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Video ya Cetilistat (Oblean) powder

Makhalidwe Oyambira

Kodi Cetilistat powder ndi chiyani?

Cetilistat, yomwe imadziwikanso kuti ATL-962, Oblean, kapena Cetilistat, ndi mankhwala atsopano komanso othandiza omwe amapangidwira kuchiza kunenepa kwambiri. Ndilochokera ku alkylamine komanso m'mimba lipase inhibitor yomwe imayang'ana makamaka ndikuletsa ma enzyme omwe amaphwanya mafuta am'zakudya. Poletsa ma enzymes awa, cetilistat, omwe amatha kutengedwa kuchokera kwa ogulitsa odalirika ngati AASraw, amachepetsa kuyamwa kwa mafuta kuchokera m'zakudya, zomwe zimayambitsa kuwonda.

Cetilistat imagwiritsidwa ntchito limodzi ndi zakudya zochepa zama calorie, mafuta ochepa, komanso masewera olimbitsa thupi oyenera kuti athandizire. kuwonda. Izi zotsutsana ndi kunenepa kwambiri mankhwala amagulitsidwa pansi pa mayina osiyanasiyana, kuphatikiza Cetislim, Kilfat, Oblean, ndi Checkwt.

Monga mankhwala a benzoxazine, njira yoyamba ya cetilistat imaphatikizapo kuletsa chimbudzi ndi kuyamwa kwa mafuta a m'mimba m'mimba, potsirizira pake kuthandiza anthu paulendo wawo wochepa thupi. Ndi AASraw monga wothandizira wodalirika, anthu omwe akufuna njira zochepetsera zowonda akhoza molimba mtima kuphatikiza cetilistat mu regimen yawo.

Mbiri yachidule ya Cetilistat (Oblean) ufa

Mbiri ya chitukuko ndi chivomerezo cha cetilistat kuyambira 2013 pamene mankhwala adalandira chivomerezo chake choyamba cha kasamalidwe ka kunenepa kwambiri ku Japan. Kwa zaka zambiri, cetilistat yakhala ikudziwika m'mayiko osiyanasiyana padziko lonse lapansi chifukwa cha mphamvu zake komanso kulekerera kwake pochiza kunenepa kwambiri.

Cetilistat(Oblean) Powder application ndipo imagwira ntchito bwanji?

(1)Kuwongolera m'mimba lipases

Cetilistat imagwira ntchito poyang'ana m'mimba lipases, omwe ndi ma enzyme omwe amaphwanya ndi kugaya mafuta m'thupi la munthu.

(2)Kulepheretsa chimbudzi cha mafuta ndi kuyamwa

Poletsa lipases izi, cetilistat imalepheretsa kuwonongeka ndi kuyamwa kwamafuta m'matumbo am'mimba. Kenako mafuta amene sanagayidwe amachotsedwa m’thupi kudzera m’ndowe. Njirayi imayambitsa kuchepa kwa calorie kudya ndipo potsirizira pake imayambitsa kuwonda.

Kodi Ubwino wa Cetilistat (Oblean) ufa ndi chiyani?

Cetilistat(Oblean) imapereka mndandanda wa zopindulitsa kwa anthu omwe akufuna kuchita bwino kasamalidwe ka kunenepa kwambiri. Monga mankhwala amphamvu ochepetsa thupi komanso oletsa kunenepa kwambiri, sikuti amangothandizira kuchepetsa thupi komanso amapereka maubwino angapo owonjezera omwe amasiyanitsa ndi mankhwala ena ochepetsa thupi. Zina mwazofunikira za cetilistat ndi izi:

(1) Kuthandizira moyo wathanzi mwa kuchepetsa thupi

Cetilistat imachepetsa mwachangu kuchuluka kwa mafuta m'thupi, kuthandizira kukhala ndi BMI yathanzi ndikuchepetsa mwayi wokhala ndi moyo pachiwopsezo chokhudzana ndi kunenepa kwambiri, monga mtundu wa 2 shuga, matenda a mtima, kuthamanga kwa magazi, ndi khansa zina.

