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β-Nicotinamide Mononucleotide

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AASraw ndi katswiri wopanga β-Nicotinamide Mononucleotide(NMN) yaiwisi yaiwisi yomwe ili ndi labu yodziimira payekha ndi fakitale yaikulu monga chithandizo, zonse zopanga zidzachitidwa motsogozedwa ndi CGMP ndi dongosolo loyendetsa khalidwe labwino. Dongosolo lothandizira ndi lokhazikika, malonda onse ogulitsa ndi ogulitsa ndi ovomerezeka.Takulandirani kuyitanitsa kuchokera ku AASraw!

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Mafotokozedwe Akatundu

1. β-Nicotinamide Mononucleotide (NMN) Ufa Video-AASraw

Tikuyembekezera kukwezedwa


2. yaiwisi β-Nicotinamide Mononucleotide (NMN) Makhalidwe Oyambira Ufa

Name mankhwala β-Nicotinamide Mononucleotide (NMN)
Nambala ya CAS 1094-61-7
Molecular Formula C11H15N2O8P
Kulemera kwa Fomu 334.22
Mafananidwe NMN;

β-D-NMN;

BETA-NMN;

beta-D-NMN;

Ufa wa NMN;

Zmitterion ya NMN;

NICOTINAMIDE RIBOTIDE;

Nicotinamide nucleotide;

Nicotimide mononucleotide.

Maonekedwe White powder
Kusungirako ndi Kusamalira 2-8 ° C pamalo ouma

3. yaiwisi β-Nicotinamide Mononucleotide (NMN) Lipoti Loyesa Ufa-HNMR

β-Nicotinamide Mononucleotide HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.

4.Nicotinamide Mononucleotide(NMN) kwa anti-kukalamba

Kukalamba ndi njira yachilengedwe yomwe imatha kuwononga thanzi lanu, thanzi lanu komanso malingaliro anu. Zizindikiro zoyamba za ukalamba zimaonekera pankhope ndi m'khosi ngati mawonekedwe a mizere yabwino ndi makwinya. Zodzikongoletsera zimakhudza kukalamba nthawi zambiri zimakokomezedwa chifukwa cha zinthu zina monga kuwonetseredwa kwa UV komwe kumayambitsa khungu lowonongeka komanso kupsinjika, kuda nkhawa, komanso zoipitsa zachilengedwe zomwe zimatseka ma pores omwe amayambitsa kukwiya ndi ziphuphu.

Makwinya awa ndi chizindikiro chodzikongoletsa komanso chowonekera chakukalamba koma mkati, zingakhudze kuthekera kwanu kochita zochitika zatsiku ndi tsiku mwachangu komanso mphamvu monga kale. Kuphatikiza apo, ukalamba ungakhudze kulemera kwako ndi kagayidwe kake, nthawi zambiri kumayambitsa kunenepa kophatikizana ndi kuchepa kwa metabolism.

Kusintha komwe kumakhudzana ndi ukalamba sikungapeweke kwakukulukulu chifukwa zina mwa izo ndi zotsatira za kuchepa kwa kagayidwe kake ka mitochondrial komanso kusintha kwa maginito. Zosintha zambiri zamthupi zomwe zimachitika chifukwa cha ukalamba zimachitika chifukwa cha kuchepa kwa milingo ya NAD +, coenzyme yofunika kwambiri ya homeostasis ndi metabolism yomwe imapezeka m'zinthu zonse zamoyo.

Pakati pa unyamata wathu, coenzyme iyi imatenga nawo gawo pazomwe zimapanga mphamvu zama mitochondrial ndipo imapezeka mthupi. Komabe, tikamakalamba, milingo ya NAD + imayamba kuchepa kwambiri.

Zowonjezera zakukalamba zimalimbikitsidwa ndikugwiritsidwa ntchito ndi anthu padziko lonse lapansi pofuna kuyeza zovuta zakukalamba. Komabe, si onse omwe ali othandiza chifukwa ambiri samakhudza milingo ya NAD + mthupi. Chifukwa cha maphunziro angapo. asayansi ndi ofufuza apeza yankho lolimbana ndi zizindikilo za ukalamba, mankhwala a moyo, omwe ndi, Nicotinamide Mononucleotide yemwe akangomwa pakamwa amatembenukira ku NAD + m'thupi.

