Mafotokozedwe Akatundu
Kodi CJC-1295 ndi chiyani?
Zamgululi-1295 peptide ndi peptide yopangidwa ndi kukula kwa hormone-releasing (GHRH) yomwe ili ndi 30 amino acid. Imadziwika kuti ndi GHRH yothandiza kwambiri yomwe imagwiritsidwa ntchito pakukula kwa hormone kukhathamiritsa ndipo imatha kuphatikizidwa (yodzaza) ndi ma peptides ena, monga Ipamorelin, chifukwa champhamvu ya synergistic effect, ndipo nthawi zambiri imaphatikizidwa mu pulogalamu ya HRT yosamalira ukalamba ndi pulogalamu ya TRT ya Kupititsa patsogolo ntchito.CJC-1295 yasonyeza mphamvu yowonjezera kutayika kwa mafuta ndi kulimbikitsa minofu ya minofu pamene zimathandiza kuti thupi lizipanga bwino mapuloteni. Kuphatikiza pakukulitsa pang'onopang'ono GH Kupanga, CJC-1295 imawonjezeranso katulutsidwe ka insulini-monga kukula factor 1 (IGF-1). Imatulutsidwa makamaka ndi chiwindi, IGF-1 ndi hormone ya anabolic yomwe imathandiza kulimbikitsa kukula kwa anthu m'thupi lonse, makamaka minofu ya chigoba.IGF-1 imathandizanso pakuchulukira kwa mafupa ndi kusefera kwa impso. Chimodzi mwazabwino zazikulu za CJC-1295 ndikuti sichimawonjezera kupanga kwa mahomoni omwe angakhale otsutsana monga prolactin.CJC-1295 nthawi zambiri amaperekedwa kudzera mu jekeseni wa subcutaneous.
Kodi CJC-1295 imagwira ntchito bwanji?
CJC-1295 peptide imagwira ntchito pogwiritsa ntchito GHRH receptor ndikumangiriza ku pituitary gland receptors kuti ayambe kutulutsa GH ndi insulini-monga kukula factor 1 (IGF-1). Zayesedwa mu nyama ndi maphunziro a anthu.
Kafukufuku wa zinyama wa 2005 anapeza kuti CJC-1295 inalimbikitsa "kuwonjezeka kwa 4" mumagulu a GH pamene amaperekedwa kwa makoswe amphongo a Sprague Dawley. Ochita kafukufuku adanena kuti pamene CJC-1295 inalowetsedwa pamodzi ndi hGRF1-29 amide ndi CJC-1288, inayambitsa "kutsekemera kwakukulu" kwa nyama zonse ndipo inapanga "plasma AUC yaikulu kwambiri ya GH pa nthawi ya 2-h" ya ma peptide onse.
Kuphatikiza apo, maphunziro awiri a anthu okhudzana ndi mayeso athanzi adapeza kuti kuwongolera kwa CJC-1295 DAC kunapangitsa kuwonjezeka kwa 2- mpaka 10 kwa kuchuluka kwa plasma GH kwa masiku asanu ndi limodzi kapena kuposerapo komanso kuwonjezeka kwa 1.5 mpaka 3 kwa plasma IGF-1. ndende kwa masiku 9-11.
Ubwino wa CJC-1295
①Imawonjezera Metabolism & Kuchulukitsa Mphamvu
CJC-1295 kuchokera AASraw kumawonjezera kagayidwe kanu mosalunjika potumiza ma peptides ku gland yanu ya pituitary kuti mutulutse timadzi tambiri tambiri ndikuwonjezera kuyamwa kwa zakudya. Zotsatira zake, milingo yamphamvu yanu imakulitsidwa nthawi zonse tsiku lonse; mudzamva kutopa komanso kukhala ndi mphamvu zambiri pazochitika zachizolowezi komanso zolimbitsa thupi kwambiri.
②Amachepetsa mafuta a thupi
Kuwonjezeka kukula kwa hormone kumalimbikitsanso kuonda komanso kuchepetsa mafuta m'thupi mosavuta. Maselo amatha kutumiza zakudya ku zigawo zina za thupi mofulumira, kuwotcha mafuta ambiri, ndi kuthandizira kulemera kwa thupi.Kumawonjezeranso kuwonongeka kwa triglyceride ndi okosijeni mu adipocytes, zomwe zimapangitsa kuti mafuta a metabolism ayambe kusungunuka ndikulimbikitsa kusungunuka kwa mafuta a m'mimba.
