Alprostadil, (PGE1), Prostaglandin E1

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AASraw ili ndi kaphatikizidwe ndi kapangidwe kameneka kuchokera ku gramu kupita ku dongosolo la Alprostadil, (PGE1), Prostaglandin E1 (745-65-3), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Prostaglandin E1 (PGE1), amadziwika kuti alprostadil, ndi prostaglandin yomwe imagwiritsidwa ntchito ngati mankhwala. Kwa makanda omwe ali ndi vuto la mtima, amagwiritsidwa ntchito ndi jekeseni ya pang'onopang'ono mu mitsempha kuti atsegule ductus arteriosus mpaka opaleshoni ikhoza kuchitidwa. Mwa jekeseni mu mbolo kapena malo operekera mu urethra, amagwiritsidwa ntchito pochiza matenda osokoneza bongo.

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Alprostadil, (PGE1), kanema ya Prostaglandin E1


I.Aprostadil, (PGE1), Prostaglandin E1 Basic Characters:

Name: Alprostadil, (PGE1), Prostaglandin E1
CAS: 745-65-3
Makhalidwe a Maselo: C20H34O5
Kulemera kwa maselo: 354.48
Melt Point: 115-116 ° C
Kusungirako nyengo: 2 ° -8 ° C
mtundu; White powder


II. Alprostadil, (PGE1), ntchito ya Prostaglandin E1 (745-65-3) mu steroid cycle

1. Mayina:

Alprostadil, (PGE1), Prostaglandin E1 (CAS 745-65-3), yomwe imatchedwanso Avastin ndi Mvasi.

2. Alprostadil, (PGE1), Prostaglandin E1 Ntchito:

Bevacizumab imabwera ngati njira yothetsera pang'onopang'ono mu mitsempha. Bevacizumab imayang'aniridwa ndi dokotala kapena namwino ku ofesi ya zamankhwala, malo osungirako mankhwala, kapena chipatala. Bevacizumab nthawi zambiri imaperekedwa kamodzi pa masabata 2 kapena 3.

Iyenera kutenga maminiti a 90 kuti mulandire mlingo woyamba wa bevacizumab. Dokotala kapena namwino adzakuyang'anitsitsa kuti awone momwe thupi lanu limamvera ndi bevacizumab. Ngati mulibe vuto lalikulu mukalandira mlingo wanu woyamba wa bevacizumab, nthawi zambiri mumatenga 30 kwa maminiti a 60 kuti mulandire mankhwala omwe mumakhala nawo.

Kujambulidwa kwa Bevacizumab kungayambitse kwambiri pakamwa mankhwala. Ngati mukumane ndi zizindikiro zotsatirazi, pitani kuchipatala mwamsanga: kuvutika kupuma kapena kupuma, kupweteka, kugwedezeka, kutukuta, kupweteka mutu, chifuwa, chizungulire, kukhumudwa, kuthamanga, kuyabwa, kuthamanga, kapena ming'oma. Dokotala wanu angafunikire kuchepetsa kuchepetsedwa kwanu, kapena kuchedwa kapena kusiya mankhwala ngati mukukumana ndi zotsatirazi kapena zina.

3.Ho Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) ntchito?

Pochiza Erectile Dysfunction (ED), alprostadil amatsitsimutsa minofu yosalala ya corpus cavernosum; Komabe, ndondomeko yeniyeni ya ntchito siidadziwika. Zikuwoneka kuti zotsatira zake zikuwonjezeka chifukwa cha kuchuluka kwa ma intracellular concentrations of cyclic AMP. Alprostadil imagwirizana ndi ma mempane-memphane-receptors omwe amachititsa adenylate cyclase ndikukweza AMP yopanga mapiritsi, ndipo amachititsa kuti puloteni kinase ikhale ndi mphamvu komanso kumasuka kwa thupi kumatulutsa. Izi ndi zosiyana ndi papaverine yomwe imalepheretsa kutsekemera kwa mankhwala osokoneza bongo omwe amachititsa kuti pakhale mpweya wabwino wa AMP. Alprostadil ingathenso kuthana ndi zochitika zapamwamba za norepinephrine mwa kuletsa kutulutsa kwa norepinephrine komanso kumapangitsanso ntchito za non -renrenergic, noncholinergic vasodilatory neurotransmitter. Pochiza ED, alprostadil imapangitsa kuti anthu azikhala osangalala komanso amatsitsimutsa mitsempha yambiri komanso nthambi zawo. Kusintha kwa mitsempha ya cavernosal ikuphatikizidwa ndi kuwonjezereka kwagwedezeka kolowera komanso kuwonjezeka kwa mitsempha yotuluka m'thupi. Chotsatira chake, malowa amatha kufalikira ndipo magazi amalowa mumsampha wachiwiri mpaka kumapeto kwa mitsempha yotsutsana ndi tunica albuginea. Kuti tipeze tumimba ndi kukwanira kokwanira, tunica albuginea iyenera kukhala yochuluka mwamphamvu kuti imitsani mavitamini kuti alowemo ndipo motero amalepheretsa kutuluka. Ndondomekoyi imatchulidwanso kuti chigwirizano cha veno-occlusive. Alprostadil sichimakhudza mwachindunji kutsegula kapena kutuluka.