Pali "Zofunika Kwambiri" zitatu musanawerenge zambiri za ufa wa NMN:

①NAD + ndi coenzyme yofunikira pa moyo ndi ntchito zama cell.

②Milingo ya NAD+, makamaka mawonekedwe ake a NAD+, mwachilengedwe imatsika ndi zaka m'matenda ambiri.

③Thupi limapanga NMN ngati sitepe yapakatikati kapena "chotsogolera" ku NAD+. Mwachidule: milingo yapamwamba ya NMN imatanthawuza milingo yapamwamba ya NAD+.

5.Kodi Nicotinamide Mononucleotide(NMN) ndi chiyani Powder?

Nicotinamide Mononucleotide ndi nucleotide yomwe imachokera ku niacin kapena vitamini B3 yomwe imapezekanso, monga zipatso zina ndi ndiwo zamasamba monga ma avocado ndi edamame. NMN posachedwapa yatenga chidwi ngati chowonjezera chothandizira kukalamba, makamaka chifukwa chofalitsa bukuli, Lifespan, lolembedwa ndi David Sinclair.

NAD + amadziwika kuti ndi chizindikiritso cha ukalamba kwakanthawi koma kulimbana ndi zovuta zaukalamba kumakhala kovuta. Izi zili choncho chifukwa kafukufuku woyamba adayang'ana kukulitsa milingo ya NAD + m'thupi pogwiritsa ntchito zowonjezera za NAD +. Komabe, posakhalitsa zidapezeka kuti NAD + ili ndi vuto losawoneka bwino m'thupi kutanthauza kuti silimangokhala kosavuta, ndipo kuyigwiritsa ntchito mopambanitsa sikukhudza magulu ake amkati.

NMN ufa ndi kalambulabwalo wamphamvu wa NAD+ womwe ndi wofunikira kwambiri pakupanga mphamvu m'thupi la munthu. Komabe, kafukufuku woyamba wokhudzana ndi kugwiritsa ntchito ufa wa NMN kapena wowonjezera monga chowonjezera choletsa kukalamba chinangochitika m'chaka cha 2020. NMN idakali ndi njira yayitali yopitira m'dziko la kafukufuku koma maphunziro omwe adachitika mpaka pano atsimikizira Zopindulitsa ndi zotsatira za NMN pa ukalamba.

Mulingo wa NAD + ukhoza kuchulukitsidwa ndi m'modzi mwaomwe amatsogolera, NMN monga tafotokozera pamwambapa kapena NR. NMN ndi NR zimayendera limodzi, ndikusintha kwa NMN kukhala NR kukhala kofunikira kwambiri kuti mayimbidwe am'mbuyomu abwere m'thupi. NR imayimira Nicotinamide riboside yomwe imatha kukulitsa magawo amkati a NAD + kwambiri. Zowonjezera ndi NR polimbana ndi zovuta zaukalamba zawerengedwa bwino ndi zowonjezera za NR zomwe zimanenedwa ngati zowonjezera 'zotetezeka komanso zolekerera'.

6.Kodi dndi NMN work on body?

NMN imagwira ntchito yayikulu pakupanga mphamvu ndikukonzanso DNA mthupi, ngakhale ayi. NMN imalimbikitsa kaphatikizidwe kapena kapangidwe ka NAD + m'thupi kuti athane ndikusowa kwake, kudzera munjira yopulumutsa. NAD + itha kupangidwa m'njira zingapo ndipo njira yopulumutsira imadalira magwiridwe antchito a NMN. Njira yopulumutsa imanena za njira yomwe imapanga NAD + ndi zotulukapo za kuwonongeka kwa NAD + monga niacinamide kapena NAM. NAM imatembenukira mwachindunji ku NMN yomwe, kudzera munjira zosiyanasiyana, imapanga NAD +. Uwu ndiye ntchito yofunika kwambiri ya NMN mthupi ndipo ndiye chifukwa chachikulu chomwe NMN imathandizira kutchuka.

Mukamamwa mankhwala a NMN pakamwa, amakhulupirira kuti amatembenuzidwira ku NR mthupi chifukwa chophatikizira cha NMN sichitha kudutsa m'mimbamo, kulowa m'maselo. NR ikalowa m'chipindacho, imasinthidwa kukhala NMN kudzera pamavuto enzyme; nicotinamide ribose kinase kapena NRK. NMN iyi imadutsa njira yopulumutsira biosynthesis ya NAD + kuti ikwaniritse magawo ake omaliza mthupi la munthu.

