Ufa Wowonda

1.Kulemera Kwambiri Mbiri Yamankhwala

Mankhwala oyamba kulemera koyambirira, omwe amatchedwa ochepetsa mafuta panthaŵiyo, anakhalapo kumapeto kwa 1800s. Ngakhale mankhwalawa adayambitsa mavuto akuluakulu, adapitiriza kupezeka kuti agwiritsidwe ntchito mpaka 1960s.

Chithandizo chatsopano chotchedwa Dinitrophenol chinayambitsidwa mu 1930s ndipo chinakhala chotchuka kwambiri poyesa kulemera. Mankhwalawa amachititsa kuti thupi likhale lopweteka kwambiri, kuwonetsa kuchepa kwa thupi.

Pakatikati mwa 1950s, amphetamines anakhalapo ndipo anapezeka kuti ndi mankhwala olemetsa. Icho chinathandiza kuchepetsa kulemera kwa kupondereza njala. Chomvetsa chisoni n'chakuti, chinawonjezereka chiopsezo cha kupatsirana kwapachipatala, zomwe zimapangitsa kuti asiye ku msika ku 1968.

Mu 1970s, ephedrine adayikidwa mankhwala operekera kulemera. Mankhwalawa, komabe, adayambitsa zowawa zomwe zinachititsa kuti adziwidwe kuti ndizoopsa.

2.Kuchepetsa Kulemera kwa Mankhwala Osokoneza Bongo

Mankhwala osokoneza bongo amagawidwa m'magulu akuluakulu atatu malinga ndi momwe amachitira ndi awa:

(1) Kudya chakudya chokwanira (Zakudya)

Mankhwala osokoneza bongo amatchedwa sympathomimetic agents. Kawiri kaŵirikaŵiri amaletsa chilakolako chofuna kudya panthawi yomwe amachititsa kuti satiyambe. Chisangalalo ndi "kukhuta" kumverera kapena kukhutira komwe kumapezeka popeza chakudya. Zofuna zokhudzana ndi kudya zimagwira ntchito pomatsanzira khungu la ubongo mu ubongo wa umunthu lomwe limayambitsa chilakolako, lotchedwa noradrenaline (NA).

Mankhwalawa amagawana mankhwala ofanana ndi NA ndipo amatha; Zotsatira zake zimamangiriza ku zolandilira zomwezo monga noradrenaline. Mankhwalawa amathandizanso ntchito ya noradrenaline mu "malo odyetserako" a ubongo waumunthu, hypothalamus. Hypothalamus yaumunthu imayang'anira kuchuluka kwa mphamvu m'thupi. Zambiri zokhudzana ndi malo ogulitsa mphamvu zimapangidwira mu hypothalamus yomwe imayang'anira kudya komanso kulakalaka kudya. Kumanga kwa Noradrenaline ndi ntchito mu hypothalamus kumachepetsa chilakolako cha kudya. Mankhwalawa ndi awa:

❶ Lorcaserin HCL(Belviq) CAS: 1431697-94-7

❷ Rimonabant HCL CAS: 158681-13-1

❸ DNP CAS: 119-26-6

(2) Fat Burning

Mafuta oyaka mafuta ochepetsa thupi amatha kuthandizira kutaya mafuta pochepetsa zilakolako, kupititsa patsogolo kagayidwe kazakudya, komanso kukhala ndi chidwi chofuna kudya. Athanso kukulitsa kuthekera kolimbitsa thupi powonjezera mphamvu ndi chidwi. Mankhwalawa ndi awa:

❶ Synephrine CAS: 94-07-5

❷ DMAA/1,3-Dimethylpentylamine CAS: 13803-74-2

(3) Kukulitsa chimbudzi

Mankhwalawa amatayika chifukwa amatha kusokoneza zakudya zomwe zimadya zakudya. Mwachitsanzo, Orlistat imadziwika kuletsa kuwonongeka kwa mafuta ndipo imalepheretsa kutaya mafuta. Zakudya zina zambiri zakhala zikugwiritsidwa ntchito pochepetsa caloric absorption ndi kuletsa chimbudzi. M'nkhaniyi, tikambirana zambiri za mankhwala awa:

❶ Orlistat CAS: 96829-58-2

❷ Cetilistat CAS: 282526-98-1

3.The 3 Wotchuka Kwambiri Kutaya Ufa Pamsika

(1) Orlistat CAS: 96829-58-2

Orlistat ndipamwamba kwambiri paccatic ndi gastric lipase inhibitor. Zakudya zonse za triglycerides zimagwiritsidwa ntchito mothandizidwa ndi pancreatic ndi chapamimba lipases. Lipases limapangitsa kuti triglycerides iwononge mafuta omwe amatha kutengeka m'matumbo aang'ono. Gastric ndi pancreatic lipase inhibitors zimapanga mgwirizano ndi phulusa ndipo chapamimba chimatulutsa kuwala kwa m'mimba komanso m'mimba zimapangitsa kuti mavitaminiwa asagwire bwino ntchito.

Kupyolera mu chiopsezo cha ntchito ya lipases, zakudya zamagetsi zimayambanso kuthira, ndipo triglycerides zimatulutsidwa mu nyansi. Mankhwala osokoneza bongo amachititsa kuti pakhale peresenti ya 30 ya mafuta odya kuchokera ku chakudya cha thupi (pamene 30 peresenti ya mphamvu yodyera imaperekedwa ndi triglycerides). Kuchuluka kwa kuchepetsa kulemera kwa chaka chimodzi ndi kuphatikiza kwa Xenical (orlistat) ndi kusintha kwa moyo ndikuzungulira 8.5 kg.

