Mafotokozedwe Akatundu
Hexarelin ndi chiyani?
Chifukwa cha mphamvu ya Hexarelin yowonjezera katulutsidwe ka Hormone ya Kukula kwachilengedwe, zotsatira zake zambiri zimakhala zofanana ndi za GH zopangidwa, ngakhale pang'ono pang'ono. kukula kwa ulusi wa minofu womwe ulipo kale, chitetezo cha mitsempha, kubwezeretsanso, kuteteza ndi kuchiritsa. Komanso, ma GH receptors mu minofu ya adipose (mafuta) amalola kuchepetsa mafuta ndi Hexarelin kugwiritsa ntchito. -Like Growth Factor (IGF-1) kukwera m'chiwindi.IGF-1 ndiye chifukwa chachikulu cha kukula kwa minofu poyankha kukakamiza kwa GH.
Palibe kulimbikitsa chilakolako chogwiritsa ntchito Hexarelin (mosiyana ndi kuwonjezeka kwa chilakolako cha GHRP-6) chifukwa cholephera kuonjezera kwambiri milingo ya Ghrelin yomwe imayambitsa njala yowonjezera komanso kutulutsa msanga m'mimba.
M'maphunziro omwe Hexarelin anabayidwa mochepa, Hormone ya Kukula, yoyesedwa kupyolera mu plasma, inawonjezeka kwambiri ndipo mkati mwa mphindi makumi atatu a jakisoni. kg, kuwonjezereka kwina kulikonse kwa mlingo kunapezeka kuti sikuthandiza poyambitsa kuyankha kwa GH.
Kafukufuku wasonyeza kuti zotsatira za Hexarelin pa GH stimulation tapered pakati pa masabata 4 mpaka 16. Kulekanitsa maulendo ndi masabata a 4 kuchoka nthawi, kupeŵa kusokoneza maganizo olakwika ndi kuzungulira kwa Hexarelin kunapanga zotsatira zofanana ndi zomwe zimayambira.
Hexarelin (Hexarelin Acetate) ndi hexapeptide yopangidwa m'banja la kukula komwe kumapangitsa kutulutsidwa kwa hormone ya kukula (GH) ndipo sikusokoneza mphamvu ya thupi kupanga GH. GHRP-6 koma popanda chilakolako chowonjezeka chifukwa cholephera kuonjezera kwambiri Ghrelin yomwe imayambitsa chilakolako chowonjezeka komanso kutulutsa m'mimba mwamsanga. thupi la munthu.Hexarelin m'maphunziro a nthawi inayake yasonyeza kuti imachepetsa mafuta a visceral.Hexarelin (Hexarelin Acetate) monga Ma Peptides ena a Growth Hormone Releasing Peptides amathandiza kwambiri synergistically akagwiritsidwa ntchito ndi GHRH monga Sermorelin kapena Modified GRF 1-29.
Kodi Hexarelin amagwira ntchito bwanji?
Hexarelin kuchokera ku AASraw ndi yosiyana kwambiri ndi ma GHRP ena omwe alipo lero.Ambiri amaona kuti hexarelin ndi underdog.Ndi chimodzi mwa zinthu zambiri zomwe sizinalandire chisamaliro chifukwa zimaganiziridwa kuti zilibe makhalidwe ofunika omwe ma peptides abwino ayenera kukhala nawo.Kukwanira kunena kuti hexarelin Lero, komabe, tikuwuzani chifukwa chomwe peptide iyi siyenera kukankhidwira pambali.
Muyenera kudziwa kuti hexarelin si GHRP yanu yeniyeni.Mapangidwe ake monga hexapeptide amachititsa kuti ikhale njira yabwino kwambiri yolimbikitsira kutulutsidwa kwa mahomoni akukula.Ngakhale kuti machitidwe ake sanamvetsetse bwino ndi akatswiri, amadziwika bwino kuti amachitapo kanthu. Pazigawo zonse za hypothalamic ndi pituitary gland.Chofunika kwambiri, ndi peptide imodzi yomwe imatha kupanga kuchuluka kwakukulu kwa mahomoni okulitsa.
Mofanana ndi ma peptide ambiri, hexarelin imatha kuonjezera kutulutsa kwa mahomoni akukula kwachilengedwe.Chofunikanso kwambiri, sichichepetsa mphamvu yachibadwa ya thupi kumasula mahomoni akukula.Kafukufuku wambiri wasonyezanso kuti kumawonjezera kutaya kwa mafuta, kumalimbitsa minofu yolumikizana, kusintha elasticity wa khungu ndi kuonjezera mitosis, meiosis ndi fupa mchere kachulukidwe.