Ndikofunikira kudziwa pano kuti kubwezeredwa kwa NAD + kudzera mu zowonjezera za NMN sikuti kumangowonjezera mphamvu komanso kumakhala ndi maubwino ena azaumoyo omwe amangopangitsa kuti NMN iperekedwe.

7.Kodi tingayembekezere phindu lililonse laumoyo kuchokera ku NMN?

Katundu wotsutsana ndi ukalamba wa NMN sikuti amangokhala chifukwa cha kuchuluka kwa ma NAD + komanso chifukwa cha njira za NMN ndikugwira ntchito mthupi la munthu. Phindu lalikulu la NMN ndilokhozanso kuwonjezera mphamvu zamagetsi ndi mphamvu zakuthupi popeza ndi cholimbikitsira cha NAD + komabe, maubwino ena sayenera kunyalanyazidwa makamaka ngati mukuyang'ana ngati kuwonjezera kwa NMN ndiye chisankho choyenera kwa inu.

Kukhala cholimbikitsira NAD + kumalola NMN kutulutsa maubwino ena angapo azaumoyo, monga:

 Kuwongolera Kunenepa Kwambiri

Chiwopsezo cha kunenepa kwambiri chawonjezeka kwambiri kuyambira zaka 30 zapitazo, ndipo kuchuluka kwa ana onenepa kwambiri kuwirikiza kawiri pazaka 30 izi. Izi ndizodetsa nkhawa kwambiri chifukwa kunenepa kwambiri kumakupatsani mwayi wokumana ndi zovuta zina zingapo zomwe zimatha kukupha. Kutsika kwamphamvu kwa metabolic ndiye chifukwa chachikulu chomwe chimayambitsa kunenepa kwambiri kwa zaka zambiri mwa anthu okalamba. Kuwongolera kunenepa kwamtundu umenewu kumafuna njira zambiri zomwe zimayang'ana mahomoni anjala pamodzi ndi kuchuluka kwa kagayidwe kachakudya. Kafukufuku wopangidwa ku Qatar anapeza kuti NMN supplementation mu zitsanzo za nyama zinapangitsa kuti jini liwonetsere ma hormone awiri ofunikira pakuchepetsa chilakolako ndi kufufuza kagayidwe; leptin ndi sirtuin, motero. Kafukufukuyu akuwonetsa kuti kulowetsedwa m'kamwa kwa NMN kumatha kupondereza njala kukuthandizani kuti muchepetse thupi komanso kukulitsa kuchuluka kwa kagayidwe kachakudya, zonse zomwe zimakulitsa kuchepa thupi komwe mungakumane nako.

Kuphatikiza apo, ofufuza adapeza kuti NMN imakulitsa milingo ya NAD + yomwe m'maselo amafuta imakhala ndi mphamvu yolimbitsa thupi, ndikuthandizanso kuchepa.

 Matenda a shuga

Matenda ashuga ndi amodzi mwamavuto akunenepa kwambiri ndipo kugwiritsa ntchito mankhwala a NMN kuthana ndi kuchiza kunenepa kumatha kuletsa matenda ashuga kuti asayambike. Koma sizokhazo zomwe NMN imachita pamashuga amwazi. Kuchepetsa milingo ya NAD + kunapezeka kuti ikukhudzana ndi kuchepa kwa magwiridwe antchito a maselo amtundu wa kapamba, komwe kumayambitsa insulin m'thupi. Ochita kafukufuku amakhulupirira kuti ichi ndiye njira yayikulu yopangira matenda ashuga amtundu wa 2 mwa okalamba.

Kafukufuku wopangidwa pamitundu yazinyama adawonetsa kuti mbewa za matenda ashuga komanso achikulire, atapatsidwa mankhwala owonjezera a NMN, adasintha magwiridwe antchito a beta momwe amabwezeretsanso malo ogulitsa NAD + m'thupi. Kafukufuku wina adayang'ana pakupeza chithandizo chamankhwala okhudzana ndi msinkhu komanso matenda okhudzana ndi kunenepa kwambiri omwe amapeza kuti 2 yapeza kuti zowonjezera za NMN zimatha kukhudza chiwindi ndikuwonjezera makutidwe ndi mafuta. Amathanso kuchepetsa kusungira mafuta m'thupi ndikupangitsanso kulolerana kwa glucose m'thupi.

