Kutsegula Kuthekera kwa Coluracetam: Kupititsa patsogolo Ntchito Yachidziwitso ndi Kuwongolera Nkhawa
2.Mmene Coluracetam Imagwirira Ntchito (Njira Zochita)
3.Ubwino Ndi Zotsatira Za Coluracetam
4.Kodi Coluracetam Imagwira Ntchito Bwanji mu Ubongo?
5.Coluracetam Kugwiritsa Ntchito: Mlingo Ndi Stack for Reference Only
6.Coluracetam Zotsatira Zake
7.Chidule- Coluracetam
8.Riterere
Racetam Banja la Nootropic- Coluracetam
Coluracetam (BCI-540, kapena MKC-231) ndi osungunuka mafuta osungunuka mumitundu yama racetam. Coluracetam ndi yamphamvu kwambiri kuposa racetam yoyambirira, Piracetamu. Coluracetam inali yovomerezedwa ndi Mitsubishi Tanabe Pharma waku Japan mu 2005. Kuyipanga kukhala imodzi mwama nootropics ofikira kwambiri pa racetam.
Patent ya Coluracetam idagulitsidwa kwa BrainCells, Inc. ku San Diego, California. BrainCells ndi kampani yaying'ono yodziyimira payokha yomwe imagwira ntchito yopanga mankhwala othandizira matenda osokoneza bongo (MDD), kupsinjika kwamankhwala (TRD), ndi Matenda a Alzheimer's.
Coluracetam ndi ofanana ndi mapangidwe a Piracetam. Ndipo monga ma racetam nootropics onse, ali ndi pyrrolidone phata pachimake pake. Kafukufuku waposachedwa wazachipatala akuwonetsa kuthekera kochiza matenda opsinjika, komanso kuwonongeka kwa mitsempha ya m'maso ndi m'maso.
Coluracetam ndi yamphamvu kwambiri choline kutsata supplement. Zimalimbikitsa kutembenuka kwa choline muubongo wanu kukhala acetylcholine (ACh) kudzera munjira yolumikizana kwambiri (HACU). Zomwe zimapangitsa kukhala tcheru, chidwi pazatsatanetsatane komanso kukumbukira.
Kafukufuku wina, ndi zochitika zaumwini zimasonyeza kuti Coluracetam ingakhudze ma receptors a AMPA. Kupanga kukhala ampakine zotheka nootropic. Zomwe zimatha kufotokoza zolimbikitsa ngati zotsatira popanda mbali zotsatira za chikhalidwe stimulants. Coluracetam imasonyezanso makhalidwe ena odetsa nkhawa (odana ndi nkhawa) omwe amathandiza kusintha maganizo ndi kuthetsa nkhawa.
Momwe Coluracetam Imagwirira Ntchito (Njira Zochita)
Monga mankhwala ambiri a racetam, coluracetam (CAS:135463-81-9) imagwira ntchito makamaka pakuwonjezera kwa neurotransmitter acetylcholine, yomwe imagwirizana kwambiri ndi kuphunzira, kukumbukira, komanso kuzindikira.
Komabe, momwe coluracetam imasinthira milingo ya acetylcholine ndi yapadera. Kawirikawiri, ma racetams amayambitsa acetylcholine Kupanga polimbikitsa zolandilira zoyenera, koma coluracetam imatero mwa kupititsa patsogolo choline chogwirizana kwambiri, kapena HACU. Dongosolo la HACU limatsimikizira kuchuluka komwe choline imakokedwa mu neurons kuti isinthe kukhala acetylcholine.
Powonjezera kuchuluka komwe choline imakokedwa m'maselo amitsempha, coluracetam imalimbikitsa kupanga kwa acetylcholine ndipo imapangitsa kuti ubongo wa neurotransmitter yofunikira ikwere. kupezeka mwachangu kwa choline kuti atengeke.
Zonsezi zimabweretsa milingo yambiri ya acetylcholine, yomwe imalumikizidwa ndikuzindikira komanso kukumbukira.
Ubwino ndi Zotsatira za Coluracetam
❶ Coluracetam Imathandizira Kukumbukira ndi Kuphunzira
Ubwino wa Coluracetam umagwira ntchito pakukakamiza chidziwitso ndi kukumbukira ntchito mu makoswe ndi zotsatira zofanana pa anthu. Brain Cells Inc. idachita kafukufuku yemwe akuwonetsa kusintha kwa malingaliro a makoswe atalandira AF64A kwa masiku asanu ndi atatu. Chitukukocho chinapitirirabe ngakhale kupitirira chithandizo. matenda a Alzheimer kumabweretsa kuchepa kwa acetylcholine. Mwa kukulitsa acetylcholine mu hippocampus, coluracetam imakulitsa zizindikiro za matenda a Alzheimer monga zovuta zophunzirira komanso kukumbukira kukumbukira.
