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Monomethyl auristatin E (MMAE) powder

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 474645-27-7. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kameneka kuchokera ku gramu kupita ku manda a Monomethyl auristatin E (MMAE) powder (474645-27-7), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Mafotokozedwe Akatundu

Mavidiyo a powder a monomethyl auristatin E (MMAE)


Monomethyl auristatin E (MMAE) powder Anthu oyambirira

Name: Monomethyl auristatin E (MMAE) powder
CAS: 474645-27-7
Makhalidwe a Maselo: C39H67N5O7
Kulemera kwa maselo: 717.97858
Melt Point: 238-240 ° C
Kusungirako nyengo: Sungani mu chidebe choyambirira, pakati pa 36 ndi madigiri 46
mtundu; White powder


Monomethyl auristatin E powder monga antimitotic wothandizila

Mayina

Brentuximab vedotin, MMAE ufa

Mankhwala a monomethyl auristatin E powder

• Achikulire
Monotherapy, 1.8 mg / kg (osapitilira 180 mg / mlingo) IV milungu yonse ya 3; kuphatikizapo chemotherapy, 1.2 mg / kg (osapitilira 120 mg / mlingo) IV milungu yonse ya 2.

• Zosakaniza
Monotherapy, 1.8 mg / kg (osapitilira 180 mg / mlingo) IV milungu yonse ya 3; kuphatikizapo chemotherapy, 1.2 mg / kg (osapitilira 120 mg / mlingo) IV milungu yonse ya 2.

Monomethyl auristatin E powder (MMAE powder, vedotin) ndi mankhwala amphamvu kwambiri omwe amachititsa kuti maselo aphatikizidwe asatseke poyimitsa poizoni wa tubulin. Banja la auristatin ndilofanana ndi mankhwala omwe amachititsa kuti tizilombo toyambitsa matenda Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors omwe amagwiritsidwa ntchito monga malipiro amtundu wa anti-drug conjugates. Monomethyl auristatin E powder kapena MMAE powder ndi 100-1000 nthawi zoposa doxorubicin (Adriamycin / Rubex) ndipo sungagwiritsidwe ntchito ngati mankhwala enieni. Komabe, monga mbali ya anti-mankhwala conjugate kapena ADC, MMAE ufa umagwirizanitsidwa ndi antioclonal antibody (mAb) yomwe imazindikira chizindikiro chodziwika mu maselo a kansa ndipo imatsogolera MMAE powder ku selo yeniyeni yokhudza khansa.

Mgwirizanowu umagwirizanitsa MMAE powder ndi mankhwala osungunula amtundu umodzi ndipo umakhala wosasunthika m'madzi oundana, koma umagwiritsidwa ntchito ndi cathepsin kamodzi kokha ngati anti-mankhwala-conjugate yatha kugwidwa ndi kansa ya antigen ndipo imalowa m'khungu la khansa, kenako ADC imatulutsa poizoni MMAE powder ndipo zimayambitsa njira zothana ndi mitotic. Mankhwala opatsirana pogwiritsa ntchito mankhwala opatsirana pogwiritsa ntchito mankhwalawa amachititsa kuti thupi likhale ndi zotsatira zotsutsana ndi ma antibodies komanso kuchepetsa mphamvu zovuta zogwiritsira ntchito mankhwala a cytotoxic.

Chenjezo pa Monomethyl auristatin E powder

• Pneumonitis, matenda a pulmonary, kupuma kwa matenda
Kuchuluka kwa mankhwala osapatsirana a m'magazi (mwachitsanzo, pneumonitis, matenda opatsirana, mapiritsi ovutika maganizo) wakhala akufotokozedwa ndi brentuximab therapy; milandu ina inali yoopsa. Onetsetsani odwala chifukwa cha zizindikiro za poizoni wa poizoni monga chifuwa ndi dyspnea. Ganizirani odwala omwe amachititsa zizindikiro zatsopano zamapulmoni; gwiritsani brentuximab mpaka zizindikiro zikupitirira. Kugwiritsiridwa ntchito kwabwino kwa brentuximab ndi bleomycin-containing chemotherapy (yotchedwa label), monga ABVD (adriamycin, bleomycin, vinblastine, dacarbazine), imatsutsana chifukwa cha chiopsezo chowonjezereka cha mankhwala osokoneza bongo. Kulowerera m'mimba ndi / kapena kutupa (komwe kunapezeka pa X-ray kapena zithunzi zojambula zithunzi) kunkachitika kawirikawiri ku odwala a Hodgkin lymphoma amene analandira brentuximab kuphatikizapo ABVD mu kuyezetsa magazi poyerekeza ndi odwala akale omwe analandira ABVD okha. Ambiri amatsatiridwa potengera chithandizo cha corticosteroid.