Zowonjezera za NMN zili ndi njira zingapo zomwe zimathandizira kupititsa patsogolo kulekerera kwa glucose ndi kukana kwa insulin, motero kumathandiza kuthana ndi matenda a shuga amtundu wa 2 mwa okalamba. Njira zofananazi zimagwiritsidwa ntchito pothana ndi vuto la zovuta zina zamagetsi zomwe zimayamba ukalamba.

 Ntchito Yowonjezera ya Chitetezo cha M'thupi

Popeza kuti supplementation ndi NMN posachedwapa idakhala njira yofunikira yomwe yafufuzidwa, makamaka pamitundu yazinyama, sizosadabwitsa kuti udindo wa NMN udaphunziridwa pokhudzana ndi matenda a COVID-19.

Pomwe amaphunzira maudindo osiyanasiyana a coenzyme, NAD +, ofufuza adapeza kuti imathandizanso pakugwira bwino ntchito kwa chitetezo chamthupi. Mliri waposachedwa wa COVID-19 udakakamiza ofufuzawo kuti aphunzire za kulumikizana komwe kulipo pakati pazowonjezera za NMN, kuchuluka kwa NAD +, komanso kulimbikitsa chitetezo cha mthupi kuthana ndi zovuta za kachilomboka.

Kafukufuku wina adapeza kuti NAD + yatha ndipo kenako, zaka zakubadwa, zomwe zimayambitsa matendawa. Zinapezekanso kuti odwalawa anali pachiwopsezo chachikulu chotenga comorbidity komanso kufa chifukwa cha matenda a COVID-19. Chifukwa cha zomwe apezazi, zitha kuganiziridwa kuti kuwonjezera kwa NMN kumatha kuchepetsa zovuta zomwe COVID-19 imakhudza chitetezo chamthupi komanso thupi la munthu.

 Kubereka Kwabwino Kwa Akazi

Amayi amakhudzidwa ndi wotchi yachilengedwe yomwe imalepheretsa kuthekera kwawo kubereka ndi msinkhu. Kafukufuku wosiyanasiyana wazitsanzo zazinyama apeza kuti NMN yowonjezerapo itha kuchepetsa izi komanso ingathandizire kusabereka kwazaka zina.

Kafukufuku wopangidwa ndi mbewa zachikazi zokalamba mwachilengedwe zapeza kuti kuchepa kwa milingo ya NAD + kumatha kubweretsa kutsika kwa ma oocyte komanso kutsika kwakukulu kwa manambala a oocyte, zomwe zimachepetsa kuthekera kwakubereka ndi kubereka. Kubwezeretsa milingo ya NAD + mu mitundu iyi ya nyama ndi kuwonjezera kwa NMN kunapezeka kuti kumakulitsa mtundu wa oocyte ndi kuchuluka kwake, chifukwa chake kukonzanso luso loberekera.

Kafukufuku wina adachitidwa kuti awone zomwe zimachepetsa ma oocyte azaka. Phunziroli, ma oocyte ochokera kwa akazi achikulire adasonkhanitsidwa ndikuwerengedwa, mozama kuti amvetsetse za pathophysiology. Ofufuzawo adapeza kuti kuchepa kwamtundu wa oocyte kudachitika chifukwa cha kusintha kwamphamvu mu DNA ya mitochondrial ya oocyte, yomwe imayamba chifukwa cha kusalingana kwa milingo ya NAD +. Ichi ndichifukwa chake kukhulupilira kwa NMN kukulitsa milingo ya NAD + kumakhulupirira kuti kumathandizira kubereka komanso thanzi la uchembere, makamaka azimayi okalamba.

Popeza azimayi okalamba amataya mwayi wawo wambiri wobereka pakutha kwa nthawi, NMN yowonjezerapo, komanso kuthana ndi thanzi la uchembere amathanso kusintha kusintha kwa msambo. Izi zitha kuloleza amayi kuti akhale achonde kwanthawi yayitali ndikukhala ndi ma oocyte apamwamba ngakhale atadutsa zaka zambiri.

 Kuchuluka kwa Magazi

Malinga ndi kafukufuku wopangidwa ndi Dr. DAvid Sinclair, katswiri wa sayansi ya zamoyo yemwe amachititsa kutchuka kwa mankhwala owonjezera a NMN, tikamakalamba, ma cell endothelial omwe amakhala m'mitsempha yathu amachepa. Izi zimakhudza michere yomwe imadutsa kuchokera m'magazi kupita kumatumba omwe zidutswazo zimadutsa, motero zimakhudza mtundu wonse wamagazi. Kusinthaku akukhulupirira kuti ndiye komwe kumayambitsa kukhudzika kwa mitsempha yamagazi pakati pa okalamba.

