Mafotokozedwe Akatundu
Kodi GHRP-6 ndi chiyani?
GHRP-6, kapena Growth Hormone Releasing Peptide-6, ndi hexapeptide yopanga, kutanthauza kuti imakhala ndi ma amino acid asanu ndi limodzi. Peptide iyi imakhala ngati secretagogue, chomwe ndi chinthu chomwe chimayambitsa kutulutsidwa kwa chinthu china. Pankhani ya GHRP-6, imayambitsa kutulutsidwa kwa hormone ya kukula.
GHRP-6 imagwira ntchito potengera zotsatira za ghrelin ya hormone, yomwe ndi hormone yomwe imayang'anira njala ndipo imagwira ntchito yogawa komanso kugwiritsira ntchito mphamvu. pituitary gland. Kutulutsidwa kwa timadzi tating'onoting'ono, komanso gawo la kutsanzira ghrelin, kumabweretsa chiwongola dzanja, chomwe chingakhale chopindulitsa kwa anthu omwe akufuna kupeza minofu.
Kuphatikiza apo, GHRP-6 yadziwika kuti imatha kukonza kugona, kulimbikitsa kutaya mafuta, kuthandizira chitetezo chamthupi, ndikuthandizira kuteteza mtima. Nthawi zambiri amagwiritsidwa ntchito ndi omanga thupi ndi othamanga chifukwa cha momwe zimakhudzira kukula kwa mahomoni.
Kodi GHRP-6 imagwira ntchito bwanji?
GHRP-6 (Growth Hormone Releasing Peptide-6) imagwira ntchito motsanzira ghrelin ya hormone, yomwe imayambitsa kuwonjezeka kwa endogenous (opangidwa mkati) kukula kwa hormone kumasulidwa m'thupi. Pano pali kuyang'anitsitsa kwa machitidwe ake.
Kukondoweza kwa Ghrelin
Ghrelin, yemwe amadziwika kuti "hormone yanjala," ndi timadzi timene timapangidwa ndi m'mimba poyankha kusala kudya komwe kumapangitsa chidwi, zomwe zimapangitsa kuti chakudya chichuluke. GHRP-6 imagwira ntchito ngati ghrelin agonist, zomwe zikutanthauza kuti imamangiriza ndikulimbikitsa ma ghrelin receptors muubongo, kumawonjezera kumva njala.
Kutulutsidwa kwa Hormone ya Kukula
Pamene GHRP-6 imagwirizana ndi ghrelin receptors, pituitary gland imatulutsa hormone ya kukula. Hormoni iyi imathandizira kukula, kapangidwe ka thupi, kukonza ma cell, ndi metabolism. Imalimbitsa minofu, imawonjezera mphamvu ya minofu, komanso imathandizira kuchira ku ngozi ndi zovuta.
Kuchepetsa kwa Somatostatin
GHRP-6 imathanso kupondereza somatostatin, timadzi timene timalepheretsa kupanga timadzi tambiri. Poletsa somatostatin, GHRP-6 imatsimikizira kuti kukula kwa hormone sikuletsedwa kumasulidwa, zomwe zimapangitsa kuti hormone iyi ikhale yochuluka m'thupi.
Synergistic Effect yokhala ndi GHRH
Mukatengedwa ndi kukula kwa hormone-release hormone (GHRH), GHRP-6 imakhala ndi synergistic effect. Akaphatikizidwa, amachulukitsa kuchuluka kwa timadzi tambiri tomwe timatulutsidwa ndi pituitary gland pamwamba pa zomwe zingatulutsidwe ngati peptide ina iperekedwa yokha.
Ndikofunika kugula GHRP-6 kuchokera kwa ogulitsa odziwika kuti atsimikizire mtundu wa peptide GHRP-6.AASraw, katswiri wa GHRP-6 wopanga ndi wogulitsa, akhoza kupereka GHRP-6 yapamwamba kwambiri ya R&D center ndi fakitale.Ngati muli ndi zofuna, GHRP-6 yogulitsa kuchokera ku AASraw ndi yabwino kwambiri.
