Ufa wa NMN - Wopanga Mafakitore Wopanga
AASraw imapanga ufa wa Cannabidiol (CBD) ndi Hemp Mafuta Ofunika ambiri!

β-Nicotinamide Mononucleotide

mlingo: Category:

AASraw ili ndi ziyeneretso zoperekera zotsutsana ndi ukalamba-NMN Powder mochuluka ndi malamulo a CGMP ndi dongosolo loyendetsa bwino kwambiri. Kupanga kwathu pafupifupi pamwezi kumatha kufika ku 1500kg. Takulandilani kulumikizana nafe kuti mumve zambiri zogula:
Chikhalidwe: Zilipo

Maphukusi Unit: 1kg / thumba, 25kg / ng'oma

Mafotokozedwe Akatundu

Makhalidwe Abwino

Name mankhwala β-Nicotinamide Mononucleotide (NMN)
Nambala ya CAS 1094-61-7
Molecular Formula C11H15N2O8P
Kulemera kwa Fomu 334.22
Mafananidwe NMN;

β-D-NMN;

BETA-NMN;

beta-D-NMN;

Ufa wa NMN;

Zmitterion ya NMN;

NICOTINAMIDE RIBOTIDE;

Nicotinamide nucleotide;

Nicotimide mononucleotide.

Maonekedwe White powder
Kusungirako ndi Kusamalira 2-8 ° C pamalo ouma

Chofunikira:

AD NAD + ndi coenzyme yofunikira yofunikira pamoyo ndi pamagetsi.

Magawo a NAD +, makamaka mawonekedwe ake a NAD +, amachepa mwachilengedwe ndi msinkhu m'matumba ambiri.

♣ Thupi limapanga NMN ngati gawo lapakatikati kapena "wotsogola" ku NAD +. Mwachidule: milingo yayikulu ya NMN imatanthauza milingo yayikulu ya NAD +.

Odziwika: Potsatira nkhani, NMN Yogwiritsa Ntchito m'malo mwa β-Nicotinamide Mononucleotide (NMN)


 

Mbiri ya NMN- NAD + & NMN

NAD + ndi chinthu chapadera, chopangidwa mosalekeza mthupi lathu ndipo chimagwiritsidwa ntchito ndi michere yambiri yothandizira kulimbikitsa magwiridwe antchito abwino. Komabe, popeza NAD + imagwiritsidwa ntchito pokonza ma enzyme, timayamba kulowa m'malo mwa NAD + m'malo osiyanasiyana m'miyoyo yathu, ndikuchulukirachulukira tikamakalamba. Popeza ma enzyme omwe amagwiritsidwa ntchito ndi NAD + amatenga gawo lofunikira pakusungabe mphamvu zamagetsi, ndikulimbikitsa thanzi lama cell, kuchepa kwa NAD + kumatha kuwononga thanzi lathu.

Chifukwa cha ichi, kafukufuku wambiri wayambitsidwa kulimbikitsa ma NAD + mthupi. Lingaliro lakulimbikitsa milingo ya NAD + ndikuti lithandizira kwambiri magwiridwe antchito ambiri amthupi, potero lingathandize kulimbikitsa moyo wautali. Chofunika kwambiri, komabe, kuchuluka kwa NAD +, sikuyenera kungolimbikitsa moyo wautali, kungathandizenso kukulitsa moyo wabwino tikamakalamba!

Ndiye timakweza bwanji milingo ya NAD +? Izi zikuwoneka ngati zovuta. Komabe, kafukufuku waposachedwa apeza chida chapadera chotchedwa Nicotinamide Mononucleotide (NMN), chomwe thupi lingagwiritse ntchito ngati cholozera choyenera ku NAD +. Mwachidziwitso, izi zikutanthauza kuti NMN itha kulimbikitsa moyo wautali komanso wathanzi!

Komabe, NMN siyongokhala ndi moyo wautali wosangalatsa wotsatsa zowonjezera. M'malo mwake, NMN ndizowonjezera zabwino kwa achinyamata ndi achikulire, chifukwa zimathandizira ngakhale mutakhala zaka zingati. Achinyamata ndi achikulire onse amafunikira milingo yayikulu ya NAD + kuti matupi awo ndi malingaliro awo azitha kuthamanga kwambiri. Mukakweza milingo yanu ya NAD +, mudzakhala ndi mphamvu zamagetsi zambiri, ndipo thupi lanu ndi malingaliro anu azitha kugwira bwino ntchito zovuta kwambiri. Tiyeni tikhale owona mtima, ndani amene sangagwiritse ntchito pang'ono pang'ono m'mphepete mwachangu padziko lino lapansi? Chifukwa chake, ngati mukufuna kubweza ma cell anu, ndipo mukufuna kudziwa zomwe thupi ndi malingaliro anu angakwaniritse ndi NAD + ina yowonjezerapo, ndiye tikukulimbikitsani kuti mupitilize kuwerenga blog yomwe ili yothandiza kwambiri kuchokera ku NMN supplementation!