Pamodzi ndi kuchepetsa kuyamwa kwa zakudya za triglycerides, orlistat weight loss powder yapezeka:

• Kukhala ndi zotsatira zabwino pa kuthamanga kwa magazi;
• Kuchepetsa kuyamwa kwa mafuta m'thupi ndipo motero ma cholesterol (pamodzi ndi cholesterol ya LDL);
• onjezerani kukana kwa insulini; ndi
• Limbikitsani kuwongolera kwa glycemic.

Ambiri amaganiza kuti zotsatira za orlistat zam'mimba zimakhala zofanana ndi kulimbikitsana koipa, zomwe zimalimbikitsa omwe ali ndi mankhwalawa kuti azitsatira kwambiri zakudya zopanda mafuta.

(2) CAS Ceististat: 282526-98-1

Cetilistat ndi pakamwa, buku, pancreatic ndi m'mimba lipase inhibitor. Cetilistat kulemera kwa mankhwala ndi mankhwala opangidwa pofuna kuchiza kunenepa kwambiri. Amagwira ntchito mofanana ndi mankhwala omwe takambirana kale kuti Xenical (orlistat) polamulira pancreatic lipase, puloteni yomwe imaphwanya triglycerides m'matumbo athu. Popanda ma enzymes awa, triglycerides kuchokera ku chakudya chathu amaletsedwa kugayidwa kukhala mafuta acids aulere omwe amatha kuyamwa ndikuchotsedwa m'thupi osagayidwa.

M'mayesero am'chipatala odwala ochepa omwe alibe mtundu wa shuga wa 2 komanso odwala ambiri omwe ali ndi matenda a shuga a 2. Pamene Cetilistat kutayika kwa ufa kunkaperekedwa kwa milungu khumi ndi iwiri, iyo imachepa kwambiri thupi, cholesterol chokwanira, serum yothamanga lipoprotein cholesterol mofulumira poyerekezera ndi placebo.

Chiwerengero cha odwala kwambiri omwe akuwonetsa kuchepa kwakukulu kulemera kwake kwa thupi kwa osachepera 5 peresenti chinali chapamwamba mu mikono yonse yogwira poyerekeza ndi placebo. Odwala odwala kwambiri a shuga, ma HbA1c (ma glycosylated hemoglobin) anagwedezeka kwambiri. Mankhwala osokoneza bongo amachititsa kuti thupi likhale lopweteka kwambiri, ndipo limayambitsa steatorrhea (chibadwa cha m'mimba) chokhala ndi chiwerengero chocheperapo kusiyana ndi chomwe chimapangika mu orlistat. Mankhwala awa adalandiridwa posachedwapa ku Japan kuti athetse kunenepa ndi mavuto ena.

(3) Lorcaserin HCL(Belviq) CAS: 1431697-94-7

4.Momwe Mungagule Mogwira Ntchito Kuwonda Ufa Pa intaneti?

Monga momwe tawonera pamakambirano athu, pali mankhwala ambiri ochepetsa kulemera komwe kumachokera ku mitundu yosiyanasiyana ya mankhwala. Ambiri mwa mankhwalawa apezeka kuti ali othandiza, ndipo ena avomerezedwa ndi maulamuliro osiyanasiyana monga FDA ndi Japan, kutchula owerengeka, kuti athetse kunenepa kwambiri.

Titakhala maola ambiri tikufufuza za mankhwala ochepetsa thupi, tidatha kuzindikira Zochepa Zogulitsa Padziko Lonse Zochepa Kwambiri Padziko Lonse la 2018 Powder Powder. Izi zowonjezera zowonjezera ufa zimaphatikizapo orlistat kulemera kwa ufa ndi lorcaserin kulemera kwa ufa. Mosiyana ndi zakudya zochepetsera thupi zomwe zimapezeka m'sitolo iliyonse yamankhwala, mankhwala ochepetsa thupi awa omwe aperekedwa ndi akatswiri azachipatala adutsa zaka zambiri akuyesedwa kuti alandire chivomerezo kuchokera ku FDA ndi madera ena angapo. Tikukulimbikitsani kwambiri kuti muyese mankhwalawa chifukwa atsimikiziridwa kuti ndi othandiza komanso otetezeka kugwiritsa ntchito.

Mutha kufunsa momwe mungagule zothandiza kulemera kwa ufa wa orlistat ufa ndi lorcaserin hcl ufa. Pali ambiri ogulitsa ufa pa intaneti ndipo amafunikira kudziwa kuti ndi iti yomwe ili yabwino kwa inu. Muyenera kumvetsera kwambiri khalidwe la mankhwala ndi ngati angatumize kwa inu otetezeka, ngati mukufuna kugula kuwonda ufa chochuluka, muyenera kudziwa ngati dongosolo lawo kupereka ndi ngati khola, ganizirani za kutenga dongosolo chitsanzo pamaso chochuluka. kuyitanitsa, itengeni kukayezetsa kwa akatswiri 3^rd-Labs ndikuyang'ana khalidwe. Komabe, kupeza othandizira apamwamba sizinthu zophweka, muyenera kuika nthawi ndi mphamvu zambiri pa izo.

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