Ubwino wa GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide 6) ndi peptide yopangidwa yomwe imayambitsa kutulutsidwa kwa hormone ya kukula m'thupi. Zopindulitsa zake zafufuzidwa mu kafukufuku ndi maphunziro osiyanasiyana. Komabe, ndikofunikira kuzindikira kuti zambiri mwazinthu zomwe zingapezeke zimatengera maphunziro a nyama komanso umboni wosadziwika bwino wochokera kwa ogwiritsa ntchito. Mayesero okhwima azachipatala amafunikira kuti atsimikizire izi mwa anthu. Nazi zina mwazopindulitsa za GHRP-6 malinga ndi kafukufuku omwe alipo.
Kutulutsidwa kwa Hormone ya Kukula
GHRP-6 imawonjezera kutulutsidwa kwa hormone ya kukula (GH) kuchokera ku pituitary gland. Hormone ya kukula ndiyofunikira pakukula kwa mwana ndipo imathandiza akuluakulu kukhala ndi thanzi labwino komanso kukhala ndi thanzi labwino. Kuwonjezeka kwa GH kungapangitse kuwonjezeka kwa minofu ndi mphamvu. Izi zimachitika chifukwa GH imawonjezera kupanga kwa Insulin-monga Growth Factor 1 (IGF-1) m'chiwindi, yomwe ndi hormone yofunika kwambiri ya kukula kwa minofu. Chifukwa cha zabwino izi, GHRP-6 ndi chisankho chodziwika bwino pakati pa omanga thupi ndi othamanga omwe akuyang'ana kuti apititse patsogolo machitidwe awo akuthupi ndi thupi.
kuwonda
GHRP-6 imalimbikitsa kutulutsa kwa hormone ya kukula, yomwe ingathandize kukula kwa minofu yowonda. Kuchulukitsa minofu yowonda kumatha kukulitsa kagayidwe kachakudya chifukwa minofu imawotcha zopatsa mphamvu zambiri kuposa mafuta ngakhale mutapuma. Zotsatira zake, kuwonjezeka kwa minofu kungayambitse kuwotcha kwa calorie ndi kuwonda pakapita nthawi.
Kuphatikiza apo, kafukufuku wina akuwonetsa kuti kukula kwa hormone kumatha kuthandizira kuwonongeka kwa maselo amafuta (njira yotchedwa lipolysis), yomwe ingathandize kuyesa kuchepetsa thupi. Kafukufuku wochulukirapo, komabe, akufunika kuti amvetsetse zimango ndi mphamvu ya njirayi.
Kuchiritsa Mabala
GHRP-6 yasonyezedwa kuti ifulumizitse machiritso a bala ndi kubwezeretsa minofu. Izi zitha kukhala chifukwa cha gawo lake lolimbikitsa kutulutsidwa kwa GH, yomwe imadziwika kuti imathandizira kusinthika kwa ma cell ndi kaphatikizidwe ka mapuloteni - zonse zomwe ndizofunikira pakuchiritsa kwa thupi. Ubwino uwu ungakhale wopindulitsa kwa anthu omwe achira opaleshoni, ovulala, kapena omwe ali ndi mabala omwe amachira pang'onopang'ono chifukwa cha matenda monga shuga.
Zotsatira Anti-yotupa
Kafukufuku wina akuwonetsa kuti GHRP-6 ikhoza kukhala ndi zotsutsana ndi kutupa, zomwe zingathandize matenda osiyanasiyana omwe amadziwika ndi kutupa, monga nyamakazi, mphumu, ndi matenda otupa.
Zotsatira za Cardio-protective
Kafukufuku watsopano akusonyeza kuti GHRP-6 ikhoza kukhala ndi katundu woteteza mtima. Zingathandize kuchepetsa kuwonongeka kwa minofu ya mtima, makamaka pambuyo pa zochitika monga matenda a mtima. Kuteteza kumeneku kungathe kuchepetsa chiopsezo cha matenda a mtima komanso kulimbitsa thanzi la mtima, makamaka kwa anthu omwe ali pachiopsezo.
Ndikofunikira kumvetsetsa kuti pali opanga ndi ogulitsa ambiri a GHRP-6 omwe akupezeka pa intaneti komanso pa intaneti; Komabe, si onse omwe ali odalirika.Gulani GHRP-6 kuchokera kwa wopanga odalirika komanso wogulitsa kuti mupeze zotsatira zabwino kwambiri.AASraw imakhazikika pakupanga ndi kupereka GHRP-6 potsatira zofunikira za CGMP zopanga, ndi gulu lililonse lazinthu zomwe zimayesedwa bwino. asanagulitse.
