J 147 ufa

J 147 powder video

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Ma Raw J 147 powder

Name:	J 147 ufa
CAS:	1146963-51-0
Makhalidwe a Maselo:	C18H17F3N2O2
Kulemera kwa maselo:	350.3349896
Melt Point:	177-178 ° C
Kusungirako nyengo:	4 ° C
mtundu;	Yeretsani kapena yang'anireni ufa wonyezimira

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Mafinya a J 147 powonjezera ubongo ndi ntchito yowonjezereka

Mayina

J 147 ufa

J 147 (1146963-51-0) Mlingo wa ntchito

Pogwiritsa ntchito mankhwala osokoneza bongo a Alzheimer's disease (AD) omwe amachokera pa zovuta zambiri za ukalamba, tazindikira kuti ndizomwe zimakhala zogwira mtima mu rodent memory ndi zitsanzo za AD nyama. Popeza chigawochi, J-147 powder, ndi phenyl hydrazide, kunali kudetsa nkhaŵa kuti ikhoza kukhala ndi mavitamini / ma hydrazines omwe angakhale a khansa. Kuti tifufuze izi zowoneka, tafufuza metabolites a J 147 powder mu microsomes ya anthu ndi mbewa ndi mbewa ya plasma. Zimasonyezedwa kuti ufa wa J-147 (1146963-51-0) sungagwiritsidwe ntchito mophiphiritsira kwa amines kapena hydrazines, kuti scaffold ndi yolimba kwambiri, komanso kuti metabolites ojambulidwa amakhalanso ndi ubongo. Zimatsimikiziranso kuti ufa waukulu wa J 147 (1146963-51-0) umathandiza kuti nyama zitha kugwira ntchito.
J 147, yomwe imachokera ku curcumin, yomwe imakhala ndi mankhwala osokoneza bongo, imakhala yochepa kwambiri ndipo imachepetsa kuwonongeka kwa mitsempha yotchedwa Alzheimer's.

J 147 (1146963-51-0) inali mapuloteni a mitochondrial otchedwa ATP synthase, makamaka ATP5A, gawo limodzi la mapuloteni. ATP synthase ikuphatikizidwa m'badwo wa ATP, umene maselo amagwiritsira ntchito mphamvu.

Ofufuzawa adawonetsa kuti mwa kuchepetsa ntchito ya ATP synthase, iwo amatha kuteteza maselo a neuronal ku zinthu zina zoopsa zomwe zimakhudza ukalamba wa ubongo. Chifukwa chimodzi cha zotsatirazi zokhudzana ndi ubongo ndizoyimira kuti ndizomwe zimapangitsa kuti thupi liwonongeke.

Excitotoxicity ndi njira yomwe matendawa amawonongeka ndi kuphedwa ndi kuwonjezereka kwa mapuloteni okhudzidwa ndi mpweya wotchedwa neurotransmitter glutamate. Ganizilani kuti kukhala ngati mphika wonyezimira ukutuluka ndi kutuluka mofulumira kotero kuti umatha kuchititsa babu babu kuti awombe.

Posachedwapa, ntchito ya ATP yopangira chidziwitso cha kuteteza khunyu motsutsana ndi kuwonongeka kwa excitotoxic inasonyezedwa mu phunziro la mbewa [4]. Phunziro lachiwiri linasonyeza kuti mawonekedwe a mbewa akusonyeza mawonekedwe a umunthu a mutant ATPase choletsa chinthu 1 (hIF1), chomwe chimayambitsa kutetezedwa kwa ATP synthase, anali otanganidwa kwambiri ndi imfa ya neuronal pambuyo pa kuwonongeka kwa excitotoxic. Deta iyi ikugwirizana ndi phunziro latsopano la J 147 la ufa, momwe kuwonjezeka kwa IF1 mu makoswe kunachepetsa ntchito ya ATP synthase (makamaka ATP5A) ndipo inali yothandizira.

Chenjezo pa Raw J 147 ufa

Deta yomwe ikuwonetsedwa apa ikuwonetsa kuti ufa wa J-147 uli ndi mphamvu zoteteza zoperewera zamaganizo pamene zimaperekedwa kumapeto kwa matenda. Kukhoza kwa J-147 powder kukuthandizani kukumbukira pa akale a AD okalamba kumagwirizanitsa ndi kudulidwa kwa matenda a neurotrophic NGF (nerve kukula factor) ndi BDNF (ubongo wotengedwa ndi neurotrophic factor) komanso mapuloteni angapo a BDNF omwe ndi ofunikira kuphunzira ndi kukumbukira. Kuyerekeza pakati pa J-147-1146963-51 powder ndi zojambulazo mu chitsanzo cha scopolamine zisonyeza kuti ngakhale kuti mankhwala onsewa ali ofanana ndi kupulumutsidwa kwa kanthawi kochepa, ufa wa J-0 unali wapamwamba pakupulumutsa chikumbukiro cha malo ndi kuphatikiza awiriwa zabwino pazokambirana ndi makedoni.

Maumboni ena

Matenda a Alzheimer ndi matenda a ubongo opitirirabe, posachedwapa akuwoneka kuti ndichitatu mwachitsulo chachikulu cha imfa ku United States ndipo amakhudza anthu oposa asanu miliyoni a ku America. Chimodzimodzinso chimayambitsa matenda a dementia kwa akulu akulu, malinga ndi National Institutes of Health. Ngakhale mankhwala ambiri athandizidwa m'zaka zapitazi za 20 zomwe zimalowetsa chipika cha amyloid mu ubongo (chomwe chimadziwika bwino ndi matenda), ndi owerengeka omwe atsimikiziridwa kukhala ogwira ntchito kuchipatala.

"Ngakhale kuti mankhwala ambiri amayamba m'zaka zapitazo za 20 zomwe zimapangidwa ndi chipika cha amyloid mu ubongo (chomwe chimadziwika ndi matendawa), palibe chomwe chawonetsetsa kuti chipatala chikugwira bwino ntchito," anatero Schubert, mkulu wa maphunziro.

Zaka zingapo zapitazo, Schubert ndi anzake adayamba kulandira chithandizo cha matendawa kuchokera kumbali yatsopano. M'malo mowombera amisiri, labu inaganiza zolowerera pazoopsa zazikulu za ukalamba. Pogwiritsa ntchito sewero-based screens motsutsana ndi ubongo wokalamba wokhudzana ndi ukalamba, adapanga ufa wa J 147 (1146963-51-0).

Poyamba, gululo linapeza kuti ufa wa J-147 ukhoza kuteteza ndi kubwezeretsa kuwonongeka kwa kukumbukira ndi matenda a Alzheimer mu makoswe omwe ali ndi maonekedwe a mtundu wa Alzheimer's, womwe amagwiritsidwa ntchito kwambiri pogwiritsa ntchito mbewa. Komabe, mtundu uwu wa matendawo uli ndi pafupifupi 1 peresenti ya zochitika za Alzheimer. Kwa wina aliyense, ukalamba ndiwo chinthu choopsa kwambiri, "anatero Schubert. Gululi linkafuna kufufuza zotsatira za wogwiritsira ntchito mankhwalawa pa mtundu wa mbewa zomwe zimakula msinkhu ndipo zimakhala ndi matenda a maganizo aumtima omwe amafanana kwambiri ndi matenda aumunthu omwe ali ndi zaka.

J 147 Pakuda Kwambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

Mawotchi Awotchi a J 147

Kuti aperekedwe m'tsogolomu.

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Momwe mungagulire J 147 ufa kuchokera ku AASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
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4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.

KULAMBIRA NDI KUSINTHA: Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.

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