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The 7 Best Nootropics (Mankhwala Ozindikira) mumsika wa Armodafinil

Amodafinil ndi mankhwala osokoneza maganizo omwe amayamba ndi Celphalon Pharmaceuticals ndipo adavomerezedwa ndi FDA pa June 15, 2007. Amodafinil ndi (-) - (R) -antiantiyamu ya mankhwala opangira mankhwala ozunguza bongo. Armodafinil ndizomwe zimayambitsa mankhwala modafinil (Progivil)

Armodafinil ufa, monga modafinil, ili ndi ntchito zitatu izi:

• Kumalimbikitsa kudzuka pamene akugona mokwanira komanso nthawi zambiri
• Ndi mankhwala omwe amagwiritsidwa ntchito pochiza kuchepa kwa ana ndi akulu
• Amagwiritsidwa ntchito mwa anthu omwe ayenera kusintha mazenera, chifukwa amalola kupewa tulo lomwe lingapangitse kusintha kwa ola limodzi pa nthawi ya anthu.
• Zimagwiritsidwa ntchito ndi ophunzira ena kuti azikambirana bwino.
Kampani ya Cephalon imakhalanso ndi cholinga chochita maphunziro ndi cholinga choyesa armodafinil (Nuvigil) pofuna kuchiza matenda ena monga bipolar, schizophrenia, komanso kugona ndi kutopa monga Parkinson ndi khansa.

Armodafinil Chiyambi chopanga

Armodafinil ndi chigawo cha eantiomeric cha eugeroidal modafinil (Provigil). Icho chiri ndi kokha mwa (R) - (-) - enantiomere ya racemic modafinil.

Dzina la malonda Nuvigil
Fomu ya maselo: C XUMUMU H XUMU NO 15 S
NO NO: 112111-43-0
Kulemera kwa maselo: 273.35000
PSA: 79.37000
LogP: 3.57600
Makhalidwe abwino: 273.008200

Zipangizo zamagetsi

Maonekedwe a thupi: woyera woyera
Kuchulukitsa: 1.283g / cm 3
Malo otentha: 559.1oC pa 760mmHg
Flash point: 292oC
Pulogalamu Yopera: 156-158oC
Kupanikizidwa kwa Vapor: 1.56E-12mmHg pa 25 C
Chizindikiro cha Refractive: 1.645

Mankhwalawa amavomerezedwa ku United States kuti azisamalira tulo tosana patsiku kwa odwala omwe ali ndi zaka za 18 zomwe zimagwiridwa ndi matenda osokoneza bongo ogonana (OSAS), matenda osokoneza bongo, kapena matenda osokoneza bongo.

Kulongosola kosavuta kwa ufa wa Armodafinil

Chizindikiro cha armodafinil n'chofanana ndi modafinil. US FDA imavomereza almodafinil ngati chithandizo cha matenda osokoneza bongo, kugonana kwa apnea matenda ndi matenda ogona ogona, matenda a Alzheimer's, matenda a chitukuko.

Amodafinil ndi L-mododafin ndipo ndilo gawo lopangira ntchito mu modafinil. 200 mg ya modafinil kumanja lamanzere ndi lamanja la modafinil iliyonse inkaimira hafu, koma modafinil yolondola imagwiritsidwa ntchito kwa maola a 4, kumwa mocheperachepera, modafinil anatenga maola a 2 Zotsatira zake n'zakuti mphulupulu ya magazi ndi inapezeka m'maola a 4. Pamwamba kwambiri, L-mododa amawerengera 90%, ndipo kuyembekezera kudzanja lamanja kumangokhala masamba 10%. Pambuyo pa ola lachinayi, Moda amachita mbali yaikulu. Ndi L-mododafin. Zotsatira za amodafinil ndizolimba kwambiri. Ngati Moda ayesa kukhala maso, ndiye Amoda akhoza kuganizira ndikukhala maso, kuganizira kwambiri, komanso kukhala ndi zotsatira zochepa. Pamapeto pake, idzasintha modafinil. Amoda nthawi zambiri amakhala ndi mapuloteni a plasma, choncho amatha kumanga mapuloteni a plasma. Choncho, kuchuluka kwa amoda komwe kumalowa mu ubongo ndi magazi ndi okwera kwambiri. Chikondi cha Amoda kwa ubongo katatu cha Moda.