③Amachulukitsa Minofu
CJC-1295 imalumikizana ndikuyambitsa ma receptor angapo m'thupi lonse, zomwe zimakhudza machitidwe osiyanasiyana a thupi. Kupangitsa chiwindi kupanga zambiri za IGF-1 kumalimbikitsa kukula kwa minofu ndi kaphatikizidwe ka mapuloteni, zomwe zimapangitsa kuti minofu ikhale yambiri. Osati zokhazo, komanso zimalimbikitsa kutaya mafuta, kulola kuti minofu yanu ikule kwambiri.
④Imalimbikitsa Mapangidwe a Mafupa
CJC-1295 imathandiziranso m'badwo wa insulin-monga kukula factor 1 (IGF-1), hormone yofanana ndi proinsulin yomwe imapangitsa osteoblast ndi chondrocyte ntchito, motero imalimbikitsa mapangidwe a mafupa.
⑤Imawonjezera chitetezo chamthupi
Kuphatikiza apo, CJC-1295 ikalowa m'thupi lanu, imayambitsa chitetezo chanu chamthupi kumenyana ndi olowa kunja monga ma virus ndi mabakiteriya. Ngati mulibe chitetezo chokwanira, kapena ngati chitetezo chanu chawonongeka chifukwa cha matenda kapena ukalamba, chithandizo cha peptide chingathandize kubwezeretsa mphamvu zake. Zingathandizenso anthu amene ali ndi mphamvu zoteteza thupi ku matenda.
⑥Kulimbikitsa Kugonana
Amino acid otchukawa amachepetsa zizindikiro zosiyanasiyana zomwe zimagwirizanitsidwa ndi kusowa chidwi pa kugonana kapena kugonana powonjezera milingo ya kukula kwa mahomoniCJC-1295 imapangitsa kuti maselo ofiira a m'magazi apangidwe ndi kuyendayenda, zomwe zonsezi ndizofunikira kuti erectile igwire ntchito. Zina zotsatira zoyipazi onjezerani libido yowonjezera komanso kukhala ndi moyo wabwino.
⑦Kukonza Mwachangu ndi Kuchira Pazovulala
Anthu okangalika, makamaka othamanga, nthawi zambiri samva bwino m'malo ambiri amthupi chifukwa cha kuvulala komwe kumachitika panthawi yolimbitsa thupi. Amafunikiranso mphamvu kuti akonze ndikuchira kuvulala kwawo. Kukula timadzi imalimbitsa chitetezo cha mthupi, zomwe zimapangitsa kuti ma cell apangidwe bwino komanso kuchira msanga komanso kuchira msanga kuchokera kuvulala.CJC-1295 mwachisawawa imawonjezera mapuloteni a anabolism m'magulu osiyanasiyana, zomwe zikutanthauza kuti zimatha kuonjezera mphamvu mwachindunji ndikufulumizitsa mlingo wa machiritso ovulala ndi kuchira.
Zotsatira za CJC-1295
Mwayi wochepa wa zotsatira zoyipazi ndi chimodzi mwa zifukwa zazikulu zomwe CJC-1295 peptide yochokera ku AASraw ikuvomerezedwa ndi anthu ambiri.CJC-1295 imaloledwa bwino ndi anthu ambiri, ndipo zotsatira zoyipazi Nthawi zambiri amakhala odzichepetsa, ngati alipo.CJC-1295 nthawi zambiri zotsatira zoyipa zimaphatikizapo mayankho a malo a jekeseni monga kusapeza bwino, redness, edema, flushing, chizungulire, mutu, kapena hyperactivity.
Zikatengedwa molakwika kapena mopitilira muyeso, zotsatira zoyipa zimakwera mosiyanasiyana, kutengera munthu. Kuchuluka kwa njala, kuuma pakamwa, kumva kulasalasa kapena dzanzi, kuthamanga kwa magazi, vuto la aimpso, kusalumikizana bwino kwa mafupa, timadontho tating'onoting'ono kapena mawanga, komanso kuchepa kwa chonde ndi zina mwazowopsa.
