Mafotokozedwe Akatundu
Hexarelin ndi chiyani?
Chifukwa cha mphamvu ya Hexarelin yowonjezera kutulutsa kwa Hormone ya Kukula kwachilengedwe, zotsatira zake zambiri zimakhala zofanana ndi zomwe zimapangidwa ndi GH, ngakhale pang'ono pang'ono. Zotsatira za kugwiritsiridwa ntchito kwake zimaphatikizapo kuwonjezeka kwa mphamvu, kukula kwa ulusi watsopano wa minofu, kuwonjezeka kwa kukula kwa minofu yomwe ilipo kale, chitetezo cha mitsempha, kutsitsimula pamodzi, chitetezo, ndi machiritso. Komanso, ma GH receptors mu minofu ya adipose (mafuta) amalola kuchepetsa mafuta ndikugwiritsa ntchito Hexarelin. Kuwonjezeka kwa kuyendayenda kwa GH kupyolera mu ntchito ya Hexarelin kumayambitsa milingo ya Insulin-Like Growth Factor (IGF-1) kukwera mu chiwindi.IGF-1 ndiye chifukwa chachikulu cha minofu kukula poyankha kukondoweza kwa GH.[3][5]
Palibe kulimbikitsa chilakolako chogwiritsa ntchito Hexarelin (mosiyana ndi kuwonjezeka kwa chilakolako cha GHRP-6) chifukwa cholephera kuonjezera kwambiri milingo ya Ghrelin yomwe imayambitsa njala yowonjezera komanso kutulutsa msanga m'mimba.
M'maphunziro omwe Hexarelin adabayidwa pansi pakhungu, Kukula Timadzi, yoyezedwa kudzera m'magazi a plasma, inawonjezeka kwambiri mkati mwa mphindi makumi atatu a jekeseni. Kuwonjezeka kwa GH kwapezeka kuti n'kothandiza mpaka 2mg / kg, kuwonjezeka kwina kulikonse kwa mlingo kunapezeka kuti sikungatheke poyambitsa GH kuyankha.
Kafukufuku wasonyeza kuti zotsatira za Hexarelin pa GH stimulation tapered pakati pa masabata 4 mpaka 16. Kulekanitsa maulendo ndi masabata a 4 kuchokera nthawi, kupeŵa kusokoneza maganizo olakwika, ndipo Hexarelin yotsatira inatulutsa zotsatira zofanana ndi zoyamba.
Hexarelin (Hexarelin Acetate) ndi hexapeptide yopangira mu banja la kukula komwe kumathandizira kutulutsidwa kwa kukula kwa hormone (GH) ndipo sichimasokoneza mphamvu ya thupi kupanga GH yake. Mwadongosolo, Hexarelin (Hexarelin Acetate) ndi yofanana ndi kapangidwe kake GHRP-6 koma popanda chilakolako chowonjezeka chifukwa chakulephera kuonjezera kwambiri ma Ghrelin omwe amachititsa kuti chilakolako chiwonjezeke komanso kutaya msanga m'mimba. Hexarelin ndi secretagogue ya kukula kwa mahomoni opangidwa kuchokera ku ma amino acid asanu ndi limodzi. Lili ndi mphamvu kukula kwa hormone-kutulutsa katundu mwa munthu thupi. Hexarelin mu maphunziro pa nthawi inayake yasonyeza kuti amachepetsa mafuta a visceral. Hexarelin (Hexarelin Acetate) monga ena Kukula kwa Hormone Kutulutsa Peptides kumakhala kothandiza kwambiri polumikizana ndi GHRH monga Sermorelin kapena Modified GRF 1-29.
Kodi Hexarelin amagwira ntchito bwanji?
Hexarelin kuchokera AASraw ndizosiyana kwambiri ndi ma GHRP ena omwe alipo lero. Ambiri amaona kuti hexarelin ndi yachibwana. Ndi chimodzi mwazinthu zambiri zomwe sizinalandire chidwi chifukwa zimaganiziridwa kuti zilibe mikhalidwe yofunika yomwe ma peptides abwino kwambiri ayenera kukhala nayo. Ndikokwanira kunena kuti hexarelin ndi peptide yomwe yachepetsedwa kwambiri. Lero, komabe, tikuwuzani chifukwa chake izi Peptide sichiyenera kukankhidwira pambali.
