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Phala la Bortezomib (179324-69-7)

mlingo:
5.00 kuchokera 5 kutengera 1 kasitomala mlingo
SKU: 179324-69-7. Category:

AASraw ili ndi kaphatikizidwe ndi kapangidwe kake kuchokera ku gramu mpaka kulemera kwake kwa Bortezomib powder (179324-69-7), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Bortezomib ndi mankhwala odana ndi khansa komanso njira yoyamba yothandizira anthu odwala khansa. Ma proteasomes ndi makompyuta omwe amawononga mapuloteni. Mu khansa zina, mapuloteni amene amapha maselo a khansa amathyoka mofulumira kwambiri. Bortezomib amasokoneza ndondomekoyi ndipo amalola mapuloteniwa kuti aphe maselo a khansa. Amavomerezedwa ku US ndi Europe chifukwa chochiza matenda ambiri a myeloma ndi mantle cell lymphoma. M'magulu angapo a myeloma, kwathunthu mayankho a kachipatala amapezeka kwa odwala omwe amatsutsa zina kapena matenda opitirira mofulumira.

Mafotokozedwe Akatundu

Bortezomib powder kanema


Phala la Bortezomib Anthu oyambirira

Name: Phala la Bortezomib
CAS: 179324-69-7
Makhalidwe a Maselo: C19H25BN4O4
Kulemera kwa maselo: 384.24
Melt Point: 122-124 ° C
Kusungirako nyengo: -20 ° C Freezer
mtundu; Oyera kuti achoke woyera wa ufa wa Crystalline


Dothi lakuda la Bortezomib pogwiritsa ntchito

Mayina

Boronic acid, Velcade, Neomib, Bortecad

Ntchito ya ufa wa Bortezomib

Phala la Bortezomib ndi mankhwala odana ndi khansa ndipo njira yoyamba yothandizira anthu kuti azigwiritsidwa ntchito mwa anthu. Ma proteasomes ndi makompyuta omwe amawononga mapuloteni. Mu khansa zina, mapuloteni amene amapha maselo a khansa amathyoka mofulumira kwambiri. Phala la Bortezomib limasokoneza njirayi ndikulola mapuloteniwa kupha maselo a khansa. Amavomerezedwa ku US ndi Europe chifukwa chochiza matenda ambiri a myeloma ndi mantle cell lymphoma. M'magulu angapo a myeloma, kwathunthu mayankho a kachipatala amapezeka kwa odwala omwe amatsutsa zina kapena matenda opitirira mofulumira.

Atomu ya boron mu Bortezomib yaiwisi yaiwisi imayambitsa malo othandizira a 26S proteasome ndi kukondana kwambiri. M'maselo abwino, proteasome imayendetsa mapuloteni ndikugwira ntchito mwa kuwonongeka kwa mapuloteni otchedwa ubiquitylated, komanso imatsuka selo la mapuloteni osadziwika kapena olakwika. Dokotala ndi deta zimathandiza kuti pakhale maselo a myeloma osapitiriza kufa, ndipo deta ndi chikhalidwe cha xenograft zimathandizanso kuti zikhale zofanana ndi khansa yoyamba. Ngakhale kuti njira zambiri zingagwiritsidwe ntchito, chitetezo cha proteasome chingalepheretse kuwonongeka kwa zinthu zowonjezereka, motero zimayambitsa selo lokonzedwera imfa mu maselo osakanikirana. Posachedwapa, anapeza kuti ufa wa Bortezomib unachititsa kusintha kwakukulu komanso kochititsa chidwi kwambiri m'magulu a peptides omwe amatuluka ndi proteasome. [8] Ena a peptide osakanikirana nawo amasonyeza kuti ali ndi mphamvu yogwira ntchito, ndipo zotsatira zake zimakhala zowopsa kwambiri kwa Bortezomib. ma level of peptides opracellarlar angapangitse chilengedwe ndi / kapena zotsatira za mankhwala.