 

Kodi NMN ndi chiyani?

NMN (Nicotinamide Mononucleotide) ndi ya banja la ma nucleotide, mamolekyulu omwe amapezeka muzakudya zambiri zomwe timadya. Monga ma nucleotide onse, NMN ili ndi magawo atatu: maziko a nitrogenous, shuga, ndi gulu la phosphate.

Ngakhale ma nucleotide ambiri amagwiritsidwa ntchito popanga DNA, NMN imagwiritsidwa ntchito kupanga nicotinamide adenine dinucleotide (NAD +) ndikuwongolera mphamvu moyenera. Thupi limapanga NMN ngati gawo lapakatikati kapena "wotsogola" ku NAD +. Mwachidule: milingo yayikulu ya NMN imatanthauza kuchuluka kwa NAD +.

NAD + imakulitsa mphamvu yayikulu yamthupi (ATP), imayesa kayendedwe ka circadian, ndikuthandizira machitidwe mazana a enzymatic - ambiri omwe amachepetsa ukalamba. Miyeso ya NAD +, makamaka mawonekedwe ake a NAD +, amachepera mwachilengedwe ndi msinkhu m'matumba ambiri.

 

Kodi NMN Imagwira Ntchito Motani? / Chifukwa Chiyani Mukufunika kuwonjezera kwa NMN?

NR ndi NMN zonse ndizopindulitsa chifukwa zimakweza milingo ya NAD +, yomwe imachepa ndi msinkhu. NAD + ndiyofunikira pakupangika kwama cell, kusandutsa michere kukhala mphamvu yama cell, komanso kuyambitsa ma sirtuin, magulu angapo a mapuloteni omwe amayang'anira thanzi lama cell. Tonsefe timapeza NAD + m'matupi athu chifukwa cha zakudya zathu, mwa kudya zakudya zokhala ndi zotsogola za NAD + mmenemo. Ngakhale NR ndi NMN zitha kupezeka muzakudya zingapo, komabe, munthu sangadye chilichonse chokwanira kuti chithandizire milingo ya NAD +. Zotsatira zake, kuwonjezera ndi wotsogola wa NAD + kungathandize kuchepetsa kuchepa.

 

Phindu la NMN

  • NMN imathandizira kuwonjezera mphamvu m'maselo okalamba:

Maselo amalowa ndikusintha mafuta kuti agwire ntchito yawo. Mukamakalamba amataya kuthekera, ndikuwakakamiza kukhala mkhalidwe wodziwika ngati khungu kapena kukalamba kwachilengedwe komwe kumadza ndi zoyipa zina. Izi zikutanthauza kuti kuwonjezera ndi NMN kumapereka maselo anu njira yofulumira kwambiri yopangira mphamvu ndikulimbikitsa magawano ndikukula kwamaselo.

 

  • NMN imathandizira polimbana ndi matenda amadzimadzi:

Mukamakalamba, matenda monga matenda ashuga, kunenepa kwambiri, matenda opatsirana pogonana, komanso matenda a chiwindi (NAFLD) omwe si oledzera amakhala ofala. Zimayambitsidwa ndi kuchepa kwa milingo ya NAD +. NMN imagwira ntchito kudzera munjira yopulumutsa kuti ipititse patsogolo milingo ya NAD + potero imathandizira izi ndi matenda ena amadzimadzi.

 

  • NMN imayambitsanso kuthamanga kwa magazi:

M'kupita kwa nthawi thupi, kuchuluka ndi ntchito yama cell endothelial (ECs) olumikiza mitsempha yamagazi ikuchepa. Omasulira a NAD + monga NMN ndi nicotinamide riboside (NR) akugwira ntchito kudzera mu Sirtuin Pathway, atha kuthandiza kubwezeretsa mphamvu yama cell endothelial kuti apange magazi atsopano zotengera.

