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Rimonabant powder video
Raw Rimonabant powder Basic Characters
| Name: | Rimonabant Powder (SR141716) |
| CAS: | 168273-06-1 |
| Makhalidwe a Maselo: | C22H21Cl3N4O |
| Kulemera kwa maselo: | 463.8 |
| Melt Point: | 230 ° C - 240 ° C |
| Kusungirako nyengo: | Powonjezera -20 ° C zaka 3 |
| mtundu; | Gray-white ufa |
Mbiri ya Rimonabant
Mbiri yakale ya Rimonabant inayamba kumapeto kwa 1990s ndi kumayambiriro kwa 2000s pamene ochita kafukufuku anayamba kufufuza dongosolo la endocannabinoid ndi zotsatira zake zomwe zingatheke pazochitika zosiyanasiyana za thupi, kuphatikizapo kulamulira chilakolako ndi mphamvu.
Panthawi imeneyi, asayansi adazindikira ma cannabinoid receptors m'thupi, omwe amadziwika kuti CB1 receptors, omwe nthawi zambiri amapezeka muubongo ndi zotumphukira.
Molimbikitsidwa ndi kumvetsetsa komwe kukukula kwa dongosolo la endocannabinoid pakuchita kuwongolera kudya, makampani opanga mankhwala adayambitsa kupanga osankhidwa a CB1 receptor antagonists kuti athe kulimbana ndi kunenepa kwambiri ndi zina zofananira.
Mu 1999, kampani yopanga mankhwala ya ku France Sanofi-Synthélabo (tsopano Sanofi) inayamba kupanga mankhwala otchedwa Rimonabant.
Mayesero a zachipatala anachitidwa kuti ayese mphamvu ndi chitetezo cha Rimonabant poyang'anira kunenepa kwambiri ndi matenda okhudzana ndi kagayidwe kachakudya.Zofukufukuzo zinawonetsa zotsatira zolimbikitsa, kusonyeza kulemera kwa thupi ndi kusintha kwa chiopsezo cha mtima, monga cholesterol ndi insulin kukana.
Malingana ndi zotsatira zabwino kuchokera ku mayeserowa, Rimonabant adalandira chilolezo chovomerezeka ku 2006 ku European Union pansi pa dzina la malonda Acomplia.Ndiwo mankhwala oyambirira omwe anapangidwa kuti athetse kunenepa kwambiri pazaka khumi.
Komabe, ngakhale kuti anapambana koyamba, Rimonabant anakumana ndi mavuto ndi mikangano. Malipoti a zotsatira za maganizo, kuphatikizapo kuvutika maganizo, nkhawa, ndi malingaliro ofuna kudzipha, adawonekera panthawi yowunika pambuyo pa malonda. mayiko angapo, kuphatikiza European Union mu 2008.
Kuchotsedwa kwa Rimonabant kunawonetsa kufunikira kowunika mosamala za chitetezo ndi zoopsa zomwe zingachitike m'maganizo zomwe zimakhudzana ndi mankhwala osokoneza bongo omwe akutsata dongosolo la endocannabinoid. dongosolo ndi metabolic regulation.
Chiyambireni kuchotsedwa kwa Rimonabant, zoyesayesa za kafukufuku zapitiliza kufufuza kuthekera kwachirengedwe koyang'ana dongosolo la endocannabinoid, koma ndikuyang'ana kwambiri pakupanga mankhwala omwe amachepetsa kuopsa kwamisala komwe kumakhudzana ndi blockade ya CB1 receptor.
Rimonabant Powder
Rimonabant Powder ndi mankhwala omwe adapeza chidwi chifukwa cha kugwiritsidwa ntchito kwake m'chipatala.Ndi m'gulu la mankhwala omwe amadziwika kuti selective cannabinoid receptor antagonists. chilakolako ndi kulemera.
Mtundu wa ufa wa Rimonabant umalola kuti zisamalidwe mosavuta komanso zimabalalika panthawi yopangira. propylene glycol.Makhalidwe osungunula a Rimonabant ndi ofunika kwambiri panthawi yopanga mapangidwe.
Rimonabant limagwirira ntchito
Njira yogwiritsira ntchito Rimonabant imaphatikizapo kuyanjana kwake ndi dongosolo la endocannabinoid m'thupi.Rimonabant ndi wosankha cannabinoid receptor antagonist, makamaka akuyang'ana ma CB1 receptors omwe amapezeka mu ubongo ndi zotumphukira.