Zowonjezera za NMN kapena NR zowonjezerapo zimapangitsa kuchuluka kwa NAD +, komwe malinga ndi kafukufukuyu kumapangitsa kuti ma cell endothelial azigwira ntchito mwamphamvu ndikupanga mitsempha yatsopano yamagazi akale atasiya kugwira ntchito moyenera.

 Kupititsa patsogolo Kuzindikira Ntchito

Matenda a Neurodegenerative ndimavuto omwe amakhudza ubongo, kuchepa kwa magwiridwe antchito komanso moyo wabwino. Zowonjezera ndi NMN kukulitsa milingo ya NAD + zimakhulupirira kuti ndizothandiza kwambiri pakukweza magwiridwe antchito ndikuthandizira kupulumuka kwamaselo aubongo.

Pakufufuza komwe nyama zokhala ndi kuvulala kowopsa muubongo ndi kusokonezeka kwaubongo zidapatsidwa gulu linalake, P7C3-A20, zidapezeka kuti gululi limathandizira kuzindikira ndikuyimitsa njira za neurodegenerative.

P7C3-A20 ndi gulu lopanga NMN lomwe limatulutsa NAD +. Kupereka mbewa ndi TBI pompopompo kunapezeka kuti sikungokhala ndi phindu lokhalanso ndi chidziwitso koma kunapezekanso kukulitsa kukhulupirika kwa kapangidwe kake kotchinga magazi ndiubongo, popeza gawo ili ndi gawo la nembanemba.

 Kupititsa patsogolo Ntchito Ya Minyewa ndi Kupirira Kwakukulu

Ochita masewera omwe angafune kupititsa patsogolo kupirira kwawo ayenera kutenga zowonjezerapo za NMN popeza zidapezeka posachedwa kuti zowonjezera izi zimatha kukonza kuthekera kwawo kwa ma aerobic. Phindu la zowonjezera za NMN makamaka chifukwa cha mphamvu yopanga mphamvu ya NAD + mu minofu, koma ndikofunikira kudziwa kuti othamanga awa nawonso akuwonjezeka kwambiri pakukula kwa minofu yawo ya oxygen.

8.Chiani NMN pzofunikira risks?

NMN ndi gawo lopezeka mwachilengedwe mthupi la munthu, lomwe pambuyo pofufuza ndi kusanthula kwakukulu kunapezeka kuti kulibe zoopsa kapena zovuta zomwe zimakhudzana ndi izi. NMN, ikapangidwa bwino ndi omwe amapereka kwa NMN ndikusungidwa moyenera mu fakitale ya NMN ufa ndi nyumba yanu, ndiyotetezeka kwathunthu kuti anthu azidya. Kusunga ufa wa NMN ndikofunikira chifukwa ngati kusungidwa pamalo otentha, kudzasanduka niacinamide ndikuyamba kuwononga thupi lanu pang'onopang'ono mukamadya.

Simuyenera kuda nkhawa kuti ufa wa NMN weniweni ndi kampani ya NMN imasungidwa moyenera nthawi zonse, m'malo ozizira komanso owuma. Kuphatikiza apo, opanga ufa wa NMN amasindikizanso momwe angagwiritsire ntchito ndikusunga pabwino pa zowonjezerazo kuti mudziwe momwe mungagwiritsire ntchito, popanda zovuta zina.

Tiyeneranso kudziwa kuti kugwiritsa ntchito ma NMN pafupipafupi kumatha kubweretsa kuchepa kwa zowonjezera zowonjezera kuti zitulutse zomwe zikufuna. Pachifukwa ichi, tikulimbikitsidwa kuti mupume pang'ono kuchokera ku zowonjezera mukayamba kuwona phindu locheperako la NMN monga kuchepa kwa kugona komanso kuchuluka kwa matenda.

Malingana ndi chisamaliro choyenera chomwe chimatengedwa panthawi yopanga ndikusunga, kunyumba ndi kufakitole, palibe zowopsa zilizonse zomwe zimadza chifukwa chogwiritsa ntchito NMN.

9.Kuti ku buy ndi bndi NMN Powder?

