Kasupe wa Achinyamata: NAD + & NMN ngati Supplement
AASraw imapanga ufa wa Cannabidiol (CBD) ndi Hemp Mafuta Ofunika ambiri!

NAD + & NMN

 

Kutulutsidwa kwa zomwe asayansi apeza momwe NMN imathandizira m'matupi a mbewa pamitu yamanyuzipepala ndi mitu ya magazini, kutcha kupezeka ngatiKasupe wa unyamata. "

Kafukufukuyu adati mbewa zakale zidayamba kukhala zazing'ono, zamphamvu, komanso zowonda zikapatsidwa kampanda. Chifukwa chake, mutha kusintha ukalamba wanu potenga chowonjezera. Ngakhale muyenera kukambirana zakumwa chilichonse ndi dokotala.

 

HisNkhani ya NMN ndi NAD +

Nicotinamide adenine dinucleotide, kapena NAD mwachidule, ndi amodzi mwamolekyulu ofunikira kwambiri komanso osunthika mthupi. Chifukwa ndichofunikira popereka ma cell ndi mphamvu, palibe njira iliyonse yazachilengedwe yomwe sikutanthauza NAD. Zotsatira zake, NAD ndiye cholinga chofufuza kafukufuku wachilengedwe.

Mu 1906, Arthur Harden ndi William John Young adapeza "chinthu" m'madzi omwe adachotsedwa yisiti ya brewer adalimbikitsa kutentha kwa shuga kukhala mowa. "Fact" imeneyo, yotchedwa "coferment" panthawiyo, idakhala NAD.

A Harden, limodzi ndi a Hans von Euler-Chelpin, adapitilizabe kufotokozera zinsinsi za kutentha. Adapatsidwa Mphotho ya Nobel mu 1929 chifukwa chodziwa zambiri za njirazi, kuphatikiza mawonekedwe ndi zinthu zomwe zingatchedwe NAD.

Nkhani ya NAD idakulitsidwa m'ma 1930, motsogozedwa ndi Otto Warburg, winanso wopambana Nobel, yemwe adapeza gawo lalikulu la NAD pakuthandizira zochitika zambiri zamankhwala. Warburg adazindikira kuti NAD imagwira ntchito ngati mtundu wina wamtundu wamagetsi wamagetsi. Kutumiza kwa ma elekitironi kuchokera ku molekyulu kupita ku inzake, kumakhala ngati maziko a mphamvu zofunika kuchita zonse zamankhwala amthupi.

Mu 1937, Conrad Elvehjem ndi ogwira nawo ntchito ku Yunivesite ya Wisconsin, Madison, adazindikira kuti NAD + supplementation idachiritsa agalu a pellagra, kapena "Lilime lakuda". Mwa anthu, pellagra imayambitsa zizindikilo zambiri, kuphatikizapo kutsegula m'mimba, matenda amisala, ndi zilonda mkamwa. Zimachokera ku kusowa kwa niacin ndipo tsopano amathandizidwa pafupipafupi ndi nicotinamide, imodzi mwazomwe zimayambitsa NMN.

Kafukufuku wa Arthur Kornberg pa NAD + mzaka zonse za 40 ndi 50 'adamuthandiza kuti apeze mfundo zomwe zimayambitsa kubwereza kwa DNA ndikulemba kwa RNA, njira ziwiri zofunika pamoyo. Mu 1958, Jack Preiss ndi Philip Handler adawulula njira zitatu zamagetsi, zomwe nicotinic acid imasinthidwa kukhala NAD. Masitepe angapo awa, otchedwa njira, amadziwika lero ngati Preiss-Handler Pathway.

Mu 1963, Chambon, Weill, ndi Mandel adatinso nicotinamide mononucleotide (NMN) idapereka mphamvu zofunikira pakupanga enzyme yofunikira ya nyukiliya. Kupeza kumeneku kunapereka njira yoti zinthu zambiri zodziwika bwino zizidziwike pamtundu wa mapuloteni otchedwa PARP. Ma PARP amatenga gawo lofunikira pakukonzanso kuwonongeka kwa DNA, kuwongolera kufa kwa maselo, komanso zomwe zochitika zake zimakhudzana ndi kusintha kwa moyo wawo.