Ikamwedwa, Rimonabant imamangiriza ndi kutsekereza zolandilira za CB1, kuletsa kutsegulira kwa zolandilira izi ndi ma cannabinoids amkati monga anandamide. kuwongolera, kuwongolera mphamvu, ndi lipid metabolism.
Makamaka, kutsekedwa kwa ma CB1 receptors ndi Rimonabant kumakhudza izi:
Kuwongolera Kulakalaka
Ma CB1 receptors amakhudzidwa ndi kuwongolera chilakolako cha kudya komanso kudya.Pamene ma CB1 receptors atsegulidwa, amathandizira kutulutsidwa kwa ma neuropeptides omwe amachititsa njala ndikuwonjezera zopindulitsa za chakudya. kuchepetsa chilakolako cha kudya ndi kuchepetsa kudya.
Kugwiritsa Ntchito Mphamvu
Dongosolo la endocannabinoid limakhudza kugwiritsa ntchito mphamvu zamagetsi poyang'anira thermogenesis, njira yomwe thupi limatulutsa kutentha ndikuwotcha ma calories.Mwa kuletsa ma CB1 receptors, Rimonabant ikhoza kulimbikitsa kugwiritsa ntchito mphamvu zowonjezera mphamvu, zomwe zimathandizira kuchepetsa thupi.
Lipid Metabolism
CB1 receptor activation imagwirizanitsidwa ndi kuwonjezeka kwa lipogenesis (kusungirako mafuta) ndi kuchepa kwa lipolysis (kuwonongeka kwa mafuta) .
Ndikofunika kuzindikira kuti ngakhale Rimonabant makamaka amachita ngati CB1 receptor antagonist, ikhoza kuwonetsanso zina zowonjezera kapena kuyanjana ndi zolandilira zina kapena machitidwe m'thupi. kafukufuku.
Njira yogwiritsira ntchito Powder ya Rimonabant ndi yofanana ndi ya Rimonabant mumitundu ina.
Pamene Rimonabant Powder imayendetsedwa, kaya pakamwa kapena popanga mitundu yosiyanasiyana ya mlingo, imasungunuka ndi kuyamwa m'thupi. Ikatengeka, imagwirizana ndi dongosolo la endocannabinoid poyang'ana ma CB1 receptors omwe amapezeka mu ubongo ndi zotumphukira.
Kodi zotsatira za Rimonabant ndi ziti?
Rimonabant, mankhwala oletsa kunenepa kwambiri, adapangidwa poyamba kuti athandize anthu omwe akulimbana ndi kulemera kwa thupi.
Kugonjetsa Kudya
Rimonabant idapangidwa kuti ichepetse kulakalaka komanso kulimbikitsa kuchepa thupi mwa kutsekereza zolandilira za CB1 muubongo zomwe zimakhudzidwa ndi kuwongolera kudya.
kuwonda
Chifukwa cha chilakolako chofuna kudya, Rimonabant ankayembekezeredwa kuti awonongeke kwa anthu omwe ali ndi kunenepa kwambiri kapena olemera kwambiri.
Kusintha kwa Metabolic
Rimonabant adawonetsa zopindulitsa pakuwongolera magawo a metabolic omwe amakhudzana ndi kunenepa kwambiri, monga mbiri ya lipid, kukana insulini, komanso zowonetsa za chiopsezo cha mtima.
Thandizo Losiya Kusuta
Rimonabant anafufuzidwa kuti agwiritse ntchito ngati chithandizo chosiya kusuta. Ankaganiziridwa kuti poletsa ma CB1 receptors, Rimonabant akhoza kuchepetsa zilakolako za chikonga ndi zizindikiro zosiya, kuthandizira anthu poyesera kusiya kusuta.
Chifukwa chiyani Rimonabant imayambitsa kukhumudwa?
Njira zenizeni zomwe Rimonabant angayambitse kuvutika maganizo sizikumveka bwino.
Rimonabant, monga cannabinoid receptor antagonist, amalepheretsa ntchito ya CB1 receptors mu endocannabinoid system. endocannabinoid system, yomwe ingathandize kusintha malingaliro ndi malingaliro abwino.
