Mafotokozedwe Akatundu
Kodi GHRP-6 ndi chiyani?
GHRP-6, kapena Growth Hormone Releasing Peptide-6, ndi hexapeptide yopanga, kutanthauza kuti imakhala ndi ma amino acid asanu ndi limodzi. Peptide iyi imakhala ngati secretagogue, chomwe ndi chinthu chomwe chimayambitsa kutulutsa kwa chinthu china. Pankhani ya GHRP-6, imalimbikitsa kutulutsidwa kwa mahomoni okula.
GHRP-6 imagwira ntchito potengera zotsatira za hormone ghrelin, yomwe ndi hormone yomwe imayang'anira njala ndipo imagwira nawo ntchito yogawa komanso kugwiritsa ntchito mphamvu. Pamene GHRP-6 imamangiriza ku ghrelin receptors, imayambitsa kutulutsidwa kwa kukula kwa hormone kuchokera ku chithokomiro cha pituitary. Kutulutsidwa kwa hormone ya kukula uku, pamodzi ndi ntchito ya ghrelin kutsanzira, kumabweretsa kuwonjezeka kwa chilakolako, zomwe zingakhale zopindulitsa kwa anthu omwe akufunafuna kupeza minofu.
Kuonjezera apo, GHRP-6 yadziwika kuti imatha kukonza kugona, kulimbikitsa kutaya mafuta, kuthandizira chitetezo cha mthupi, ndikuthandizira kuteteza mtima. Nthawi zambiri amagwiritsidwa ntchito ndi bodybuilders ndi othamanga chifukwa zotsatira zake pa kukula mlingo wa mahomoni.
Kodi GHRP-6 imagwira ntchito bwanji?
GHRP-6 (Growth Hormone Releasing Peptide-6) imagwira ntchito potsanzira ghrelin ya hormone, yomwe imayambitsa kuwonjezeka kwa endogenous (opangidwa mkati) kukula kwa hormone kumasulidwa m'thupi. Nayi kuyang'ana mozama pamachitidwe ake.
Kukondoweza kwa Ghrelin
Ghrelin, Nthawi zambiri amatchedwa "hunger hormone," ndi mahomoni opangidwa ndi m'mimba poyankha kusala kudya komwe kumapangitsa chidwi, zomwe zimapangitsa kuti chakudya chiwonjezeke. GHRP-6 imagwira ntchito ngati ghrelin agonist, zomwe zikutanthauza kuti zimamangiriza ndikulimbikitsa ma ghrelin receptors mu ubongo, ndikuwonjezera kumva njala.
Kutulutsidwa kwa Hormone ya Kukula
Pamene GHRP-6 imagwirizana ndi ghrelin receptors, pituitary gland imatulutsa hormone ya kukula. Homoni imeneyi imathandiza kukula, kamangidwe ka thupi, kukonza ma cell, ndi kagayidwe kachakudya. Imalimbitsa minofu, imawonjezera mphamvu ya minofu, ndikuthandizira kuchira ku ngozi ndi zovuta.
Kuchepetsa kwa Somatostatin
GHRP-6 imathanso kupondereza somatostatin, mahomoni omwe amalepheretsa kukula kwa timadzi. Poletsa somatostatin, GHRP-6 imatsimikizira kuti kukula kwa hormone sikuletsedwa kumasulidwa, zomwe zimapangitsa kuti hormone iyi ikhale yambiri m'thupi.
Synergistic Effect yokhala ndi GHRH
Mukatengedwa ndi kukula kwa hormone-release hormone (GHRH), GHRP-6 imakhala ndi synergistic effect. Akaphatikizidwa, amachulukitsa kuchuluka kwa timadzi tambiri tomwe timatulutsidwa ndi pituitary gland pamwamba pa zomwe zingatulutsidwe ngati peptide ina iperekedwa yokha.
Ndikofunikira kugula GHRP-6 kuchokera ku odziwika ogulitsa kuti atsimikizire mtundu wa peptide GHRP-6.AASraw, katswiri wa GHRP-6 wopanga ndi wogulitsa, akhoza kupereka GHRP-6 yapamwamba pa malo odziimira a R & D ndi fakitale. Ngati muli ndi zofuna, GHRP-6 yogulitsa kuchokera AASraw ndichisankho chabwino kwambiri.