Theka la moyo wa amodafinil ndi maola 13-15. Zotsatira zake ndizochepa.
Kupitiriza mankhwala a amodafinil, mankhwala osokoneza bongo m'magazi adzapitirirabe, chifukwa mankhwala osokoneza bongo amayamba kuchepa, mankhwala atsopano alowa m'magazi, kupititsa patsogolo amodafinil kudzachedwa kuchepa kwa mankhwala osokoneza bongo.

The 7 Best Nootropics (Mankhwala Ozindikira) mumsika wa Armodafinil

Armodafinil Pharmacology

Njira yogwirira ntchito

Armodafinil amachulukira mwakachetechete kwa odwala omwe akuvutika kwambiri ndi tulo. Icho chimapangitsa zotsatira zake mwa kuyambitsa othandizira ena a ubongo ndi kuyambitsa dongosolo lachisomo lachisomo. Njira yeniyeni yochitapo kanthu, monga ndi Modafinil, sichidziwika. Mu vitro, osati mwachindunji kapena mwachindunji monga α 1 -adrenoceptor - kapena dopamine receptor agonist angapezeke. Kukhoza kwa armodafinil kukhalabe wolimba kumakhala kofanana ndi amphetamine, ngakhale kuti izo zimasiyana ndi izo mu mbiri yake ya mankhwala.

Metabolism

Miyoyo ya hafu ya eantiomers awiri ya modafinil imasiyana ndi chinthu cha 3 kwa wina ndi mzake. The pharmacokinetics ya Armodafinil ndi odziimira mlingo wodziimira komanso okhwima mu 50 mpaka 400 mg. Mankhwalawa amadziwika mofulumira ndipo amatha kusokoneza chiwindi ndi ma metabolites awiri akuluakulu. Armodafinil ndi metabolite zake zimadulidwa kwambiri ndi impso. Odwala omwe ali ndi vuto lopanda mphamvu kapena lachiwerewere, mlingowo uyenera kuchepetsedwa.

Ntchito ya Armodafinil:

Armomafinil ndi mankhwala osokoneza bongo. Pamsika, monga lamulo, chidziwitso ndi 50 mg, 150 mg, 200 mg, 250 mg. Kwa anthu okhala ndi mormalia, ayenera kuchitika pa 150-250 mcg pa tsiku.

Chizindikiro cha armodafinil n'chofanana ndi modafinil. US FDA imavomereza almodafinil ngati chithandizo cha matenda osokoneza bongo, kugonana kwa apnea matenda ndi matenda ogona ogona, matenda a Alzheimer's, matenda a chitukuko.

Kuyanjana

Dothi la Armodafinil limayambitsidwa ndi cytochrome P450 3A4 ndipo imalepheretsanso tizilombo tina tating'onoting'ono ta mtundu wa cytochrome P450. Pali mwayi wothandizana ndi mankhwala ena ambiri, omwe amaletsa kapena kusokoneza ptochrome P450 subtypes yomweyo. Izi zimaphatikizapo makamaka mankhwala opatsirana pakamwa, mankhwala osokoneza bongo (anticonvulsants), anticoagulants (anticoagulants), antidepressants kapena immunosuppressant cyclosporine.

Zotsatira zoyipa

Zotsatira zofala kwambiri zomwe zimapezeka ndizo: mutu, chiseru, chizungulire, kusokonezeka kugona. Armodafinil ikhoza kuyambitsa zotsatira zochepetsetsa monga zotupa kapena chimfine. Matenda a khungu oopsa, monga omwe amachitidwa ndi Modafinil, kuphatikizapo matenda a Stevens-Johnson, sali ochotsedwa ndipo amafunika kuti asiye mwamsanga mankhwala.

Armomafinil VS Modafinil

1.Armodafinil ndi Modafinil ndi mankhwala osagwiritsa ntchito amphetamine omwe amachititsa kuti anthu azikhala olimba komanso kuthandizira anthu kulimbana ndi matenda obisala, kupweteka kwambiri kapena kugona kwambiri. ... Poyambirira, Modafinil ankagwiritsidwa ntchito pochiza matenda osokoneza bongo komanso kukhala ndi moyo wabwino

2. Armomafinil imapezeka ngati 50 mg / 150 mg / 200 mg / 250 mg. Modafinil imapezeka ngati 100 / 200 mg.

3. Moyo wa service wa Armodafinil ndi maola 15, pomwe Modafinil ufa ndi maola 12. Zotsatira za Armodafinil ndi maola 8, pamene Modafinil amatenga 6 kwa maola 12.