Kuphatikiza apo, dongosolo la endocannabinoid limakhudzidwa ndi kuwongolera kuyankha kwa kupsinjika komanso kusintha kwa ma neurotransmitters monga serotonin, omwe amadziwika kuti amagwira ntchito yofunika kwambiri pakuwongolera malingaliro.
Ndikofunika kuzindikira kuti mayankho amunthu payekha pamankhwala amatha kukhala osiyanasiyana, ndipo sikuti aliyense amene amatenga Rimonabant adzakumana ndi kupsinjika maganizo kapena zotsatirapo zina. msika m'mayiko angapo.Choncho pakali pano mwina sikophweka kugula Rimonabant Powder mu pharmacy yakomweko.Ngati mukufuna kugula Rimonabant Powder pa intaneti, ngakhale pali ambiri ogulitsa Rimonabant Powder, muyenera kusankha odalirika.
Ngati muli ndi nkhawa zokhudzana ndi kupsinjika maganizo kapena zovuta zina zokhudzana ndi matenda amisala, ndikofunikira kukaonana ndi akatswiri azachipatala kuti akuwunikeni bwino ndikuwongolera.
Kuchotsa kwa Rimonabant ndi kafukufuku wopitilira
Chifukwa cha nkhawa za chitetezo, makamaka zotsatira za matenda amisala, Rimonabant pamapeto pake adachotsedwa pamsika m'maiko angapo. .
Kafukufuku wamtsogolo angaphatikizepo kukonzanso kumvetsetsa kwa dongosolo la endocannabinoid, kufufuza momwe angagwiritsire ntchito kusintha kwa endocannabinoid muzochitika zosiyanasiyana zachipatala, ndikupanga mankhwala otetezeka komanso othandiza kwambiri pa ntchitoyi.
Kodi mungagule kuti Rimonabant Powder?
Ndikofunika kuzindikira kuti ngakhale pali zambiri za Rimonabant Powder zomwe zimagulitsidwa pa intaneti.Sizipezeka mosavuta kuti munthu agule kapena agwiritse ntchito.Rimonabant Powder imagwiritsidwa ntchito makamaka popanga kafukufuku ndi chitukuko, kuphatikizapo makampani opanga mankhwala ndi ma laboratories, pofuna kuphunzira za mankhwala. katundu, kuchita mayesero a preclinical ndi chipatala, ndikupanga mankhwala atsopano a mankhwala.Chifukwa cha nkhawa za chitetezo ndi zotsatira zomwe zingakhalepo, nkofunika kugula Rimonabant Powder yapamwamba kuti mupewe zotsatira zosafunikira.Momwe mungasankhire kupanga odalirika kwa Rimonabant, muyenera kufufuza malipoti awo odziimira a HPLC ndi COA.AASRAW ndi wothandizira wodalirika kuti akhulupirire. Timapereka ufa wabwino wa Rimonabant. Pakugula kwa Rimonabant Powder, mupeza mtengo wampikisano kwambiri.
Rimonabant Powder Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji Rimonabant Powder kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Soyka M.”Rimonabant and depression.
[2] Boyd ST,Fremming BA. Ann Pharmacother.1 Apr;2005(39):4-684.doi: 90/aph.10.1345E1.Epub 499 Mar 2005.PMID: 8
[3] Curioni C, André C.” Rimonabant chifukwa cha kunenepa kwambiri kapena kunenepa kwambiri.
[4] Wierzbicki AS."Rimonabant: endocannabinoid inhibition for the metabolic syndrome."Int J Clin Pract.2006 Dec;60(12):1697-706.doi: 10.1111/j.1742-1241.2006.01210.x. 17109677
[5] Cox SL.”Rimonabant hydrochloride: wofufuza wofufuza zinthu zowopsa za mtima.” Drugs Today (Barc).2005 Aug;41(8):499-508.doi: 10.1358/dot.2005.41.8.893709. PMID: 16234873
[6] Bifulco M,Grimaldi C,Gazzerro P,Pisanti S,Santoro A.”Rimonabant: mankhwala oletsa kunenepa chabe? Umboni wamakono pa zotsatira zake za pleiotropic."Mol Pharmacol.2007 Jun;71(6):1445-56.doi: 10.1124/mol.106.033118.Epub 2007 Feb 27.PMID: 17327463