Kusiyana pakati pa CJC-1295 ndi DAC komanso popanda DAC
Kusiyanitsa kwakukulu pakati pa CJC-1295 ndi DAC ndi CJC-1295 popanda DAC kumawoneka m'mapangidwe awo osiyanasiyana ndi theka la moyo. Nazi mwachidule za kusiyana kwawo:
kapangidwe: Onse CJC-1295 ndi DAC ndi CJC-1295 opanda DAC ndi kupanga ma peptides otengedwa ku kukula kwachilengedwe Hormone-release hormone (GHRH). Komabe, amasiyana pakusintha kwawo kwamankhwala.
DAC (Drug Affinity Complex): CJC-1295 yokhala ndi DAC ili ndi kusinthidwa kwina kotchedwa Drug Affinity Complex. Vutoli ndi mawonekedwe a mamolekyu omwe amawonjezeredwa ku peptide kuti apititse patsogolo kukhazikika kwake ndikukulitsa theka la moyo wake m'thupi.
Theka lamoyo: Kukhalapo kwa DAC mu CJC-1295 ndi DAC kumapangitsa kuti moyo ukhale wautali kwambiri poyerekeza ndi CJC-1295 popanda DAC. Kusintha kwa DAC kumalola kutulutsa kwapang'onopang'ono komanso kosalekeza kwa peptide, zomwe zimapangitsa kuti pakhale ntchito yayitali komanso yogwira ntchito.
Mlingo pafupipafupi: Chifukwa cha kutalika kwa theka la moyo, CJC-1295 yokhala ndi DAC imafuna kuchepetsedwa pafupipafupi. Amaperekedwa kamodzi kapena kawiri pa sabata. Kumbali ina, CJC-1295 yopanda DAC imakhala ndi theka laufupi ndipo nthawi zambiri imaperekedwa kangapo patsiku kuti ikhale yosasinthasintha.
Administration: Onse a CJC-1295 okhala ndi DAC ndi CJC-1295 opanda DAC nthawi zambiri amaperekedwa kudzera mu jekeseni wa subcutaneous. Malo opangira jakisoni nthawi zambiri amakhala pamimba kapena ntchafu.
Kugwiritsa Ntchito Zachipatala: CJC-1295 yokhala ndi DAC ndi CJC-1295 popanda DAC ili ndi ntchito zosiyanasiyana.CJC-1295 yokhala ndi DAC imagwiritsidwa ntchito makamaka chifukwa cha kukula kwake kwa hormone-kutulutsa katundu pa nkhani ya mankhwala, kupititsa patsogolo ntchito, kapena mankhwala ochiritsira okalamba.CJC-1295 Popanda DAC, kumbali ina, imagwiritsidwa ntchito kwambiri pazolinga zofufuza komanso kafukufuku wasayansi.
Chonde dziwani kuti AASraw amapereka onse CJC-1295 ndi DAC ndi CJC-1295 popanda DAC.
FAQ
①Kodi njira yabwino yoperekera CJC-1295 ndi iti?
Pachiyambi, jakisoni amalola kuti mayamwidwe mwachindunji mwachindunji m'magazi. Kuti mupeze zotsatira zabwino, bayani CJC nthawi yomweyo tsiku lililonse, m'mimba yopanda kanthu, pamlingo womwe watchulidwa.
Pambuyo pake, malo abwino obayamo ndi m'mimba, ntchafu, kapena kumtunda kwa mkono. Muyenera kudikirira mphindi 30 kutsatira jakisoni musanadye kapena kumwa chilichonse. Ngati mukumwa jekeseni wopitilira umodzi patsiku, lolani osachepera maola atatu pakati pa Mlingo.
Pomaliza, ngati mukufuna kukwaniritsa zomwe mukufuna, muyenera kukhala osasinthasintha.
②Kodi CJC-1295 iyenera kusungidwa bwanji?
Pankhani ya moyo wa alumali, CJC-1295 Peptide iyenera kusungidwa mosamala nthawi zonse ndi kugwiritsidwa. Muyenera kuigwiritsa ntchito pofika tsiku linalake kapena idzasiya kugwira ntchito ndikuwonongeka.