Mutha kugula ufa wa NMN ndi mitundu ina ya zowonjezera za NMN kuchokera kuma pharmacies apa intaneti, malo ogulitsa, ndi anzawo. Muthanso kugula matumba ambiri a ufa wa NMN omwe ali ndi ufa wochuluka wa NMN, ngakhale ndiwopangidwa ndi mafakitale ndipo amagulidwa kwambiri ndi makampani akulu omwe akuyesera kupanga mapiritsi ndi makapisozi a NMN.

Muthanso kugula ufa wa NMN kuchokera ku Amazon kapena Amazon Prime, koma muyenera kukhala osamala kuti mugule zomwe zilipo kwa ogulitsa otsimikizika monga ambiri omwe amakugulitsani angakupusitseni kuti mulipire ndalama zambiri kapena zabodza, zomwe sizingachitike thanzi lanu kapena limasokoneza thanzi lanu.

Musanayambe kugula ufa wa NMN, muyenera kuyang'ana zinthu zingapo kuti muwonetsetse kuti mukugula zabwino kwambiri.

Chowonjezera chabwino cha NMN ndichomwe chimapangidwa ndi malangizo ndi chitetezo chonse chomwe chilipo. Ogulitsa a NMN akuyenera kuwonetsetsa kuti akutetezedwa kwambiri popewa kuipitsidwa kwa ufa wa NMN ndi poizoni kapena zoipitsa zilizonse zomwe zitha kupweteketsa thupi.

Kuphatikiza apo, ufa wa NMN uyenera kukhala, monga tafotokozera pamwambapa, uyenera kusungidwa m'malo oyenera omwe akuyenera kusamalidwa posamutsa zowonjezera.

10. Funsani pafupipafupi mafunso (FAQ) apa NMN Powder

  • Kodi ufa wa NMN ungasinthe ukalamba?

Ufa wa NMN umalengezedwa kuti ndiwowonjezera kukalamba ndipo ndizoyenera kutero, chifukwa ukuwonjezera milingo ya NAD + yomwe imathandiza kwambiri pakuchepetsa mphamvu zanu mukamakalamba. Osati zokhazo, ufa wa NMN ungasinthe zomwe zakalamba zimakhudza ziwalo zosiyanasiyana za thupi lanu, ndikubwezeretsani ku masiku anu achichepere, mwamphamvu.

  • Kodi Ndiyenera Kutenga Powder ya NMN?

NMN Powder ili ndi maubwino angapo omwe aphunziridwa mwatsatanetsatane, mwa mitundu yazinyama komanso labotale. Zina mwazabwinozi zaphunziridwa mwa anthu, ndipo zatulutsa zotsatira zabwino. Ngati mukuyamba kuwona zizindikilo za ukalamba kaya zili ngati kuchepa kwa kupirira, luso lamasewera, kapena zodzikongoletsera, mutha kupindula ndi kutenga zowonjezera za NMN. Kugwiritsa ntchito kwawo kumalimbikitsidwa makamaka kwa iwo omwe akuyesera kuthetsa zizindikiro za ukalamba.

  • Kodi ufa wa NMN ndiwotetezeka?

Ufa wa NMN wafufuzidwa bwino kuti aunike ntchito zosiyanasiyana ndi maubwino omwe amagwiritsidwa ntchito pathupi la munthu. Munthawi yamaphunzirowa, zomwe zingachitike zidawunikiridwanso pokhapokha kuti zotsatira ziwonetsetse kuti kugwiritsa ntchito NMN kulibe zovuta zoyanjanitsidwa nazo. Zovuta zilizonse zomwe zingachitike ndikugwiritsa ntchito ufa wa NMN ndizotsatira zolakwika zaumunthu kapena zachipembedzo zomwe zimachitika mukamanyamula kapena kusungira. Palibe chilichonse chokhudzana ndi zosakaniza zenizeni zowonjezera.

  • Kodi ufa wa NMN umawononga ndalama zingati?

Ufa wa NMN ndiwowonjezera wopezeka mosavuta komanso wokwera mtengo koma amawerengedwa kuti ndiwofunika, chifukwa pamndandanda wake waukulu wazopindulitsa zasayansi. Mtengo wokwera wa ufa wa NMN suli chifukwa cha mndandanda wautali wazopindulitsa koma chifukwa chazinthu zambiri zopanga zomwe ndizokwera mtengo kwambiri kwa omwe amapanga NMN ambiri. Popeza mtengo wowonjezera umakhala wokwera mtengo, muyenera kuwonetsetsa kuti mukugula zotsimikizika kwa ogulitsa otsimikizika, makamaka ngati mukugula NMN pa intaneti.