Phala la Bortezomib limagwirizanitsidwa ndi matenda opatsirana m'mimba mwa 30% a odwala; nthawi zina, zingakhale zopweteka. Izi zikhoza kukhala zovuta kwambiri kwa odwala omwe ali ndi matendawa. Kuonjezera apo, kupweteka kwa mitsempha yochititsa mitsempha ndi thrombocytopenia kungakhalenso ndi kuchepetsa mlingo. Komabe, zotsatirazi zimakhala zochepa poyerekeza ndi mafupa osakaniza mafupa komanso njira zina zothandizira odwala omwe ali ndi matenda akuluakulu. Mafuta a Bortezomib akugwirizanitsidwa ndi mlingo wamakono, ngakhale kuti prophylactic acyclovir ingachepetse chiopsezo cha izi. Mankhwala osokoneza bongo aphatiki amvekanso.

Matenda a gastro-m'mimba (GI) ndi asthenia ndizochitika zovuta kwambiri.

Mankhwala a Bortezomib yaiwisi monga osakaniza amodzi omwe amasonyeza kuti ali ndi matenda ambirimbiri a myeloma, akuluakulu a T-cell a khansa ya m'magazi, mapapo, mawere, prostate, pancreatic, mutu ndi khosi, khansa ya coloni, komanso khansa ya khansa. Oral Bortezomib ufa 1.0 mg / kg tsiku lililonse kwa masiku 18 amachititsa kuti chifuwa chimachepetse, komanso kuchepa kwa chiwerengero cha metastases mu kansa ya khansa ya lungwa. Dothi la Bortezomib pa mlingo umodzi mpaka 5 mg / makilogalamu kwambiri linachepetsanso kachigawo kakang'ono kamene kamakhala kathupi ka m'mawere. Phala la Bortezomib 1.0 mg / kg yomwe imayendetsedwa mlungu uliwonse kwa masabata a 4 imachepetsa kukula kwa chotupa ndi 60% m'maganizo a murine xenograft a kansa ya prostate. 1.0 mg / makilogalamu a Bortezomib ghawuni yakuda kwa masabata a 4 amatha kuchepetsa 72% kapena 84% kuchepetsa khansa ya pancreatic murine xenografts kukula, komanso kuwonjezeka kwa chifuwa cha maselo. 1.0 mg / kg Mankhwala a fettezomib opanga ufa amachititsa kuti anthu asawonongeke pochita masewera olimbitsa thupi, kuwonjezeka kwa maselo amtundu wa apoptosis komanso kupulumuka kwa moyo wonse, komanso kuchepa kwa chifuwa cha angiogenesis.

Chenjezo pa Bortezomib yai yaiwisi

Kuwongolera njira yotchedwa ubiquitin-proteasome yakhala ngati njira yolingalira pochiza khansa yaumunthu. Malinga ndi kafukufuku wamakono ndi zamakono, Bortezomib ufa wofiira unavomerezedwa kuti chipatala chigwiritsidwe ntchito monga chithandizo cha kutsogolo kwa odwala atsopano a myeloma ndi mankhwala ochiritsidwa / osokoneza ambiri a myeloma ndi mantle cell lymphoma, omwe mankhwalawa ali nawo khalani odwala kwambiri. Chivomerezo cha Bortezomib ufa ndi US Food and Drug Administration (FDA) chimaimira chofunikira kwambiri pamene choyamba choyambitsa proteasome chidzagwiritsidwe ntchito pochiza matenda oopsa. Bokosi lopangidwa ndi Bortezomib lawonetsa zopindulitsa zabwino zokhazokha zokha kapena ngati mbali ya mankhwala othandizira kuti apangitse chemo- / kutsegula ma radio kapena kugonjetsa mankhwala osokoneza bongo. Imodzi mwa njira zikuluzikulu za ufa wa Bortezomib yomwe imagwirizanitsidwa ndi ntchito yake yamagetsi ndi kupyolera kwa NOXA, yomwe imakhala ndi prothoptotic protein, ndipo NOXA ingagwirizane ndi mapuloteni odana ndi apoptotic a Bcl-2 ana a Bcl-XL ndi Bcl-2, ndipo zotsatira zake mu selo la apoptotic imfa m'maselo oopsa. Njira ina yofunika ya Bortezomib yaiwisi yaiwisi ndiyo kudutsa njira ya NF-κB yowonetsera njira zomwe zimapangitsa kuti zisawonongeke. Ngakhale kuti kupambana kwakukulu komwe kunapindula ndi Bortezomib ufa wakhala mu matenda a hematological, zomwe zimakhudza ziwalo zamphamvu zakhala zopanda kulimbikitsa. Kuonjezera apo, kupititsa patsogolo kwa mankhwala a Bortezomib ufa kumapitirizabe kuchepetsedwa ndi maonekedwe a toxicities, kuchepetsa mankhwala ndi kusokonezeka kwa mankhwala ena. Zotsatirazi zingathandize kutsogolera madokotala pakukonza mankhwala a Bortezomib ufa wosalala, ndikulimbikitsanso asayansi kuti apange tizilombo toyambitsa matenda omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Zofuna zina zogwiritsira ntchito proteasome inhibitors zikuphatikizapo kukula kwa ziwalo zotsutsana ndi E3 ligases, zomwe zimachitika mwamsanga mu njira yotchedwa ubiquitin-proteasome, ndi kupezeka kwa mankhwala osokoneza bongo ndi ochepa omwe amachokera ku zinthu zachilengedwe ndi mankhwala, omwe angapereke othandizira odwala mankhwala opatsirana khansa komanso chithandizo cha khansa m'tsogolo.

