Mafotokozedwe Akatundu
Video ya Cetilistat (Oblean) powder
Chotilistat (Oblean) powder Basic Characters
| Name: | Mpweya wa Cetilistat (Oblean) |
| CAS: | 282526-98-1 |
| Maselo chilinganizo: | C25H39NO3 |
| Kulemera kwa Maselo: | 316.31 |
| Melt Point: | 190-200 ° C |
| Kusungirako nyengo: | Kutentha kwa Chipinda |
| mtundu; | Powderu Wofiira |
Kodi Cetilistat powder ndi chiyani?
Cetilistat, yomwe imadziwikanso kuti ATL-962, Oblean, kapena Citilistat, ndi mankhwala atsopano komanso othandiza omwe amapangidwira kuchiza kunenepa kwambiri. Ndilochokera ku alkylamine komanso m'mimba lipase inhibitor yomwe imayang'ana makamaka ndikuletsa ma enzyme omwe amaphwanya mafuta azakudya. Poletsa ma enzymes awa, cetilistat, omwe amatha kutengedwa kuchokera kwa ogulitsa odalirika ngati AASraw, amachepetsa kuyamwa kwa mafuta kuchokera m'zakudya, zomwe zimayambitsa kuwonda.
Cetilistat imagwiritsidwa ntchito limodzi ndi zakudya zochepa zama calorie, mafuta ochepa komanso machitidwe ochita masewera olimbitsa thupi kuti athe kuchepetsa thupi. Mankhwala oletsa kunenepa kwambiri amagulitsidwa pansi pa mayina osiyanasiyana, kuphatikiza Cetislim, Kilfat, Oblean, ndi Checkwt.
Monga gulu la benzoxazine, njira yoyamba ya cetilistat imaphatikizapo kuletsa chimbudzi ndi kuyamwa kwa mafuta a m'mimba m'mimba, potsirizira pake kuthandiza anthu paulendo wawo wochepa thupi. Ndi AASraw monga wothandizira wodalirika, anthu omwe akufunafuna njira zochepetsera zolemetsa akhoza molimba mtima kuphatikiza cetilistat mu regimen yawo.
Mbiri yachidule ya Cetilistat (Oblean) ufa
Mbiri ya chitukuko ndi kuvomereza kwa cetilistat inayamba mu 2013 pamene mankhwala adalandira chivomerezo chake choyamba cha kasamalidwe ka kunenepa kwambiri ku Japan. Kwa zaka zambiri, cetilistat yakhala ikudziwika m'mayiko osiyanasiyana padziko lonse lapansi chifukwa cha mphamvu zake komanso kulekerera kwake pochiza kunenepa kwambiri.
Cetilistat(Oblean) Powder application ndipo imagwira ntchito bwanji?
(1)Kuwongolera m'mimba lipases
Cetilistat imagwira ntchito poyang'ana m'mimba lipases, omwe ndi ma enzyme omwe amaphwanya ndi kugaya mafuta m'thupi la munthu.
(2)Kulepheretsa chimbudzi cha mafuta ndi kuyamwa
Poletsa lipases izi, cetilistat imalepheretsa kuwonongeka ndi kuyamwa kwamafuta m'matumbo am'mimba. Kenako mafuta amene sanagayidwe amachotsedwa m’thupi kudzera m’ndowe. Njirayi imayambitsa kuchepa kwa calorie kudya ndipo potsirizira pake imayambitsa kuwonda.
Kodi Ubwino wa Cetilistat (Oblean) ufa ndi chiyani?
Cetilistat(Oblean) imapereka maubwino angapo kwa anthu omwe akufuna kuwongolera kunenepa kwambiri. Monga mankhwala amphamvu ochepetsa thupi komanso oletsa kunenepa kwambiri, sikuti amangothandizira kuchepetsa thupi komanso amapereka maubwino angapo owonjezera omwe amasiyanitsa ndi mankhwala ena ochepetsa thupi. Zina mwazofunikira za cetilistat ndi izi:
(1) Kuthandizira moyo wathanzi mwa kuchepetsa thupi
Cetilistat imachepetsa mwachangu kuchuluka kwa mafuta m'thupi, kuthandizira kukhala ndi BMI yathanzi ndikuchepetsa mwayi wokhala ndi moyo pachiwopsezo chokhudzana ndi kunenepa kwambiri, monga mtundu wa 2 shuga, matenda a mtima, kuthamanga kwa magazi, ndi khansa zina.
(2) Kuchepetsa kuwonda komanso kuchepetsa hemoglobin ya glycosylated kwa odwala matenda ashuga onenepa kwambiri
Kafukufuku wazachipatala awonetsa mphamvu ya cetilistat pochepetsa thupi komanso kuchuluka kwa glycosylated hemoglobin (HbA1c) mwa odwala onenepa kwambiri omwe ali ndi matenda amtundu wa 2, ndikuwongolera bwino matenda a shuga.