Muyenera kudziwa kuti hexarelin si GHRP yanu. Kapangidwe kake ngati hexapeptide kumapangitsa kuti ikhale njira yabwino kwambiri yolimbikitsira kutulutsa kwamphamvu kwa mahomoni okula. Ngakhale kuti machitidwe ake sanamvetsetse bwino ndi akatswiri, amadziwika bwino kuti amagwira ntchito m'dera la hypothalamic ndi pituitary gland. Chofunika kwambiri, ndi peptide imodzi yomwe imatha kupanga mahomoni okulirapo.
Mofanana ndi ma peptides ambiri, hexarelin imatha kuonjezera kutulutsidwa kwa mahomoni achilengedwe akukula. Chofunika kwambiri, sichichepetsa mphamvu yachilengedwe ya thupi kutulutsa mahomoni okula. Kafukufuku wambiri wasonyezanso kuti kumawonjezera kutayika kwa mafuta, kumalimbitsa minofu yolumikizana, kumapangitsa kuti khungu likhale losalala, ndikuwonjezera mitosis, meiosis, ndi fupa la mchere.
Kafukufuku, komabe, awonetsa kuti hexarelin ikangobayidwa kudzera munjira yodutsa, imayambitsa kugwira ntchito kwa pituitary gland kudzera kugunda. Mofanana ndi GHRP-6, imathandizira kupititsa patsogolo kayendedwe ka kukula kwa mahomoni mkati mwa thupi. Ngakhale kukhala ndi zofanana ndi GHRP-6, imachita mosiyana m'njira zina. Chifukwa chimodzi, sichimayambitsa vuto lililonse la njala. Ndizowona kuti hexarelin imatha kukulitsa kuchuluka kwa timadzi tating'ono m'thupi komabe, imathanso kuchepetsa somatostatin-chimodzi mwazomwe zimayambitsa kusapanga kwa mahomoni okula. Izi zikutanthauza kuti padzakhala kuchuluka kwa mahomoni okula.[2][5]
Ndi mphamvu yake yokweza IGF-1 ndi kukula kwa hormone, imatha kugwira ntchito yabwino kwambiri Chida cha PCT cha anthu omwe akuyenda panjinga kusiya kupanga IGF-1 kapena mahomoni ena akukula. Ndikwabwinonso kuti ogwiritsa ntchito asachepetse mphamvu zake, makamaka pakuchulukitsa kwa prolactin ndi cortisol. Ili ndi mgwirizano wamphamvu kwambiri wowonjezera cortisol ndi prolactin poyerekeza ndi ma GHRP ena omwe alipo.
Ubwino wa Hexarelin
①Kukula kwa Minofu Yowonda
Simuli nokha ngati simukusangalala ndi kulemera kwanu kapena thupi lanu. Komabe, kupeza chowonjezera chotetezeka komanso chodalirika chopezera minofu yowonda sikophweka nthawi zonse. Pali mankhwala ambiri pamsika ndipo ena amakhala owopsa kwambiri zotsatira zoyipazi kuposa momwe ikuyesera kuchiza.
Mwamwayi, kafukufuku woyamba pa Hexarelin akulonjeza ndipo ambiri amaima kumbuyo kwa peptide m'dera lonyamula zolemera.[4] Hexarelin amadziwika kuti amalimbikitsa kupanga kwachilengedwe kwa mahomoni omwe amathandizira kukula kwa minofu yowonda.[4] Peptide imakhala ngati agonist yosankha kwambiri ya GHSR ndi Insulin-like Growth Factor 1 (IGF-1).[6] Zimagwiranso ntchito ngati ghrelin poyambitsa kukula kwa secretagogue receptor ndikupondereza zoletsa ngati somatostatin. Iwo omwe amagwiritsa ntchito Hexarelin pakuchita masewera olimbitsa thupi komanso kulimbitsa thupi amazindikira zotsatira zabwino potengera kupindula kwa minofu ndi mphamvu.
②Kuwotcha Mafuta & Kuchepetsa Kuwonda
Kumanga minofu yowonda kumatheka pokhapokha pochotsa mafuta osafunika. Ndivuto lomwe ambiri aife timalimbana nalo pamene tikuyesera kuti tidye bwino komanso tizichita masewera olimbitsa thupi.