❷ Coluracetam Amachepetsa Matenda Osagonjetsedwa ndi Chithandizo
Pofufuza za anthu a 101 omwe ali ndi vuto la kupsinjika, omwe sanapeze chithandizo chamankhwala opondereza nkhawa, zidawathandiza kuti moyo ukhale wabwino pa 80 mg katatu patsiku. Komabe, uku ndi kuphunzira kokha kwa anthu. Mphamvu yomwe imagwira yochepetsa kuchepa kwa glutamate itha kukhala yoyipa pazabwino zake pakuthandizira kukhumudwa.
❸ Coluracetam Imachepetsa Nkhawa
Pakafukufuku wamakoswe, kutulutsa masiku 21 a coluracetam kumawonetsa kusintha kwa 20% mu nkhawa, yomwe inali yayikulu kuposa momwe 12% imathandizira valium muyezo umodzi wamaphunziro omwewo.
❹ Coluracetam Amalimbikitsa Neurogeneis
Kafukufuku wina amatchula kuti zimathandiza ndi neurogenesis. Njira yoyamba sinadziwikebe, koma ikukhudzana ndi kayendetsedwe kake kwa milungu ingapo, yomwe imawonjezeka mu acetylcholine m'dera la hippocampus.'' Patents amanena kuti imalimbikitsa kukula kwa mitsempha ya mitsempha (neurogenesis). Makinawa sakudziwika, komabe akuganiza kuti akugwirizana ndi kuwonjezeka kwa hippocampal acetylcholine pamene coluracetam imamwa tsiku lililonse kwa milungu ingapo.
❺ Coluracetam Amathandizira ndi Schizophrenia
Coluracetam imakulitsa zochitika za CHAT mu makoswe omwe amawonongeka ndi mitsempha. Kuwonjezeka uku kukuwonetsa kuti kungapindulitse odwala omwe ali ndi schizophrenia kudzera mu ma enzyme omwewo. Kafukufuku wambiri mwachindunji kwa anthu omwe ali ndi schizophrenia akuchitika.
❻ Coluracetam Kupititsa patsogolo Maso
Coluracetam yawonetsa mphamvu zake zamagetsi monga kuzindikira bwino mtundu, masomphenya, komanso kuwonekera bwino. Makamaka, imalimbikitsa kukula kwa mitsempha ya matenda opatsirana a retinal. Kafukufuku wambiri amatchulapo mawonekedwe abwinoko ndikuwongolera maso, koma palibe kafukufuku wasayansi wotsimikizira izi.
Kodi Coluracetam imagwira ntchito bwanji mu ubongo?
Coluracetam imathandizira thanzi lamaubongo ndikugwira ntchito m'njira zingapo. Koma awiri makamaka amaonekera.
Coluracetam imathandizira ubongo wanu'S choline amatenga poyang'ana ndikugwira ntchito yolumikizana kwambiri ya choline (HACU) m'mitsempha ya ubongo.
Acetylcholine (ACh) imapangidwa ndi choline ndi acetate. Izi ziyenera kupezeka ku ma neuron nthawi zonse. Kuti ACh ipangidwe nthawi iliyonse pakufunika.
Choline yaulere yoyenda m'magazi imadutsa chotchinga magazi-ubongo. Ndipo amatengedwa ndi ma cholinergic neuron terminals. Amalowetsedwa mu neuron ndimachitidwe oyandikana kwambiri a choline (HACU). Kuphatikizika kwa ACh kumachitika mu synaptic cleft. Malo pakati pa ma neuron pamene amayenda kupita ku neuron.
Dongosolo la HACU limadalira kutentha-, mphamvu-, komanso kudalira sodium. Njirayi ndiyo njira yoyamba yomwe choline yofunikira pakuphatikizira kwa ACh imatumizidwira ku neuron. Ndipo ndiye gawo lochepetsera pakupanga kwa neurotransmitter yovuta kwambiri.Dongosolo ili likawonongeka kapena siligwira ntchito moyenera monga momwe lidapangidwira, mumakumana ndi zovuta kukumbukira, kuphunzira, komanso ubongo waubongo.
Zotsatira za Coluracetam zimathandizira ndikuchita bwino. M'malo mwake, zikuwoneka ngati zikuthandizira njira ya HACU. Ngakhale m'mitsempha yowonongeka. Kuchuluka kwa acetylcholine mu neurons kumathandizira kukonza kukumbukira, kumakulitsa chizindikiritso ndipo imapereka kuthekera kopanga zisankho bwino.
Coluracetam imawonekeranso kuti ikuthandizira kuthekera kwa AMPA. Ma AMPA receptors amakhudzidwa ndi glutamate. Zomwe zimagwira ntchito muubongo ndi chapakati dongosolo lamanjenje kuti likhale tcheru ndi kuzindikira.