(3) Kulekerera ndi chitetezo
Cetilistat nthawi zambiri imalekerera bwino, yokhala ndi zotsatira zochepa zomwe nthawi zambiri zimachepa ndikugwiritsabe ntchito. Poyerekeza ndi mankhwala ena ochepetsa thupi, monga orlistat, cetilistat yapezeka kuti imayambitsa zotsatira zochepa komanso zochepa.
(4) Kupindula kofulumira kwa zolinga zochepetsera thupi
Ngakhale kuti mankhwala ena oletsa kunenepa kwambiri amafunikira nthawi yayitali kuti achepetse thupi, cetilistat ikhoza kupereka zotsatira zomwe mukufuna mkati mwa masabata a 12 akagwiritsidwa ntchito limodzi ndi zakudya zopanda mafuta ambiri komanso masewera olimbitsa thupi nthawi zonse.
(5) Kuchepetsa cholesterol
Cetilistat ikhoza kuthandizira kuchepetsa mafuta onse a kolesterolini ndi LDL cholesterol, potero zimathandizira kupititsa patsogolo thanzi la mtima ndi kuchepetsa chiopsezo cha matenda a mtima.
(6) Kuchepetsa chiopsezo cha matenda a mtima
Pothana ndi kunenepa kwambiri komanso kulimbikitsa zakudya zopatsa thanzi, cetilistat imatha kuchepetsa chiopsezo cha matenda amtima. Kafukufuku wopangidwa mwachisawawa kwa masabata 12 okhudza odwala onenepa kwambiri omwe ali ndi matenda a shuga adawonetsa kuchepa kwakukulu kwa kunenepa, kuwongolera bwino kwa glycemic, komanso kuchepa kwa m'chiuno, zomwe zimayambitsa matenda amtima.
(7)Kutsitsa magazi
Monga cetilistat imathandizira kuchepetsa thupi, imatha kuchepetsa kuthamanga kwa magazi, kuthandizira kupewa matenda oopsa komanso zoopsa zomwe zimakhudzidwa ndi thanzi monga sitiroko, matenda a impso, ndi matenda a chiwindi.
Mukapezedwa kuchokera kwa ogulitsa odalirika monga AASraw, cetilistat imakhala chida chamtengo wapatali polimbikitsa moyo wathanzi komanso kuthana ndi mavuto a kunenepa kwambiri. Pophatikizira cetilistat mu dongosolo lowongolera zolemetsa, anthu amatha kusangalala ndi izi ndikugwira ntchito kuti akhale ndi thanzi labwino.
Kugwiritsa Ntchito Mankhwala a Cetilistat (Oblean)
(1)Chithandizo cha kunenepa kwambiri kwa akulu
Cetilistat imagwiritsidwa ntchito makamaka pochiza kunenepa kwambiri kwa akuluakulu. Nthawi zambiri amaperekedwa limodzi ndi ma calorie ochepa, zakudya zopanda mafuta ambiri komanso kuchita masewera olimbitsa thupi pafupipafupi kuti ziwonjezeke.
(2)Kuwongolera zovuta zokhudzana ndi kunenepa kwambiri
Kuphatikiza pa kulimbikitsa kuchepa kwa thupi, cetilistat yasonyezedwanso kuti ikuwongolera zovuta zokhudzana ndi kunenepa kwambiri, monga:
① Type 2 shuga mellitus
Cetilistat ingathandize kusintha glycemic control mwa odwala onenepa kwambiri omwe ali ndi matenda amtundu wa 2 pochepetsa kulemera kwa thupi komanso kutsitsa glycosylated hemoglobin (HbA1c).
②Cholesterol wambiri
Cetilistat yasonyezedwa kuti imachepetsa kuchuluka kwa mafuta m'thupi ndi otsika kwambiri a lipoprotein (LDL) cholesterol, omwe amadziwikanso kuti "cholesterol" choipa, chomwe chingathandize kuti chitukuko cha matenda a mtima.
③Kuthamanga kwa magazi
Kuwonda komwe kumapezeka kudzera mu cetilistat kungathandizenso kuchepetsa kuthamanga kwa magazi mwa anthu onenepa kwambiri, kuchepetsa chiopsezo chokhala ndi matenda oopsa komanso zovuta zina.
Kodi Cetilistat(Oblean) amathandizira bwanji kunenepa kwambiri?
Kunenepa kwambiri ndi vuto lalikulu kwambiri padziko lonse lapansi masiku ano. Ndi matenda ovuta, osatha komanso ophatikizika ambiri omwe amadziwika ndi kuchuluka kwa mafuta / minofu ya adipose.