Mu 1976, Rechsteiner ndi anzawo adapeza umboni wokhutiritsa kuti NAD + ikuwoneka kuti ili ndi "ntchito ina yayikulu" m'maselo am'mamayi, kupitilira gawo lawo lachilengedwe ngati molekyulu yamagetsi.

Kupeza kumeneku kunapangitsa kuti a Leonard Guarente ndi anzawo azindikire kuti mapuloteni omwe amatchedwa sirtuins amagwiritsa ntchito NAD kutalikitsa moyo wawo mosiyanitsa kusiyanitsa majini ena "chete". Kuyambira pamenepo, chidwi chakula ku NAD ndi apakatikati ake, NMN ndi NR, kuti athe kuthana ndi zovuta zingapo zokhudzana ndi ukalamba.

NAD + & NMN

Wchipewa Zakudya Zili Ndi NMN?

NMN imapezeka mwachilengedwe mu zakudya monga avocado, broccoli, kabichi, ndi tomato. Tsopano, mwina mukuganiza kuti: "Ngati NMN ipezeka mchakudya, sindingathe kuwonjezera milingo yanga ya NAD + ndikamadya zambiri za zakudya izi? “Ili ndi funso labwino ndipo tikukulimbikitsani kuti mudye chakudya chopatsa thanzi. Koma nayi vuto:

Ngakhale NMN imapezeka mu zakudya izi, kuchuluka kwake kumakhala kochepera 1 mg pa kg ya chakudya. Mwanjira ina, kuti mupeze 1mg ya NMN, muyenera kudya pafupifupi 1kg ya broccoli!

Zapezeka kuti kukulitsa milingo ya NAD + mwa anthu, milingo ya NMN iyenera kukhala mamiligalamu mazana pamlingo uliwonse. Izi ndizokwera kwambiri kuposa zomwe titha kupeza kuchokera pazakudya zathu, ngakhale titadya broccoli wochuluka motani.

 

Chifukwa Chowonjezera ndi NMN?

Monga tawonetsera, NMN ili ndi gawo lofunikira pakupanga NAD +. Tikakhala ndi NAD + yambiri mthupi lathu, mphamvu zama cell zimawonjezeka zomwe zimakhala mafuta a moyo-kulimbitsa chiwalo chilichonse ndi khungu lathu ndikutiteteza ku kuwonongeka kwa DNA. NAD + imayambitsanso Sirtuins zomwe ndizofunikira pakuwonjezera chiyembekezo cha moyo wathu ndikuchepetsa ukalamba.

Kuphatikiza ndi NMN kumawonjezera mwachindunji milingo ya NAD + m'matupi athu, yomwe imalimbana ndi kuchepa kwachilengedwe komwe kumachitika tikakalamba. Kafukufuku wasonyeza kuti powonjezera ndi NMN, the NAD + milingo mwa anthu okalamba atha kukwezedwa kukhala wazaka 20!

 

(1) Kodi Nicotinamide Adenine Dinucleotide (NAD +) ndi chiyani ndi Ntchito zake?

NAD + ndi coenzyme yofunikira yofunikira pamoyo komanso pamagetsi. Mavitamini ndi omwe amachititsa kuti zinthu zamoyo zitheke. Coenzymes ndi mamolekyulu "othandizira" omwe ma enzymes amafunikira kuti agwire ntchito.

NAD + ndiye molekyulu wochuluka kwambiri mthupi kupatula madzi, ndipo popanda iyo, chamoyo chitha kufa. NAD + imagwiritsidwa ntchito ndi mapuloteni ambiri mthupi lonse, monga ma sirtuin, omwe amakonza DNA yowonongeka. Ndikofunikanso kwa mitochondria, yomwe ndi nyumba zamagetsi zamaselo ndikupanga mphamvu zamagetsi zomwe matupi athu amagwiritsa ntchito.