Matenda a ubongo
Mphuno ya ubongo, makamaka matenda a ubongo, yakhala ikudziwika ndi brentuximab vedotin therapy; pulogalamu yokhala ndi ubongo wa m'mimba ndi yowonjezera. Onetsetsani odwala kuti azidwala matenda a mphuno (mwachitsanzo, hypoesthesia, hyperesthesia, paresthesia, kusautsika, kutentha, kupweteka kwa mtima, kapena kufooka). Kusokonekera kwa mankhwala, kuchepa kwa mlingo, kapena kuchoka kwa mankhwala kungakhale kofunikira kwa odwala amene amachititsa kuti pakhale matenda atsopano.

• Kuchepetsa magazi, kuchepa kwa magazi, neutropenia, thrombocytopenia
Kuopsa kwa hematologic toxicities (mwachitsanzo, kuchepa magazi m'thupi, thrombocytopenia, neutropenia) ndi matenda oopsa ndi oopsa a febrile neutropenia akhala akufotokozedwa ndi brentuximab vedotin treatment; neutropenia ikhoza kukhala yaitali (yokhazikika kwa sabata la 1 kapena lalitali). Odwala achikulire omwe ali ndi zaka 65 ndi zaka zambiri ndi Hodgkin lymphoma amene analandira brentuximab vedotin kuphatikizapo mankhwala a chemotherapy omwe ali ndipamwamba kwambiri ya febrile neutropenia poyerekeza ndi odwala ochepa. Pezani magazi okwanira musanafike pa mlingo uliwonse wa mankhwalawa komanso nthawi zambiri ngati kalasi ya 3 kapena 4 neutropenia imapezeka; kuyang'anitsitsa odwala onse chifukwa cha malungo. Kusokonezeka kwa mankhwala, kuchepetsa mlingo, kapena kuchoka kwa mankhwala kungakhale kofunikira kwa odwala omwe amapanga kalasi ya 3 kapena 4 neutropenia; ganizirani kuwonjezera kwa prophylactic granulocyte-colony factor stimulating factor (G-CSF) ndi mankhwala owonjezera. Gwiritsani ntchito G-CSF kuyambira kumapeto kwa 1 kwa odwala omwe akulandira brentuximab vedotin kuphatikizapo chemotherapy.

• Kutupa lysis syndrome (TLS)
Tumor lysis syndrome (TLS) yawonetsedwa kwa odwala omwe analandira brentuximab vedotin. Odwala omwe ali ndi zotupa mofulumira komanso / kapena chotupa chokwanira angakhale ndi chiopsezo chowonjezereka chokhala ndi TLS. Onetsetsani odwala chifukwa cha zizindikiro za TLS (mwachitsanzo, serum electrolytes, uric acid, serum creatinine) musanafike nthawi ndi nthawi; kuyambitsa mankhwala oyenera komanso mankhwala (monga hydration, uric acid lowering therapy) ngati n'kofunikira.

• Kupititsa patsogolo ma letifencephalopathy
Mavuto oopsa a ma multifocal leukoencephalopathy (PML), omwe amachititsidwa ndi kachilombo ka John Cunningham (JC kachilombo), awonetsedwa ndi brentuximab therapy; zina zinachitika m'miyezi yoyamba ya 3 yoyamba mankhwala. Odwala omwe ali ndi matenda opatsirana pogonana kapena matenda opatsirana pogonana angakhale pangozi yowopsa ya JC kachilombo ka HIV ndi PML. Yerekezerani odwala amene amayamba zizindikiro zatsopano zamaganizo, zoganizira, kapena zizindikiro monga kusintha kwa maganizo kapena khalidwe; chisokonezo; kupweteka kukumbukira; kusintha m'masomphenya, kulankhula, kapena kuyenda; ndi / kapena kuchepa mphamvu kapena kufooka mbali imodzi ya thupi. Gwiritsani ntchito mankhwalawa ngati PML akukayikira; kusiya brentuximab kwa odwala omwe anatsimikiziridwa ndi PML.