Moyo wa alumali wa Mbale ukhoza kuwonjezedwa pouzizira.CJC-1295 ingokhala milungu ingapo pa kutentha kwa firiji, komabe, refrigerate imatha kukulitsa moyo wa alumali mpaka mwezi umodzi. Popereka jakisoni, nthawi zonse tsatirani malangizo a dokotala.
③KODI CJC-1295 IGWIRA NTCHITO ALIYENSE?
Kukumana nazo kuwonda ndi kuwotcha mafuta a thupi, muyenera kupanganso kusintha kwa moyo wanu pankhani ya zakudya ndi masewera olimbitsa thupi.
Ngakhale mutatsatira njira yochiritsira yolangizidwa, kudya koipa ndi kusachita masewera olimbitsa thupi kungakhale ndi zotsatira zovulaza pa thanzi lanu ndikuthandizira kulemera. Komabe, zikaphatikizidwa ndi zakudya zoyenera komanso masewera olimbitsa thupi, peptide iyi ya CJC-1295 ikhoza kukuthandizani kukwaniritsa zolinga zanu zolimbitsa thupi bwino! Ngati pakufunika, ndinu olandiridwa kugula CJC-1295.
Kodi Mungagule Kuti CJC-1295?
Thandizo la CJC-1295 peptide limakhudza kwambiri thanzi lathunthu. Zimathandizira kukulitsa minofu, kugaya mafuta, kuwonjezera mphamvu, ndi zina zambiri. Imakwaniritsa zonsezi pothandizira thupi lanu kuphatikizika kwa mahomoni okula. Pano pa AASraw, tadzipereka kupereka ma peptides angapo kuphatikiza kuchepetsa thupi, chithandizo chamankhwala pakugonana, ndi mahomoni ena. Ngati mukufuna malonda a CJC-1295 kapena ma peptide ena aliwonse, lembani mawonekedwe omwe ali pansipa kuti mukonzekere zokambirana zanu ndikulankhula ndi antchito athu apadera. Sitingadikire kumva kuchokera kwa inu!
Lipoti Loyesa la CJC-1295-HNMR
Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji CJC-1295 kuchokera ku AASraw?
❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani m'maola 12.
❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.
❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. Bernd Peschke
Health Care Chemistry, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark
2. Peter B. Johansen
Dipatimenti ya Pharmacological Research, Novo Nordisk A/S, Bagsværd, DK-2880, Denmark
3. NB Andersen
Dipatimenti ya Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus C, DK-8000, Denmark
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Henninge J, Pepaj M, Hullstein I, Hemmersbach P (2010). Chidziwitso cha CJC-1295, kukula kwa hormone-kutulutsa Peptide, pokonzekera mankhwala osadziwika. Mankhwala kuyezetsa ndi Analysis. 2 ( 11–12 ): 647–50. doi:10.1002/dta.233. PMID 21204297.
[2] Hartvig RA, Holm NB, Dalsgaard PW, Reitzel LA, Müller IB, Linnet K (2014). "Kuzindikiritsa ma peptide ndi mapuloteni okhudzana ndi mankhwala osokoneza bongo omwe adalandidwa ku Denmark pakati pa 2007-2013". Scandinavia Journal of Forensic Science. 20 (2): 42-49. doi:10.2478/sjfs-2014-0003. Chithunzi cha ISSN 2353-0707.
[3] Ionescu M, Frohman LA (December 2006). "Pulsatile secretion of growth hormone (GH) ikupitirirabe panthawi yolimbikitsidwa ndi CJC-1295, GH-release hormone analog ya nthawi yayitali". Journal of Clinical Endocrinology ndi Metabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. Chithunzi cha PMID 17018654.
[4] Thorner MO (June 2008). "Kupezeka kwa hormone yotulutsa kukula kwa hormone: kusintha". Journal ya Neuroendocrinology. 20 (6): 653–4. doi:10.1111/j.1365-2826.2008.01740.x. PMID 18601685. S2CID 29788809.
[5] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). "Kukondoweza kwa nthawi yaitali kwa hormone ya kukula (GH) ndi insulini-monga kukula factor I secretion ndi CJC-1295, analogue ya nthawi yayitali ya GH-release hormone, mwa akuluakulu athanzi". Journal of Clinical Endocrinology ndi Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. Mtengo wa PMID 16352683.