Zotsatira za GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide 6) nthawi zambiri imaloledwa bwino, koma monga mankhwala aliwonse kapena zowonjezera, zimatha kukhala ndi zotsatira zoyipa. Nthawi zonse ndikofunikira kukaonana ndi azachipatala musanayambe chithandizo china chilichonse.
- Kusungidwa kwa Madzi
- Kuchulukitsa Chilakolako
- Hypoglycemia
- Jekeseni malo zimachitikira
- Carpal Tunnel Syndrome
- Gynecomastia
Kumbukirani, uwu si mndandanda wathunthu ndipo zotsatira zake zimatha kusiyana pakati pa munthu kutengera zinthu zambiri, kuphatikiza thanzi, mlingo, komanso momwe munthu aliyense angayankhire chithandizo. Nthawi zonse funsani ndi wothandizira zaumoyo kuti mumvetsetse zoopsa ndi zopindulitsa zomwe zingakhalepo musanayambe GHRP-6 kapena mankhwala atsopano.
Musanagwiritse ntchito GHRP-6, monga peptide iliyonse kapena chithandizo chamankhwala, ndi bwino kukaonana ndi katswiri wa zaumoyo.Atha kupereka uphungu, kuwunika zoopsa zomwe zingatheke, ndikuyang'ana momwe mukupitira patsogolo kuti mutsimikizire kugwiritsa ntchito moyenera komanso moyenera. gwero loyenera ndilofunika kwambiri.AASraw imasunga khalidwe lolimba kwambiri ndipo yapanga gulu lapamwamba la GHRP-6 yogulitsa.Ngati kuli kofunikira, mwalandiridwa kugula peptide GHRP-6.
GHRP-6 vs GHRP-2
GHRP-6 ndi GHRP-2 onse ndi ma peptides opangidwa omwe ali m'gulu la ma peptides otulutsa timadzi (GHRPs). Amalimbikitsa kupanga kwa thupi kwa hormone ya kukula (GH), yomwe ingapangitse kuwonjezeka kwa minofu ndi mphamvu, komanso kuchira bwino komanso kutaya mafuta. Pano pali kufananitsa kwa ma peptides awiriwa.
| GHRP-6 | GHRP-2 | |
| ntchito | Amalimbikitsa kutulutsa kwa hormone ya kukula | Amalimbikitsa kutulutsa kwa hormone ya kukula |
| Kugwiritsa Ntchito Choyamba | Amagwiritsidwa ntchito pomanga minofu, kupititsa patsogolo magwiridwe antchito, komanso ngati gawo la ma protocol ena oletsa kukalamba | Amagwiritsidwa ntchito pomanga minofu, kupititsa patsogolo magwiridwe antchito, komanso ngati gawo la ma protocol ena oletsa kukalamba |
| Kutulutsidwa kwa GH | Kutulutsidwa kwakukulu kwa GH, koma kocheperako pang'ono kuposa GHRP-2 | Kutulutsidwa kwamphamvu kwa GH poyerekeza ndi GHRP-6 |
| Zotsatira Zotsatira | Kuthekera kwa kusungirako madzi, kuchulukitsitsa kwa njala, hypoglycemia, zomwe zimachitika pamalo ojambulira, kuthekera kwa chitukuko cha matenda a carpal tunnel, komanso nthawi zina za gynecomastia. | Zofanana ndi zotsatira za GHRP-6, koma zimatha kukhala ndi zotsatira zochulukirapo chifukwa cha kuchuluka kwake. |
GHRP-6 stacks ndi ma peptides ena
GHRP-6, mtundu wa peptide yotulutsa timadzi timene timatulutsa timadzi tambiri, nthawi zambiri imagwiritsidwa ntchito kuphatikiza, kapena "yodzaza," ndi ma peptides ena kuti apititse patsogolo mphamvu zake. Izi ndichifukwa choti GHRP-6 imagwira ntchito mogwirizana ndi ma peptide awa, kutanthauza kuti kuphatikiza kwake kumakhala kwakukulu kuposa kuchuluka kwa zotsatira zake. Nawa ma peptides ochepa omwe amakhala ndi GHRP-6.