 

  • NMN imapondereza kulemera kokhudzana ndi zaka:

Anthu akamakalamba, amanenepa. Pakafukufuku wa 2016, zidapezeka kuti maphunziro omwe adapatsidwa NMN adawona kuti mafuta awo akucheperachepera. Powonjezera ndi NMN, mutha kuchepa thupi ndikumanga minofu-njira ziwiri zamphamvu zokulitsira thanzi la minofu ndikuwoneka ndikumverera kuti ndinu achichepere!

 

  • NMN imalimbikitsa mphamvu zamagetsi:

Mwa kuyanjanitsa kaphatikizidwe ka NAD +, NMN imathandizira kuthyola michere mu mphamvu, kuyambitsa magwiridwe antchito amtundu wama cell ndikuchepetsa kupsinjika kwa okosijeni. Njira zachilengedwezi zimachedwetsa pang'onopang'ono ndipo zimatha kuyimitsa ukalamba. NMN sikuti imangolimbikitsa mphamvu zanu koma imathandizira kukonzanso maselo anu!

 

Chitetezo cha NMN ndi zoyipa zake

NMN imawerengedwa kuti ndi yotetezeka munyama, ndipo zotsatira zake zikulonjeza mokwanira kuti mayesero amunthu ayamba. Molekyuluyu amadziwika kuti ndiwotetezeka osati wowopsa, ngakhale atakhala mbewa zambiri komanso kafukufuku wamunthu. Kuyang'anira pakamwa kwakanthawi yayitali (chaka chimodzi) mu mbewa sikukhala ndi zowopsa. Chiyeso choyamba chachipatala mwa anthu chidamalizidwa ndipo umboni umatsimikizira lingaliro loti siliri poizoni pamlingo umodzi.

Ngakhale kafukufuku m'modzi wa amuna aku Japan omwe adasindikizidwa mu Novembala 2019 adazindikira kuti mituyo idakulitsa milingo ya bilirubin m'magazi awo kutsatira maulamuliro a NMN, milingo iyi idakhalabe yofanana. Kafukufuku wamtsogolo akuyenera kuganizira za chitetezo cha nthawi yayitali komanso kugwiritsa ntchito moyenera. NMN siyokhudzana ndi zovuta zina zilizonse zodziwika.

 

NMN ngati Supplement ya NAD + -Yotchuka kwambiri

Kuyika kwamkati mwa NAD + kumachepa kuyambira ukalamba monga magwiridwe antchito apakompyuta kumathera zopereka za NAD + pakapita nthawi. Magulu athanzi a NAD + amaganiza kuti abwezeretsedwanso ndikuwonjezeranso ndi omwe adatsogolera a NAD +. Malinga ndi kafukufuku, otsogola monga NMN ndi nicotinamide riboside (NR) amawonedwa ngati zowonjezera zowonjezera za NAD +, kukulitsa kuchuluka kwa NAD +. David Sinclair, wofufuza wa NAD + wochokera ku Harvard, akuti, "Kudyetsa kapena kupereka NAD + mwachindunji kuzinthu sizotheka. Molekyulu ya NAD + imatha kudutsa mosavuta ma cell kuti alowe m'maselo, chifukwa chake sangapezeke kuti athane ndi metabolism. M'malo mwake, ma molekyulu am'mbuyomu ku NAD + ayenera kugwiritsidwa ntchito kuwonjezera kuchuluka kwa NAD +. Izi zikutanthauza kuti NAD + silingagwiritsidwe ntchito ngati chowonjezera chachindunji, chifukwa sichikhala chosavuta. Otsatsa a NAD + amatengeka mosavuta kuposa NAD + ndipo ndi othandizira kwambiri.

 

Muyenera Kudziwa Musanagule Powder ya NMN Paintaneti

 

Structure Kapangidwe kosakhazikika.

Mbadwo woyamba wa NMN wokhala ndi otsika kwambiri sunakhale ndi madzi abwino kwambiri. Mtundu wabwino wa AASraw wa NMN ubweretsa zotsika mtengo pakupanga kutulutsa bwino kwa ufa komwe kumapangitsa kuti pakhale mphamvu zochulukirapo pakupanga chifukwa kumakhala kosavuta kuyendetsa makina. Kuphatikiza apo, mtunduwu umabweretsa mulingo wofanana wa makapisozi popeza mtundu wotsikawo ndi wovuta kusakaniza mofananamo. Pomaliza, ufa wocheperako wa NMN wothinidwa mu mawonekedwe apiritsi amatha kubalalika mosavuta popita.