• Kufooka kwachinyengo
Pewani kugwiritsa ntchito brentuximab vedotin kwa odwala omwe ali ndi vuto lalikulu la chiwindi (creinine clearance (CrCl) zosakwana 30 mL / min). Zotsatira za kalasi ya 3 kapena zochitika zovuta kwambiri ndi imfa zinali zazikulu kwa odwala omwe ali ndi vuto lalikulu la nthendayi poyerekeza ndi odwala omwe ali ndi chizoloŵezi chodzipha (CrCl wamkulu kuposa 80 mL / min) mu kafukufuku wamagetsi amodzi.

• Matenda achilendo
Pewani kugwiritsa ntchito brentuximab vedotin kwa odwala omwe ali ndi vuto lochepa (Child-Pugh B) kapena woopsa (Child-Pugh C) matenda opatsirana; Kuchepetsa kuchepa kwa mlingo kumalimbikitsa odwala omwe ali ndi vuto lopweteka kwambiri (Child-Pugh A). Zotsatira za kalasi ya 3 kapena zochitika zovuta kwambiri ndi imfa zinali zazikulu kwa odwala omwe ali ndi vuto lopanda malire kapena lopweteka kwambiri poyerekezera ndi odwala omwe ali ndi chizoloŵezi chodziwika bwino mu kafukufuku wamagetsi amodzi. Hepatotoxicity (mwachitsanzo, kuvulala kwa hepatocellular, mapuloteni okwera kwambiri, ndi hyperbilirubinemia) zafotokozedwa ndi brentuximab vedotin mankhwala. Zochitika zina zinachitika pambuyo pa mlingo woyamba kapena pa mankhwala rechallenge; imfa yokhudzana ndi matenda a hepatotoxicity. Yang'anani mayeso a chiwindi (LFTs), kuphatikizapo bilirubin, musanayambe komanso pakutha mankhwala. Kusokonezeka kwa mankhwala, kupatsirana kwa mlingo, kapena kuchoka kwa mankhwala kungakhale kofunikira kwa odwala omwe amachititsa kuti matenda a hepatotoxicity akhale atsopano, owonjezereka, kapena obwerezabwereza. Odwala omwe ali ndi matenda a hepatic omwe alipo kale kapena a LFTs apamwamba pazotsatira ndi odwala omwe akulandira mankhwala osokoneza bongo angawonjezeke ndi chiopsezo chotenga matenda a hepatotoxicity.
• Kutenga, sepsis
Matenda osadziwika ndi matenda ena akuluakulu, kuphatikizapo chibayo, bacacteremia, ndi sepsis (zina zimafa), zakhala zikufotokozedwa ndi brentuximab vedotin therapy. Yang'anani mosamala odwala pa chithandizo cha zizindikiro za mabakiteriya, fungal, kapena mavairasi.

• Zochita zokhudzana ndi kulowetsedwa
Zomwe zimakhudzana ndi kulowetsedwa kuphatikizapo anaphylaxis zalembedwa ndi brentuximab vedotin mankhwala; Choncho, yang'anani odwala omwe ali pafupi ndi zizindikiro za zomwe zimachitika pa brentuximab kulowetsedwa. Mwamsanga ndikusiya mankhwala ngati anaphylaxis ikupezeka. Lekani kulowetsedwa ndikuyambitsa chithandizo choyenera cha mankhwala kwa odwala omwe amachititsa zomwe zimakhudzana ndi kulowetsedwa. Kukonzekera (mwachitsanzo, acetaminophen, antihistamine, ndi / kapena corticosteroid) musanayambe kugwidwa ndi odwala omwe kale adakumana ndi kulowetsedwa.

• Kutupa, Kutaya magazi, Matenda a GI, kulepheretsa GI, kuperewera kwa GI, leus, matenda a zilonda zam'mimba
Matenda aakulu a m'mimba (GI) kuphatikizapo GI perforation, GI magazi, kutentha kwa GI, matenda a chilonda, matenda a GI, neutropenic colitis, enterocolitis, ndi ileus zakhala zikufotokozedwa ndi brentuximab vedotin therapy; zina zinachititsa imfa. Kufufuza mwamsanga ndikuchiza matenda a GI kwa odwala omwe amayamba zizindikiro zatsopano za GI kapena zowonjezereka. Gwiritsani ntchito brentuximab mosamala kwa odwala omwe ali ndi mbiri ya matenda a GI. Odwala omwe ali ndi mbiri ya lymphoma ndi kugawidwa kwa GI akhoza kukhala ndi chiopsezo chowonjezereka cha kugonana kwa GI.