Coluracetam imagwira ntchito limodzi ndi kuthekera kwa AMPA komanso kukulitsa kukweza kwa choline. Kuphatikizaku kumawoneka ngati kukuthandizira kukonza zovuta zamavuto osakhudza milingo ya serotonin.
Serotonin Selective Reuptake Inhibitors (SSRIs) ndi njira yodziwika bwino yachipatala yomwe imakonda kuthana ndi kusokonezeka kwamalingaliro ndi kupsinjika maganizo. Iwo amabwera ndi mndandanda wa zowononga zotsatira zoyipazi. Ndipo musagwire ntchito kwa wodwala aliyense wovutika maganizo.
Ofufuza adanena kuti Coluracetam inali yopindulitsa pochiza kuvutika maganizo kwakukulu kwachipatala ndi matenda ovutika maganizo. Popanda kukhudza milingo ya serotonin mu ubongo. Ndipo popanda zotsatira zoyipazi zomwe zimayenda ndi kusokoneza serotonin.
Kugwiritsa Ntchito Coluracetam: Mlingo Ndi Stack for Reference Only
Coluracetam ndi gulu lomwe silingapezeke muzakudya zilizonse ndipo matupi athu sangatulutse. Chifukwa chake, njira yokhayo yopezera zabwino za molekyu iyi ndi kupitilira.
Coluracetam imagulitsidwa ngati ufa kapena kapisozi ndipo imatha kumwedwa pakamwa. Mlingo ungathenso kutengedwa mozungulira (pansi pa lilime) kuti umwenso mwachangu komanso moyenera.
Popeza coluracetam ndi mankhwala amphamvu kwambiri, ndi bwino kuyamba ndi mlingo wotsika kwambiri. Mukakupezani ayenera kuonjezera mlingo kumva ubwino, izi ziyenera kuchitika pang'onopang'ono ndipo zisapitirire 80mg.
Coluracetam ndi yopanda poizoni ndipo imatengedwa kuti ndi yotetezeka komanso yolekerera.Pali ochepa ochepa chabe zotsatira zoyipazi kugwirizana ndi pawiri, monga nkhawa, mutu, kutopa ndi nseru. Izi zotsatira zoyipazi ndizosowa ndipo nthawi zambiri zimachitika pokhapokha ngati palibe dziwe lalikulu lokwanira la choline kuti ligwiritsidwe ntchito popanga acetylcholine. Ichi ndichifukwa chake tikupangira kuyambitsa kaphatikizidwe-kuwonjezera coluracetam ndi choline level enhancer monga citicoline.
Coluracetam imatha kulumikizana ndi mankhwala ena, makamaka omwe amalumikizana ndi wolandila wa NMDA. Izi zimaphatikizapo kupondereza chifuwa ndi mankhwala oletsa kupweteka. Zinthu zina zomwe zimagwirizana ndi cholinergic system, monga mankhwala a glaucoma ndi chikonga, amathanso kulumikizana ndi zotsatira za coluracetam. Coluracetam ikhoza kuthana ndi zovuta za anti-cholinergic drug (monga Benadryl, antipsychotic ndi mankhwala a Parkinson).
Mofanana ndi chithandizo chilichonse, ngati muli ndi mankhwala kapena mukudwala, ndizomveka kuti mumalankhula ndi dokotala musanayambike kuwonjezera boma.
※ Kodi stacks WEll Wit Mankhwala Ena
♦ Coluracetam ndimamolekyu osungunuka mafuta, chifukwa chake imakhala yabwino kwambiri ndi mafuta athanzi monga coconut kapena MCT mafuta.
♦ Coluracetam iyeneranso kukhala yolimba ndi choline supplement monga citicoline. Citicoline imakulitsa dziwe la choline yomwe ilipo kuti iphatikizidwe. Katunduyu amatha kuyambitsa mphamvu powonjezera choline (citicoline) komanso kutha kupanga acetylcholine (coluracetam).
※ Mlingo Wovomerezeka: 5-80mg patsiku
Timalimbikitsa pakati pa 5-80mg ya coluracetam patsiku.
Malire apamwamba otetezera coluracetam ndi 80mg patsiku. Komabe, tikulimbikitsa kuti tizikhala ndi 35mg patsiku popeza zotsatira za kuchuluka kwakukulu sizinayesedwe bwino mwa anthu.
Ndizotheka kugawaniza mlingowu m'mawa kapena m'mawa. Mwachitsanzo, mlingo wa 20mg wa 10mg m'mawa komanso 10mg masana.
Monga tanenera kale, muyenera kuyamba kumapeto kwenikweni kwa dosing scale. Kuyamba kwa mlingo wotsika kwambiri kumachepetsa mwayi wokumana ndi zovuta zina.
