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γ-Aminobutyric acid (GABA)

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GABA amatengedwa pakamwa kuti athetse nkhawa, kusintha malingaliro, kuchepetsa zizindikiritso za premenstrual syndrome (PMS), komanso kuthandizira kuchepa kwa vuto la kuchepa kwa magazi (ADHD). Amagwiritsidwanso ntchito popititsa patsogolo kukula kwa minofu, mafuta oyaka, kukhazikika kwa magazi, komanso kuchepetsa ululu.

Mafotokozedwe Akatundu

Makhalidwe Abwino

Name mankhwala γ-Aminobutyric acid (GABA)
Nambala ya CAS 56-12-2
Molecular Formula C4H9NO2
Kulemera kwa Fomu 103.12
Mafananidwe 4-aminobutyric acid

4-Aminobutanoic acid

gamma-aminobutyric acid

GABA

56-12-2

Maonekedwe White powder
Kusungirako ndi Kusamalira Youma, mdima ndi 0 - 4 C kwakanthawi kochepa, kapena -20 C kwakanthawi.

 

γ-Aminobutyric acid (GABA)Kufotokozera

γ-aminobutyric acid, kapena gamma-Aminobutyric acid, kapena GABA, ndiye choletsa chachikulu choteteza ma neurotransmitter mu dongosolo lamanjenje lam'mayi lokoma. Udindo wake waukulu ndikuchepetsa kuchepa kwa mitsempha m'mitsempha yonse.

GABA imagulitsidwa ngati zowonjezera zakudya m'maiko ambiri. Amaganiziridwa kale kuti GABA yachilendo (yotengedwa ngati chowonjezera) siyidutsa chotchinga chamaubongo am'magazi, komabe zomwe zapezeka pakufufuza kwaposachedwa zikuwonetsa kuti mwina ndizotheka.

 

γ-Aminobutyric acid (GABA) Njira Yogwirira Ntchito

Mankhwala osokoneza bongo omwe amakhala ngati ma allosteric modulators a GABA receptors (omwe amadziwika kuti ma GABA ofanana nawo kapena mankhwala a GABAergic), kapena kuwonjezera kuchuluka komwe kulipo kwa GABA, amakhala ndi zotsatira zotsitsimula, zotsutsana ndi nkhawa, komanso zotsutsana. Zambiri mwazinthu zomwe zili pansipa zimadziwika kuti zimayambitsa anterograde amnesia ndikubwezeretsanso amnesia.

Mwambiri, GABA sikuwoloka chotchinga magazi-ubongo, ngakhale madera ena aubongo omwe alibe magwiridwe antchito am'magazi, monga ma periventricular nucleus, amatha kufikiridwa ndi mankhwala monga mwadongosolo jekeseni GABA. Kafukufuku m'modzi akuwonetsa kuti GABA yapakamwa imakulitsa kuchuluka kwa mahomoni okula (HGH). GABA yomwe idalowetsedwa muubongo idanenedwa kuti imakhala ndi zoyambitsa komanso zolepheretsa pakupanga mahomoni okula, kutengera momwe thupi limakhalira. Mankhwala ena opatsirana a GABA (ex. Picamilon) apangidwa kuti azitha kutchinga magazi-ubongo, kenako nkupatukana ndi GABA ndi molekyulu yonyamula kamodzi mkati mwa ubongo.

GABA idathandizira kutulutsa kwa serotonin kukhala N-acetylserotonin (woyamba wa melatonin) mu makoswe. Zikukayikiridwa kuti GABA imakhudzidwa ndi kaphatikizidwe ka melatonin ndipo potero imatha kuyambitsa zovuta pakugona komanso ntchito zobereka.