• Mimba
Brentuximab vedotin ikhoza kuvulaza mwana ngati ataperekedwa pa nthawi yomwe ali ndi pakati pogwiritsa ntchito njira ndi deta kuchokera ku maphunziro a zinyama. Amuna omwe ali ndi mphamvu zobereka ayenera kulangizidwa kuti asamakhale ndi pakati pamene alandira brentuximab. Ngati mayi atenga mimba akamamwa mankhwalawa, ayenera kuphunzitsidwa za vuto lomwe angakhale nalo mwanayo. Phunziro la zinyama, chiberekero-fetus toxicities kuphatikizapo kupwetekedwa kwapachirombo kameneka chinawonetseredwa pa mitsempha ya brentuximab yomwe inachititsa kuti amayi asamawonongeke omwe anali ofanana ndi chiwonongeko cha anthu pa mlingo woyenera.

• Kufuna kusamalidwa, kusabereka, kugwirizanitsa amuna, kutenga mimba, chiopsezo chobereka
Alangizi othandizira okhudzana ndi chiopsezo chotenga kachilombo ka HIV ndi matenda opatsirana pogonana pafupipafupi. Kuyesera kwa mimba kuyenera kuchitidwa musanayambe brentuximab mu odwala omwe ali ndi mphamvu zobereka. Odwalawa ayenera kugwiritsa ntchito njira zowathandiza kulera komanso kupewa mimba nthawi ndi miyezi iwiri ya 6 pambuyo pa chithandizo cha brentuximab. Azimayi amene amatenga mimba akalandira brentuximab ayenera kuphunzitsidwa za vuto lomwe angakhale nalo mwana. Kuwonjezera apo, odwala amuna omwe ali ndi zibwenzi zokhuza kubereka ayenera kugwiritsa ntchito njira zothandiza pakulera panthawi yopereka chithandizo komanso kwa miyezi ingapo ya 6 mankhwalawa chifukwa cha chiopsezo chokhalira pakati pa amuna. Malingana ndi maphunziro a zinyama, brentuximab ingayambitse kusabereka kwa amuna.

• Kudyetsa m'mimba
Palibe zambiri zokhudzana ndi kukhalapo kwa brentuximab vedotin mkaka wa anthu, zotsatira za mwana wakhanda, kapena zotsatira za kupanga mkaka. Chifukwa cha zomwe zingayambitse ana okalamba (mwachitsanzo, cytopenias ndi neurologic kapena m'mimba toxicities), kuyamwitsa sikuvomerezedwa panthawi yomwe imapangidwanso. Ganizirani phindu la kuyamwitsa, chiopsezo cha mankhwala osokoneza bongo, komanso chiopsezo chosachitidwa kapena chosakwanira. Ngati mwana wakhanda akumana ndi zotsatira zovuta zokhudzana ndi mankhwala opatsirana ndi amayi, osowa chithandizo chaumoyo amalimbikitsidwa kuti afotokoze zotsatira zovuta kwa FDA.

Maumboni ena

Monomethyl auristatin E powder (MMAE powder) imamasulidwa bwino kuchokera ku SGN-35 mkati mwa maselo a kansa ya CD30 + ndipo, chifukwa cha chiŵerengero chake, imatha kugwira ntchito ya cytotoxic pamaselo oima. Mafuta a MMAE amachititsa kuti IR azikhala ndi khansa yowonongeka komanso yosaopsa. Ma Radiosensitization amatsimikiziridwa ndi kupulumuka kwachinsinsi komanso kupitirira kwa DNA kawiri kawiri m'maselo osakanizidwa.

Monomethyl auristatin E yaiwisi

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

Monomethyl auristatin E yaiwisi Maphikidwe a Powder

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Monomethyl auristatin E powder Marketing

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IV. Kodi kugula Monomethyl auristatin E powder; Gula MMAE powder kuchokera ku AASRAW?

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5.Goods inalandira ndi kupereka ndemanga.


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COA

COA 474645-27-7 Monomethyl auristatin E (MMAE) AASRAW

HNMR

Tili ndi monomethyl auristatin e powder supplie, MMAE powder podulitsa, Monomethyl auristatin E (MMAE) powder (474645-27-7) ≥98% | AASraw

Maphikidwe

Monomethyl auristatin E Zakudya Zam'madzi Zowonjezera:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Antinoplastic Agent Monomethyl auristatin E (MMAE)