 

(2) Njira Zowonjezera milingo ya NAD +

Kusala kudya kapena kuchepetsa kudya kwa kalori, komwe kumadziwika kuti choletsa kalori, kwawonetsedwa kuti kumakulitsa milingo ya NAD + ndi ntchito ya sirtuin. Mu mbewa, kuwonjezeka kwa NAD + ndi ntchito ya sirtuin kuchokera pakuletsa kalori kwawonetsedwa kuti kumachepetsa ukalamba. Ngakhale NAD + imapezeka pazakudya zina, zozama ndizotsika kwambiri kuti zisakhudze kuchuluka kwama cell. Kutenga zowonjezera zina, monga NMN, zawonetsedwa kuti zikuwonjezera milingo ya NAD +.

 

(3) NAD+ Wowonjezera monga NMN

Kuyika kwamkati mwa NAD + kumachepa kuyambira ukalamba monga magwiridwe antchito apakompyuta kumathera zopereka za NAD + pakapita nthawi. Magulu athanzi a NAD + amaganiza kuti abwezeretsedwanso ndikuwonjezeranso ndi omwe adatsogolera a NAD +. Malinga ndi kafukufuku, zoyambilira monga NMN ndi nicotinamide riboside (NR) zimawonedwa ngati zowonjezera zowonjezera za NAD +, kukulitsa kuchuluka kwa NAD +. David Sinclair, wofufuza wa NAD + wochokera ku Harvard, akuti, "Kudyetsa kapena kupereka NAD + mwachindunji kuzinthu sizotheka. Molekyulu ya NAD + silingathe kudutsa mosavuta ma cell kuti alowe m'maselo, chifukwa chake sangapezeke kuti akhudze kagayidwe kake. M'malo mwake, ma molekyulu am'mbuyomu ku NAD + ayenera kugwiritsidwa ntchito kuwonjezera kuchuluka kwa NAD +. Izi zikutanthauza kuti NAD + singagwiritsidwe ntchito mwachindunji kuwonjezera, chifukwa sichikhala chosavuta kulowa. Otsatsa a NAD + amatengeka mosavuta kuposa NAD + ndipo ndi othandizira kwambiri.

 

Kodi Nikotinamide Mononucleotide (NMN) ndi chiyani?

Nicotinamide Mononucleotide (CAS:1094-61-7), yotchedwanso NMN, yomwe ndi gawo lachilengedwe lomwe limakhala laling'ono mthupi la munthu komanso zakudya zina. NMN imapezeka pakamwa, ndipo ikamamveka pakamwa imatha kuthandizira milingo ya NAD + mkati mwa ziwindi ndi minofu.

Kafukufuku waposachedwa akuti NMN itha kuthandizira thanzi lamtima, kupanga mphamvu, thanzi lanzeru, komanso thanzi la m'maso ndi mafupa. Chimodzi mwazosangalatsa zomwe kafukufuku wa NMN adachita ndikuti zitha kulimbikitsa kukonza kwa DNA ndikuthandizira kuyambitsa kwa majini a SIRTUIN omwe akuganiza kuti amathandizira kukalamba bwino.

 

 Kodi NMN Imapangidwa Bwanji M'thupi?

NMN imapangidwa kuchokera ku mavitamini B amthupi. Enzyme yomwe imayambitsa kupanga NMN m'thupi imatchedwa nicotinamide phosphoribosyltransferase (NAMPT). NAMPT imayika nicotinamide (vitamini B3) ku phosphate ya shuga yotchedwa PRPP (5'-phosphoribosyl-1-pyrophosphate). NMN itha kupangidwanso kuchokera ku 'nicotinamide riboside' (NR) kudzera pakuphatikiza kwa gulu la phosphate.

'NAMPT' ndiye ma enzyme ochepetsa kuchuluka pakupanga NAD +. Izi zikutanthauza kuti kuchepa kwa NAMPT kumapangitsa kuchepa kwa kupanga kwa NMN, zomwe zimapangitsa kutsika kwa NAD +. Kuphatikiza ma molekyulu am'mbuyomu monga NMN amathanso kufulumizitsa kupanga kwa NAD +.