Ubwino wa GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide 6) ndi peptide yopangidwa yomwe imayambitsa kutulutsidwa kwa hormone ya kukula m'thupi. Zake zopindulitsa zafufuzidwa mu kafukufuku ndi maphunziro osiyanasiyana. Komabe, ndikofunikira kuzindikira kuti zambiri mwazinthu zomwe zingapezeke zimatengera maphunziro a nyama komanso umboni wosadziwika bwino wochokera kwa ogwiritsa ntchito. Mayesero okhwima azachipatala amafunikira kuti atsimikizire izi mwa anthu. Nazi zina mwazopindulitsa za GHRP-6 malinga ndi kafukufuku omwe alipo.
Kutulutsidwa kwa Hormone ya Kukula
GHRP-6 imawonjezera kutulutsidwa kwa hormone ya kukula (GH) kuchokera ku pituitary gland. Kukula kwa timadzi ndi kofunikira pakukula kwa mwana ndipo kumathandiza akuluakulu kukhala ndi thanzi labwino komanso kukhala ndi thanzi labwino. Kuwonjezeka kwa GH kungapangitse kuwonjezeka kwa minofu ndi mphamvu. Izi zimachitika chifukwa GH imawonjezera kupangika kwa Insulin-monga Growth Factor 1 (IGF-1) m'chiwindi, yomwe ndi hormone yofunika kwambiri. minofu kukula. Chifukwa cha zabwino izi, GHRP-6 ndi chisankho chodziwika bwino pakati pa omanga thupi ndi othamanga omwe akuyang'ana kuti apititse patsogolo machitidwe awo akuthupi ndi matupi awo.
kuwonda
GHRP-6 imalimbikitsa kutulutsidwa kwa hormone ya kukula, yomwe ingathandize kukula kwa minofu yowonda. Kuchulukitsa minofu yowonda kumatha kukulitsa kagayidwe kachakudya chifukwa minofu imawotcha zopatsa mphamvu zambiri kuposa mafuta ngakhale mutapuma. Chotsatira chake, kuwonjezeka kwa minofu kungapangitse kuwonjezereka kwa calorie kuwotcha ndi kuwonda popita nthawi.
Kuphatikiza apo, kafukufuku wina akuwonetsa kuti kukula kwa hormone kungathandize pakuwonongeka kwa maselo amafuta (njira yotchedwa lipolysis), yomwe ingathandize kuyesa kuchepetsa thupi. Kafukufuku wochulukirapo, komabe, akufunika kuti amvetsetse zimango ndi mphamvu ya njirayi.
Kuchiritsa Mabala
GHRP-6 yasonyezedwa kuti ifulumizitse machiritso a bala ndi kubwezeretsa minofu. Izi zikhoza kukhala chifukwa cha ntchito yake yolimbikitsa kutulutsidwa kwa GH, yomwe imadziwika kuti imathandizira kusinthika kwa ma cell ndi kaphatikizidwe ka mapuloteni - zonsezi ndizofunikira kwambiri pakuchiritsa kwa thupi. Ubwino uwu ungakhale wopindulitsa kwa anthu omwe achira opaleshoni, ovulala, kapena omwe ali ndi mabala omwe amachira pang'onopang'ono chifukwa cha matenda monga shuga.
Zotsatira Anti-yotupa
Kafukufuku wina amasonyeza kuti GHRP-6 ikhoza kukhala ndi makhalidwe odana ndi kutupa, omwe angathandize matenda osiyanasiyana omwe amadziwika ndi kutupa, monga nyamakazi, mphumu, ndi matenda otupa.
Zotsatira za Cardio-protective
Kafukufuku watsopano akusonyeza kuti GHRP-6 ikhoza kukhala ndi katundu woteteza mtima. Zingathandize kuchepetsa kuwonongeka kwa minofu ya mtima, makamaka pambuyo pa zochitika monga matenda a mtima. Chitetezo ichi chili ndi mphamvu kuthekera kochepetsa chiopsezo cha matenda a mtima ndikuwonjezera thanzi la mtima, makamaka mwa anthu omwe ali pachiwopsezo kale.
Ndikofunikira kumvetsetsa kuti pali opanga ndi ogulitsa ambiri a GHRP-6 omwe akupezeka pa intaneti komanso pa intaneti; komabe, si onse odalirika. Gulani GHRP-6 kuchokera kwa opanga odziwika komanso ogulitsa chifukwa cha zotsatira zabwino kwambiri.AASraw imakhazikika pakupanga ndi kupereka GHRP-6 motsatira zofunikira za CGMP zopanga, ndi gulu lililonse la mankhwala pansi khalidwe yesani musanagulitse.