Kafukufuku, komabe, awonetsa kuti hexarelin ikangobayidwa kudzera munjira yocheperako, imayambitsa kugwira ntchito kwa pituitary gland kudzera mu pulse.Mofanana ndi GHRP-6, imathandiza kupititsa patsogolo kufalikira kwa mahomoni okulitsa mkati mwa thupi.Ngakhale kukhala ndi zofanana ndi GHRP-6, imachita mosiyana m'njira zina. Chifukwa chimodzi, sichimayambitsa vuto lililonse la njala. Ndizowona kuti hexarelin imatha kukulitsa kuchuluka kwa mahomoni m'thupi komabe, imathanso kuchepetsa somatostati-imodzi mwa zifukwa zazikulu zomwe sizipanga kukula kwa hormone.Izi zikutanthawuza kuti padzakhala kuwonjezeka kwa kukula kwa mahomoni.
Ndi mphamvu yake yokweza IGF-1 ndi kukula kwa hormone, imatha kugwira ntchito ngati zida zabwino kwambiri za PCT kwa anthu omwe akuyendetsa njinga ndi IGF-1 kapena mahomoni ena okulirapo. kuchuluka kwa prolactin ndi cortisol.Ili ndi mgwirizano wamphamvu kwambiri wowonjezera cortisol ndi prolactin poyerekeza ndi GHRP zina zomwe zilipo.
Ubwino wa Hexarelin
①Kukula kwa Minofu Yowonda
Simuli nokha ngati simukusangalala ndi kulemera kwanu kapena thupi lanu. vuto lomwe likuyesera kuchiza.
Mwamwayi, kafukufuku woyambirira pa Hexarelin akulonjeza ndipo ambiri amaima kumbuyo kwa peptide m'dera lonyamula zolemera.Hexarelin imadziwika kuti imapangitsa kuti thupi likhale lopangidwa ndi kukula kwa hormone yomwe imathandizira kukula kwa minofu.Peptide imakhala ngati agonist wosankha kwambiri wa GHSR ndi insulini. -monga Growth Factor 1 (IGF-1) .Imachitanso mofanana ndi ghrelin poyambitsa kukula kwa hormone secretagogue receptor pamene kupondereza inhibitors monga somatostatin.Omwe amagwiritsa ntchito Hexarelin mu kulimbitsa thupi ndi kulimbitsa thupi amazindikira zotsatira zochititsa chidwi ponena za kupindula kwa minofu ndi mphamvu.
②Kuwotcha Mafuta & Kuchepetsa Kuwonda
Kumanga minofu yowonda ndi kotheka pokhapokha pochotsa mafuta osafunika. Ndi vuto lomwe ambiri aife timalimbana nalo pamene tikuyesera kuti tikhalebe ndi zakudya zopatsa thanzi komanso zolimbitsa thupi.
Mwamwayi, Hexarelin imatha kufulumizitsa kuwonda poyang'ana zochitika zachilengedwe zofunika kwambiri m'thupi. Kutaya mafuta mwachangu kumatha kukuthandizani kukwaniritsa zolinga zanu zoonda mwachangu kuposa kale. Chofunika kwambiri, muchita izi motetezeka kwambiri komanso njira yabwino poyerekeza ndi mankhwala ena ovulaza kapena mapulogalamu a zakudya.Kuphatikizika kwa mafuta oyaka ndi kupindula kwa minofu yowonda kuchokera ku Hexarelin kungayambitse kukonzanso thupi lonse.
③Imawonjezera Mphamvu ndi Kusinthasintha
Pamene mukulandira kusintha kwa thupi lathunthu mumakhalanso ndi mwayi wokhala ndi mphamvu zowonjezera komanso kusinthasintha.
Hexarelin imadziwika kuti imathandizira kwambiri kulimba kwa tendon ndi ligament. Kuphatikiza apo, peptide imalumikizidwa ndi kusinthasintha komanso thanzi labwino. Ndikofunikira kuyang'ana kwambiri ma tendon, ligaments, ndi minofu mukamakalamba chifukwa ali pachiwopsezo chovulala.
Chifukwa chake, simungapindule pang'ono ngati mutakhala kumbali chifukwa chakuvulala kwakanthawi. Hexarelin sikuti imakuthandizani kuti muchiritsidwe ndikugunda masewera olimbitsa thupi mwachangu komanso kupewa kuvulala koopsa poyamba chifukwa cha kusinthasintha.
④Kuchira Kwamphamvu & Kuchita Bwino Kwambiri
Palinso maubwino owonjezera pakuchepetsa thupi, kukhala ndi minofu yowonda, ndikuwongolera mphamvu / kusinthasintha kwathunthu.
Poyamba, muchira msanga zomwe zimakupatsani mwayi wobwerera ku masewera olimbitsa thupi ndikubwerera kuntchito.