NAD + & NMN

Zopindulitsa za NMN

Mukakhala mkati mwa maselo amtundu wa nyama, NMN imadyetsa kupanga NAD +, yomwe imapatsa mphamvu mphamvu zofunikira ndipo imaganiziridwa kuti ndiyofunikira pakukalamba bwino. NAD + imathandizanso kwambiri kuti mapuloteni azisunga kukhulupirika kwa DNA yathu. Popeza ili ndi gawo lalikulu pamagetsi ambiri, zabwino zomwe NMN ingafikire pafupifupi thupi lonse. M'munsimu muli zitsanzo zodziwika bwino.

 

 Imalimbikitsa Zaumoyo Wa Mitsempha ndi Kutuluka Kwa Magazi

Timadalira minofu yathu yamafupa poyenda, kukhazikika komanso kulimba. Kuti akhalebe olimba komanso athanzi, minofu imeneyi iyenera kugwiritsa ntchito mamolekyulu ofunikira kwambiri, monga shuga ndi mafuta acids. Chifukwa NAD + imafunika kusungunula mamolekyuluwa, minofu yathu imafunikira zida zomangira, monga NMN.

Kafukufuku wama mbewa asonyeza kuti NMN imateteza ku kuchepa kwathanzi, monga kuuma kwa mitsempha yamagazi, kupsinjika kwa okosijeni, kuthekera kwama cell athu kupitilizabe kugawa, ngakhale kusintha momwe magwiridwe antchito amtundu wathu, zomwe asayansi amatcha jini kufotokoza.

 

 Bwino Kupirira Minofu ndi Mphamvu

Kafukufuku akuwonetsa kuti mbewa zomwe zimadyetsa NMN kwa nthawi yayitali zimakhala ndi mphamvu zamagetsi zopanda zovuta zilizonse. Thanzi la minofu yathu limakulirakulirabe pamene tikukalamba ndipo kupezeka kwathu kwa NAD + kumachepa.

 

 Zimateteza ku Matenda a Mtima

Minofu yanu yamafupa imayamba kupuma. Sikuti mtima wanu sungapume, sungachedwe kuthamanga kwambiri osayambitsa mavuto akulu. Mphamvu ya mtima, chifukwa chake, ndi yayikulu kwambiri. Ndipo kuti chiwoneke, chikuyenera kupanga NAD + yonse yomwe ingathe. Ichi ndichifukwa chake maselo amtima amafunikira NMN.

 

 Amachepetsa Kuopsa Kwa Kunenepa Kwambiri

Kunenepa kwambiri kumalumikizidwa ndi zovuta zambiri ndipo kumakhala kovuta kuchiza. Palibe njira yophweka yothetsera kunenepa kwambiri komanso zochitika zina monga matenda ashuga ndi kagayidwe kachakudya. Ngakhale kusintha kwa moyo monga kuchita masewera olimbitsa thupi komanso kudya zakudya zopatsa thanzi ndizofunikira kwambiri, zochepa zimathandiza.

M'maphunziro a mbewa, NMN imawonetsa zotsatira zomwe zimatsanzira mbali zoletsa kalori (CR). Ngakhale CR yawonetsedwa kuti imapereka zabwino zambiri pakukalamba ndi thanzi, ndi boma lovuta kulisunga kwakanthawi. Kutsanzira mapindu ake osatsata kudya mopitirira muyeso kungakhale kopindulitsa mosakayikira.