(2) Kuchepetsa kuwonda komanso kuchepetsa hemoglobin ya glycosylated kwa odwala matenda ashuga onenepa kwambiri

Kafukufuku wazachipatala awonetsa mphamvu ya cetilistat pochepetsa thupi komanso kuchuluka kwa glycosylated hemoglobin (HbA1c) mwa odwala onenepa kwambiri omwe ali ndi matenda amtundu wa 2, ndikuwongolera bwino matenda a shuga.

(3) Kulekerera ndi chitetezo

Cetilistat nthawi zambiri imaloledwa bwino, yofatsa mpaka yocheperako zotsatira zoyipazi zomwe nthawi zambiri zimachepa ndikugwiritsa ntchito mosalekeza. Poyerekeza ndi mankhwala ena ochepetsa thupi, monga orlistat, cetilistat yapezeka kuti imayambitsa zochepa komanso zochepa kwambiri. zotsatira zoyipazi.

(4) Kupindula kofulumira kwa zolinga zochepetsera thupi

Ngakhale kuti mankhwala ena oletsa kunenepa kwambiri amafunikira nthawi yayitali kuti achepetse thupi, cetilistat ikhoza kupereka zotsatira zomwe mukufuna mkati mwa masabata a 12 akagwiritsidwa ntchito limodzi ndi zakudya zopanda mafuta ambiri komanso masewera olimbitsa thupi nthawi zonse.

(5) Kuchepetsa cholesterol

Cetilistat ikhoza kuthandizira kuchepetsa mafuta onse a kolesterolini ndi LDL cholesterol, potero zimathandizira kupititsa patsogolo thanzi la mtima ndi kuchepetsa chiopsezo cha matenda a mtima.

(6) Kuchepetsa chiopsezo cha matenda a mtima

Pothana ndi kunenepa kwambiri komanso kulimbikitsa zakudya zopatsa thanzi, cetilistat imatha kuchepetsa chiopsezo cha matenda amtima. Kafukufuku wopangidwa mwachisawawa kwa masabata 12 okhudza odwala onenepa kwambiri omwe ali ndi matenda a shuga adawonetsa kuchepa kwakukulu kwa kunenepa, kuwongolera bwino kwa glycemic, komanso kuchepa kwa m'chiuno, zomwe zimayambitsa matenda amtima.

(7)Kutsitsa magazi

Monga cetilistat imathandizira kuchepetsa thupi, imatha kuchepetsa kuthamanga kwa magazi, kuthandizira kupewa matenda oopsa komanso zoopsa zomwe zimakhudzidwa ndi thanzi monga sitiroko, matenda a impso, ndi matenda a chiwindi.

Zikatengedwa kuchokera kwa anthu odalirika ogulitsa ngati AASraw, cetilistat imagwira ntchito ngati chida chamtengo wapatali polimbikitsa moyo wathanzi komanso kuthana ndi mavuto a kunenepa kwambiri. Mwa kuphatikiza cetilistat mu dongosolo lonse lowongolera kulemera, anthu akhoza kusangalala ndi izi zopindulitsa ndi kuyesetsa kukhala ndi thanzi labwino.

Kugwiritsa Ntchito Mankhwala a Cetilistat (Oblean)

(1)Chithandizo cha kunenepa kwambiri kwa akulu

Cetilistat imagwiritsidwa ntchito makamaka pochiza kunenepa kwambiri kwa akuluakulu. Nthawi zambiri amaperekedwa limodzi ndi ma calorie ochepa, zakudya zopanda mafuta ambiri komanso kuchita masewera olimbitsa thupi pafupipafupi kuti ziwonjezeke.

(2)Kuwongolera zovuta zokhudzana ndi kunenepa kwambiri

Kuphatikiza pa kulimbikitsa kuchepa kwa thupi, cetilistat yasonyezedwanso kuti ikuwongolera zovuta zokhudzana ndi kunenepa kwambiri, monga:

① Type 2 shuga mellitus

Cetilistat ingathandize kusintha glycemic control mwa odwala onenepa kwambiri omwe ali ndi matenda amtundu wa 2 pochepetsa kulemera kwa thupi komanso kutsitsa glycosylated hemoglobin (HbA1c).