11.Summary

Zowonjezera za NMN zikukhala zotchuka kwambiri tsikulo, chifukwa cha ntchito ya wasayansi David Sinclair yemwe adagwiritsanso ntchito gawo lalikulu pantchito yake yophunzira ndikuphunzira zotsatira za vitamini B3 yotengedwa ndi nucleotide.

NMN ndiyotsogola ya NAD + yomwe ndi coenzyme yofunikira kuti mugwire bwino njira zingapo zamagetsi, chitetezo chamthupi, ndi mahomoni. Ntchito yayikulu ya NAD + ndi gawo lomwe limagwira pakupanga mphamvu. Popeza NAD + ndiyofunikira pakupanga mphamvu, kuchepa kwa thupi m'mbali zake monga m'badwo umodzi kumapangitsa kuchepa kwamphamvu kwamagetsi. Zowonjezera za NMN zitha kuwonjezera mphamvu polimbikitsa milingo ya NAD + m'thupi.

NMN ilinso ndi maubwino ena angapo monga kupititsa patsogolo kagayidwe kachakudya, kupititsa patsogolo mtima, chidziwitso, kuzungulira kwa magazi, komanso chitetezo cha mthupi. Ntchitoyi imathandizidwa ndi maumboni asayansi komanso zambiri, zomwe zimafuna kuti anthu ambiri okalamba azigwiritsa ntchito njira zowonjezerera za NMN kuti ziwathandize kuyenda mpaka masiku awo achichepere.

Kupatula maubwino angapo a NMN, kutchuka kwake kungatchulidwenso kuti ilibe chiwopsezo chilichonse kapena zovuta zomwe zimadza chifukwa chogwiritsa ntchito. Ngati mukumva kuti msinkhu wanu ukukumana nanu ndipo mukufuna kumwa kuchokera ku kasupe wachinyamata, zowonjezera za NMN zitha kukhala chisankho chabwino kwa inu.

12.Riterere

[1] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. [2018] (Meyi 27). "+ Chepetsa". Cell kagayidwe. Chizindikiro. 5 (1081): 1095-10.e10.1016. onetsani: 2018.03.016 / j.cmet.5935140. Mphatso ya PMC 29719225.

[2] Stipp D (Marichi 11, 2015). "Beyond Resveratrol: Anti-Kukalamba NAD Fad". Sayansi ya American Blog Network.

[3] Cambronne XA, Kraus WL (Okutobala 2020). "+ Kuphatikizika ndi Ntchito mu Maselo Amamayi". Zochitika mu Sayansi Yachilengedwe. 45 (10): 858-873. onetsani: 10.1016 / j.tibs.2020.05.010. MAFUNSO OTHANDIZA:

[4] Bogan KL, Brenner C (2008). "Nicotinic acid, nicotinamide, ndi nicotinamide riboside: kuwunika kwa maselo a NAD + precursor mavitamini muzakudya zamunthu". Ndemanga ya Pachaka ya Nutrition. 28:115-30 . doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.

[5] Yue Yang, Anthony A. Sauve. NAD + metabolism: Bioenergetics, kusaina komanso kusokoneza mankhwala. Biochim Biophys Acta, 2016; CHINSINSI: 10.1016 / j.bbapap.2016.06.014.

[6] Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Kulamulira Kwa Nthawi Yaitali Kwa Nicotinamide Mononucleotide Kumachepetsa Kuthupi Kogwirizana Ndi Zamoyo Pamagulu. Cell Metab, 2016; DOI: 10.1016 / j.cmet.2016.09.013.

[7] Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen. NAD + metabolism ngati chandamale cha thanzi lamafuta: tapeza bullet ya siliva? Matenda a shuga, 2019; DOI: 10.1007 / s00125-019-4831-3.

[8] Ann Katrin-Hopp, Patrick Grüter, Michael O. Wotentha. Lamulo la Glucose Metabolism lolembedwa ndi NAD + ndi ADP-Ribosylation. Maselo, 2019; DOI: 10.3390 / maselo8080890.

13. Momwe mungagule β-Nicotinamide Mononucleotide (NMN) Ufa wochokera ku AASraw?

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