 

 Zimathandizira Kukonzanso kwa DNA

NAD + yopangidwa kuchokera ku NMN imayambitsa gulu la mapuloteni otchedwa sirtuins. Sirtuins, omwe nthawi zina amaganiziridwa kuti ndi omwe amatisamalira paumoyo wathu, amatenga gawo lofunikira pakusunga umphumphu wa DNA. Nthawi iliyonse maselo athu akagawanika, DNA kumapeto kwenikweni kwa ma chromosomes athu imakula pang'ono kwambiri. Nthawi ina, izi zimayamba kuwononga majini athu. Sirtuins amachepetsa njirayi pokhazikitsa bata kumapeto, odziwika mwasayansi ngati ma telomere. Kuti agwire ntchito, ma sirtuin amadalira NAD +. Kafukufuku waposachedwa awonetsa kuti kudyetsa mbewa NMN adayambitsa ma sirtuin ndikuwatsogolera ku ma telomere okhazikika.

 

 Kuchulukitsa Ntchito ya Mitochondrial

Mwachidule, sitingakhale popanda mitochondria yathu. Makina apadera apaderawa amadziwika kuti ndi malo osungira magetsi a selo. Amasintha mamolekyulu kuchokera pachakudya chomwe timadya kukhala mphamvu yomwe maselo athu amagwiritsa ntchito. NAD + ndichofunikira kwambiri pantchitoyi. M'malo mwake, kusakhazikika kwa mitochondrial komwe kumachitika chifukwa cha kutayika kwa NAD + kumatha kukhudzanso matenda amitsempha monga Alzheimer's. Kafukufuku wopangidwa mu mbewa asonyeza kuti NMN supplementation yapulumutsa zovuta zina za mitochondrial.

 

How Long Does It Take To See Ezimayambitsa Of NMN?

AASrawufa wa NMN umakulitsa kuchuluka kwa NMN mthupi lanu mphindi zochepa, pomwe milingo ya NAD + imakulitsidwa mkati mwa mphindi 60. Komabe, kuti NAD + iyambe kukonzanso maselo anu, zimatenga milungu ingapo.

Ogwiritsa ntchito ambiri akuti amadzimva kuti ndi achichepere komanso athanzi mkati mwa milungu iwiri kapena itatu. Phindu lathunthu la NMN limatha kumveka patatha miyezi ingapo mukugwiritsa ntchito — koma mudzamva kale kusiyana pakadutsa milungu ingapo!

Kotero ngati mukufuna kuwona kusintha kwa NMAS ya AASraw, tsopano muli ndi mwayi wapadera wotero. Ndipo gawo labwino kwambiri? Simuyenera kuchita chilichonse. NMN ya AASraw ili ndi chitsimikizo chokwanira. Izi zikutanthauza kuti chifukwa ali otsimikiza kuti mukonda NMN yawo, ali ofunitsitsa kukupatsirani chitsimikizo.

NAD + & NMN

Zotsatira zoyipa za NMN Supplement

Ndi zilizonse zatsopano kuwonjezera, pali nkhawa zokhudzana ndi zotsatirapo. Pakadali pano, kafukufuku wasayansi sanawonetse zovuta zilizonse zowopsa kapena zomaliza zokhudzana ndi kugwiritsa ntchito chowonjezerachi.

Chodandaula chokhacho chokhudza nicotinamide mononucleotide ndikosagwirizana, koma zimachitika pamagawo atsopano owonjezera. Zachidziwikire, muyenera kufunsa adotolo za zakumwa izi, makamaka ngati muli ndi pakati kapena mukuyamwitsa.

 

Is NMN Bkukhazikitsa Than NAD +?

Kwa zaka zambiri, zimaganiziridwa kuti mamolekyulu a NAD + anali akulu kwambiri kuti angatengeredwe mwachindunji ndipo amafunikira kuti akwezedwe pogwiritsa ntchito wotsogola monga NMN. Posachedwa, zapezeka kuti NAD + imatha kuwoloka chotchinga magazi-ubongo ndikufika ku hypothalamus ngati itengedwa mozama. Ikhoza kulimbikitsa ma NAD + mu gland iyi yomwe ipindulitse thupi lonse chifukwa imayang'anira kagayidwe kake. Itha kukhalanso kotheka kuwonjezera kuthandiza iwo omwe ali ndi vuto la kagayidwe kake chifukwa chakuchepa kwama NAD + mu hypothalamus.