Kunenepa kwambiri kumalumikizidwa ndi zovuta zathanzi monga mtundu wachiwiri wa matenda ashuga, matenda oopsa, hyperlipidemia, cholesterol yambiri, khansa zina, ndi matenda ena amtima monga sitiroko ndi matenda amtima.
Kunenepa kwambiri m'maiko ambiri kwafika pachimake cha mliri motero ndi vuto ladziko lonse lapansi.
Kafukufuku akuwonetsa kuti kuonda kosalekeza kwa 5 mpaka 10% ya kulemera kwanu koyamba kungachepetse kwambiri matenda okhudzana ndi kunenepa kwambiri. Anti-obesity agents nthawi zambiri amachulukitsa kugwiritsa ntchito mphamvu motero kuchepetsa thupi kudzera mu dongosolo la neural ndi metabolism. Cetilistat ndi m'mimba pancreatic lipase inhibitor yomwe imakhala yothandiza kwambiri polimbana ndi kunenepa kwambiri m'maphunziro a anthu.
Cetilistat imagwira ntchito poletsa chimbudzi ndi kuyamwa kwamafuta mkati mwa chakudya chomwe mumadya. Mafutawo akapanda kugayidwa amatuluka mu ndowe pamene akuyenda m’matumbo. Zimakwaniritsa izi mwa kulepheretsa enzyme lipases yomwe imayambitsa kuphwanya triglycerides (mafuta / lipid m'thupi) m'matumbo.Zotsatira za cetilistat zimasonyezedwa m'matumbo a m'mimba. Izi zikutanthauza kuti cetilistat ndi yosiyana ndi zina zotsutsana ndi kunenepa kwambiri zomwe zimakhudza ubongo wanu kuchepetsa chilakolako chifukwa zimagwira ntchito mozungulira.
Pamene chimbudzi ndi kuyamwa kwa mafuta odyetserako kumaletsedwa, kuyika kwa mafuta kumakhala kochepa motero kugwiritsira ntchito mphamvu zochepa zomwe zimapangitsa kuti thupi likhale lolemera. kasamalidwe kabwino ka kunenepa kwambiri.
Kodi ufa wa Cetilistat (Oblean) uli ndi Zotsatira Zake?
Odwala omwe akudwala kunenepa kwambiri ndi Cetilistat ufa akhoza kuvutika ndi zotsatirapo. Muyenera kudziwitsa dokotala ngati izi zichitika. Zitsanzo zina zaperekedwa apa:
▪Wonenepa m’chimbudzi
▪Kupweteka kwam'mimba
▪Kutuluka kumaliseche
▪Kuwona mafuta
▪Kusadziletsa m'matumbo
▪Kutuluka m'mimba
▪Kupweteka kwa M'mimba
▪Kutsegula m'mimba
▪Zimbudzi zofewa
▪Kutsekeka kwa mphuno
▪Kuchita chimbudzi pafupipafupi
▪Kupweteka m'mimba
Ngakhale kuti mwachibadwa anthu amawaona kuti ndi ochepa, zochitika zazikulu zingayambenso. Funsani dokotala wanu nthawi yomweyo izi zikachitika.
Cetilistat vs Orlistat
(1) Zofanana mu njira yochitira
Cetilistat ndi Orlistat amagawana njira yofananira yochitira, zonse zomwe zimayang'ana ndi kuletsa m'mimba lipases kuti muchepetse kuyamwa kwamafuta ndikulimbikitsa kuchepa thupi.
(2) Kusiyana kwa mankhwala ndi katundu
Ngakhale kuti njira zawo zogwirira ntchito ndizofanana, cetilistat ndi Orlistat zimasiyana m'magulu awo a mankhwala, zomwe zimapangitsa kuti pakhale kusiyana kwa mankhwala awo a pharmacokinetic ndi zotsatira zake.
(3) Kuyerekeza zotsatira zogwira mtima ndi zolemetsa
Mayesero azachipatala awonetsa kuti cetilistat ikufanana ndi Orlistat potengera kuchepa kwa thupi. Mankhwala onsewa amatha kuthandiza odwala kuti achepetse thupi kwambiri akagwiritsidwa ntchito ngati gawo la pulogalamu yowongolera kunenepa kwambiri.
(4) Kulekerera ndi kufananitsa kwambiri
Cetilistat nthawi zambiri imakhala ndi mbiri yabwino yolekerera poyerekeza ndi Orlistat. Odwala omwe amatenga cetilistat sakhala ndi zotsatirapo za m'mimba, zomwe zimapangitsa kuti ikhale yokongola kwambiri kwa iwo omwe amavutika kulekerera Orlistat.