4. Farmafinil ikufika pachimake pamapeto pake, chifukwa cha kukhazikika kwautali ndizitali, ndipo nthawi yayitali kuposa Modafinil. Komanso, ngati mutenga 150 mg Armodafinil, 200 mg wa Modafinil adzafunika. Chifukwa cha nthawi yaitali, Armodafinil ufa amaonedwa kuti ndi abwino kwambiri awiriwa, ngakhale akatswiri azaumoyo amanena kuti onsewa ali ofanana, ndipo zotsatira zake nthawi zambiri zimakhala zofanana.

Asanagwiritse ntchito

Pofuna kugwiritsira ntchito mankhwala, ubwino wogwiritsa ntchito sikuyenera kuvulaza, ndipo inu ndi dokotala muyenera kusankha ngati mukugwiritsa ntchito mankhwala kapena ayi.

Muyenera kuganizira:

ana

Maphunziro oyenerera sanachitidwe pa mgwirizano pakati pa zaka ndi zotsatira za armodafinil pa ana osakwana zaka 17. Chitetezo ndi kuthandizira kwa mankhwalawa sanakhazikitsidwe.

okalamba

Ngakhale kuti palibe maphunziro omwe apangidwa pa mgwirizano pakati pa zaka ndi zotsatira za armodafinil pa anthu okalamba, mavuto okhudzana ndi kukalamba sayembekezere kuchepetsa kuthekera kwa kugwiritsa ntchito armodafinil kwa anthu okalamba. Komabe, odwala okalamba amatha kuchotsa pang'onopang'ono mankhwalawa kuchokera ku thupi, zomwe zingafunikire kusintha kwa mlingo kwa odwala opatsidwa mankhwala.

Mimba ndi kuyamwitsa

Pregnancy

Mndandanda wa armodafinyl mu mimba ndi (C). Maphunziro a zinyama asonyeza zotsatira zoipa ndipo palibe maphunziro okwanira pa mimba ya munthu. Palibe maphunziro a nyama ndipo palibe maphunziro okwanira pa mimba ya munthu.

Kudyetsa m'mimba

Samalani, sizikudziwika ngati mankhwalawa amachotsedwa mkaka wa m'mawere.

Kuyanjana ndi kuyanjana kwa mankhwala

Ngakhale kuti mankhwala ena sayenera kugwiritsidwa ntchito pandekha, nthawi zina mankhwala osiyana angagwiritsidwe ntchito ngakhale atakhala ndi mankhwala. Ndipo pakadali pano, dokotala wanu anakakamiza kusintha mlingo, kapena njira zina zomwe zingakhale zofunikira. Mukamamwa mankhwalawa, ndikofunika kuti dokotala wanu adziwe ngati mukugwiritsa ntchito mankhwala omwe ali pansipa. Zotsatira zotsatirazi zinasankhidwa malinga ndi kufunikira kwake Potheka, zomwe sizikuphatikizapo zonse.

Mankhwala omwe amagwirizana nawo Armodafinil ufa

Kuyanjana kwina

Mankhwala ena sayenera kugwiritsidwa ntchito kapena nthawi yoyenera kudya kapena kudya mitundu ina ya chakudya chifukwa kuyanjana pakati pa mankhwala ndi zakudya zina zimapezeka. Kugwiritsa ntchito mowa kapena fodya kungayambitsenso kugwiritsira ntchito mankhwala osokoneza bongo. Kambiranani ndi dokotala ngati kugwiritsa ntchito mankhwalawa ndi chakudya kapena mowa, kapena fodya.

Matenda ena azachipatala

Kukhalapo kwa mavuto ena azachipatala kungakhudze kugwiritsa ntchito mankhwala awa:

Kusokonezeka maganizo kapena kukhala ndi mbiri yake, kapena kuthamanga kwa magazi, obsession, kapena psychosis: gwiritsani ntchito mankhwala mosamala. Izi zikhoza kukhala zoipira.

Kuchokera kumalo otsekemera, kapena kugwa kwa mitral: sayenera kugwiritsidwa ntchito kwa odwala omwe ali ndi vutoli.

Matenda a chiwindi (aakulu): amagwiritsidwa ntchito mosamala. Zotsatira za mankhwalawa zikhoza kuwonjezeka chifukwa cha kuchotsedwa kwake pang'onopang'ono kuchokera ku thupi.

