J 147 ufa (1146963-51-0) | neuroprotective ndi neurotrophic
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J 147 ufa

mlingo: SKU: 1146963-51-0. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga mphamvu kuchokera ku gramu mpaka kulemera kwa J 147 powder (1146963-51-0), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

J147 ufa Choyamba chinapangidwa ku 2011, ndipo ofufuza achita kafukufuku angapo omwe amasonyeza kuti ikhoza kusokoneza kutayika kwa kukumbukira komanso kuchepetsa kapena kutembenuka kwa Alzheimer mu mbewa. Koma mpaka phunziro ili, iwo sankadziwa momwe izo zinagwirira ntchito mu maselo. Iwo anatha kusonyeza kuti ufa wa J147 umagwira ntchito pogwiritsa ntchito ATP, mapuloteni mu mitochondria ndi magetsi a thupi. Pamene J147 ufa unalipo, neurons anali otetezedwa ku poizoni okhudzana ndi ukalamba. Zowonjezera zowonjezera zasonyeza kuti ufa wa J147 umachulukitsa magulu a ATP ndipo umalimbikitsa thanzi labwino, lokhazikika mitochondria

Mafotokozedwe Akatundu

 

J 147 powder video

 

 


 

Ma Raw J 147 powder

 

Name: J 147 ufa
CAS: 1146963-51-0
Maselo chilinganizo: C18H17F3N2O2
Kulemera kwa Maselo: 350.3349896
Melt Point: 177-178 ° C
Kusungirako nyengo: 4 ° C
mtundu; Yeretsani kapena yang'anireni ufa wonyezimira

 


 

Mafinya a J 147 powonjezera ubongo ndi ntchito yowonjezereka

 

Mayina

J 147 ufa

 

J 147 (1146963-51-0) Mlingo wa ntchito

Pogwiritsa ntchito njira yodziwitsa anthu za matenda a Alzheimer's (AD) yomwe idakhazikitsidwa ndimatenda angapo okalamba, tidazindikira gulu lamphamvu lomwe limagwira bwino kukumbukira kwa mbewa ndi mitundu yazinyama za AD. Popeza chophatikizira ichi, J-147 ufa, ndi phenyl hydrazide, panali nkhawa kuti itha kupangika ndi amino / ma hydrazines onunkhira omwe atha kupangitsa khansa. Kuti tifufuze kuthekera uku, tidasanthula ma metabolites a J 147 ufa mu microsomes a anthu ndi mbewa ndi plasma yama mbewa. Zikuwonetsedwa kuti ufa wa J-147 (1146963-51-0) samagwiritsidwa ntchito ndimankhwala amine kapena ma hydrazines, kuti scaffold ndiyokhazikika bwino, komanso kuti ma metabolite ophatikizika amakhalanso othandizira. Zimatsimikiziridwa kuti ma metabolites akuluakulu a J 147 (1146963-51-0) ufa angapangitse kuti akhale nawo zochitika zachilengedwe mu nyama.
J 147, yochokera ku curry yowunkhira ya zonunkhira, imakhala ndi poizoni wochepa ndipo imasinthiratu kuwonongeka kwa ma neuron omwe amapezeka ndi Alzheimer's.

J 147 (1146963-51-0) inali mapuloteni a mitochondrial otchedwa ATP synthase, makamaka ATP5A, gawo limodzi la mapuloteni. ATP synthase ikuphatikizidwa m'badwo wa ATP, umene maselo amagwiritsira ntchito mphamvu.

Ofufuzawa adawonetsa kuti mwa kuchepetsa ntchito ya ATP synthase, iwo amatha kuteteza maselo a neuronal ku zinthu zina zoopsa zomwe zimakhudza ukalamba wa ubongo. Chifukwa chimodzi cha zotsatirazi zokhudzana ndi ubongo ndizoyimira kuti ndizomwe zimapangitsa kuti thupi liwonongeke.