Hexarelin imadziwika kuti imathandizira kuchira msanga kuchokera kuvulala ndi maphunziro. Imalimbana kwambiri ndi kuvulala kwa minofu ndi mafupa omwe amalepheretsa kupita patsogolo kwa masewera olimbitsa thupi.
Kuphatikiza apo, mudzawona kusintha kwakukulu pamasewera othamanga.
⑤ Imalimbitsa Magonedwe Abwino & Umoyo Wabwino Konse
Phindu lina la Hexarelin ndi maumboni okhudza momwe peptide imasinthira kugona bwino.
Ndipo, popeza kugona n'kofunika kwambiri kuti munthu akhale ndi thanzi labwino, peptide imathandizira kuti munthu akhale ndi thanzi labwino.
Simudzangogona bwino komanso kumva bwino chifukwa cha zabwino za Hexarelin.
Zotsatira zoyipa za Hexarelin
Mwamwayi, zotsatira zoyipa za Hexarelin ndizochepa.
Zotsatira zofala kwambiri zimaphatikizapo kutopa kapena kutopa.Ndi chifukwa cha mphamvu ya kukula kwa hormone kuonjezeranso chilakolako cha kugona.Komabe, kusunga mlingo wochepa kumatha kuthetsa vutoli mosavuta. kusunga madzi.
Chotsatira china chomwe chanenedwa ndicho kumva kumva kumva kuwawa kapena dzanzi m'manja kapena kumapazi.
Amene ali ndi zizindikiro ayenera kuchepetsa mlingo kapena kuganizira kuchotsa ku supplementation palimodzi.
Ndi bwino kukaonana ndi dokotala musanagwiritse ntchito ngati mwamwa kale mankhwala ena.
Hexarelin motsutsana ndi ma peptides ena
Hexarelin vs Ipamorelin
Ngakhale kuti njira yogwiritsira ntchito komanso phindu lalikulu la ma peptide onsewa ndi ofanana, kusiyana kumabwera muzopindulitsa zachiwiri.Ipamorelin imatsimikiziridwa kuti imapangitsa kuti mafupa azikhala bwino, pamene hexarelin imapangitsa kuti mtima ukhale wathanzi.
Hexarelin vs GHRP-6
Ma peptides onsewa amagwira ntchito mofanana.Komabe, GHRP-6 (9) sichiyambitsa njira zina za neuroendocrine monga hexarelin.Potengera potency, GHRP-6 ili ndi theka la moyo wautali kuti ligwire ntchito m'thupi kuposa hexarelin. .Chifukwa chake, hexarelin imapambana mpikisano wotsutsana ndi GHRP-6 motsimikiza!
Kodi Mungagule Kuti Hexarelin?
Thandizo la peptide la Hexarelin limakhudza kwambiri thanzi lathunthu.Imathandiza kupeza minofu, kuchepetsa mafuta, kuwonjezera mphamvu, ndi zina zambiri.Pano ku AASraw, tadzipereka kuti tipereke peptide yambiri kuphatikizapo kuwonda, mankhwala okhudzana ndi kugonana, ndi zina. hormone.Ngati mukufuna Hexarelin yogulitsa kapena ma peptide ena aliwonse, lembani mawonekedwe omwe ali pansipa kuti mukonzekere zokambirana zanu ndikulankhula ndi akatswiri athu apadera.
Hexarelin Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji Hexarelin kuchokera ku AASraw?
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
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[2] Ezio Ghigo (1999). Kukula kwa Hormone Secretagogues: Zopeza Zoyambira ndi Zachipatala. Elsevier. tsamba 178-. ISBN 978-0-444-82933-7.
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[4] Ghigo E, Arvat E, Gianotti L, Imbimbo BP, Lenaerts V, Deghenghi R, et al. (1994). "Kukula kwa hormone-kutulutsa ntchito ya hexarelin, hexapeptide yatsopano yopangira, pambuyo pa intravenous, subcutaneous, intranasal, and oral administration mwa munthu". Journal of Clinical Endocrinology & Metabolism. 78 (3): 693–8. doi:10.1210/jcem.78.3.8126144. Chithunzi cha PMID 8126144.
[5] Imbimbo, BP; Mantha, T.; Edwards, M.; Amin, D.; Dalton, N.; Bougnon, F.; Lenaerts, V.; Wďż˝thrich, P.; Deghenghi, R. (1994). "Kukula kwa mahomoni otulutsa hexarelin mwa anthu". European Journal of Clinical Pharmacology. 46 (5): 421–5. doi:10.1007/bf00191904. PMID 7957536. S2CID 19573322.
[6] CR Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. masamba 617-. ISBN 978-0-412-46630-4.