Ntchito yoyenera

Tengani mankhwala awa monga momwe adalangizidwira ndi dokotala wanu. Musati muwonjezere mlingo wa mankhwala, ndipo musati muonjezere kuchuluka kwa nthawi yomwe mankhwalawa amatengedwa, ndipo musagwiritse ntchito kwautali kuposa momwe adokotala aganizira.
Mankhwalawa amabwera ndi Odwala Information Information (Internal Bulletin). Ndikofunika kuti muwerenge komanso kumvetsetsa izi. Onetsetsani kufunsa dokotala ngati muli ndi mafunso.
Ngati mukudwala matenda ogona tulo ndikugwiritsabe ntchito usiku, pitirizani kugwiritsa ntchito chipangizochi ndi mankhwala.
Tengani mankhwala awa nthawi imodzimodzi tsiku lililonse. Osasintha nthawi yopita kuchipatala musanalankhule ndi dokotala poyamba.
Mukhoza kumwa mankhwalawa kapena opanda chakudya.

Zotsatira zake

Pogwiritsa ntchito mankhwala ozunguza bongo, mankhwalawa amachititsa mavuto ena osayenera. Ngakhale kuti zonsezi sizitha kuchitika, koma ngati mutero, mukufunika kuchipatala.

Funsani dokotala mwamsanga ngati zotsatirapo zotsatirazi zakhala zikukuchitikirani:

Zosagwirizana kwambiri

Kutsekemera, kuyaka, kuthamanga, kuuma, kapena kutaya khungu
Kuwotchera, kupweteka, kapena kugwedeza
kupuma zovuta
Kupita mofulumira kapena kulakwitsa kwa mtima
malungo
kukodza nthawi zambiri
Mutu wamphamvu kwambiri
Zonjezerani kuchuluka kwa kukodza
Kuwotcha, kapena kupukusa kwakukulu, kapena wrench, kapena khungu lotupa
Kuthamanga kwa khungu
Kutenthezeka m'milingo, manja, manja kapena mapazi
Kupuma pang'ono

CHENJEZO

Ndikofunika kuti dokotala wanu ayang'ane kupita patsogolo ndi mankhwala pafupipafupi kuti awonetsetse kuti mankhwalawa akugwira ntchito bwino ndikuonetsetsa kuti palibe zotsatira zoipa.

Mankhwalawa samalowe m'malo ogona mokwanira. Mankhwalawa ayenera kugwiritsidwa ntchito pokhapokha ngati matendawa akupezeka ngati matenda osokoneza bongo, obstructive sleep apnea (wotchedwanso apnea syndrome), kapena mavuto ogona chifukwa cha psoriasis.

Mankhwalawa amachititsa mitundu yambiri ya chifuwa, kuphatikizapo hypersensitivity ndi mitsempha ya edema.

Musagwiritse ntchito mankhwalawa ndipo muwone dokotala mwamsanga ngati muli ndi zizindikiro zotsatirazi: zilonda zam'mimba, kupukuta khungu, kuchepa khungu, chifuwa, chifuwa, kutsegula m'mimba, malungo, kapena kupweteka kwa thupi. Kapena khungu lofiira khungu. Kapena kupweteka; zilonda, kapena mawanga oyera m'kamwa kapena milomo. Kapena kutopa kapena zofooka zachilendo.

Musayendetse galimoto, musagwiritse ntchito makina, pewani kuchita china chilichonse chomwe chingakhale choopsa ngati simunayang'anire, kotero mukudziwa momwe mungayankhire mankhwalawa.

Zingayambitse anthu ena kukhala okwiya, okwiya, kapena kukhala ndi makhalidwe ena olakwika. Zingathandizenso anthu ena kudzipha kapena kuvutika maganizo.

Musanachite mayesero alionse a zachipatala, auzani dokotala kuti akumwa mankhwalawa. Zotsatira za mayesero ena zingakhudzidwe ndi mankhwala awa.

Musatenge mankhwala ena pokhapokha mutakambirana ndi dokotala wanu. Izi zimaphatikizapo mankhwala osamalidwa kapena osagwiritsidwa ntchito (OTCs), zitsamba zowonjezera kapena mavitamini.

yosungirako

Sungani mankhwala mu chidebe chosindikizidwa kutentha kutentha, kutali ndi kutentha, chinyezi ndi kuwala kolunjika.

Chokani kuzizira.

Sungani mankhwala kutali ndi ana.

Osasunga mankhwala omwe amatha nthawi yaitali kapena mankhwala omwe sakufunikanso.

Funsani dokotala wanu wa zaumoyo momwe angachotsere mankhwala omwe simukuwagwiritsanso ntchito.


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