Momwe mungagwiritsire ntchito ufa wa Cetilistat (oblean) mosamala?
(1) Mlingo wovomerezeka ndi malangizo oyendetsera
Cetilistat nthawi zambiri amalembedwa pa mlingo wa 60 mg, wotengedwa katatu patsiku ndi chakudya. Ayenera kumwa nthawi yomweyo musanadye, mkati, kapena ola limodzi mutatha kudya. Ngati chakudya chaphonya kapena mulibe mafuta, mlingo ukhoza kudumpha.
(2) Contraindications ndi chenjezo
Anthu ena sayenera kumwa cetilistat, kuphatikizapo omwe ali ndi matenda aakulu a malabsorption, cholestasis, kapena hypersensitivity ku zigawo zonse za mankhwala. Amayi oyembekezera kapena oyamwitsa ayenera kukaonana ndi azaumoyo asanagwiritse ntchito cetilistat. Odwala omwe ali ndi matenda omwe alipo kale kapena omwe akumwa mankhwala ena ayenera kukambirana za zoopsa zomwe zingachitike ndi zopindulitsa ndi othandizira awo azaumoyo.
(3)Kuyanjana kwamankhwala komwe kungachitike
Cetilistat (oblean) ingagwirizane ndi mankhwala ena, kuphatikizapo anticoagulants, matenda a shuga, ndi mankhwala a chithokomiro. Odwala ayenera kudziwitsa wothandizira zaumoyo wawo za mankhwala onse ndi zowonjezera zomwe akumwa kuti apewe kuyanjana komwe kungachitike.
(4) Kuyang'anira ndi kutsata panthawi ya chithandizo
Kuwunika pafupipafupi komanso kutsatiridwa ndi dokotala ndikofunikira panthawi ya chithandizo cha cetilistat. Maudindowa amalola kuwunika momwe chithandizo chikuyendera, kasamalidwe ka zotsatira zoyipa, ndi kusintha kwa mlingo ngati kuli kofunikira.
Kodi mungagule kuti Cetilistat (Oblean) ufa?
Pali magwero ambiri a Cetilistat ufa wogulitsidwa pa intaneti pamsika, ndipo pali magwero ambiri omwe amanyenga makasitomala ndi zinthu zachinyengo. Ngati mukufuna kugula ufa wochuluka wa Cetilistat (oblean) kapena ufa wapamwamba wa Cetilistat wogulitsa, wodalirika komanso wodalirika wa Cetilistat powder wopanga / wogulitsa / fakitale / wogulitsa ndi chisankho chabwino. Mutha kusaka ndemanga zabwino kapena zoyipa za iwo pa intaneti, zomwe zingakuthandizeni kusankha bwino. Ngati mukuyang'ana wothandizira wodalirika komanso wodalirika wa Cetilistat powder, ndiye AASraw ndi chisankho chanu chabwino.
Monga mtundu umodzi wodalirika wa Cetilistat wopanga ufa ku China, AASraw imapanga mankhwala onse motsatira ndondomeko ya cGMP ndipo imagwira ntchito yovomerezeka ya FDA yovomerezeka kuti ikhale yoyera kwambiri. AASraw ili ndi fakitale yake yodziimira ya Cetilistat powder, malo ofufuzira ndi chitukuko. Dongosolo lawo loperekera ufa la Cetilistat ndi lokhazikika ndipo limatha kukhala ndi maoda ogulitsa komanso ogulitsa ambiri a Cetilistat ufa. Kuonjezera apo, AASraw ikhoza kupereka mtengo wampikisano wa Cetilistat ufa pamsika kwa iwo omwe akufuna kugula ufa wa Cetilistat.
Mukayitanitsa kuchokera ku AASraw, mukhoza kukhala otsimikiza kuti phukusi lililonse la Cetilistat ufa, kaya ndi malonda kapena ochuluka a Cetilistat ufa, adzatumizidwa pa nthawi ndi kuperekedwa mosamala. Kuonjezera apo, AASraw ikhoza kutumiza ufa wa Cetilistat kupita kulikonse padziko lapansi, kuphatikizapo USA, Canada, Mexico, Europe, ndi Australia. Musatenge mwayi ndi thanzi lanu kapena ndalama zanu - sankhani AASraw monga Cetilistat (oblean) wothandizira ufa ndikukhala ndi mtendere wamaganizo umene umabwera ndikugwira ntchito ndi wopanga ufa wodalirika komanso wodalirika wa Cetilistat.
Cetilistat ufa (282526-98-1) -COA
Cetilistat ufa (282526-98-1) -COA
Momwe mungagulire ufa wothira mafuta: Gulani Zilonda zamtundu kuchokera ku AASraw
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