②Cholesterol wambiri

Cetilistat yasonyezedwa kuti imachepetsa kuchuluka kwa mafuta m'thupi ndi otsika kwambiri a lipoprotein (LDL) cholesterol, omwe amadziwikanso kuti "cholesterol" choipa, chomwe chingathandize kuti chitukuko cha matenda a mtima.

③Kuthamanga kwa magazi

Kunenepa imfa zopezedwa kudzera mu cetilistat zingathandizenso kuchepetsa kuthamanga kwa magazi mwa anthu onenepa kwambiri, kuchepetsa chiopsezo chokhala ndi matenda oopsa komanso mavuto ena.

Kodi Cetilistat(Oblean) amathandizira bwanji kunenepa kwambiri?

Kunenepa kwambiri ndi vuto lalikulu kwambiri padziko lonse lapansi masiku ano. Ndi matenda ovuta, osatha komanso ophatikizika ambiri omwe amadziwika ndi kuchuluka kwa mafuta / minofu ya adipose.

Kunenepa kwambiri kumalumikizidwa ndi zovuta zathanzi monga mtundu wachiwiri wa matenda ashuga, matenda oopsa, hyperlipidemia, cholesterol yambiri, khansa zina, ndi matenda ena amtima monga sitiroko ndi matenda amtima.

Kunenepa kwambiri m'mayiko ambiri kwafika povuta kwambiri ndipo ndichifukwa chake vuto laumoyo padziko lonse lapansi ladetsa nkhawa.

Kafukufuku akuwonetsa kuti kuonda kosalekeza kwa 5 mpaka 10% ya kulemera kwanu koyamba kungachepetse kwambiri vuto la kunenepa kwambiri. Cetilistat imatengedwa ngati wothandizira kunenepa kwambiri. Anti-obesity agents nthawi zambiri amachulukitsa kugwiritsa ntchito mphamvu motero kuchepetsa thupi kudzera mu dongosolo la neural ndi metabolism. Cetilistat ndi m'mimba pancreatic lipase inhibitor yomwe imakhala yothandiza kwambiri polimbana ndi kunenepa kwambiri m'maphunziro a anthu.

Cetilistat imagwira ntchito poletsa chimbudzi ndi kuyamwa kwamafuta mkati mwa chakudya chomwe mumadya. Mafutawo akapanda kugayidwa amatuluka mu ndowe pamene akuyenda m’matumbo. Imakwaniritsa izi poletsa enzyme lipases yomwe imayambitsa kuphwanya triglycerides (mafuta / lipid m'thupi) m'matumbo. Zotsatira za cetilistat zimawonetsedwa m'matumbo am'mimba. Izi zikutanthauza kuti cetilistat ndi yosiyana ndi zina zotsutsana ndi kunenepa kwambiri zomwe zimakhudza ubongo wanu kuchepetsa chilakolako chifukwa zimagwira ntchito mozungulira.

Pamene chimbudzi ndi mayamwidwe a mafuta a m'zakudya amaletsedwa, kuyika kwa mafuta kumakhala kochepa, motero kuwononga mphamvu zochepa zomwe zimabweretsa kuwonda. Ngakhale Cetilistat ikuthandizani kuti muchepetse kunenepa zili pa inu kukhala ndi zakudya zopatsa thanzi zokhala ndi mafuta ochepa limodzi ndi masewera olimbitsa thupi kuti muchepetse kunenepa kwambiri.

Kodi ufa wa Cetilistat (Oblean) uli ndi Zotsatira Zake?

Odwala omwe akulandira chithandizo cha kunenepa kwambiri ndi Cetilistat ufa ukhoza kukhala ndi zotsatira zoyipa. Muyenera kudziwitsa dokotala ngati izi zichitika. Zitsanzo zina zaperekedwa apa:

▪Wonenepa m’chimbudzi

▪Kupweteka kwam'mimba

▪Kutuluka kumaliseche

▪Kuwona mafuta

▪Kusadziletsa m'matumbo

▪Kutuluka m'mimba

▪Kupweteka kwa M'mimba

▪Kutsegula m'mimba

▪Zimbudzi zofewa

▪Kutsekeka kwa mphuno

▪Kuchita chimbudzi pafupipafupi

▪Kupweteka m'mimba

Ngakhale kuti mwachibadwa anthu amawaona kuti ndi ochepa, zochitika zazikulu zingayambenso. Funsani dokotala wanu nthawi yomweyo izi zikachitika.

