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Mitoxantrone HCL ufa

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 70476-82-3. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita ku misala ya Mitoxantrone HCL powder (70476-82-3), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Mitoxantrone hydrochloride powder ndi mankhwala a khansa omwe amalepheretsa kukula ndi kufalikira kwa maselo a khansa m'thupi. Mitoxantrone HCL ufa umagwiritsidwa ntchito pochizira kansa ya prostate ndi mitundu ina ya khansa ya m'magazi. Mitoxantrone HCL ufa imagwiritsidwanso ntchito pochiza zizindikiro za kubwezeretsanso matenda ambiri. Mankhwalawa sangachiritse matenda ambiri.

Mafotokozedwe Akatundu

Mitoxantrone hydrochloride powder video


Mitoxantrone hydrochloride powder Anthu oyambirira

Name: Mitoxantrone hydrochloride powder
CAS: 70476-82-3
Makhalidwe a Maselo: C22H30Cl2N4O6
Kulemera kwa maselo: 517.4
Melt Point: 160-162 ° C
Kusungirako nyengo: Firiji
mtundu; Yoyera kapena kuchotsa nyemba yakuyera ya Crystalline


Mitoxantrone hydrochloride powder mu ntchito

Mayina

Dzina la Dzina: Novantrone
Dzina la mankhwala: 1,4-dihydroxy-5,8-bis [[2- [2-hydroxyethyl] amino] ethyl] amino] 9,10-anthracenedione dihydrochloride

Ntchito ya Mitoxantrone hydrochloride powder

Mitsempha Yambiri ya Myeloid Leukemia

Chigawo chimodzi cha mankhwala otchedwa chemotherapy amachititsa kuti munthu atuluke mu myeloid (myelogenous, nonlymphocytic) khansa ya m'magazi (AML, ANLL). AML imaphatikizapo mankhwala othandizira kwambiri, monocytic, myelomonocytic, megakaryoblastic, ndi larythroid leukemias.

Amagwiritsidwa ntchito limodzi ndi othandizira ena opanga mankhwala opangira mankhwala m'thupi mwachidziwitso chotsatira cha kukhululukidwa kwathunthu.

Kansa ya Prostate
Amagwiritsidwa ntchito ngati njira ina yothandizira kuti ayambe kusamalitsa khansa ya prostate (yosakaniza ndi prednisone). Chithandizo choyamba choyambirira cha chithandizo cha khansa ya prostate ya prostate yamakono ndi docetaxel kuphatikizapo prednisone.

Multiple Sclerosis (MS)
Kuchiza kwa MS kachiwiri (kosatha), kupitiriza-kubwezeretsa, kapena kubwezeretsa kubwezeretsa MS. Anachepetsa kuchepa kwa ubongo ndi / kapena kubwereza kwafupipafupi.

Aphunzirapo kwa odwala omwe ali ndi matendawa: Kuwonjezereka kowonjezereka kwapadera kapena popanda kubwezeretsedwa kuchipatala (kupititsa patsogolo kwapang'onopang'ono ndi kubwereza kwapang'onopang'ono) ndi kubwezeretsa kuchipatala kumayambitsa kuwonjezeka kwaumphawi, chifukwa cha matenda okhudza ubongo pakati pa kubwezeretsa- kulandira matenda).

Osakonzedwe kuti agwiritsidwe ntchito kwa odwala omwe ali ndi pulasitiki yoyamba.

Sitiyenera kugwiritsidwa ntchito pochiza MS mu odwala okhala ndi mzere woyamba LVEF <50% (onani Myocardial Toxicity mu Mchenjezo Wotsatiridwa). Kawirikawiri sivomerezedwa kuti agwiritsidwe ntchito kwa iwo omwe ali ndi vuto lopweteka (onani Kuwonongeka kwa Hepatic Under Cautions) kapena kwa omwe ali ndi neutrophil chiwerengero <1500 / mm3.

Lymphoma ya Non-Hodgkin
Amagwiritsidwa ntchito monga mankhwala a combination of chemotherapy omwe amachititsa kuti munthu asamapereke mankhwala ochepa omwe si a Hodgkin's lymphoma †.

Kodi mlingo wa Mitoxantrone hydrochloride powder ndi chiani?

