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MMAF (Hydrochloride) (1415246-68-2)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 1415246-68-2. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita ku dongosolo la MMAF (Hydrochloride) (CAS 1415246-68-2), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

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Video ya MMAF (Hydrochloride)


Mankhwala a MMAF (Hydrochloride)

Name: MMAF (Hydrochloride)
CAS: 1415246-68-2
Makhalidwe a Maselo: C39H66ClN5O8
Kulemera kwa maselo: 768.42
Melt Point: 314.3 ° C pa 760 mmHg (Zinanenedweratu)
Kusungirako nyengo: Powonjezera -20 ° C zaka 3
4 ° C zaka 2
Mu zosungunulira -80 ° C miyezi 6
-20 ° C mwezi wa 1
mtundu; White crystalline powder


Ntchito ya MMAF (Hydrochloride) mu steroid cycle

Mayina

MMAF (Hydrochloride) (1415246-68-2) imatchedwanso Monomethylauristatin F Hydrochloride, MMF HCL

Ntchito ya MMAF (Hydrochloride)

Wasayansi wa zamankhwala amachita reseach ambiri pa MMAF, pansipa pali ndemanga zowonjezera:
In Vitro: MMAF imasonyeza mu vitro cytotoxicity motsutsana ndi gulu la maselo. Miyambo ya IC50 ya Karpas 299, H3396, 786-O ndi Caki-1 ndi 119, 105, 257, ndi 200 nM, motero. MMAF yowunikiridwa ndi yowonjezera kwambiri kuposa mankhwala osungira, komanso kuti cAC10 conjugates ya ntchito ya MMAF ikuwonetsedwa. Mogwirizana, cAC10-L1-MMAF4 ndiyposa pafupifupi 2200 kuposa mphamvu ya MMAF ndipo ikugwira ntchito pazitsulo zonse za CD30 zoyesedwa.

Mu Vivo: Mlingo wochuluka wolekerera m'magulu a MMAF (1415246-68-2) (> 16 mg / kg) ndi wapamwamba kuposa MMAE (1 mg / kg). CAC10-L1-MMAF4 imakhala ndi MTD ya 50 mg / kg mu mbewa komanso 15 mg / kg mu makoswe. CAC10-L4-MMAF4 ADC inali yochepa kwambiri poizoni, pokhala ndi ma MTD mu makoswe ndi makoswe a> 150 mg / kg ndi 90 mg / kg pa makoswe, motero

Chenjezo pa MMAF (Hydrochloride)

Kwa kafukufuku wogwiritsidwa ntchito kokha

Maumboni ena

Zinalembedwa kuti Monomethylauristatin F Hcl (MMAF Hcl) ndi wothandizira antitubulin omwe amaletsa kupatulidwa kwachinsinsi mwa kulepheretsa poizoni ya tubulin; ndipo ntchito ya thecytotoxic ili yochepa kuposa MMAE; ndipo ndi anti-drug anti-cytotoxin.

Cell Assay
Maselo amachiritsidwa ndi maselo ofanana a ma selolekiti ndipo amayambira masiku 4-6 malinga ndi mzere wa selo. Kuyesera kwa kukula kwa maselo ndi kuchepetsa deta kuti apange miyezo ya IC50 ikugwiritsidwa ntchito pogwiritsa ntchito kuchepetsa dothi la Alamar Blue
MCE sinavomereze mwachindunji kulondola kwa njira izi. Iwo ali oti aziwongolera okha.

Ulamuliro wa Zinyama
Ntchentche: Kafukufuku amasonyeza kuti pamene Karpas 299 chotupa chachikulu chikufika ku 300 mm3, nyama zitatu zimagwiritsa ntchito jekeseni imodzi ya 10 mg antibody chigawo / kg kulemera kwake kwa cAC10-L1-MMAF4 kapena cBR96-L1-1415246 ) 68 mwachangu. Ziphuphu zimachotsedwa kenako zimayikidwa muzigawo zowonjezera kutentha, ndipo 2 μm-magawo ozizira a mazira amayambitsidwa pogwiritsa ntchito immunohistochemistry
MCE sinavomereze mwachindunji kulondola kwa njira izi. Iwo ali oti aziwongolera okha.


Momwe mungagulire MMAF; Gulani Hydrochloride kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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HNMR

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