Maumboni ena

Bokosi la Bortezomib ndi mankhwala omwe amaletsa mammalian 26S proteasome. Njira yotchedwa ubiquitin-proteasome imathandiza kwambiri poyang'anira ndondomeko ya mapuloteni enieni omwe amachititsa kuti mavitamini azikhala osakanikirana. Kuletsa kwa 26S proteasome kumalepheretsa kuti puloteniyi ikhale yovuta, yomwe ingakhudze mabala ambiri omwe ali mkati mwa selo. Kusokonezeka kwa njira zozoloŵera za homeostatic kungachititse kuti maselo afe. Zofufuza zasonyeza kuti Bortezomib yaiwisi yakuda ndi cytotoxic kwa mitundu yosiyanasiyana ya khansa ya mtundu wa vitro. Bokosi la Bortezomib limayambitsa kuchepetsa kukula kwa zotupa mu vivo mu zovuta zowonongeka, kuphatikizapo multipleeloma. Maselo obisala, ndiko kuti, kugawa maselo mofulumira, akuwonekera kukhala ovuta kwambiri ku proteasome inhibition.

Phalasitiki la Bortezomib ndilowetsanso njira yowonongeka ya 26S proteasome m'maselo a mammalian. The 26S proteasome ndi mapuloteni akuluakulu omwe amachititsa kuti mapuloteni ambiri asatulukidwe. Malo otetezeka a proteasome ali ndi chymotrypsin-like, trypsin-like, ndi postglutamyl peptide hydrolysis ntchito. The 26S proteasome imadula mapuloteni osiyanasiyana omwe amachititsa kuti matenda a khansa asapitirire, monga ma cyclins, tumor suppressors, BCL-2, ndi cyclin-dependent kinase inhibitors. Kuletsedwa kwa zonyansazi kumapangitsa maselo kukhala apoptosis. Bortezomib ufa wochuluka ndi woletsa kwambiri wa 26S proteasome, womwe umalimbikitsa ntchito yogawira maselo ambiri a myeloma ndi aumagazi, motero amachititsa kuti apoptosis ayambe kugwira ntchito. Kuwonjezera pamenepo, ufa wa Bortezomib umawoneka kuti uwonjezere mphamvu ya khansa kumalo osokoneza bongo (monga gemcitabine, cisplatin, paclitaxel, irinotecan, ndi radiation).

Phala la Bortezomib Raw

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

Malonda a Malonda a Raw Bortezomib

Kuti aperekedwe m'tsogolomu.


Mungagule bwanji ufa wa Bortezomib kuchokera ku AASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

HNMR

Phala la Bortezomib (179324-69-7) hplc =98% | Ikani ma Reagents a R & D

Maphikidwe

Mapuloteni a Bortezomib Raw Powder:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

Izi ndizo zonse zomwe muyenera kudziwa zokhudza Bortezomib