Zotsatira za GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide 6) nthawi zambiri imaloledwa bwino, koma monga mankhwala aliwonse kapena chowonjezera, imatha kukhala nayo. zotsatira zoyipa. Nthawi zonse ndikofunikira kukaonana ndi azachipatala musanayambe chithandizo china chilichonse.
- Kusungidwa kwa Madzi
- Kuchulukitsa Chilakolako
- Hypoglycemia
- Jekeseni malo zimachitikira
- Carpal Tunnel Syndrome
- Gynecomastia
Kumbukirani, izi si mndandanda wathunthu, ndi zotsatira zoyipazi zingasiyane munthu ndi munthu kutengera zinthu zambiri, kuphatikizapo thanzi, mlingo, ndi kuyankha kwa munthu pa chithandizo. Nthawi zonse funsani ndi wothandizira zaumoyo kuti mumvetsetse zoopsa ndi zopindulitsa zomwe zingakhalepo musanayambe GHRP-6 kapena mankhwala atsopano.
Musanagwiritse ntchito GHRP-6, monga iliyonse Peptide kapena chithandizo chamankhwala, ndi bwino kukaonana ndi katswiri wazachipatala. Atha kukupatsani upangiri, kuwunika zoopsa zomwe zingachitike, ndikuwunika momwe mukuyendera kuti mutsimikizire kugwiritsa ntchito moyenera. Komanso, kugula peptides kuchokera ku gwero loyenera ndilofunika kwambiri.AASraw imasunga kulamulira kolimba kwa khalidwe ndipo yapanga gulu lapamwamba la GHRP-6 yogulitsa. Ngati ndi kotheka, mwalandiridwa kugula peptide GHRP-6.
GHRP-6 vs GHRP-2
GHRP-6 ndi GHRP-2 onse ndi ma peptides opangidwa omwe ali m'gulu la ma peptides otulutsa timadzi (GHRPs). Amalimbikitsa kupanga kwa thupi la kukula kwa hormone (GH), yomwe ingapangitse kuwonjezeka kwa minofu ndi mphamvu, komanso kuchira bwino komanso kutaya mafuta. Pano pali kufananitsa kwa ma peptides awiriwa.
| GHRP-6 | GHRP-2 | |
| ntchito | Amalimbikitsa kutulutsa kwa hormone ya kukula | Amalimbikitsa kutulutsa kwa hormone ya kukula |
| Kugwiritsa Ntchito Choyamba | Amagwiritsidwa ntchito pomanga minofu, kupititsa patsogolo magwiridwe antchito, komanso ngati gawo la ma protocol ena oletsa kukalamba | Amagwiritsidwa ntchito pomanga minofu, kupititsa patsogolo magwiridwe antchito, komanso ngati gawo la ma protocol ena oletsa kukalamba |
| Kutulutsidwa kwa GH | Kutulutsidwa kwakukulu kwa GH, koma kocheperako pang'ono kuposa GHRP-2 | Kutulutsidwa kwamphamvu kwa GH poyerekeza ndi GHRP-6 |
| mbali zotsatira | Kuthekera kwa kusungirako madzi, kuchuluka kwa njala, hypoglycemia, zomwe zimachitika pamalo opangira jakisoni, kuthekera kwakukula kwa carpal tunnel syndrome, komanso nthawi zina za gynecomastia. | Zofanana zotsatira zoyipazi mpaka GHRP-6, koma ikhoza kukhala ndi zotsatira zochepa pang'ono chifukwa cha kuchuluka kwake potency |
GHRP-6 stacks ndi ma peptides ena
GHRP-6, mtundu wa peptide yotulutsa hormone, nthawi zambiri imagwiritsidwa ntchito pamodzi, kapena "yodzaza," ndi ma peptides ena kuti apititse patsogolo mphamvu zake. Izi ndichifukwa choti GHRP-6 imagwira ntchito mogwirizana ndi ma peptide awa, kutanthauza kuti kuphatikiza kwake kumakhala kwakukulu kuposa kuchuluka kwa zotsatira zake. Nawa ma peptides ochepa omwe amakhala ndi GHRP-6.