Cetilistat vs Orlistat

(1) Zofanana pamakina ochitira

Cetilistat ndi Orlistat amagawana njira yofananira yochitira, zonse zomwe zimayang'ana ndi kuletsa m'mimba lipases kuti muchepetse kuyamwa kwamafuta ndikulimbikitsa kuchepa thupi.

(2) Kusiyana kwa mankhwala ndi katundu

Ngakhale kuti njira zawo zogwirira ntchito ndizofanana, cetilistat ndi Orlistat zimasiyana m'magulu awo a mankhwala, zomwe zimapangitsa kuti pakhale kusiyana kwa mankhwala awo a pharmacokinetic ndi mbiri ya zotsatira zake.

(3) Kuyerekeza zotsatira zogwira mtima ndi zolemetsa

Mayesero azachipatala awonetsa kuti cetilistat ikufanana ndi Orlistat potengera kuchepa kwa thupi. Mankhwala onsewa amatha kuthandiza odwala kuti achepetse thupi kwambiri akagwiritsidwa ntchito ngati gawo la pulogalamu yowongolera kunenepa kwambiri.

(4) Kulekerera ndi kufananitsa kwambiri

Cetilistat nthawi zambiri imakhala ndi mbiri yabwino yolekerera poyerekeza ndi Orlistat. Odwala omwe amatenga cetilistat sakhala ndi vuto la m'mimba zotsatira zoyipazi, ndikupangitsa kuti ikhale yokongola kwambiri kwa iwo omwe amavutika kulekerera Orlistat.

Momwe mungagwiritsire ntchito ufa wa Cetilistat (oblean) mosamala?

(1) Mlingo wovomerezeka ndi malangizo oyendetsera

Cetilistat nthawi zambiri amalembedwa pa mlingo wa 60 mg, wotengedwa katatu patsiku ndi chakudya. Ayenera kumwa nthawi yomweyo musanadye, mkati, kapena ola limodzi mutatha kudya. Ngati chakudya chaphonya kapena mulibe mafuta, mlingo ukhoza kudumpha.

(2) Contraindications ndi chenjezo

Anthu ena sayenera kumwa cetilistat, kuphatikizapo omwe ali ndi matenda aakulu a malabsorption, cholestasis, kapena hypersensitivity ku zigawo zonse za mankhwala. Amayi oyembekezera kapena oyamwitsa ayenera kukaonana ndi azaumoyo asanagwiritse ntchito cetilistat. Odwala omwe ali ndi matenda omwe alipo kale kapena omwe amamwa mankhwala ena ayenera kukambirana zoopsa zomwe zingatheke ndi ubwino wake ndi othandizira awo azaumoyo.

(3)Kuyanjana kwamankhwala komwe kungachitike

Cetilistat (oblean) ingagwirizane ndi mankhwala ena, kuphatikizapo anticoagulants, matenda a shuga, ndi mankhwala a chithokomiro. Odwala ayenera kudziwitsa wothandizira zaumoyo wawo za mankhwala onse ndi zowonjezera zomwe akumwa kuti apewe kuyanjana komwe kungachitike.

(4) Kuyang'anira ndi kutsata panthawi ya chithandizo

Kuwunika pafupipafupi komanso kutsatiridwa ndi dokotala ndikofunikira panthawi ya chithandizo cha cetilistat. Kusankhidwa uku kumathandizira kuwunika momwe chithandizo chikuyendera, zotsatira zoyipa kasamalidwe, ndi kusintha kwa mlingo ngati kuli kofunikira.

Kodi mungagule kuti Cetilistat (Oblean) ufa?

