USA Kutumiza Kwawo Kumudzi, Canada Kutumiza Kwawo, Kunyumba kwa ku Ulaya

Sunifiram (DM235) powder

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 314728-85-3. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kake kuchokera ku gramu kupita ku maulendo a Sunifiram (DM235) powder (314728-85-3), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe.

Mafotokozedwe Akatundu

Mavidiyo a ufa wa Sunifiram (DM235)


Sunifiram (DM235) powder

Name: Sunifiram (DM235) powder
CAS: 314728-85-3
Makhalidwe a Maselo: C15H13F2NO2S
Kulemera kwa maselo: 309.33
Melt Point: 57-58 ° C
Kusungirako nyengo: Sungani kutentha kapena kutentha
mtundu; White kapena off-woyera woyera


Dothi la Sunifiram (DM235) mukulingalira kwa ubongo

Mayina

Sunifiram ufa, DM235 ufa ndi dzina la malonda monga BisfluoroModafinil, Flmodafinil.

DM235 Kugwiritsa ntchito ufa

DM235 ufa ndilo buku, lolimba kwambiri la nootropic ndi la AMPAkine monga chigawo chodziwitsidwa-kuwonjezereka kwa zitsanzo zamtundu.

Dothi la Sunifiram ndi piperazine yomwe imakhala yofanana ndi piracetam. Piracetamu inakonzedwa chifukwa cha matenda osokoneza bongo monga matenda a Alzheimer, ndi Sunifiram powder amadziwika kuti apititse patsogolo chidziwitso m'zoyesera zina. M'maphunziro opangira mapulogalamu, Sunifiram ufa wosawoneka sasonyeza ubwino wa mapulogalamu othandizira anthu odwala matenda a neurotransmitter kapena njira (palibe kugwirizana kwa 1μM kwa serotoninergic, dopaminergic, muscarinic, nicotinic, adrenergic, glutamatergic, histaminergic, opioid, kapena GABAergic receptors), komabe amalimbikitsa kumasulidwa kwa acetylcholine kuchokera ku makoswe a cerebral cortex, mwinamwake pogwiritsa ntchito njira yabwino ya kuyankha kwa AMPA.

Sunifiram ufa amalepheretsa amnesia kupangidwa ndi scopolamine, itatha ip ndi poyendetsedwe, mu mbewa yosafuna kugwiritsidwa ntchito mosagwiritsidwa ntchito pang'ono ndi 0.01 mg / kg po Mmene mankhwala a Sunifiram akugwiritsira ntchito ndi ofanana ndi omwe amagwiritsidwa ntchito ndi mankhwala otchedwa nootropic monga piracetam (30 mg / kg ip), aniracetam (100 mg / kg po) ndi rolipram (30 mg / kg po), koma ndi potency nthawi 1,000 - 10,000.

Chenjezo pa zotsatira za DM235 powder

Dothi la Sunifiram (DM-235) ndi mankhwala ofufuza a piperazine omwe ali ndi zotsatira zotsutsana ndi amnesiac mu maphunziro a nyama omwe ali ndi mphamvu zopambana kuposa piracetam. Sunifiram ufa wosalala ndi kuphweka kwa maselo a unifiram. Malingana ndi maphunziro a vitro ndi nyama, zikuwoneka kuti ufa wa Sunifiram umagwira ntchito kudzera mu AMPA-receptor activation.

Sunifiram ufa wofiira umagwira ntchito popanga machipatala a AMPA; ndiko kuti, obwezeretsa omwe ali ndi udindo wothetsera mgwirizano wa synaptic mkatikatikati mwa zamanjenje. Mankhwala ake amachititsanso kuti phosphorylation ya AMPAR ndi NMDAR ipitirize kupyolera mu mapulotini kinase activation, omwe amachititsa kuti pakhale nthawi yaitali yomwe ingatengeke.

Kutsegula kwa kinase komwe kumakhudzidwa ndi ufa wa Sunifiram kumathandizanso kuchepa kwa chidziwitso. Kuonjezerapo, Sunifiram ufa wofiira amagwira ntchito mu ubongo wamtundu wa masewero a zinyama pothandizira kumasulidwa kwa acetylcholine, molekyule wa chilengedwe omwe amachititsa kuti thupi likhale ndi tizilombo tosiyanasiyana. Njirazi zimathandiza mphamvu ya Sunifiram kukhala ndi katundu wotsutsa amnesiac.

Maumboni ena

Sunifiram ufa imathandizanso kuti amnesia ayambe kutsutsidwa ndi mecamylamine wotsutsana ndi nicotinic, GABAB agonist baclofen, α2 agonist clonidine ndi NPAQ ya AMPA yothandizira kulandira mankhwala.