Mwamwayi, Hexarelin imatha kuthamanga kuwonda poyang'ana njira zovuta zachilengedwe m'thupi. Kutaya msanga kwamafuta kumatha kukuthandizani kuti mufikire kwanu kulemera kutaya zolinga mofulumira kuposa kale. Chofunika koposa, muchita izi motetezeka kwambiri komanso mogwira mtima poyerekeza ndi mankhwala ena owopsa kapena mapulogalamu a zakudya. Kuphatikizika kwa mafuta oyaka ndi kupindula kwa minofu yowonda kuchokera ku Hexarelin kungayambitse kukonzanso thupi lonse.
③Imawonjezera Mphamvu ndi Kusinthasintha
Pamene mukulandira kusintha kwa thupi lathunthu mumakhalanso ndi mwayi wokhala ndi mphamvu zowonjezera komanso kusinthasintha.
Hexarelin imadziwika kuti imakulitsa mphamvu ya tendon ndi ligament. Kuphatikiza apo, the peptide imagwirizana kupititsa patsogolo kusinthasintha komanso thanzi labwino lonse. Ndikofunikira kuyang'ana kwambiri ma tendon, ligaments, ndi minofu mukamakula chifukwa ali pachiwopsezo chovulala.
Chifukwa chake, simungapindule pang'ono ngati simukhala pamzere chifukwa chakuvulala kwakanthawi. Hexarelin sikuti imangokupangitsani kuti muchiritsidwe ndikugunda masewera olimbitsa thupi posachedwa komanso kupewa kuvulala koopsa koyambirira chifukwa chakupeza bwino pakusinthasintha.
④Kuchira Kwamphamvu & Kuchita Bwino Kwambiri
Palinso maubwino owonjezera pakuchepetsa thupi, kupeza minofu yowonda, komanso kuwongolera mphamvu / kusinthasintha kwathunthu.
Poyamba, muchira msanga zomwe zimakupatsani mwayi wobwerera ku masewera olimbitsa thupi ndikuyambiranso ntchito. Kuchira ndikofunikira kuti kuwonda ndi kupindula kwa minofu, kotero kupeza zowonjezera zowonjezera zomwe zimathandizira mchitidwewu ndizofunikira.
Hexarelin amadziwika kuti amalimbikitsa kuchira msanga kuchokera kuvulala ndi maphunziro. Ndizovuta kwambiri kuvulala kwa minofu ndi mafupa omwe amalepheretsa kupita patsogolo kwa masewera olimbitsa thupi.
Kuphatikiza apo, mudzawona kusintha kwakukulu pamasewera othamanga.
⑤ Imalimbitsa Magonedwe Abwino & Umoyo Wabwino Konse
Phindu lina kwa Hexarelin ndi maumboni okhudza momwe peptide imasinthira kugona kwathunthu. Kupititsa patsogolo luso la thupi limodzi ndi chizolowezi chochita masewera olimbitsa thupi nthawi zambiri kumabweretsa usiku wamtendere.
Ndipo, popeza kugona ndikofunikira kwambiri paumoyo wonse, peptide imathandizira kukhala ndi moyo wabwino. Kuchepetsa thupi ndi kukhala wamphamvu kumabweretsa kudzidalira komanso kudzidalira.
Simudzangogona bwino komanso kumva bwino chifukwa cha zabwino za Hexarelin.
Zotsatira zoyipa za Hexarelin
Mwamwayi, lipoti zotsatira zoyipazi a Hexarelin ndi ochepa.
Chofala kwambiri zotsatira zoyipazi monga kutopa kapena kutopa.[3][4] Ndi chifukwa cha mphamvu ya kukula kwa hormone kuonjezeranso chilakolako cha kugona. Komabe, kusunga mlingo wochepa kungathe kuthetsa vutoli mosavuta.Kuchuluka / kuchuluka kwa mlingo wa Hexarelin kungathandize kuti madzi asungidwe.
china zotsatira zoyipa zomwe zanenedwa kuti ndi kumva kumva kumva kumva kumva kuwawa kapena dzanzi m'manja kapena kumapazi.
Omwe ali ndi zizindikiro ayenera kuchepetsa mlingo kapena ganizirani kuchotsa ku supplementation zonse.