Zotsatira za Coluracetam
Coluracetam ndi yopanda poizoni. Chifukwa chake zimawerengedwa kuti ndi zolekerera komanso zotetezeka. Ogwiritsa ntchito nthawi yoyamba Coluracetam amafotokoza kutopa komwe nthawi zambiri kumachitika chifukwa choyambira ndi kuchuluka kwambiri.
Kumbukirani, Coluracetam imagwira ntchito popititsa patsogolo kutenga choline mu ubongo wanu. Choline ndi kalambulabwalo wa kupanga acetylcholine. Ngati palibe choline chokwanira mu dongosolo lanu, mudzamva zotsatira zoyipazi.
mbali zotsatira ndizosowa koma zingaphatikizepo nkhawa, kutopa, kupweteka mutu, mantha ndi nseru. Apanso, zotsatira zoyipazi Nthawi zambiri zimachitika chifukwa cha kuchuluka kwachilendo kwa nootropic.
Kupweteka kwa mutu pogwiritsa ntchito Coluracetam nthawi zambiri kumachitika mukaiwala kuphatikiza ndi choline chowonjezera. Mutu nthawi zambiri umakhala chizindikiro cha kuchepa kwa choline muubongo wanu.
Mwachidule - Coluracetam
Coluracetam ndi m'modzi mwa mamembala atsopano komanso osadziwika bwino a racetam class of nootropics, koma ndimakonda ogwiritsa ntchito ambiri.
Imawonjezera milingo ya ''learning neurotransmitter'' acetylcholine, yomwe imatha kulimbikitsa kuzindikira, ndipo kafukufuku wa nyama akuwonetsa kuti imatha kuthana ndi vuto la kukumbukira popanda chidwi. zotsatira zoyipazi. Ngakhale pali kafukufuku wochepa wa anthu pa coluracetam, maphunziro omwe alipo akuwonetsa kuti akhoza kukhala chithandizo chamtengo wapatali cha nkhawa ndi kuvutika maganizo.
Ogwiritsa ntchito ambiri amawerengera ngati chodalirika chosinthira komanso kukumbukira zomwe zimawapatsa chidwi ndi chidwi. Ena amati zimawapatsa zofanana ndi "HD masomphenya", kupangitsa mitundu kukhala yowala, kusiyanitsa kwambiri, ndikuwala kwambiri.
Coluracetam ndi chinthu cholimba, chifukwa chake kuchuluka kwake kumakhala kotsika, ndipo amadziwika kuti akuchita mwachangu. Amagulitsidwa ngati zakudya kuwonjezera ku US ndipo akhoza kutumizidwa mwalamulo ku Canada ndi UK pang'ono.
Pali zambiri zoti muphunzire za coluracetam, koma zikuwoneka ngati zotetezeka kwa ogwiritsa ntchito ambiri akawatenga moyenera. Ngati mukufuna kuwonjezera china chatsopano komanso chosiyana ndi chanu nootropic okwana, coluracetam ikhoza kukhala yofunika kuganizira.
Coluracetam ilibe kafukufuku wochuluka, maphunziro omwe alipo akuwonetsa kuthekera kwakukulu pakugwiritsa ntchito. Ndi imodzi mwamipikisano yodziwika bwino kwambiri posachedwa, limodzi ndi Fasoracetam. Komabe, posachedwapa, a FDA avomereza mtundu "wowonjezera" wa Fasoracetam wothandizira ADHD.
AASraw ndi katswiri wopanga Coluracetam (BCI-540, kapena MKC-231) yomwe ili ndi labu yodziyimira pawokha komanso fakitale yayikulu monga chithandizo, zonse zomwe zimapangidwa zizichitika motsogozedwa ndi CGMP ndikuwongolera kachitidwe kabwino. Dongosolo loperekera ndi lokhazikika, maoda ogulitsa ndi ogulitsa ndi ovomerezeka.Takulandilani kuti mudziwe zambiri za AASraw!
Ndifikitseni TsopanoWolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1.Yukihiko Shirayama
Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8677, Japan.
2.Akinori Akaike
Dipatimenti ya Pharmacology, Omaliza Maphunziro a Sayansi Yamankhwala, Yunivesite ya Kyoto, Kyoto 606-01, Japan
3. Shigeo Murai
Dipatimenti ya Pharmacology. Sukulu ya Udokotala wamano. Iwate Medical University. Morioka. 020, Japan.
Pharmacculicals Laboraiory 1, Yokohama Research Center, Mitsubishi Chemical Corporation, Yokohama 227, JAPAN.
Pharmaceutical Lab. Ine, Mitsubishi Chemical Co., Yokohama 227, Japan
Dipatimenti Yachitatu ya Internal Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
