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MMAD (Demethyldolastatin 10)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 203849-91-6. Category:

AASraw ali ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kuti apange masewera a MMAD (Demethyldolastatin 10) (CAS 203849-91-6), pansi pa malamulo a CGMP ndi kayendedwe ka khalidwe labwino.

Komanso, MMAD amavomereza kuti amagwiritsidwa ntchito popanga mankhwala omwe amadziwika ndi anti-antijactic (NDCs). Mu NDCs, MMAD ili ndi anti-5T4 antibody kapena anti-Her2 antibody. Zimasonyezedwa kuti NDCs ikuwonetsa bwino ntchito komanso pharmacokinetics.

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MMAD (Demethyldolastatin 10) kanema


MMAD (Demethyldolastatin 10) ofunika kwambiri

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Makhalidwe a Maselo: C41H66N6O6S
Kulemera kwa maselo: 771.06
Melt Point: N / A
Kusungirako nyengo: Powonjezera -20 ° C zaka 3
4 ° C zaka 2
Mu zosungunulira -80 ° C miyezi 6
-20 ° C mwezi wa 1
mtundu; Kuyera mpaka woyera (olimba)


MMAD (Demethyldolastatin 10) (203849-91-6) ntchito mu steroid cycle

Mayina

Mafanowo: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Chenjezo pa MMAD (Demethyldolastatin 10)

Zamtengo wapangidwe sizinatsimikizidwe kwathunthu pa ntchito zamankhwala. Kufufuza kumagwiritsa ntchito kokha

Kuti mupeze kutentha kwapadera, chonde muziwotcha chubu pa 37 ℃ ndikugwedezani mu akusamba kwa kanthawi. Njira yothetsera imatha kusungidwa pansipa -20 ℃ kwa miyezi ingapo.

Maumboni ena

In Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) imagwirizanitsidwa kudzera mu njira yokhazikika ya oxime kuti iwonetsetse ma antijeni (ADCs) omwe ali pafupi ndi omwe amadziwika bwino ndi omwe amamwa mankhwalawa ndi 2.0. Zotsatira zake zimagwiritsa ntchito mankhwala abwino kwambiri, omwe amachititsa kuti vitro cytotoxic isakane ndi maselo a khansa ya HER2 +. Poyerekeza ndi ADCs yokonzedwanso ndi cysteine ​​alkylation motsatira njira zochepetsera za disulfide kuchepetsa, zizindikiro zapadera za amino-acid-based ADCs zikuwonetsedwa kuti zawonjezeka mu vitro cytotoxicity

Mu Vivi: Zotsatira za anti-drug conjugates (ADCs) zimasonyeza kuti thupi lonse limakhala ndi makoswe. Amakhalanso ndi mbiri yabwino ya poizoni m'ma rats.


Momwe mungagulire MMAD; Gwiritsani Demethyldolastatin 10 ku AASraw

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