Pali magwero ambiri a Cetilistat ufa wogulitsidwa pa intaneti pamsika, ndipo pali magwero ambiri omwe amanyenga makasitomala ndi chinyengo. mankhwala. Ngati inu muyenera kugula zambiri Cetilistat (oblean) ufa kapena ufa wapamwamba wa Cetilistat wogulitsa, wodalirika komanso wodalirika wa Cetilistat powder wopanga / wogulitsa / fakitale / wogulitsa ndi chisankho chabwino. Mutha kusaka ndemanga zabwino kapena zoyipa za iwo pa intaneti, zomwe zingakuthandizeni kusankha bwino. Ngati mukuyang'ana wothandizira wodalirika komanso wodalirika wa Cetilistat powder, ndiye AASraw ndi chisankho chanu chabwino.

Monga mtundu umodzi wodalirika wa Cetilistat powder wopanga ku China, AASraw imapanga mankhwala onse motsatira ndondomeko ya cGMP ndipo imagwira ntchito yovomerezeka ndi FDA. opanga unit kuonetsetsa chiyero chapamwamba. AASraw ali ndi ufa wake wodziimira wa Cetilistat fakitale, ndi kafukufuku ndi chitukuko Center. Dongosolo lawo loperekera ufa la Cetilistat ndi lokhazikika ndipo limatha kukhala ndi maoda ogulitsa komanso ogulitsa ambiri a ufa wa Cetilistat. Kuonjezera apo, AASraw ikhoza kupereka mtengo wampikisano wa Cetilistat ufa pamsika kwa omwe akufuna kugula Cetilistat ufa.

Mukayitanitsa kuchokera AASraw, mutha kukhala otsimikiza kuti phukusi lililonse la ufa wa Cetilistat, kaya ndi malonda ogulitsa kapena ochuluka a Cetilistat ufa, adzatumizidwa pa nthawi ndi kuperekedwa mosamala. Kuonjezera apo, AASraw ikhoza kutumiza ufa wa Cetilistat kulikonse padziko lapansi, kuphatikizapo USA, Canada, Mexico, Europe, ndi Australia. Osatengera thanzi lanu kapena ndalama zanu - sankhani AASraw monga Cetilistat (oblean) wothandizira ufa wanu ndikukhala ndi mtendere wamaganizo umene umabwera ndikugwira ntchito ndi wopanga ufa wodalirika komanso wodalirika wa Cetilistat.

Lipoti la Cetilistat Powder Testing-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Cetilistat ufa (282526-98-1) -COA

Cetilistat ufa (282526-98-1) -COA

Momwe mungagulire ufa wa Cetilistat kuchokera ku AASraw

❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani m'maola 12.

❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.

❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).

❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.

❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Nahid Shahabadi
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. William E. Acree Jr
Dipatimenti ya Chemistry, University of North Texas, 1155 Union Circle Drive #305070, Denton, TX 76203, USA
3. Shuofeng Yuan
Center for Virology, Vaccinology and Therapeutics, Health@InnoHK, University of Hong Kong, Hong Kong Special Administrative Region
4. Padwal R
Malingaliro Amakono pa Mankhwala Ofufuza (London, England: 2000)
5. Gras J
Barcelona, ​​Spain
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Reference

[1] Padwal, R. "Cetilistat, lipase inhibitor yatsopano yochizira kunenepa kwambiri". Malingaliro Amakono pa Mankhwala Ofufuza. 2008;PMID 18393108.

[2] Yamada Y, Kato T, Ogino H, Ashina S, Kato K. "Cetilistat (ATL-962), buku la pancreatic lipase inhibitor, limapangitsa kuti thupi likhale lolemera komanso limapangitsa kuti lipid profiles mu makoswe ". Kafukufuku wa Hormone ndi Metabolic. 2008;PMID 18500680.

[3] Kopelman, P.; Groot Gde, H.; Rissanen, A.; Rossner, S.; Toubro, S.; Palmer, R.; Hallam, R.; Bryson, A.; Hickling, RI Kulemera imfa, HbA1c kuchepetsa, ndi kulolerana kwa cetilistat mu mayesero osasinthika, olamulidwa ndi placebo mu gawo lachiwiri la odwala matenda a shuga: poyerekeza ndi orlistat (Xenical). Kunenepa kwambiri. 2 Januware; PMID 2010.

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