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Nicotinamide riboside mankhwala enaake

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Mafotokozedwe Akatundu

Makhalidwe Abwino

Name mankhwala Nicotinamide riboside mankhwala enaake
Nambala ya CAS 23111-00-4
Molecular Formula C11H15ClN2O5
Kulemera kwa Fomu 290.7
Mafananidwe 23111-00-4

Nicotinamide riboside mankhwala enaake

Nicotinamide riboside (mankhwala enaake)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

Nicotinamide ribose mankhwala enaake

Maonekedwe White powder
Kusungirako ndi Kusamalira 0 - 4 C kwakanthawi kochepa (masiku mpaka masabata), kapena -20 C kwakanthawi (miyezi).

 

Nicotinamide riboside mankhwala enaake Kufotokozera

Nicotinamide Riboside Chloride (NIAGEN) ndi mtundu wina wamchere wamchere wa nicotinamide riboside (NR) .NR ndi mtundu watsopano wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati kalambulabwalo wa nicotinamide adenine dinucleotide (NAD) kapena NAD +. (GRAS) ku United States kuti igwiritsidwe ntchito popanga zakudya. Nicotinamide riboside chloride ndi mawonekedwe a kristalo a Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride imakulitsa milingo ya NAD [+] ndikuyambitsa SIRT1 ndi SIRT3, yomwe imafikira pakulimbikitsanso kagayidwe kazakudya kamene kamakhala koteteza komanso kuteteza ku zovuta zamafuta zomwe zimayambitsa zovuta zamafuta. Nicotinamide riboside chloride powder amagwiritsidwa ntchito pazakudya zowonjezera.

 

Njira ya Action ya Nicotinamide riboside chloride

Nicotinamide Riboside Chloride (NIAGEN) ndi mtundu wamchere wa chloride wa nicotinamide riboside (NR). NR ndi mtundu wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati chithunzithunzi cha nicotinamide adenine dinucleotide kapena NAD +. NR imalepheretsa kuchepa kwa mizu yotsekemera yamitsempha yamagulu yamagulu ex vivo ndipo imateteza motsutsana ndi phokoso lakumva phokoso mu mbewa zamoyo. Nicotinamide riboside powder amaletsa minofu, neural ndi melanocyte stem cell senescence. Kuchulukanso kwaminyewa yama mbewa kwawonedwa atalandira chithandizo ndi nicotinamide riboside, zomwe zimapangitsa kuti anthu aziganiza kuti zitha kusintha kusintha kwa ziwalo monga chiwindi, impso, ndi mtima. Nicotinamide riboside imachepetsanso magazi m'magazi ndi chiwindi chamafuta m'mankhwala oyeserera komanso mtundu wa 2 wa matenda ashuga poletsa kukula kwa matenda ashuga a m'mitsempha ya m'mitsempha. Chidziwitso: Nicotinamide Riboside chloride ndi osakaniza α / β.

 

Nicotinamide riboside mankhwala enaake Ntchito

Nicotinamide riboside chloride powder amalembedwa ndi CAS nambala 23111‐00‐4 ndi EC nambala 807-820‐5. Dzinalo la IUPAC ndi 1 - [(2R, 3R, 4S, 5R) ,3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. Mlingo wa nicotinamide riboside chloride ndi C11H15N2O5Cl, ndi kulemera kwake kwa 290.7 g / mol. Nicotinamide Riboside Chloride (NIAGEN) ndi mtundu wina wamchere wamchere wa nicotinamide riboside (NR) .NR ndi mtundu watsopano wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati cholozera cha nicotinamide adenine dinucleotide (NAD) kapena NAD +. Thupi limafunikira NAD + kuti igwire bwino ntchito. Magulu otsika a NAD + amatha kuyambitsa mavuto azachipatala. Kutenga nicotinamide riboside kungathandize kukweza milingo yotsika ya NAD +.

 

ubwino Nicotinamide riboside mankhwala enaake

Nicotinamide riboside Chloride, yemwe amatsogolera pakamwa pa NAD +, amachulukitsa milingo ya NAD + ndikuyambitsa SIRT1 ndi SIRT3. Nicotinamide riboside Chloride powder ndi gwero la vitamini B3 (niacin) ndipo gwiritsani ntchito Nicotinamide riboside Chloride powder imatha kupangitsanso kagayidwe kazakudya, kuteteza ku mafuta omwe amadza chifukwa cha zovuta zamafuta. Nicotinamide riboside Chloride amachepetsa kuwonongeka kwazidziwitso pamtundu wama mbewa wamatenda a Alzheimer's.

 

Reference

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[5] Kupulumutsa AA. NAD + ndi vitamini B3: kuchokera ku metabolism mpaka kuchipatala. J Pharmacol Kutulutsa Ther. 2008 Mar; 324 (3): 883-93. onetsani: 10.1124 / jpet.107.120758. Unikani. Adatuluka PMID: 18165311.

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[7] Cantó C, ndi al. Chithunzithunzi cha NAD (+) choyambirira cha nicotinamide riboside chimathandizira kagayidwe kake ka oxidative ndikuteteza kunenepa kwambiri komwe kumayambitsa kunenepa kwambiri. Cell Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Nicotinamide Riboside Imabwezeretsanso Kuzindikira Kudzera Mukukonzanso kwa Proliferator-activated Receptor-γ Coactivator 1α Yoyendetsedwa β-Secretase 1 Kuwonongeka ndi Kufotokozera kwa Gene Mitochondrial mu Mitundu ya Alzheimer's Mouse. Kukalamba kwa Neurobiol. 2013 Jun; 34 (6): 1581-8. (Adasankhidwa)

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