BPC-157

BPC-157 ndi chiyani?

BPC-157, chidule cha "Body Protection Compound 157", ndi peptide yopangidwa kuchokera kumagulu angapo a Body Protection Compound (BPC) ochokera ku madzi a m'mimba mwa munthu. Amakhala ndi unyolo wa 15 amino acid ndipo amakhulupirira kuti ali ndi mphamvu zotsitsimutsa komanso zochiritsa.BPC-157 imadziwika ndi zotsatira zake zochiritsira pamagulu osiyanasiyana ndi machitidwe a thupi. machitidwe osiyanasiyana a thupi, makamaka kulimbikitsa machiritso ndi kukonza minofu. Zimakhulupirira kuti zimakhala ndi zotsatira zabwino pamatumbo a m'mimba, musculoskeletal system, ndi dongosolo lapakati la mitsempha.

Popeza kafukufuku wasonyeza kuti peptide BPC-157 ikhoza kulimbikitsa kukonzanso minofu ndi kusinthika kwa minofu musculoskeletal system, kuphatikizapo tendons, ligaments, ndi minofu, ndipo zasonyeza zotsatira zabwino pochiza matenda monga kuvulala kwa tendon Achilles, misozi ya minofu, ndi fractures. .BPC-157 yakopa chidwi cha othamanga, omanga thupi, ndi anthu omwe ali ndi chidwi cholimbikitsa kuchira ndi kuchiritsa. Miliyoni, Dan Bilzerian, adagawana nawo PED (Performance Enhancing Drugs) yomwe adagwiritsa ntchito pa Instagram, kuphatikiza BPC-157.

Kodi BPC-157 imagwira ntchito bwanji?

Njira yeniyeni ya BPC-157 sichikumveka bwino ndipo ikufufuzidwabe. Njira zomwe zikuperekedwa zikuphatikiza kulimbikitsa angiogenesis, kusinthasintha kwa kuyankha kwa kutupa, kukondoweza kwa collagen. Kupanga, kuteteza kupsinjika kwa okosijeni, ndi kugwirizana ndi kukula kwa zinthu.BPC-157 yasonyezedwa kuti imalimbikitsa mapangidwe a mitsempha yatsopano ya magazi, yomwe imathandizira kukonza minofu ndikuwongolera magazi. Zingathenso kuchepetsa kutupa mwa kusintha momwe chitetezo cha mthupi chimayankhira komanso kulimbikitsa kumasulidwa kwa zinthu zotsutsana ndi kutupa. Kuphatikiza apo, BPC-157 imathandizira kupanga kolajeni, komwe kumathandizira kukonza minofu ndi kukhulupirika kwadongosolo. Imawonetsa katundu wa antioxidant, kuteteza maselo ndi minofu ku kuwonongeka kwa okosijeni.

Komanso, AASraw BPC-157 ingagwirizane ndi kukula kwa zinthu zomwe zimakhudzidwa ndi kukonzanso minofu ndi kusinthika, kulimbikitsa kuchuluka kwa ma cell, kusiyanitsa, ndi kukonzanso minofu. Ndikofunika kuzindikira kuti njira zomwe zaperekedwazi zimachokera ku maphunziro a preclinical omwe amachitidwa makamaka mu zinyama. Kafukufuku wowonjezereka akufunika kuti amvetsetse bwino momwe BPC-157 imagwirira ntchito mwa anthu komanso njira zake zothandizira.

Ndikofunika kugula BPC-157 kuchokera kwa ogulitsa odziwika bwino kuti mtundu wa peptide BPC-157 utsimikizike. Professional BPC-157 wopanga ndi ogulitsa AASraw akhoza kupereka BPC-157 ndi apamwamba thandizo la paokha R&D pakati ndi fakitale. Ngati muli ndi zosowa, BPC-157 yogulitsa kuchokera AASraw ndichisankho chabwino.

Ubwino wa BPC-157

BPC-157, kapena Body Protection Compound 157, ndi Peptide zomwe zimachokera ku mapuloteni omwe amapezeka m'mimba. Zakhala nkhani ya maphunziro ambiri chifukwa cha zotsatira zake zochiritsira. Ndikofunika kuzindikira kuti ngakhale kafukufuku woyambirira akulonjeza, kufufuza kowonjezereka, makamaka mwa anthu, kumafunika kuti amvetsetse zotsatira zake mokwanira komanso momwe angagwiritsire ntchito. Nawa ena zopindulitsa Mtengo wa BPC-157.

