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Hydroxypinacolone Retinoate

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Hydroxypinacolone Retinoate ufa ndizopewera kukalamba, zolumikizidwa ndi retinoic acid. Hydroxypinacolone Retinoate ndi zodzikongoletsera kalasi ester ya zonse trans retinoic acid yomwe ndi ya ma retinoid, omwe ndi achilengedwe komanso opanga mavitamini A.

Mafotokozedwe Akatundu

Makhalidwe Abwino

Name mankhwala Hydroxypinacolone Retinoate
Nambala ya CAS 893412-73-2
Molecular Formula C26H38O3
Kulemera kwa Fomu 398.6
Mafananidwe Mankhwala otchedwa Hydroxypinacolone retinoate

893412-73-2

UNII-NJ3V2F02E1

Chithunzi cha NJ3V2F02E1

(2E,4E,6E,8E)-3,3-Dimethyl-2-oxobutyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

Maonekedwe Mpweya wofiira
Kusungirako ndi Kusamalira Kutentha kouma, kwamdima komanso kotsika.

 

Kufotokozera kwa Hydroxypinacolone Retinoate

Hydropinazone retinoic acid ester (HPR) ndi malo opangira zodzikongoletsera a ATRA. Mbali yake yapadera ndiyakuti imagwira ntchito ya retinoic acid ndipo imamangiriza mwachindunji kwa ma retinoid receptors popanda kuwonongeka kwa kagayidwe kake kuti akhale olimba kwambiri. Hydroxypinacolone retinoate (HPR) ili ndi zinthu zabwino zobwezeretsa komanso zotsutsana ndi ukalamba.

 

Njira ya Hydroxypinacolone Retinoate Action

Hydroxypinacolone Retinoate ndi chinthu cholimbana ndi ukalamba, cholumikizidwa ndi retinoic acid. Hydroxypinacolone Retinoate imakhalanso ndi zodzikongoletsera za esteric acid yotulutsa ma retinoid, omwe ndi mavitamini achilengedwe komanso opangidwa ndi vitamini A.

Hydroxypinacolone Retinoate m'malo moyenera kusandulika kukhala chinthu chenicheni chogwira ntchito, retinoic acid, kudzera mu retinal, monga retinol, Hydroxypinacolone Retinoate (HPR) imagwira ntchito mwachindunji, ndipo SKINWELL HPR imakhalanso yolimba komanso yosavulaza thanzi la munthu.

 

Zopindulitsa za Hydroxypinacolone Retinoate

Hydroxypinacol retinoic acid ester (HPR) ndichotengera cha retinols, chomwe chimatha kulumikizana mwachindunji ndi ma retinoic acid receptors (RARs), ndipo imagwira ntchito yoyang'anira kagayidwe ka epidermis ndi stratum corneum. Ubwino wake ndikuti ikhoza:

Anti-kukalamba,

♦ Itha kuchepetsa seborrhea

♦ Sakanizani khungu la khungu

Vent Pewani kukalamba pakhungu

Chitani ziphuphu

♦ Kuyera ndi kupenya

Poyerekeza ndi retinol, imakhala yolimba kwambiri ndipo siyikhala ndi oxidized. Itha kuchepetsa bwino mizere ndi makwinya ndikuwunikira. Pakuwonetsetsa mphamvu ya retinoic acid, imachepetsanso kukwiya kwake. Amagwiritsidwa ntchito makamaka kwa makwinya olimbana ndi ukalamba komanso kupewa ziphuphu.

 

Zotsatira za Hydroxypinacolone Retinoate

Hydropinazone retinoic acid ester (HPR) ndi malo opangira zodzikongoletsera a ATRA. Mbali yake yapadera ndiyoti imagwira ntchito ya retinoic acid ndipo imamangiriza mwachindunji kwa ma retinoid receptors popanda kuwonongeka kwa kagayidwe kake kuti azigwira ntchito kwambiri. mawonekedwe. Zatsimikizika kuti ndizokhazikika kuposa retinol komanso zosakhumudwitsa khungu. Apa, timagwiritsa ntchito RARE kuwunika kumangiriza kwa retinoic acid receptors ku retinoic acid reaction element (RARE) mu DNA, ndikufanizira HPR, ATRA, retinol (Rol), retinal (Ral) ndi retinol palmitate Mulingo wamasamba olembedwa a esters (RP). Kuphatikiza apo, tinayerekezera zotsutsana ndi ukalamba za HPR ndi ATRA poyesa zotsatira za khungu la organotypic pamlingo wa collagen komanso kukwiya pakhungu.

 

Reference

  1. abc Nora Ruth, Thomas Mammone (2018). "Kuteteza kukalamba kwa retinoid hydroxypinacolone retinoate pakhungu lachikopa". Zolemba pa American Academy of Dermatology 79 (3): AB44. onetsani: 10.1016 / j.jaad.2018.05.215.
  2. Katie Rodan, Kathy Fields, George Majewski, Timothy Falla (2016-12). "Skincare Bootcamp: Udindo Wofalikira wa Skincare". Opaleshoni ya pulasitiki komanso yomanganso. Global lotseguka 4 (12 Suppl Anatomy and Safety in cosmetic Medicine: cosmetic Bootcamp): e1152. doi: 10.1097 / GOX.0000000000001152. PMC: 5172479. PMID28018771.
  3. Truchuelo, Maria Teresa; Jiménez, Natalia; Jaén, Pedro (2014). "Kuunika kwa mphamvu ndi kulolerana kwa kuphatikiza kwatsopano kwa ma retinoid ndi othandizira pantchito yothandizira melasma". Zolemba Pazodzikongoletsera Zofufuza 13 (4): 261-268. onetsani: 10.1111 / jocd.12110.
  4. Veraldi, M. Barbareschi, E. Guanziroli; Et al (2015-4). "Chithandizo cha ziphuphu zochepa pang'ono mpaka pang'ono zophatikizika ndi hydroxypinacolone retinoate, retinol glycospheres ndi papain glycospheres". Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 150 (2): 143–147. MAFUNSO: PMID25876142.
  5. Ruth, N., ndi T. Mammone. "1310 Zotsutsana ndi ukalamba za retinoid hydroxypinacolone retinoate pakhungu." Zolemba pa Investigative Dermatology 138.5 (2018): S223.
  6. Giornale italiano di dermatologia e venereologia, 2015 Apr; 150 (2): 143-7., Chithandizo cha ziphuphu zochepa mpaka zolimbitsa thupi kuphatikiza kophatikizana kwa hydroxypinacolone retinoate, retinol glycospheres ndi papain glycospheres.
  7. Giornale Italiano di Dermatologia e Venereologia, 2016/03, Kuchita bwino ndi chitetezo cha mankhwala a miyezi 12 kuphatikiza mankhwala a hydroxypinacolone retinoate ndi retinol glycospheres ngati mankhwala osamalira odwala ziphuphu pambuyo pakamwa isotretinoin.

 

AASraw ndiwodalirika komanso wololedwa mwalamulo wopanga mtundu wapamwamba kwambiri wa Hydroxypinacolone Retinoate  ufa. Mwalandiridwa kuyika dongosolo kwa ife!