Amapezeka ngati ufa wa Mitoxantrone hydrochloride; mlingo wofotokozedwa monga mwa mitoxantrone HCL ufa.

akuluakulu
Mitsempha Yambiri ya Myeloid Leukemia
Thandizo la Kuchulukitsa
IV
12 mg / m2 tsiku ndi tsiku 1-3 kuphatikizapo cytarabine 100 mg / m2 tsiku lililonse (monga kupitirira kwa IV kupitirira maola 24) masiku 1-7.

Ngati njira yothetsera vutoli isanafike, njira yachiwiri yopangira zolembera imakhala ndi masiku 2 a HCL powder (12 mg / m2 tsiku ndi tsiku) ndi masiku 5 a cytarabine (100 mg / m2 tsiku ndi tsiku) angaperekedwe.

Ngati nthendayi yowopsya kapena yoopsa yowonongeka ikuwonetsedwa panthawi yoyamba yopititsa patsogolo, sungani njira yachiwiri yophunzitsira poyambitsa matendawa.

Kugwirizanitsa
IV
12 mg / m2 tsiku ndi tsiku 1 ndi 2 kuphatikizapo cytarabine 100 mg / m2 tsiku lililonse (monga kupitirira kwa IV kupitirira maola 24) masiku 1-5. Sungani masewero oyambitsanso oyambanso pafupifupi masabata a 6 pambuyo pa maphunziro omaliza opangira maphunziro; Gwiritsani ntchito njira yachiwiri yophatikizira pamodzi masabata a 4 pambuyo pa maphunziro oyambirira.

Kansa ya Prostate
IV
12-14 mg / m2 kamodzi pa masiku 21; perekani monga chithandizo cha mankhwala a corticosteroid (mwachitsanzo, prednisone 5 mg pamlomo kawiri tsiku lililonse, hydrocortisone 40 mg pamlomo tsiku lililonse). Madokotala ena amalimbikitsa kuti HCL ya mitoxantrone isapitirire (komanso kupitirira kwa corticosteroid therapy yokha) kwa odwala omwe akutsatira mzere wa mchere wa HCL wa 140 mg / m2 chifukwa cha kuopsa kwa poizoni wa mtima.

angapo ofoola ziwalo
IV
12 mg / m2 kamodzi pa miyezi 3 iliyonse.

Kulemba malire
akuluakulu
angapo ofoola ziwalo
IV
Kuchuluka kwa mlingo wa moyo wathanzi: 140 mg / m2.

Anthu Odziwika
Imfa yachinyengo
Kuchotsa chilolezo; Kusintha kwa mlingo kungafunike, komabe, palibe ndondomeko ya kusintha kwa mlingo. (Onani Kuwonongeka kwa Chiwongosoledwe Chakumvera Pakati pa Chenjezo.)

Kuwonongeka kwa Renal
Kuchepetsa kwa mlingo sikufunika.

chenjezo

Zochitika za Wopata Udokotala

Muziyang'anira kokha poyang'aniridwa ndi odwala omwe ali oyenerera pogwiritsira ntchito mankhwala a cytotoxic.

Machenjezo Otsogolera
Muziwongolera pang'onopang'ono njira yothetsera ubongo. Musagwirizane ndi IM, sub-Q, injini ya intra-arterial, kapena intrathecal.

Matenda ambiri a m'deralo necrosis ngati extravasation imachitika. (Onani Zotsatira Zomwe Zili M'kati mwa Chenjezo.)

Neurotoxicity yowopsya komanso yowonjezereka inalembedwa pambuyo potsatira ulamuliro wotsutsana. (Onani Neurotoxicity pansi pa Chenjezo.)

Myelosuppression
Kugonjetsa mimba koopsa kungabwere. Kawirikawiri musagwiritse ntchito odwala omwe ali ndi chiwerengero choyambirira cha neutrophil <1500 / mm3, kupatulapo mankhwala a myeloid (myelogenous, nonlymphocytic) a khansa ya m'magazi. Onetsetsani kuti hematologic imachitika mosamala. (Onani Zotsatira za Hematologic Under Cautions.)

Myocardial Toxicity
Kachilombo kotchedwa cardiotoxicity ndi CHF yomwe ingathe kupha nthawi kapena miyezi patatha zaka patatha chithandizo; chiopsezo chikuwonjezeka ndi kuchuluka kwa mlingo wochuluka.

Zowopsa (mbiri ya matenda kapena mtima wamaganizo, matenda oyambirira kapena osokoneza bongo kumalo opatsirana pogonana / apericardial, mankhwala oyamba ndi anthracyclines kapena anthracenediones, kapena kugwiritsa ntchito mankhwala ena a cardiotoxic) angapangitse ngozi ya cardiotoxicity. Komabe, poizoni akhoza kuchitika mosasamala kanthu kuti ziwalo za mtima wa mtima zilipo. (Onani Cardiotoxicity pansi pa Chenjezo.)