Pochiza ductus arteriosus-amadalira zofooka zapachiyambi za mtima, alprostadil imakhala ndi ductal patency mwa kupumula minofu yosalala ya ductus arteriosus. Alprostadil imakhala yogwira bwino ngati itaperekedwa patsogolo pa kutsekedwa kwathunthu kwa anatomic ya makina arteriosus. Kuteteza kwa alprostadil kumalo osakanikirana ndi maginito okhudzidwa m'mitima yaumtima (yoletsedwa m'magazi otuluka m'magazi) kumabweretsa kuwonjezeka kwamagazi a m'magazi komanso / kapena kuwonjezeka kwa kusakaniza pakati pa dongosolo ndi pulmonary circulation yomwe imapangitsa kuti pang'onopang'ono kuwonjezeredwa kwa mpweya woipa (PaO2) ndi saturation saturation. Yankho la mankhwala osokoneza bongo ku alprostadil therapy nalinso lokhudzana kwambiri ndi maulendo apadera a PO2. Yankho lalikulu kwambiri likuoneka kuti liri m'mabukuwa omwe ali ndi zochepa zapakati pa PaO2 (<20 torr), kuchepetsa ductus arteriosus, ndi omwe ali masiku a 4 akale kapena aang'ono. Zosakanikirana ndi ma PaO2 miyezo ya 40 torr kapena zambiri samayankha pang'ono kwa alprostadil.

Kuphatikizana ndi njira zowonongeka za magazi, dongosolo la alprostadil lingapangitse kuteteza kapena kukonza mpweya wa asimia, kuchuluka kwa mtima wamagulu ndi kuwonjezereka kwa mphamvu ya magazi, kuwonjezereka kwa chiwerengero cha mphamvu ya magazi, kuwonjezeka kwamagazi kuthamanga ndi ntchito, kuchepa kwakukulu kwakutsika kukwera kwa magazi aortic (kumalo osokoneza bongo ndi aorta), ndi / kapena kuchepetsa chiŵerengero cha mitsempha ya pulmonomu imakakamiza kutsika kwa aortic kupanikizika (mu chisokonezo ndi kusokoneza kwa aortic chinsalu). Mosiyana ndi zowonongeka, mphamvu ya alprostadil mu acyanotic neonates sichidalira zaka kapena zolembera PaO2.

4.Inanso malangizo:

Alprostadil (Prostglandin E1) amagwiritsidwa ntchito pochiza matenda ophera erectile (ED) mwa amuna akuluakulu. Kuchita bwino kwa alprostadil pakuchitira ED kumasiyana ndi chifukwa; Mtengo wa mayankhidwe kawirikawiri umachepetsedwa kwa odwala omwe ali ndi ED chifukwa cha zolemba zosiyana ndi zomwe zili ndi ED chifukwa cha chizunguliro, psychogenic, kapena chifukwa cha vasculogenic. Mafomu awiri omwe amagulitsidwa amatha kugwiritsira ntchito ED: chinthu chotchedwa transurethral (Muse) chomwe chimagwiritsa ntchito mapepala opangidwa ndi mankhwala opangidwa mu urethra ndi jekeseni (Caverject kapena Edex) yomwe imayikidwa mwachindunji mu corpus cavernosa. Mafomu ena a dothi monga gelisi yowonongeka komanso njira yoperekera mauthenga amomwe amavomereza. Malinga ndi malangizo a ED, mankhwala amodzi a phosphodiesterase a 5 inhibitors (PDE5 inhibitor) amatengedwa ngati mankhwala oyamba. Njira zothandizira odwala paziwirizi zimaphatikizapo jekeseni wa intracavernous ndi mankhwala a intra-urethral. Thandizo la Intracavernous ndi injini yothandiza kwambiri ya ED, ndi yankho lodziwika ndi lokhazikika. Komabe, ndizowonongeka ndipo zimadwalitsa zotsatira zoyipa zomwe zikuphatikizapo priapism ndi penile fibrosis. Mavomerezo a FDA ndi awa: Kusokonezeka mu July 1995, MUSE mu October 1996, ndi Edex mu June 1997.

Alprostadil ndi prostaglandin zina m'matchulidwe osiyana siyana mwachibadwa amakhalapo mu placenta ndi ma ductus arteriosus a fetus. Mtundu wa E-prostaglandins vasodilate arterioles mwa kutulutsa mwachindunji minofu yosalala. Zotsatira zina zamagetsi zimaphatikizapo kuwonjezeka kwa chiwonongeko cha mtima, kuchepetsa ziwiya za systemic ndi pulmonary, kuchepetsa ductus arteriosus, kulepheretsa kugwiritsidwa ntchito kwaphalasitiki, kusungunuka kwa mitsempha yowonongeka, kuwonjezeka kwa magazi, ndi kuchedwa kwa msana. Intravenous alprostadil imagwiritsidwa ntchito pazitsulo zokhala ndi chitetezo cha kumanja kapena kumanzere kwa ventricular outflow kuti pitirize kukhala ndi chizoloŵezi cha ma ductus arteriosus mpaka nthawi yothandizira kapena opaleshoni yolimbitsa thupi. Alprostadil kawirikawiri imakhala yothandiza kwambiri m'matendawa omwe ali ndi kachilombo kochepetsetsa magazi PO2 ndipo ali ndi masiku a 4 akale kapena osachepera. M'magulu okalamba oposa masiku a 4, kuchepa kwa mitsempha yowonongeka kwa mimba chifukwa cha kusintha kwa msinkhu kumasana a ductus arteriosus. Intravenous alprostadil imafuna kuyang'anira kupuma pa nthawi ya mautumiki chifukwa apnea imayamba mu 10-12% ya zowonongeka. Alprostadil ndi FDA yomwe imavomerezedwa ndi odwala ngati odwala. Prostin VR Pediatric inavomerezedwa ndi FDA mu 1981.


III. Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) HCML

Ndife aprepitant ufa wophimba, ufa wa Aprepitant wogulitsidwa, ufa wochuluka wa Aprepitant (170729-80-3) hplc =98% | Ikani ma Reagents a R &amp; D


IV. Kodi mungagule bwanji Alprostadil, (PGE1), Prostaglandin E1 kuchokera ku AASraw?

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