①Kusinthika kwa Minofu ndi Kukonza

BPC-157 imadziwika kuti imatha kulimbikitsa machiritso ndi kusinthika kwa minofu. Peptide iyi ikhoza kufulumizitsa kuchira kwa minyewa yovulala, minyewa, minofu, ndi mafupa, ndikupangitsa kuti ikhale yamtengo wapatali pochiza kuvulala kwamasewera, kusokonezeka kwa minofu ndi mafupa, ndi zina zokhudzana ndi kuwonongeka kwa minofu.

②Zinthu Zotsutsana ndi Kutupa

BPC-157 imawonetsa zotsutsana ndi zotupa. Pochepetsa kutupa ndikusintha momwe chitetezo cha mthupi chimayankhira, chikhoza kukhala chida chofunikira kwambiri chothandizira matenda omwe amadziwika ndi kutupa kosatha monga matenda otupa a m'matumbo (IBD), nyamakazi, ndi matenda osiyanasiyana a autoimmune.

③Kubwezeretsa M'mimba

BPC-157 ikufufuzidwa chifukwa cha kuthekera kwake pakubwezeretsa ndi kuteteza thirakiti la m'mimba (GI). Itha kuthandizira kukonza zilonda zam'mimba, matenda otupa, kuwonongeka kwa matumbo, ndi zovuta zina za GI polimbikitsa kusinthika kwa minofu ya GI, kuchepetsa kutupa, komanso kulimbikitsa ntchito yotchinga m'matumbo.

④Maluso a Neuroprotective

BPC-157 yawonetsa katundu wa neuroprotective mu maphunziro oyambirira. Itha kupereka chitetezo ku kuwonongeka kwaubongo komwe kumachitika chifukwa chovulala muubongo (TBI), sitiroko, ndi matenda a neurodegenerative. Kuwonjezera apo, akanatha Itha kupititsa patsogolo kusinthika kwa minyewa ndikuwonjezera kugwira ntchito kwa minyewa.

⑤Angiogenesis ndi Mapangidwe a Mitsempha ya Magazi

BPC-157 yapezeka kuti imapangitsa angiogenesis, kapena mapangidwe a mitsempha yatsopano ya magazi. Izi zitha kukulitsa kukonzanso kwa minofu ndikuchira kwa mabala pothandizira kufalikira kwa magazi kumalo owonongeka.

⑥Zopindulitsa Zina

Kafukufuku woyambirira amasonyeza kuti peptide BPC-157 ikhoza kupereka zowonjezera zowonjezera, kuphatikizapo kuchepetsa ululu, kupititsa patsogolo thanzi labwino ndi kusinthasintha, kupititsa patsogolo chitetezo cha mthupi, ndi kusintha ma neurotransmitters okhudzana ndi maganizo ndi kuzindikira. Komabe, kafukufuku wathunthu akufunika kuti atsimikizire zotsatira zomwe zingatheke mokwanira.

Ndikofunikira kudziwa kuti pali opanga ndi ogulitsa ambiri a BPC-157 pa intaneti kapena pa intaneti, komabe, si onse omwe ali odalirika. Kuti mupeze zotsatira zabwino, onetsetsani kuti mugule BPC-157 kuchokera kwa akatswiri opanga ndi ogulitsa.AASraw imakhazikika pakupanga ndi kupereka BPC-157 molingana ndi zofunikira za CGMP, ndi gulu lililonse la mankhwala ayenera kuchita khalidwe yesani musanagulitse.

Zotsatira za BPC-157

BPC-157 nthawi zambiri imatengedwa kuti ndi yotetezeka komanso yololedwa ikagwiritsidwa ntchito moyenera. Komabe, monga momwe zimakhalira ndi chithandizo chilichonse chamankhwala, pali kuthekera zotsatira zoyipazi. Ndikofunika kuzindikira kuti zomwe zilipo zasayansi pa BPC-157's zotsatira zoyipazi mwa anthu ndi ochepa, monga maphunziro ambiri achitika mu zitsanzo za nyama. Mayankho a munthu aliyense payekha akhoza kusiyana, ndipo zotsatirazi zotsatira zoyipa zimachokera ku malipoti osadziwika komanso kafukufuku wochepa.

Kukwiya kwanuko

Ogwiritsa ntchito ena anena kuti akumva kupweteka pang'ono, kufiira, kapena kuyabwa pamalo ojambulira. Izi zitha kuyendetsedwa posintha njira ya jakisoni kapena kugwiritsa ntchito singano zazing'ono.

