BPC-157

BPC-157 ndi chiyani?

BPC-157, lalifupi la "Body Protection Compound 157", ndi peptide yopangidwa kuchokera ku dongosolo la Body Protection Compound (BPC) lochokera ku madzi a m'mimba mwa anthu. ndi kuchiritsa katundu.BPC-15 imadziwika ndi zotsatira zake zochiritsira pamagulu osiyanasiyana ndi machitidwe a thupi.BPC-157 yapeza chidwi chifukwa cha zotsatira zake zochiritsira pamagulu osiyanasiyana a thupi, makamaka polimbikitsa machiritso ndi kukonzanso minofu. kukhala ndi zotsatira zabwino pamatenda a m'mimba, musculoskeletal system, ndi dongosolo lapakati lamanjenje.

Popeza kafukufuku wasonyeza kuti peptide BPC-157 ikhoza kulimbikitsa kukonzanso minofu ndi kusinthika kwa minofu ndi mafupa, kuphatikizapo tendons, mitsempha ndi minofu, ndipo zawonetsa zotsatira zabwino pochiza matenda monga kuvulala kwa tendon Achilles, misozi ya minofu ndi fractures.BPC -157 yakopa chidwi cha othamanga, omanga thupi, komanso anthu omwe akufuna kulimbikitsa kuchira ndi kuchiritsa.Millionaire, Dan Bilzerian, adagawana nawo PED (Performance Enhancing Drugs) yomwe adagwiritsa ntchito pa Instagram, kuphatikiza BPC-157.

Kodi BPC-157 imagwira ntchito bwanji?

Njira yeniyeni ya BPC-157 sichidziwika bwino ndipo ikufufuzidwabe.Njira zomwe zikugwiritsidwa ntchito zikuphatikizapo kupititsa patsogolo angiogenesis, kusintha kwa kuyankha kwa kutupa, kulimbikitsa kupanga kolajeni, kuteteza kupsinjika kwa okosijeni, ndi kugwirizana ndi kukula kwa zinthu.BPC -157 yasonyezedwa kuti imalimbikitsa mapangidwe a mitsempha yatsopano ya magazi, yomwe imathandizira kukonza minofu ndi kupititsa patsogolo kutuluka kwa magazi. Ikhozanso kuchepetsa kutupa mwa kusintha machitidwe a chitetezo cha mthupi komanso kulimbikitsa kumasulidwa kwa zinthu zotsutsana ndi kutupa.Kuonjezera apo, BPC-157 imalimbikitsa Kupanga kolajeni, komwe kumathandizira kukonza minofu ndi kukhazikika kwamapangidwe, kumawonetsa antioxidant katundu, kuteteza maselo ndi minyewa kuti isawonongeke ndi okosijeni.

Komanso, AASraw BPC-157 ingagwirizane ndi kukula kwa zinthu zomwe zimakhudzidwa ndi kukonzanso minofu ndi kusinthika, kulimbikitsa kukula kwa ma cell, kusiyanitsa, ndi kukonzanso minofu. ndikofunikira kuti mumvetsetse bwino momwe BPC-157 imagwirira ntchito mwa anthu komanso njira zake zochizira.

Ndikofunika kugula BPC-157 kuchokera kwa ogulitsa odalirika, kuti khalidwe la peptide BPC-157 litsimikizidwe.Wopanga BPC-157 wopanga ndi wogulitsa AASraw akhoza kupereka BPC-157 ndi khalidwe lapamwamba kuti athandizidwe ndi R & D yodziimira. pakati ndi fakitale.Ngati muli ndi zosowa, BPC-157 yogulitsa kuchokera ku AASraw ndi chisankho chabwino.

Ubwino wa BPC-157

BPC-157, kapena Body Protection Compound 157, ndi peptide yomwe imachokera ku mapuloteni omwe amapezeka m'mimba. Yakhala nkhani ya maphunziro ambiri chifukwa cha zotsatira zake zochiritsira. Ndikofunika kuzindikira kuti ngakhale kuti kafukufuku woyambirira akulonjeza, kufufuza kowonjezereka, makamaka mwa anthu, kumafunika kuti timvetsetse zotsatira zake mokwanira komanso momwe angagwiritsire ntchito.Nazi zina mwa ubwino wa BPC-157.

①Kusinthika kwa Minofu ndi Kukonza

BPC-157 imadziwika chifukwa cha kuthekera kwake kulimbikitsa machiritso ndi kusinthika kwa minofu. Peptide iyi imatha kufulumizitsa kuchira kwa minyewa yovulala, mitsempha, minyewa, ndi mafupa, ndikupangitsa kuti ikhale yamtengo wapatali pochiza kuvulala kwamasewera, matenda a minofu ndi mafupa, ndi zina. zokhudzana ndi kuwonongeka kwa minofu.

②Zinthu Zotsutsana ndi Kutupa

BPC-157 imawonetsa zinthu zotsutsana ndi zotupa. Pochepetsa kutupa ndikusintha momwe chitetezo cha mthupi chimayankhira, chikhoza kukhala chida chofunikira kwambiri chothandizira matenda omwe amadziwika ndi kutupa kosatha monga matenda otupa a m'matumbo (IBD), nyamakazi, ndi matenda osiyanasiyana a autoimmune.