 

γ-Aminobutyric acid (GABA) ntchito

Gamma-Aminobutyric Acid ndimitsempha yachilengedwe yomwe imachitika mwadongosolo lokhala ndi machitidwe apakati a mitsempha (CNS). Gamma-aminobutyric acid (GABA), yotembenuzidwa kuchokera ku glutamate yotulutsa chidwi chachikulu muubongo, imathandizira kukhazikitsa chisangalalo cha neuronal pomangiriza kwa omwe amalandila, GABA-A ndi GABA-B, potero kuyambitsa njira yotsegulira ion, hyperpolarization ndipo pamapeto pake chopinga cha neurotransmission.

Gamma-aminobutyric acid ndi gamma-amino acid yomwe ndi butanoic acid yokhala ndi cholowa cha amino ku C-4. Ili ndi gawo ngati molekyulu yosonyeza, metabolism yaumunthu, Saccharomyces cerevisiae metabolite ndi neurotransmitter. Ndi gamma-amino acid ndi monocarboxylic acid. Amachokera ku asidi butyric. Ndi conjugate acid wa gamma-aminobutyrate. Ndi tautomer wa gamma-aminobutyric acid zwitterion.

 

Ubwino wa γ-Aminobutyric acid (GABA)

GABA amatengedwa pakamwa kuti athetse nkhawa, kusintha malingaliro, kuchepetsa zizindikiritso za premenstrual syndrome (PMS), komanso kuthandizira kuchepa kwa vuto la kuchepa kwa magazi (ADHD). Amagwiritsidwanso ntchito popititsa patsogolo kukula kwa minofu, mafuta oyaka, kukhazikika kwa magazi, komanso kuchepetsa ululu.

 

Reference

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2, Campagna JA, Miller KW, Forman SA (Meyi 2003). "Njira za zochita za mankhwala oletsa kupuma". N. Engl. J. Med. 348 (21): 2110–24. onetsani: 10.1056 / NEJMra021261. PMID 12761368. (Adasankhidwa)

3, Müller EE, Locatelli V, Cocchi D (Epulo 1999). "Neuroendocrine kuwongolera kukula kwa mahomoni obisa". Thupi. Chibvumbulutso 79 (2): 511-607. onetsani: 10.1152 / physrev.1999.79.2.511. PMID 10221989. (Adasankhidwa)

4, Mphamvu INE, Yarrow JF, McCoy SC, Borst SE (Januware 2008). "Hormone ya kukula isoform imayankha GABA kumeza panthawi yopuma komanso mutatha kuchita masewera olimbitsa thupi". Mankhwala ndi Sayansi mu Masewera ndi Kuchita Masewera Olimbitsa Thupi. 40 (1): 104-10. onetsani: 10.1249 / mss.0b013e318158b518. PMID 18091016. (Adasankhidwa)

5, Balemans MG, Mans D, Smith I, Van Benthem J (1983). "Mphamvu ya GABA pakapangidwe ka N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol ndi O-acetyl-5-methoxytryptophol mu gland wa pineal wamphongo wamwamuna Wistar". Kubereka, Zakudya Zakudya, Kukula. 23 (1): 151-60. onetsani: 10.1051 / rnd: 19830114. PMID 6844712. (Adasankhidwa)

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Kusintha kwa kugonana kwa GABA (A) mafunde olandila ndi melatonin mu makoswe gonadotropin-kutulutsa ma hormone neurons". J Physiol Sci. 58 (5): 317-322. onetsani: 10.2170 / physiolsci.rp006208. PMID 18834560. (Adasankhidwa)

7, Kuriyama K, Sze PY (Januware 1971). "Cholepheretsa magazi ndi magazi ku H3-γ-aminobutyric acid munthawi yanyama komanso nyama za amino oxyacetic acid". Neuropharmacology. 10 (1): 103-108. onetsani: 10.1016 / 0028-3908 (71) 90013-X. PMID 5569303.

8, Foster AC, Kemp JA (February 2006). "Glutamate- ndi GABA yochokera ku CNS Therapeutics". Wotsogola Opin Pharmacol. 6 (1): 7-17. onetsani: 10.1016 / j.coph.2005.11.005. MAFUNSO OTHANDIZA: