Mafotokozedwe Akatundu
Kodi CJC-1295 ndi chiyani?
Zamgululi-1295 peptide ndi peptide yopangidwa ndi kukula kwa hormone (GHRH) yomwe imakhala ndi 30 amino acid. Imadziwika kuti ndi GHRH yothandiza kwambiri yomwe imagwiritsidwa ntchito pakukula kwa hormone kukhathamiritsa ndipo ikhoza kuphatikizidwa (kusungidwa) ndi ma peptide ena, monga Ipamorelin, chifukwa mphamvu ya synergistic effect, ndipo nthawi zambiri imaphatikizidwa mu pulogalamu ya HRT yosamalira ukalamba, komanso pulogalamu ya TRT yopititsa patsogolo ntchito.CJC-1295 yasonyeza mphamvu yowonjezera kutayika kwa mafuta ndi kulimbikitsa minofu ya minofu pamene ikuthandizira kuti thupi likhale lopanga mapuloteni. Kuwonjezera pa kuchulukitsa pang'onopang'ono kupanga GH, CJC-1295 imathandizanso kutulutsa insulini-monga kukula factor 1 (IGF-1) .Chomwe chimatulutsidwa ndi chiwindi, IGF-1 ndi hormone ya anabolic yomwe imathandiza kulimbikitsa kukula kwaumunthu m'thupi lonse. ,makamaka minofu ya mafupa.IGF-1 imathandizanso kuchulukira kwa mafupa ndi kusefera kwa impso.Mmodzi mwa ubwino waukulu wa CJC-1295 ndikuti sichikuwonjezera kupanga mahomoni omwe angakhale otsutsana monga prolactin.CJC-1295 nthawi zambiri amaperekedwa kudzera mwa subcutaneous. jekeseni.
Kodi CJC-1295 imagwira ntchito bwanji?
CJC-1295 peptide imagwira ntchito pogwiritsira ntchito GHRH receptor ndikumangiriza ku pituitary gland receptors kuti ayambe kutulutsa GH ndi insulini-monga kukula factor 1 (IGF-1) .
Kafukufuku wa zinyama za 2005 anapeza kuti CJC-1295 inalimbikitsa "kuwonjezeka kwa 4" mu GH mazinga pamene amaperekedwa kwa makoswe amphongo a Sprague Dawley. "acuteGH secretions" mu nyama zonse ndipo inapanga "plasma AUC yaikulu kwambiri ya GH pa nthawi ya 1295-h" ya ma peptide onse.
Kuphatikiza apo, maphunziro awiri a anthu okhudzana ndi mayeso athanzi adapeza kuti kayendetsedwe ka CJC-1295 DAC idapanga kuwonjezeka kwa 2- mpaka 10 kwa kuchuluka kwa plasma GH kwa masiku asanu ndi limodzi kapena kuposerapo komanso kuwonjezeka kwa 1.5 mpaka 3 kwa plasma IGF-1. ndende kwa masiku 9-11.
Ubwino wa CJC-1295
①Imawonjezera Metabolism & Kuchulukitsa Mphamvu
CJC-1295 kuchokera ku AASraw imathandizira kagayidwe kanu mwachindunji mwa kutumiza ma peptides ku gland yanu ya pituitary kuti mutulutse kukula kwa hormone komanso mwa kuwonjezera kudya kwa zakudya. pazochitika zachizolowezi komanso zolimbitsa thupi kwambiri.
②Amachepetsa mafuta a thupi
Maselo amatha kutumiza zakudya kumadera ena a thupi mofulumira, kuwotcha mafuta ambiri, ndikuthandizira kuchepetsa kulemera kwake. Kumawonjezeranso kuwonongeka kwa triglyceride ndi okosijeni mu adipocytes, zomwe zimathandizira kagayidwe ka mafuta. ndikuthandizira kusungunuka kwa mafuta m'mimba.
③Amachulukitsa Minofu
CJC-1295 imalumikizana ndi kuyambitsa ma receptor angapo m'thupi lonse, zomwe zimakhudza ntchito zosiyanasiyana za thupi. zimalimbikitsanso kutaya mafuta, kulola minofu yanu kukula kwambiri.
④Imalimbikitsa Mapangidwe a Mafupa
CJC-1295 imathandizanso m'badwo wa insulin-monga kukula factor 1 (IGF-1), hormone yofanana ndi proinsulin yomwe imayambitsa osteoblast ndi chondrocyte ntchito, motero imalimbikitsa mapangidwe a mafupa.
⑤Imawonjezera chitetezo chamthupi
Komanso, CJC-1295 ikalowa m'thupi lanu, imayambitsa chitetezo chanu cham'thupi kulimbana ndi olowa kunja monga ma virus ndi mabakiteriya. .Zingathenso kuthandiza anthu amene ali ndi chitetezo champhamvu cha mthupi.
⑥Kulimbikitsa Kugonana
Amino acid otchukawa amachepetsa zizindikiro zosiyanasiyana zomwe zimagwirizanitsidwa ndi kusowa chidwi pa kugonana kapena kugonana mwa kuwonjezera kuchuluka kwa hormone ya kukula kwaumunthu, yomwe imathandiza madera onse omwe amagwira ntchito. zomwe ndizofunikira pakuchita kwa erectile.Zotsatira zina zimaphatikizapo kulimbikitsa libido komanso kukhala ndi moyo wabwino.
⑦Kukonza Mwachangu ndi Kuchira Pazovulala
Anthu okangalika, makamaka othamanga, nthawi zambiri samva bwino m'malo ambiri amthupi chifukwa cha kuvulala komwe kumachitika panthawi yochita masewera olimbitsa thupi. Amafunikanso mphamvu kuti akonze ndikuchira kuvulala kwawo. Hormone yakukula imalimbitsa chitetezo chamthupi, zomwe zimapangitsa kuti ma cell apangidwe bwino komanso machiritso mwachangu komanso CJC-1295 imawonjezera puloteni ya anabolism m'magulu osiyanasiyana, zomwe zikutanthauza kuti imatha kupititsa patsogolo mphamvu ndikufulumizitsa mlingo wa machiritso ovulala ndi kuchira.
Zotsatira za CJC-1295
Mpata wochepa wa zotsatirapo ndi chimodzi mwa zifukwa zazikulu zomwe CJC-1295 peptide yochokera ku AASraw ikuvomerezedwa ndi anthu ambiri.CJC-1295 imaloledwa bwino ndi anthu ambiri, ndipo zotsatira zake nthawi zambiri zimakhala zochepa, ngati zilipo Zonse.CJC-1295 zotsatira zoyipa zomwe zimachitika pafupipafupi ndizomwe zimayankhidwa pamalo ojambulira monga kusapeza bwino, kufiira, edema, kutuluka thukuta, chizungulire, kuwawa kwa mutu, kapena kusachita bwino.
Zikatengedwa molakwika kapena mopitirira muyeso, zotsatira zoyipa zimakwera mosiyanasiyana, kutengera munthu. Kuchuluka kwa njala, mkamwa youma, kumva kuwawa kapena dzanzi, kuthamanga kwa magazi, aimpso, kusalumikizana bwino, mabala kapena mabala, komanso kuchepa kwa chonde ndi zina. za zotsatira zoipa.
Kusiyana pakati pa CJC-1295 ndi DAC komanso popanda DAC
Kusiyana kwakukulu pakati pa CJC-1295 ndi DAC ndi CJC-1295 popanda DAC kumawoneka m'mapangidwe awo osiyanasiyana ndi theka la miyoyo yawo. Nazi mwachidule kusiyana kwawo:
kapangidwe: Onse a CJC-1295 okhala ndi DAC ndi CJC-1295 opanda DAC ndi ma peptide opangidwa kuchokera ku hormone ya kukula kwachilengedwe (GHRH) .Komabe, amasiyana ndi kusintha kwawo kwa mankhwala.
DAC (Drug Affinity Complex):CJC-1295 yokhala ndi DAC ili ndi kusinthidwa kwina kotchedwa Drug Affinity Complex.Zovutazi ndizopangidwa ndi molekyulu zomwe zimawonjezeredwa ku peptide kuti zikhazikitse kukhazikika kwake ndikuwonjezera theka la moyo m'thupi.
Theka lamoyo:Kupezeka kwa DAC mu CJC-1295 ndi DAC kumapangitsa kuti moyo ukhale wautali kwambiri poyerekeza ndi CJC-1295 popanda DAC. Kusintha kwa DAC kumapangitsa kuti peptide itulutsidwe pang'onopang'ono komanso mokhazikika, zomwe zimapangitsa kuti pakhale ntchito yayitali komanso yogwira mtima.
Mlingo pafupipafupi:Chifukwa cha kutalika kwa theka la moyo, CJC-1295 yokhala ndi DAC imafunikira dosing pafupipafupi. Imaperekedwa kamodzi kapena kawiri pa sabata.Kumbali ina, CJC-1295 yopanda DAC imakhala ndi theka la moyo wamfupi ndipo nthawi zambiri imaperekedwa kangapo. nthawi patsiku kuti musunge milingo yofananira.
Administration: Onse a CJC-1295 okhala ndi DAC ndi CJC-1295 opanda DAC nthawi zambiri amaperekedwa kudzera mu jekeseni wa subcutaneous.Malo a jekeseni amakhala m'mimba kapena ntchafu.
Kugwiritsa Ntchito Zachipatala:CJC-1295 yokhala ndi DAC ndi CJC-1295 popanda DAC ili ndi ntchito zosiyanasiyana.CJC-1295 yokhala ndi DAC imagwiritsidwa ntchito makamaka chifukwa cha kukula kwake kwa hormone-kutulutsa katundu pa nkhani ya mankhwala, kupititsa patsogolo ntchito, kapena mankhwala oletsa kukalamba.CJC-1295 Popanda DAC, mbali inayi, imagwiritsidwa ntchito kwambiri pofufuza komanso kufufuza kwasayansi.