③Kubwezeretsa M'mimba

BPC-157 ikufufuzidwa chifukwa cha kuthekera kwake pakubwezeretsa ndi kuteteza thirakiti la m'mimba (GI). Ikhoza kuthandizira kukonza zilonda zam'mimba, matenda a m'mimba, kuwonongeka kwa m'mimba, ndi matenda ena a GI polimbikitsa kusinthika kwa minofu ya GI. , kuchepetsa kutupa, ndi kulimbikitsa ntchito yotchinga m'matumbo.

④Maluso a Neuroprotective

BPC-157 yawonetsa mphamvu zoteteza mitsempha m'maphunziro oyambilira. Itha kupereka chitetezo ku kuwonongeka kwa ubongo chifukwa chovulala kwambiri muubongo (TBI), sitiroko, ndi matenda a neurodegenerative.

⑤Angiogenesis ndi Mapangidwe a Mitsempha ya Magazi

BPC-157 yapezeka kuti imapangitsa angiogenesis, kapena mapangidwe atsopano a mitsempha ya magazi.

⑥Zopindulitsa Zina

Kafukufuku woyambirira amasonyeza kuti peptide BPC-157 ikhoza kupereka zowonjezera zowonjezera, kuphatikizapo kuchepetsa ululu, kupititsa patsogolo thanzi labwino ndi kusinthasintha, kupititsa patsogolo chitetezo cha mthupi, komanso kusintha ma neurotransmitters okhudzana ndi maganizo ndi kuzindikira.

Ndikofunika kudziwa kuti pali ambiri opanga ndi ogulitsa BPC-157 pa intaneti kapena pa intaneti, komabe, si onse omwe ali odalirika.Pa zotsatira zabwino, onetsetsani kuti mukugula BPC-157 kuchokera kwa akatswiri opanga ndi ogulitsa. Kupereka kwa BPC-157 molingana ndi zofunikira za CGMP, ndipo gulu lililonse lazinthu liyenera kuyesa mayeso asanagulitse.

Zotsatira za BPC-157

BPC-157 nthawi zambiri imatengedwa kuti ndi yotetezeka komanso yolekerera pamene ikugwiritsidwa ntchito moyenera. , monga momwe kafukufuku wambiri wachitikira pazitsanzo za zinyama.Mayankho a munthu aliyense akhoza kukhala osiyana, ndipo zotsatira zotsatilazi zimachokera ku malipoti osadziwika komanso kafukufuku wochepa.

Kukwiya kwanuko

Ogwiritsa ntchito ena anena kuti akumva kuwawa pang'ono, kufiira, kapena kuyabwa pamalo opangira jakisoni. Izi zimatha kuyendetsedwa ndikusintha njira ya jakisoni kapena kugwiritsa ntchito singano zazing'ono.

Mavuto a Digestive

BPC-157 imatha kuyambitsa kusapeza bwino kwa kagayidwe kachakudya, monga nseru, kutsekula m'mimba, kapena kutsekula m'mimba. Zizindikirozi nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.

Zomwe Zimayambitsa Matenda

Ngakhale kuti sizichitikachitika, anthu ena amakumana ndi vuto la BPC-157. Zizindikiro zake zingaphatikizepo zidzolo, kuyabwa, kutupa, kapena kupuma movutikira.

Kuyanjana ndi Mankhwala

BPC-157 ikhoza kuyanjana ndi mankhwala kapena mankhwala enaake.Ndikofunikira kukaonana ndi katswiri wa zaumoyo ngati mukumwa mankhwala aliwonse kapena muli ndi vuto linalake musanayambe BPC-157.

Monga momwe zilili ndi peptide kapena chithandizo chamankhwala, tikulimbikitsidwa kukaonana ndi katswiri wa zachipatala musanagwiritse ntchito BPC-157.Atha kupereka chitsogozo, kufufuza zoopsa zomwe zingatheke, ndikuyang'anira momwe mukupita kuti muwonetsetse kuti zikugwiritsidwa ntchito moyenera komanso moyenera.Kuonjezera apo, kugula peptides kuchokera ku gwero loyenera ndilofunika kwambiri.AASraw imayendetsa mosamalitsa khalidweli ndipo yatulutsa gulu lapamwamba la BPC-157 logulitsa.Mwalandiridwa kuti mugule peptide BPC-157 ngati kuli kofunikira.

BPC-157 VS.TB 500 VS.IGF-1 LR3

BPC-157,IGF-1 LR3 (Long arginine 3-IGF-1),ndi TB500 (Thymosin Beta-4) ndi ma peptides omwe amadziwika kwambiri chifukwa chakuthandizira kwawo pakuchiritsa, kuchira, ndi kukonza minofu. peptide iliyonse ili ndi maubwino ndi ntchito zake. Pano pali chithunzithunzi cha ma peptide awa omwe angathandize kumvetsetsa bwino kusiyana kwawo.