NMN, komano, imakweza milingo ya NAD + m'maselo mthupi lonse ndipo ndiwowonjezera wofunikira kuti muthe kukulitsa milingo yanu yonse ya NAD + ndikuchedwa kukalamba.

 

Phatikizani

Nicotinamide mononucleotide (NMN) ndichinthu chachilengedwe m'thupi lanu chomwe chimapangitsa kupanga chinthu china chotchedwa nicotinamide adenine dinucleotide. Onse NMN ndi NAD amatenga gawo lofunikira popewa ukalamba. Makamaka NAD, popeza mukamakalamba, thupi lanu liyenera kutulutsa NAD. Ndipamene chowonjezera cha NMN chingathandizire popeza, akadyedwa ndi mbewa, imalimbikitsa NAD m'matumbo apansi nthawi yomweyo.

Zotsatira zake, chowonjezeracho chimapangidwa kukhala "kasupe wa unyamata", ndipo kukalamba kwa thupi kumachedwetsa ndikudzibweza. Kafukufuku wasonyeza kuti njira zotsutsana ndi ukalamba ndizovomerezeka, koma chowonjezera cha NMN chithandizanso kupewa kapena kuchiza matenda ena monga khansa, mtima ndi matenda ashuga. Mu 2016, gulu la asayansi lidayamba kafukufuku woyamba wazachipatala ndi anthu pazabwino za kutenga zowonjezera za NMN. Ngakhale mphamvu ya NMN ikadali koyambirira, malipoti ochulukirapo amatsimikizira kuti chowonjezera chimagwira bwino.

Mukasankha kugula zowonjezera za NMN pa intaneti, chonde werengani zambiri za NMN ndi NAD +. Muyenera kudziwa ngati zili zabwino kwa thupi lanu, zimagwira ntchito bwanji pa thupi lanu, mukamamwa ndi kuchuluka kwa NMN, zoopsa zilizonse zomwe zingakukhudzeni. Titsatireni kuti tipeze zosintha zambiri za NMN mtsogolo.

 

Reference Pa Nkhani

[1] Lautrup S, Sinclair D et al. (Adasankhidwa) 2019. NAD + mu Kukalamba kwa Ubongo ndi Matenda a Neurodegenerative. Cell Metabolism 30,630-655. (Adasankhidwa)

[2] Zhang, H., 2016. Kubwezeretsa kwa NAD + kumathandizira magwiridwe antchito a mitochondrial ndi stem cell ndikuthandizira kutalika kwa nthawi yama mbewa. Sayansi 352, 1436-1443.

[3] "NMN vs NR: Kusiyana Pakati pa Izi 2 NAD + Precursors". www.nmn.com. Zobwezeredwa 2021-01-11.

[4] Imai, S., & Guarente, L. 2014. NAD ndi ma sirtuin okalamba ndi matenda. Zochitika mu Cell Biology, 24 (8), 464-471.

[5] Woluka, CK Lim, R. Grant, BJ Brew, ndi GJ Guillemin. 2013. Serum Nicotinamide Adenine Dinucleotide Levels Through Disease Course in Multiple Sclerosis. Tsamba la ubongo 1537: 267-272.

[6] Stipp D (Marichi 11, 2015). "Beyond Resveratrol: Anti-Kukalamba NAD Fad". Sayansi ya American Blog Network.

[7] Prolla, T., Denu, J. 2014. Kulephera kwa NAD mu Kusokonekera Kwa Mitochondrial Kwakukalamba. Cell kagayidwe, 19 (2), 178-180.

[8] Fletcher RS, Lavery GG (Okutobala 2018). "Kupezeka kwa nicotinamide riboside kinases pakukhazikitsa kwa NAD + metabolism". Zolemba pa Molecular Endocrinology. 61 (3): R107 – R121. onetsani: 10.1530 / JME-18-0085. PMC 6145238. PMID 30307159.

1 Likes
1020 Views

Mukhozanso ndimakonda

Comments atsekedwa.