| okwana | Ubwino Umene Ungatheke | okwana |
| GHRP-6 + CJC-1295 | Kuchulukitsa katulutsidwe ka GH, kukulitsa kukula kwa minofu, kutayika bwino kwamafuta, ndikuchira msanga | GHRP-6 + CJC-1295 |
| GHRP-6 + Ipamorelin | Kutulutsa kwamphamvu kwa GH, kugona bwino, kukula kwa minofu, komanso kutaya mafuta | GHRP-6 + Ipamorelin |
| GHRP-6 + IGF-1 | Kupititsa patsogolo kukula kwa minofu, kuchira bwino, kuwonjezeka kwa kutaya mafuta, kuthekera mapindu odana ndi ukalamba | GHRP-6 + IGF-1 |
| GHRP-6 + Hexarelin | Kutulutsa kwamphamvu kwa GH, kukulitsa kukula kwa minofu, komanso kutaya mafuta | GHRP-6 + Hexarelin |
Chonde dziwani kuti zomwe zalembedwazo ndi zongonena chabe, osati malingaliro achipatala. Kumbukirani, ngakhale milu iyi imagwiritsidwa ntchito nthawi zambiri, iyenera kugwiritsidwa ntchito moyang'aniridwa ndi dokotala kapena katswiri wazachipatala. Kugwiritsira ntchito molakwa kungayambitse zotsatirapo zoipa pa thanzi, ndipo mapindu ndi ngozi zomwe zingakhalepo ziyenera kuunika mosamala.
Chenjezo: Mukamagula GHRP-6 kuchokera kwa ogulitsa, ndikofunikira kuika patsogolo ubwino ndi chitetezo cha mankhwala. Onetsetsani kuti ogulitsa GHRP-6 ndi odalirika komanso owunikiridwa bwino, komanso kuti amapereka chidziwitso chokwanira pakupeza, kupanga, ndi kuwongolera khalidwe lazinthu zawo. Ayeneranso kukhala omveka bwino pazosakaniza ndi kuchuluka kwa peptide. Nthawi zonse funsani dokotala musanayambe kumwa mankhwala atsopano, ndipo kumbukirani kuti mankhwalawa ayenera kugwiritsidwa ntchito moyang'aniridwa ndi achipatala.
Lipoti la Kuyesa kwa GHRP-6-HNMR
Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji GHRP-6 kuchokera ku AASraw?
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. Miriam Granado
Dipatimenti ya Endocrinology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain
2. Liz Hernández
Chipatala cha St. James' University, Leeds, UK,
3. Geneviève Frégeau
Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada4.
4. Andrea Giustina
Gawo la Endocrine, Dipatimenti ya Internal Medicine, Brescia, Italy
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
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[2] Cabrales A,Gil J,Fernández E,Valenzuela C,Hernández F,García I,Hernández A,Besada V,Reyes O,Padrón G,Berlanga J,Guillén G,González LJ (2013). "Phunziro la Pharmacokinetic la Growth Hormone-Releasing Peptide 6 (GHRP-6) mwa amuna asanu ndi anayi odzipereka athanzi". Eur J Pharm Sci. 48 (1–2): 40–6.
[3] Argente,J.,García-Segura,LM,Pozo,J.,& Chowen,JA (1996). Kukula kwa ma peptides otulutsa mahomoni: zachipatala komanso zofunikira. Kafukufuku wa Hormone, 46 (4-5), 155-159.
[4] Chen, C., Pullar, M., Loneragan, K., Zhang, J., & Clarke, IJ (1998). Zotsatira za kukula kwa hormone-release peptide-2 (GHRP-2) ndi GH-releasing hormone (GHRH) pamagulu a cAMP ndi GH kumasulidwa ku zotupa za acromegalic. Journal ya Neuroendocrinology, 10 (6), 473-480.
[5] Peñalva, A; Carballo, A; Pombo, M; Casanueva, FF; Dieguez, C (1993). "Zotsatira za kukula kwa hormone (GH) -release hormone (GHRH), atropine, pyridostigmine, kapena hypoglycemia pa GHRP-6-induced GH secretion mwa munthu". Journal of Clinical Endocrinology ndi Metabolism. 76 (1): 168-71.
[6] McGirr, R; McFarland,MS; McTavish, J; Luyt, LG; Dhanvantari, S (2011). "Kupanga ndi mawonekedwe a analog ya fluorescent ghrelin pojambula kukula kwa hormone secretagogue receptor 1a". Regulatory Peptides. 172 (1–3): 69–76.
[7] Ghigo,E.,Arvat,E.,Muccioli,G.,& Camanni,F. (1997). Kukula kwa ma peptides otulutsa mahomoni. European Journal of Endocrinology, 136 (5), 445-460.