| okwana | Ubwino Umene Ungatheke | okwana |
| GHRP-6 + CJC-1295 | Kuchulukitsa katulutsidwe ka GH, kukulitsa kukula kwa minofu, kutayika kwamafuta, ndikuchira msanga | GHRP-6 + CJC-1295 |
| GHRP-6 + Ipamorelin | Kutulutsa kwamphamvu kwa GH, kugona bwino, kukula kwa minofu, komanso kutaya mafuta | GHRP-6 + Ipamorelin |
| GHRP-6 + IGF-1 | Kupititsa patsogolo kukula kwa minofu, kuchira bwino, kuwonjezeka kwa kutaya mafuta, zopindulitsa zotsutsana ndi ukalamba | GHRP-6 + IGF-1 |
| GHRP-6 + Hexarelin | Kutulutsa kwamphamvu kwa GH, kukulitsa kukula kwa minofu, komanso kutaya mafuta | GHRP-6 + Hexarelin |
Chonde dziwani kuti izi ndi zongonena, osati malingaliro azachipatala. Kumbukirani, ngakhale milu iyi imagwiritsidwa ntchito nthawi zambiri, iyenera kugwiritsidwa ntchito moyang'aniridwa ndi achipatala kapena katswiri wazachipatala. Kugwiritsa ntchito molakwika kungayambitse mavuto azaumoyo, ndipo mapindu omwe angakhalepo ndi kuopsa kwake kuyenera kuyesedwa mosamala.
Chenjezo: Mukamagula GHRP-6 kuchokera kwa ogulitsa, ndikofunikira kuika patsogolo ubwino ndi chitetezo cha malonda. Onetsetsani kuti ogulitsa GHRP-6 ndi odalirika komanso owunikiridwa bwino, komanso kuti amapereka chidziwitso chokwanira pakupeza, kupanga, ndi kuwongolera khalidwe lazinthu zawo. Ayeneranso kukhala omveka ponena za zosakaniza ndi kuchuluka kwa peptide. Nthawi zonse funsani katswiri wa zaumoyo musanayambe mankhwala atsopano kapena mankhwala, ndipo kumbukirani kuti mankhwalawa ayenera kugwiritsidwa ntchito moyang'aniridwa ndi achipatala.
Lipoti la Kuyesa kwa GHRP-6-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji GHRP-6 kuchokera ku AASraw?
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Liu,Q.,Lei,T.,Adams,EF,Buchfelder,M.,& Fahlbusch,R. (1997) .Ubale pakati pa GHRP-6 ndi TPA mu lamulo la kukula kwa hormone secretion ndi human pituitary somatotrophinomas. Journal of Tongji Medical University,17(3),132-135.
[2] Cabrales A,Gil J,Fernández E,Valenzuela C,Hernández F,García I,Hernández A,Besada V,Reyes O,Padrón G,Berlanga J,Guillén G,González LJ (2013). "Phunziro la Pharmacokinetic la Growth Hormone-Releasing Peptide 6 (GHRP-6) mwa amuna asanu ndi anayi odzipereka athanzi". Eur J Pharm Sci. 48 (1–2): 40–6.
[3] Argente,J.,García-Segura,LM,Pozo,J.,& Chowen,JA (1996). Kukula kwa ma peptides otulutsa mahomoni: zachipatala komanso zofunikira. Kafukufuku wa Hormone, 46 (4-5), 155-159.
[4] Chen, C., Pullar, M., Loneragan, K., Zhang, J., & Clarke, IJ (1998). Zotsatira za kukula kwa hormone-release peptide-2 (GHRP-2) ndi GH-releasing hormone (GHRH) pamagulu a cAMP ndi GH kumasulidwa ku zotupa za acromegalic. Journal ya Neuroendocrinology, 10 (6), 473-480.
[5] Peñalva, A; Carballo, A; Pombo, M; Casanueva, FF; Dieguez, C (1993). "Zotsatira za kukula kwa hormone (GH) -release hormone (GHRH), atropine, pyridostigmine, kapena hypoglycemia pa GHRP-6-induced GH secretion mwa munthu". Journal of Clinical Endocrinology ndi Metabolism. 76 (1): 168-71.
[6] McGirr, R; McFarland,MS; McTavish, J; Luyt, LG; Dhanvantari, S (2011). "Kupanga ndi mawonekedwe a analog ya fluorescent ghrelin pojambula kukula kwa hormone secretagogue receptor 1a". Regulatory Peptides. 172 (1–3): 69–76.
[7] Ghigo,E.,Arvat,E.,Muccioli,G.,& Camanni,F. (1997). Kukula kwa ma peptides otulutsa mahomoni. European Journal of Endocrinology, 136 (5), 445-460.