Zomwe zaperekedwa pano siziyenera kuganiziridwa ngati upangiri wachipatala.Ubwino ndi njira zogwirira ntchito za IGF-1 LR3,TB500,ndi BPC 157 zomwe zatchulidwa pamwambapa zimachokera ku maphunziro a preclinical ndi chiwerengero chochepa cha mayesero achipatala.Ngakhale zinthu izi zasonyezedwa Kuthekera kwa machiritso ndi kubadwanso mwazinthu zina, kugwiritsidwa ntchito kwawo kuyenera kukhala motsogozedwa ndi akatswiri azachipatala chifukwa cha zotsatirapo zake, zotsatira zanthawi yayitali zosadziwika, komanso kusiyanasiyana kwamunthu.

 Kodi BPC-157 imathandizira pakumanga thupi?

BPC-157 yapeza chidwi m'magulu omanga thupi chifukwa cha ubwino wake wobwezeretsa minofu, machiritso ovulala, ndi thanzi labwino.

Kubwezeretsa Minofu

BPC-157 ikhoza kuthandizira kukonzanso minofu mwa kulimbikitsa kukonzanso minofu ndi kuchepetsa kutupa.Zasonyezedwa kuti zifulumizitsa kubwezeretsa kuvulala kwa minofu, zovuta, ndi misozi. kuchepetsa kupuma pakati pa magawo a maphunziro.

Kuchiritsa Kuvulala

Kumanga thupi, makamaka kunyamula katundu, kungayambitse kupsinjika kwa minofu, tendons, ndi mitsempha, kuonjezera mwayi wovulala. polimbikitsa kukonza minofu ndi kuchepetsa kutupa.

Thanzi Labwino

Omanga thupi amafunikira mafupa athanzi chifukwa amalimbikitsa mawonekedwe abwino, kayendetsedwe kake, ndi ntchito yonse.BPC-157 ili ndi makhalidwe odana ndi kutupa ndipo yaperekedwa ngati chithandizo cha ululu wamagulu ndi kutupa. thanzi limodzi ndi kuchepetsa kusapeza bwino.

Ndikofunika kuzindikira kuti zochitika za munthu ndi BPC-157 zimatha kusiyana, ndipo kafukufuku wa sayansi wofufuza zotsatira zake pakumanga thupi ndi ochepa. kulimbitsa thupi bwino.

Ngati mukuganiza kugwiritsa ntchito BPC-157 pazolinga zomanga thupi, ndi bwino kukaonana ndi katswiri wazachipatala yemwe amadziwa bwino za mankhwala a peptide. ya BPC-157 pamodzi ndi mbali zina za dongosolo lanu lomanga thupi.

BPC-157 Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.

Kodi mungagule bwanji BPC-157 kuchokera ku AASraw?

❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.

❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.

❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).

❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.

❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Fosgerau K,Hoffmann T.Peptide Therapeutics: panopa ndi mayendedwe amtsogolo.Drug Discov Today.2015;20: 122–128.

[2] Gwyer D,Wragg NM,Wilson SL.Gastric pentadecapeptide body protection compound BPC 157 ndi ntchito yake pofulumizitsa machiritso a minofu ndi mafupa ofewa.Cell Tissue Res.2019

[3] Amic F,Drmic D,Bilic Z,Krezic I,Zizek H,Peklic M,et al.Kudutsa kutsekeka kwakukulu kwa venous ndi zilonda zam'mimba mwa makoswe, komanso kuchiza ndi gastric pentadecapeptide BPC 157,L-NAME ndi L-arginine. J Gastroenterol.2018;24: 5366-5378.

[4] Sikiric P,Seiwerth S,Rucman R,Turkovic B,Rokotov DS,Brcic L,et al.Toxicity by NSAIDs.Kulimbana ndi stable gastric pentadecapeptide BPC 157.Curr Pharm Des.2013;19: 76–83.

[5] Jelovac, Nikola; Sikiric, Predrag; Rucman, Rudolf; Petek, Marijan; Marovic, Anton; Perovic, Darko; Seiwerth, Sven; Mise, Stjepan; Turkovic, Branko; Dodig, Goran; Miklic, Pavle; Buljat, Gojko; Prkacin,Ingrid (1999)."Pentadecapeptide BPC 157 imachepetsa kusokonezeka koyambitsidwa ndi ma neuroleptics: zotsatira za catalepsy ndi zilonda zam'mimba mu mbewa ndi makoswe". European Journal of Pharmacology. 379 (1): 19-31.

[6] Sikiri, P; Seiwerth,S; Rucman, R; Kolenc,D; Vuletic,LB; Drmic, D; Grgic,T; Strbe,S; Zukanovic,G; Crvenkovic, D; Madzarac,G; Rukavina, I; Sucic, M; Baric, M; Starcevic, N; Krstonjevic, Z; Bencic,ML; Filipcic, ine; Rokotov, DS; Vlainic, J (2016). "Brain-gut Axis ndi Pentadecapeptide BPC 157: Theoretical and Practical Implications". Neuropharmacology Yamakono. 14 (8): 857–865.

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