Makasitomala ambiri amayesetsa kuthetsa izi powonjezerapo zina koma izi zimabweretsa mapiritsi akulu, omwe siabwino kwenikweni kwa ogula omwe akukalamba. Chifukwa chake, kuchepa kwa NMN kumangoyenera kupanga mitundu yamafuta a ufa.

 

Ingredients Zowonjezera Zosakanikirana ndi NMN.

Tsoka ilo pamsika ladzaza ndi NMN yabodza komanso yabodza. Kuyambira pomwe NMN idalowa msika chaka chatha mitundu yatsopano yatsopano ya NMN yakhala ikuwonekera motsatana. Ndizovuta kwambiri kwa opanga ndi makasitomala athu kuti anene zinthu zenizeni zenizeni kuchokera kuzinthu zabodza komanso zoyera zomwe zimagulitsidwa pa intaneti.

Zogulitsa zina za NMN zogulitsidwa zimakhala zosayera 80%. Makasitomala ndi makasitomala samangodziwa zomwe zimadzaza kapena zonyansa zomwe zili mu 20% ina yazogulitsa.

Tidapeza kuti ogulitsa ma NMN ambiri amagulitsa nicotinamide (vitamini B3 yotsika mtengo) kapena nicotinamide riboside m'malo mwa NMN. Ogulitsa ambiri amawonjezera ufa kuti asungunule NMN ndikunyengerera makasitomala awo. Izi nthawi zambiri zimakhala zotchipa komanso zopanda phindu lililonse.

 

Ack Kupanda chitetezo komanso chidziwitso chokwanira.

NMN ikuchulukirachulukira ku US, Europe, Japan ndi China, ndi zina zambiri, koma zambiri zachitetezo komanso zothandiza zimasowa. Anthu ambiri samakhulupirirabe izi, chifukwa chake msika wa NMN nthawi zonse umakhala wochepa. Kwenikweni NMN idalipo kale m'thupi la munthu komanso masamba ena ngati broccoli, chifukwa chake ilibe chitetezo. Koma ndi nthawi yabwino kuti deta iwonetsetse kuti ndiyothandiza.

 

[Reference]

[1] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. [2018] (Meyi 27). "+ Chepetsa". Cell kagayidwe. Chizindikiro. 5 (1081): 1095-10.e10.1016. onetsani: 2018.03.016 / j.cmet.5935140. Mphatso ya PMC 29719225.

[2] Stipp D (Marichi 11, 2015). "Beyond Resveratrol: Anti-Kukalamba NAD Fad". Sayansi ya American Blog Network.

[3] Cambronne XA, Kraus WL (Okutobala 2020). "+ Kuphatikizika ndi Ntchito mu Maselo Amamayi". Zochitika mu Sayansi Yachilengedwe. 45 (10): 858-873. onetsani: 10.1016 / j.tibs.2020.05.010. MAFUNSO OTHANDIZA:

[4] Bogan KL, Brenner C (2008). "Nicotinic acid, nicotinamide, ndi nicotinamide riboside: kuwunika kwama molekyulu a mavitamini a NAD + omwe amatsogolera m'thupi la anthu". Kukambirana Kwapachaka pa Zakudya Zabwino. 28: 115-30. onetsani: 10.1146 / annurev.nutr.28.061807.155443. MAFUNSO OTHANDIZA:

[5] Yue Yang, Anthony A. Sauve. NAD + metabolism: Bioenergetics, kusaina komanso kusokoneza mankhwala. Biochim Biophys Acta, 2016; CHINSINSI: 10.1016 / j.bbapap.2016.06.014.

[6] Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Kulamulira Kwa Nthawi Yaitali Kwa Nicotinamide Mononucleotide Kumachepetsa Kuthupi Kogwirizana Ndi Zamoyo Pamagulu. Cell Metab, 2016; DOI: 10.1016 / j.cmet.2016.09.013.

[7] Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen. NAD + metabolism ngati chandamale cha thanzi lamafuta: tapeza bullet ya siliva? Matenda a shuga, 2019; DOI: 10.1007 / s00125-019-4831-3.

[8] Ann Katrin-Hopp, Patrick Grüter, Michael O. Wotentha. Lamulo la Glucose Metabolism lolembedwa ndi NAD + ndi ADP-Ribosylation. Maselo, 2019; DOI: 10.3390 / maselo8080890.

[9] Shuang Zhou, Xiaoqiang Tang, Hou-Zao Chen. Sirtuins ndi Kukaniza kwa Insulin. Kutsogolo Endocrinol (Lausanne), 2018; DOI: 10.3389 / fendo.2018.00748.