Ndi bwino kukaonana ndi dokotala musanagwiritse ntchito ngati mwamwa kale mankhwala ena.
Hexarelin motsutsana ndi ma peptides ena
Hexarelin vs Ipamorelin
Pamene limagwirira ntchito ndi choyambirira zabwino zonse za peptides ndi ofanana ndithu, kusiyana kumachitika mu ubwino yachiwiri. Ipamorelin imatsimikiziridwa kuti imapangitsa kuti mafupa azikhala bwino, pamene hexarelin imapangitsa kuti mtima ukhale wathanzi.
Hexarelin vs GHRP-6
Ma peptides onse amagwira ntchito mofanana. Komabe, GHRP-6 (9) sichiyambitsa mosavuta njira zina za neuroendocrine monga hexarelin.Mwa mawu a potency, GHRP-6 ili ndi theka laufupi la moyo kuti ligwire ntchito m'thupi kuposa hexarelin. Chifukwa chake, hexarelin amapambana mpikisano wotsutsana ndi GHRP-6 motsimikiza!
Kodi Mungagule Kuti Hexarelin?
Thandizo la peptide la Hexarelin limakhudza kwambiri thanzi lathunthu.[1][6] Zimathandizira kukulitsa minofu, kugaya mafuta, kuwonjezera mphamvu, ndi zina zambiri. Pano pa AASraw, tadzipereka kupereka ma peptides angapo kuphatikiza kuchepetsa thupi, chithandizo chamankhwala pakugonana, ndi mahomoni ena. Ngati mukufuna Hexarelin yogulitsa kapena ma peptide ena aliwonse, lembani mawonekedwe omwe ali pansipa kuti mukonzekere zokambirana zanu ndikulankhula ndi antchito athu apadera. Sitingadikire kumva kuchokera kwa inu!
Hexarelin Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji Hexarelin kuchokera ku AASraw?
❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani m'maola 12.
❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.
❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. David Dahlgren
Dipatimenti ya Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 752 36, Sweden
2. H. McDonald
Sukulu ya Biomedical Science, University of Queensland, Brisbane, Australia
3. Giuseppe Biagini
Laboratory of Experimental Endocrinology, Department of Internal Medicine, The Sahlgrenska Academy ku Yunivesite ya Gothenburg, Gothenburg, Sweden
4. Anna Barlind
Dipatimenti ya Psychiatry, University of Medicine ndi Dentistry ya New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito izi mankhwala pa chifukwa chilichonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Kuyamwa K (2006). "Mankhwala Osiya mu 2005: mankhwala amtima". Malingaliro a Akatswiri pa Mankhwala Ofufuza. 15 (11): 1299–308. doi:10.1517/13543784.15.11.1299. PMID 17040192. S2CID 21632578.
[2] Ezio Ghigo (1999). Kukula kwa Hormone Secretagogues: Zopeza Zoyambira ndi Zachipatala. Elsevier. tsamba 178-. ISBN 978-0-444-82933-7.
[3] Rahim A, O'Neill PA, Shalet SM (1998). "Kukula kwa mahomoni panthawi ya chithandizo cha nthawi yayitali cha hexarelin". Journal of Clinical Endocrinology & Metabolism. 83 (5): 1644–9. doi:10.1210/jcem.83.5.4812. PMID 9589671.
[4] Ghigo E, Arvat E, Gianotti L, Imbimbo BP, Lenaerts V, Deghenghi R, et al. (1994). "Kukula kwa hormone-kutulutsa ntchito ya hexarelin, hexapeptide yatsopano yopangira, pambuyo pa intravenous, subcutaneous, intranasal, and oral administration mwa munthu". Journal of Clinical Endocrinology & Metabolism. 78 (3): 693–8. doi:10.1210/jcem.78.3.8126144. Chithunzi cha PMID 8126144.
[5] Imbimbo, BP; Mantha, T.; Edwards, M.; Amin, D.; Dalton, N.; Bougnon, F.; Lenaerts, V.; Wďż˝thrich, P.; Deghenghi, R. (1994). "Kukula kwa mahomoni otulutsa hexarelin mwa anthu". European Journal of Clinical Pharmacology. 46 (5): 421–5. doi:10.1007/bf00191904. PMID 7957536. S2CID 19573322.
[6] CR Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. masamba 617-. ISBN 978-0-412-46630-4.