Chonde dziwani kuti AASraw amapereka zonse za CJC-1295 ndi DAC ndi CJC-1295 popanda DAC.
FAQ
①Kodi njira yabwino yoperekera CJC-1295 ndi iti?
Poyamba, jakisoni amalola kuti mayamwidwe mosavuta mwachindunji mwachindunji m'magazi.
Kutsatira izi, malo abwino obaya ndi m'mimba, ntchafu, kapena kumtunda kwa mkono. Muyenera kudikirira mphindi 30 musanayambe jekeseni musanadye kapena kumwa chilichonse. Ngati mukumwa jekeseni imodzi patsiku, lolani katatu maola pakati pa Mlingo.
Pomaliza, ngati mukufuna kukwaniritsa zomwe mukufuna, muyenera kukhala osasinthasintha.
②Kodi CJC-1295 iyenera kusungidwa bwanji?
Zikafika pa moyo wa alumali, CJC-1295 peptide iyenera kusungidwa mosamala ndi kugwiritsidwa ntchito nthawi zonse. Muyenera kuigwiritsa ntchito pofika tsiku linalake kapena idzataya mphamvu zake ndikuwonongeka.
Moyo wa alumali wa Mbale ukhoza kuwonjezedwa pouzizira. CJC-1295 idzangotha milungu ingapo pa kutentha kwa firiji, komabe firiji imatha kuwonjezera moyo wa alumali mpaka mwezi umodzi. Pamene mukupereka jakisoni, nthawi zonse tsatirani malangizo a dokotala.
③KODI CJC-1295 IGWIRA NTCHITO ALIYENSE?
Kuti muchepetse thupi ndikuwotcha mafuta amthupi, muyenera kusinthanso moyo wanu pankhani yazakudya komanso masewera olimbitsa thupi.
Ngakhale mutatsatira ndondomeko yoyenera ya chithandizo, zakudya zoipa ndi kusachita masewera olimbitsa thupi kungakhale ndi chikoka pa thanzi lanu ndikuthandizira kunenepa kwambiri. zolinga zolimbitsa thupi bwino!Ngati zingafunike, ndinu olandiridwa kugula CJC-1295.
Kodi Mungagule Kuti CJC-1295?
CJC-1295 peptide therapy imakhudza kwambiri thanzi lathunthu.Imathandiza kupeza minofu, kusungunuka mafuta, kuwonjezera mphamvu, ndi zina zambiri.Imakwaniritsa zonsezi mwa kuthandiza thupi lanu kuwonjezereka kwa kukula kwa hormone.Pano pa AASraw, tadzipereka kwa Kupereka ma peptide angapo kuphatikiza kuwonda, chithandizo chamankhwala pakugonana, ndi ma hormone ena.Ngati mukufuna malonda a CJC-1295 kapena ma peptide ena aliwonse, lembani mawonekedwe omwe ali pansipa kuti mukonzekere zokambirana zanu ndikulankhula ndi akatswiri athu apadera.Sitingadikire kumva kuchokera kwa inu!
Lipoti Loyesa la CJC-1295-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji CJC-1295 kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Henninge J, Pepaj M, Hullstein I, Hemmersbach P (2010). "Chidziwitso cha CJC-1295, peptide yotulutsa hormone yowonjezereka, mukukonzekera mankhwala osadziwika". Kuyeza Mankhwala ndi Kusanthula. 2 ( 11–12 ): 647–50. doi:10.1002/dta.233. PMID 21204297.
[2] Hartvig RA, Holm NB, Dalsgaard PW, Reitzel LA, Müller IB, Linnet K (2014). "Kuzindikiritsa ma peptide ndi mapuloteni okhudzana ndi mankhwala osokoneza bongo omwe adalandidwa ku Denmark pakati pa 2007-2013". Scandinavia Journal of Forensic Science. 20 (2): 42-49. doi:10.2478/sjfs-2014-0003. Chithunzi cha ISSN 2353-0707.
[3] Ionescu M, Frohman LA (December 2006). "Pulsatile secretion of growth hormone (GH) ikupitirirabe panthawi yolimbikitsidwa ndi CJC-1295, GH-release hormone analog ya nthawi yayitali". Journal of Clinical Endocrinology ndi Metabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. Chithunzi cha PMID 17018654.
[4] Thorner MO (June 2008). "Kupezeka kwa hormone yotulutsa kukula kwa hormone: kusintha". Journal ya Neuroendocrinology. 20 (6): 653–4. doi:10.1111/j.1365-2826.2008.01740.x. PMID 18601685. S2CID 29788809.
[5] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). "Kukondoweza kwa nthawi yaitali kwa hormone ya kukula (GH) ndi insulini-monga kukula factor I secretion ndi CJC-1295, analogue ya nthawi yayitali ya GH-release hormone, mwa akuluakulu athanzi". Journal of Clinical Endocrinology ndi Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. Mtengo wa PMID 16352683.