Mu mayeso a madzi a kakombo a kamphanga Morris, kayendetsedwe ka scopolamine imalepheretsa kuchepetsa kupulumuka kwazomwe zimapindula poyesa kuyesedwa. Sunifiram ufa wosalala, womwe umapatsidwa 20 min musanaphunzire maphunziro a tsiku ndi tsiku, amatha kulepheretsa kukumbukira kukumbukira kwa 0.1 mg / kg ip

Mafuta a Sunifiram amachititsa kuti munthu asamagwiritse ntchito mankhwala osokoneza bongo komanso amadzidzidzimutsa popanda kusintha kwabwino kwa makoswe kapena makoswe, ndipo pa 0.1 mg / kg ip, Sunifiram ufa amachepetsa nthawi ya matenda opatsirana pogwiritsa ntchito pentobarbital mu mbewa popanda kusintha nthawi yobwezeretsa. Komanso, mbewa zogwiritsidwa ntchito ndi Sunifiram ufa wosalala zimapitiriza kuyendetsa galimoto pamayeso. Zomwe zimagwiritsidwa ntchito mofulumira ndi mbewa, zomwe zimayesedwa ndi zida za Animex, komanso khalidwe lofufuzira, kuyesedwa ndi kafukufuku, zimakhala bwino pambuyo pa Sunifiram powder management.

Sunifiram ufa wosalala amachititsa kuti thupi liziyenda bwino m'matumbo a makoswe. Monga momwe zikuwonetsedwera ndi mayesero a microdialysis, ufa wa Sunifiram umatha kuonjezera kutulutsa kwa ACh pa mlingo wa 0.01 mg / kg, ndi potency kuposa Unifiram.

Kuwonetsedwa kwa magawo a makoswe a kakompyuta kwa 100 μM NMDA amachititsa kuwonjezeka kwa [3H] NE (48). Zotsatira za NMDA zimatetezedwa makamaka ndi 100 μM kynurenic acid (KYNA). Kuonjezera kwa nanomolar concentrations ya Sunifiram yaiwisi ufa kwambiri amatsutsa KYNA antagonism. Zotsatira za ufa wa Sunifiram ndizodalira kwambiri (EC50 0.1 μM) ndipo pafupifupi kwathunthu ndi 1 μM.

Kugwira ntchito kwa AMPA receptors kungayesedwe pogwiritsa ntchito NBQX wotsutsana ndi AMPA. Pogwiritsidwa ntchito pa 5 μM, NBQX imaletsa [3H] NE kutulutsidwa chifukwa cha AMPA (100 μM), koma si 100 μM NMDA-mediated tritium yomwe imatulutsidwa kuchokera ku magawo a mphutsi (48). NBQX, yosagwira ntchito yokha, imayambitsa Sunifiram ya powder kusintha kwa KYNA kutsutsana kwa NMDA-evoked tritium kumasulidwa, kutanthauza kugwiriridwa kwa AMPA receptors pa zotsatira za Sunifiram ufa.

Chochititsa chidwi ndi chakuti, pansi pazomwe zilipo, Sunifiram mankhwala opangidwa ndi ufa wowonjezera wawonjezeka PKCa (Ser-657) ndi ntchito za Src (Tyr-416) zomwe zimakhala ndi mzere wofanana ngati wa LTP, ukuwonekera pa 10 nM. Kuwonjezeka kwa phosphorylation ya PKCa (Ser-657) ndi Src (Tyr-416) yomwe inapangidwa ndi Sunifiram ufa inali yoletsedwa ndi mankhwala a 7-ClKN. Kupititsa patsogolo kwa LTP ndi Sunifiram ufa wofiira kunali koletsedwa kwambiri ndi PP2, Src family inhibitor.

Pomaliza, atapatsidwa chithandizo cha glycine (300 lM), mankhwala a Sunifiram sankatha kukhala nawo m'dera la CA1.

Kuphatikizidwa pamodzi, umboni umene uli pamwambawu umasonyeza kuti Sunifiram yaiwisi yowonjezera imayambitsa malo a NMDAR ogwiritsira ntchito glycine ndi concomitant PKCa activation kudzera Src kinase. Kupititsa patsogolo ntchito za PKCa zokhazokha zowopsa kwa hippocampal LTP kupyolera mu kuyambitsa CaMKII.

Sunifiram (DM235) Mpweya Wambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

Malonda a DM235 powder

Kuti aperekedwe m'tsogolomu.


Mungagule bwanji DM235 powder: kugula Sunifiram ufa kuchokera ku AASraw

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


=

COA

HNMR

Dothi la Sunifiram (DM235) (314728-85-3) hplc≥98% | AASraw ogulitsa malonda HNMR

Maphikidwe

Sunifiram (DM235) Maphikidwe Owopsa a Powder:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Gwiritsani ntchito mankhwala osokoneza bongo Sunifiram ufa online

The 7 Best Nootropics (Smart drugs) mumsika wa Sunifiram