Mavuto a Digestive

BPC-157 ingayambitse kusapeza kwa kanthaŵi kochepa m'mimba, monga nseru, kupweteka m'mimba, kapena kutsekula m'mimba. Zizindikirozi nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.

Zomwe Zimayambitsa Matenda

Ngakhale ndizosowa, anthu ena amatha kukhala ndi vuto la BPC-157. Zizindikiro zingaphatikizepo zidzolo, kuyabwa, kutupa, kapena kupuma movutikira. Ngati zizindikiro za ziwengo zichitika, chithandizo chamankhwala msanga chiyenera kufunidwa.

Kuyanjana ndi Mankhwala

BPC-157 ikhoza kuyanjana ndi mankhwala kapena mankhwala ena. Ndikofunika kukaonana ndi katswiri wa zaumoyo ngati mukumwa mankhwala aliwonse kapena muli ndi vuto linalake musanayambe BPC-157.

Mofanana ndi peptide iliyonse kapena chithandizo chamankhwala, tikulimbikitsidwa kuti mufunsane ndi katswiri wa zaumoyo musanagwiritse ntchito BPC-157. Atha kukupatsani chitsogozo, kuwunika zoopsa zomwe zingachitike, ndikuwunika momwe mukuyendera kuti muwonetsetse kuti zikugwiritsidwa ntchito moyenera komanso moyenera. Komanso, kugula peptides kuchokera ku gwero lolondola ndizovuta.AASraw imayendetsa bwino khalidweli ndipo yatulutsa gulu lapamwamba la BPC-157 logulitsidwa. Takulandilani ku kugula peptide BPC-157 ngati kuli kofunikira.

BPC-157 VS.TB 500 VS.IGF-1 LR3

BPC-157, IGF-1 LR3 (Long arginine 3-IGF-1), ndi TB500 (Thymosin Beta-4) ndi ma peptide omwe amadziwika kwambiri omwe amadziwika kuti amathandizira kwambiri kuchiritsa, kuchira, ndi kukonza minofu. Ngakhale amagawana zolinga zofanana, aliyense peptide ili ndi maubwino osiyanasiyana ndi ntchito. Nawa mwachidule ma peptides awa omwe angathandize kumvetsetsa bwino kusiyana kwawo.

Zomwe zaperekedwa pano siziyenera kutengedwa ngati upangiri wachipatala. Ubwino ndi njira zogwirira ntchito za IGF-1 LR3, TB500, ndi BPC 157 zomwe zatchulidwa pamwambapa zimachokera ku maphunziro a preclinical ndi chiwerengero chochepa cha mayesero achipatala. Ngakhale kuti zinthuzi zasonyeza kuti zingathe kuchiritsidwa ndi kusinthika nthawi zina, kugwiritsidwa ntchito kwawo kuyenera kukhala motsogozedwa ndi akatswiri azachipatala chifukwa cha kuthekera. zotsatira zoyipazi, zotsatira zosadziwika za nthawi yayitali, ndi kusiyana kwa munthu payekha poyankha.

 Kodi BPC-157 imathandizira pakulimbitsa thupi?

BPC-157 yadziwika bwino mu bodybuilding community chifukwa cha ubwino wake kwa minofu kuchira, machiritso ovulala, ndi thanzi labwino. Ngakhale pali kafukufuku wochepa wasayansi wokhudza kwambiri BPC-157's zotsatira pa kumanga thupi, malipoti ena ongopeka akusonyeza zotulukapo zabwino.

Kubwezeretsa Minofu

BPC-157 ikhoza kuthandizira kukonzanso minofu mwa kulimbikitsa kukonza minofu ndi kuchepetsa kutupa. Zasonyezedwa kuti zifulumizitsa kuchira kwa kuvulala kwa minofu, zovuta, ndi misozi.BPC-157 ingathandize omanga thupi kuti abwerere mofulumira kuchokera ku ntchito zolimbitsa thupi mwa kuwonjezera machiritso, zomwe zingathe kuchepetsa kupuma pakati pa maphunziro.

Kuchiritsa Kuvulala

Kumanga thupi, makamaka kunyamula katundu wolemetsa, kungayambitse kupweteka kwa minofu, tendon, ndi mitsempha, kuonjezera mwayi wovulazidwa.BPC-157 yasonyeza lonjezo pothandizira kuchira kwa minofu, makamaka tendon ndi mitsempha. Ikhoza kuthandizira kuchira kuvulala kokhudzana ndi maphunziro mwa kulimbikitsa kukonza minofu ndi kuchepetsa kutupa.