Ngozi ya CHF yomwe imakhala ndi odwala khansa imawerengedwa kukhala 2.6% pa mlingo wokwanira wa 140 mg / m2.

Musanayambe kulandira mankhwala, fufuzani odwala onse chifukwa cha zizindikiro za mtima ndi zochitika za m'mbiri ndi kuunika kwa thupi ndikupeza gawo loyambira kumapeto kwa ventricular ejection fraction (LVEF) ndi echocardiogram kapena multigated radionuclide angiography (MUGA).

Osayambitsa mankhwala kwa odwala multiple sclerosis ngati mzere woyamba LVEF uli <50%.

Odwala omwe ali ndi multiple sclerosis, yesani LVEF ndi echocardiogram kapena MUGA musanafike mlingo uliwonse; Musapereke mlingo wowonjezereka ngati LVEF ikucheperachepera <50% kapena ngati kuchepa kwapadera ku LVEF kumachitika.

Odwala ndi multiple sclerosis sayenera kulandira mlingo wowerengeka> 140 mg / m2.

Chimake Chokhalira Myelogenous Leukemia (AML)
AML yachiwiri inalembedwa kwa odwala opatsidwa ndi mitoxantrone HCL ufa; Kuopsa kwa refractory secondary leukemias kumawonjezeka pamene anthracyclines akuphatikizidwa ndi mankhwala ena a DNA omwe amavulaza tizilombo toyambitsa matenda, atakhala ndi mankhwala otchedwa cytotoxic, kapena ngati anthracycline mlingo wawonjezeka. (Onani Carcinogenicity under Caution.)

Mayixantrone hydrochloride Raw Powder

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

Mitoxantrone hydrochloride powder Marketing

Kuti aperekedwe m'tsogolomu.

Kodi ufa wa Mitoxantrone HCL uli ndi zotsatira zoyipa

Zomwe zimachitika kawirikawiri za mitoxantrone zimaphatikizapo: matenda, matenda opatsirana m'mimba, matenda a mitsempha, matenda a fungal, matenda a khungu, sepisi, alopecia, amenorrhea, mtima wam'mimba, kudzimbidwa, kutsekula m'mimba, kuchepa kwa m'mimba, kuchepa kwa m'mimba, kuwonjezeka kwa gamma-glutamyl transfase, matenda a m'mimba, kupweteka kwa m'mimba, kupweteka kwa magazi, kupweteka kwa magazi, kuchepa kwa magazi, kuchepa kwa mimba, kupweteka kwa m'mimba, kupweteka kwa mimba, kupweteka, kutentha thupi, matenda a hyperglycemia, hypocalcemia, hypokalemia, kuchuluka kwa seramu shuga, lymphocytopenia, mucositis, pharyngitis, rhinitis, kupweteka kwa m'mimba, thrombocytopenia, kusanza, kulemera, kulemera kosawerengeka kwa neutrophil, anorexia, malaise, ndi nailbedchanges. Zotsatira zina zimaphatikizapo: chibayo, matenda osokoneza bongo, kupweteka, kupweteka kwa m'mimba, kupweteka kwa ululu, granulocytopenia, kupweteka kwa ululu, sinusitis, nkhawa, arthralgia, conjunctivitis, kuvutika maganizo, kutaya magazi, kutaya magazi, kuthamanga kwa magazi, hyperatremia, kusowa mphamvu, kuwonjezeka kwa seramu alanine aminotransferase, kuchuluka kwa serum aspartate aminotransferase, ischemic matenda a mtima, myalgia, ululu, petechia, proteinuria, sterility, kupweteka, chills, diaphoresis, ndi macchymoses. Onani m'munsimu kuti mndandanda wa zovuta zisachitike.


Mungagule bwanji Mitoxantrone hydrochloride powder kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

COA 70476-82-3Mitoxantrone HCL ufa AASRAW

HNMR

Ndife Mitoxantrone hydrochloride powder supplie, Mitoxantrone HCL ufa wogulitsa, Yaikulu Mitoxantrone HCL powder supplie (70476-82-3) hplc =98% | AASraw

Maphikidwe

Mitoxantrone hydrochloride Raw Powder Maphikidwe

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu