inhibitor yapitalo kapena mankhwala a ARB. Ngati kusinthira kapena kuchoka ku ACE inhibitor, nthawi ya 36 yofufuta nthawi imafunika pakati pa mankhwala.

(3) Kusakanikirana: LCZ696 ufa wochuluka (sacubitril / valsartan ufa) amachepetsa kuthamanga kwa magazi kupyolera muzitsulo za RAAS ndipo zingayambitse kusokoneza maganizo. Mu nthawi yachiwiri ya PARADIGM-HF, 18% ya odwala pa LCZ696 ufa wochuluka (sacubitril / valsartan ufa) adawonetsa zotsatira zowawa za hypotension vs. 12% pa odwala omwe ali ndi matendawa. Popeza pali oopsa kwambiri kwa odwala omwe ali ndi RAAS yovomerezeka, ndi bwino kukonza mchere kapena kutaya kwayomwe asanayambe. Ngati chizindikiro cha hypotension chimachitika, yesetsani kusintha mavitamini ndi ma antihypertensives ena, ndipo chitani mankhwala ena a hypovolemia ndi / kapena kuchepetsa mlingo wa LCZ696 powder (sacubitril / valsartan powder). Ngati vuto la hypotension likupitirirabe ngakhale LCZ696 ufa (sacubitril / valsartan powder), mankhwalawo angafunike kuimitsidwa.

(4) Ntchito yochuluka yamagazi: LCZ696 ufa (sacubitril / valsartan powder) ndi wothandizira RAAS; Choncho, kuchepa kwa nsomba kumakhala kotheka kuti anthu omwe ali ndi chiopsezo chachikulu, kuphatikizapo omwe ali ndi matendawa amachititsa kuti thupi likhale lopweteka kwambiri. Mu nthawi yapadera ya PARADIGM-HF, 5% mwa omwe amachitira mankhwala a LCZ696 yaiwisi yakuda (sacubitril / valsartan ufa) ndi enalapril inalephera kuwonongeka kwa nsomba ngati choipa. Kuonjezera apo, kuwonjezeka kwa Scr> = 50% kunawonetsedwa mu 16% mwa iwo omwe amachizidwa ndi LCZ696 powder (sacubitril / valsartan powder) ndi enalapril. Ntchito yansanala iyenera kuyang'anitsitsa kwambiri ndipo mlingo wa LCZ696 (sacubitril / valsartan powder) umayenera kuchepetsedwa kapena kuimitsidwa chifukwa cha kuchepa kwakukulu kwa ntchito yamphongo.

(5) Hyperkalemia: Kupyolera mu zotsatira zake pa kubisa kwa RAAS, LCZ696 powder (sacubitril / valsartan powder) ikhoza kuyambitsa hyperkalemia. Mu nthawi yawiri ya PARADIGM-HF, 12% ya odwala ankapatsidwa LCZ696 yaiwisi yakuda (sacubitril / valsartan powder) anafotokoza zotsatira zovulaza za hyperkalemia. Kuwonjezera apo, potaziyamu zowonjezera> 5.5 mEq / L zinawonetsedwa mu 16% mwa iwo omwe ankachitira limodzi ndi LCZ696 powder (sacubitril / valsartan powder) ndi enalapril. Kuyang'ana pafupi kumalangizidwa kwa odwala omwe ali ndi chiopsezo chachikulu monga matenda aakulu a shuga, shuga, hypoaldosteronism, kapena zakudya za potassium. Mankhwala amachepetsa kuchepetsa kapena kusiya mankhwalawa kungakhale kofunikira kuti pakhale phokoso la potassium.

Malinga ndi kapangidwe kake ka PARADIGM-HF komwe odwala amayenera kulekerera enalapril ndi LCZ696 ufa wochuluka (sacubitril / valsartan ufa) panthawi yomwe munthu wakhungu wosayendayenda akuthamanga, ndiye kuti zotsatira zake zimakhala zosawerengeka ndipo akhoza kukhala apamwamba mu kachipatala.

Maumboni ena

LCZ696 ufa unachititsa kuti PP kuchepetsere kuposa valsartan mu SHR mosasamala kanthu za kuchuluka kwa mchere, zomwe zimagwirizanitsidwa ndi kupititsa patsogolo kotiyaliyamu yokhala ndi ubweya wachisanu ndichisanu ndichisanu ndichisanu. Kuonjezerapo, choonjezera BP kuchepetsa mphamvu ya LCZ696 yaiwisi yaiwisi yomwe imayambitsa matenda oteteza mtima ku makoswe oopsa.

LCZ696 Pakuda Kwambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

LCZ696 Kutsatsa Poda

Kuti aperekedwe m'tsogolomu.


Momwe mungagulire LCZ696 ufa kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

COA 936623-90-4 LCZ696 ufa AASRAW

HNMR

Maphikidwe

LCZ696 Zakudya Zopangira Mphamvu

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