Thanzi Labwino

Omanga thupi amafunikira mafupa abwino chifukwa amalimbikitsa mawonekedwe abwino, kayendetsedwe kake, ndi ntchito yonse.BPC-157 ili ndi makhalidwe odana ndi kutupa ndipo yaperekedwa ngati chithandizo cha ululu wamagulu ndi kutupa. Zitha kuthandizira kupititsa patsogolo maphunziro ndi ntchito zonse polimbikitsa thanzi labwino komanso kuchepetsa kukhumudwa.

Ndikofunika kuzindikira kuti zomwe munthu akukumana nazo ndi BPC-157 zimatha kusiyana, ndipo kafukufuku wasayansi makamaka wofufuza zake. zotsatira pakumanga thupi ndi malire. Kuonjezera apo, BPC-157 siyenera kuonedwa kuti ndi m'malo mwa maphunziro abwino, zakudya, ndi zisankho zamoyo zonse zofunika kuti thupi likhale lopambana.

Ngati mukuganiza kugwiritsa ntchito BPC-157 pazolinga zomangirira thupi, ndibwino kuti mufunsane ndi katswiri wazachipatala yemwe amadziwa bwino za mankhwala a peptide. Akhoza kupereka uphungu waumwini, kuganizira zolinga zanu ndi zochitika zanu, ndi kukutsogolerani pakugwiritsa ntchito BPC-157 moyenera pamodzi ndi mbali zina za ndondomeko yanu yomanga thupi.

BPC-157 Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Kodi mungagule bwanji BPC-157 kuchokera ku AASraw?

❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.

❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.

❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).

❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.

❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Andrea Zemba Cilic
Madipatimenti a Pharmacology ndi Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
2. Anita Zenko Sever
Dipatimenti ya Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
3. Sanja Masnec
Dipatimenti ya University of Ophthalmology, Zagreb University Hospital Center, Zagreb, Croatia
4. Vedran Cesarec
Dipatimenti ya Pharmacology, Medical Faculty, University of Zagreb, Zagreb, Croatia
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Fosgerau K,Hoffmann T.Peptide Therapeutics: panopa ndi mayendedwe amtsogolo.Drug Discov Today.2015;20: 122–128.

[2] Gwyer D,Wragg NM,Wilson SL.Gastric pentadecapeptide body protection compound BPC 157 ndi ntchito yake pofulumizitsa machiritso a minofu ndi mafupa ofewa.Cell Tissue Res.2019

[3] Amic F,Drmic D,Bilic Z,Krezic I,Zizek H,Peklic M,et al.Kudutsa kutsekeka kwakukulu kwa venous ndi zilonda zam'mimba mwa makoswe, komanso kuchiza ndi gastric pentadecapeptide BPC 157,L-NAME ndi L-arginine. J Gastroenterol.2018;24: 5366-5378.

[4] Sikiric P,Seiwerth S,Rucman R,Turkovic B,Rokotov DS,Brcic L,et al.Toxicity by NSAIDs.Kulimbana ndi stable gastric pentadecapeptide BPC 157.Curr Pharm Des.2013;19: 76–83.

[5] Jelovac, Nikola; Sikiric, Predrag; Rucman, Rudolf; Petek, Marijan; Marovic, Anton; Perovic, Darko; Seiwerth, Sven; Mise, Stjepan; Turkovic, Branko; Dodig, Goran; Miklic, Pavle; Buljat, Gojko; Prkacin,Ingrid (1999)."Pentadecapeptide BPC 157 imachepetsa kusokonezeka koyambitsidwa ndi ma neuroleptics: zotsatira za catalepsy ndi zilonda zam'mimba mu mbewa ndi makoswe". European Journal of Pharmacology. 379 (1): 19-31.

[6] Sikiri, P; Seiwerth,S; Rucman, R; Kolenc,D; Vuletic,LB; Drmic, D; Grgic,T; Strbe,S; Zukanovic,G; Crvenkovic, D; Madzarac,G; Rukavina, I; Sucic, M; Baric, M; Starcevic, N; Krstonjevic, Z; Bencic,ML; Filipcic, ine; Rokotov, DS; Vlainic, J (2016). "Brain-gut Axis ndi Pentadecapeptide BPC 157: Theoretical and Practical Implications". Neuropharmacology Yamakono. 14 (8): 857–865.

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