Excitotoxicity ndi njira yomwe matendawa amawonongeka ndi kuphedwa ndi kuwonjezereka kwa mapuloteni okhudzidwa ndi mpweya wotchedwa neurotransmitter glutamate. Ganizilani kuti kukhala ngati mphika wonyezimira ukutuluka ndi kutuluka mofulumira kotero kuti umatha kuchititsa babu babu kuti awombe.

Posachedwapa, ntchito ya ATP yopangira chidziwitso cha kuteteza khunyu motsutsana ndi kuwonongeka kwa excitotoxic inasonyezedwa mu phunziro la mbewa [4]. Phunziro lachiwiri linasonyeza kuti mawonekedwe a mbewa akusonyeza mawonekedwe a umunthu a mutant ATPase choletsa chinthu 1 (hIF1), chomwe chimayambitsa kutetezedwa kwa ATP synthase, anali otanganidwa kwambiri ndi imfa ya neuronal pambuyo pa kuwonongeka kwa excitotoxic. Deta iyi ikugwirizana ndi phunziro latsopano la J 147 la ufa, momwe kuwonjezeka kwa IF1 mu makoswe kunachepetsa ntchito ya ATP synthase (makamaka ATP5A) ndipo inali yothandizira.

 

Chenjezo pa Raw J 147 ufa

Deta yomwe ikuwonetsedwa apa ikuwonetsa kuti ufa wa J-147 uli ndi mphamvu zoteteza zoperewera zamaganizo pamene zimaperekedwa kumapeto kwa matenda. Kukhoza kwa J-147 powder kukuthandizani kukumbukira pa akale a AD okalamba kumagwirizanitsa ndi kudulidwa kwa matenda a neurotrophic NGF (nerve kukula factor) ndi BDNF (ubongo wotengedwa ndi neurotrophic factor) komanso mapuloteni angapo a BDNF omwe ndi ofunikira kuphunzira ndi kukumbukira. Kuyerekeza pakati pa J-147-1146963-51 powder ndi zojambulazo mu chitsanzo cha scopolamine zisonyeza kuti ngakhale kuti mankhwala onsewa ali ofanana ndi kupulumutsidwa kwa kanthawi kochepa, ufa wa J-0 unali wapamwamba pakupulumutsa chikumbukiro cha malo ndi kuphatikiza awiriwa zabwino pazokambirana ndi makedoni.

 

Maumboni ena

Matenda a Alzheimer ndi matenda a ubongo opitirirabe, posachedwapa akuwoneka kuti ndichitatu mwachitsulo chachikulu cha imfa ku United States ndipo amakhudza anthu oposa asanu miliyoni a ku America. Chimodzimodzinso chimayambitsa matenda a dementia kwa akulu akulu, malinga ndi National Institutes of Health. Ngakhale mankhwala ambiri athandizidwa m'zaka zapitazi za 20 zomwe zimalowetsa chipika cha amyloid mu ubongo (chomwe chimadziwika bwino ndi matenda), ndi owerengeka omwe atsimikiziridwa kukhala ogwira ntchito kuchipatala.

"Ngakhale kuti mankhwala ambiri amayamba m'zaka zapitazo za 20 zomwe zimapangidwa ndi chipika cha amyloid mu ubongo (chomwe chimadziwika ndi matendawa), palibe chomwe chawonetsetsa kuti chipatala chikugwira bwino ntchito," anatero Schubert, mkulu wa maphunziro.

Zaka zingapo zapitazo, Schubert ndi anzake adayamba kulandira chithandizo cha matendawa kuchokera kumbali yatsopano. M'malo mowombera amisiri, labu inaganiza zolowerera pazoopsa zazikulu za ukalamba. Pogwiritsa ntchito sewero-based screens motsutsana ndi ubongo wokalamba wokhudzana ndi ukalamba, adapanga ufa wa J 147 (1146963-51-0).

M'mbuyomu, gululi lidapeza kuti ufa wa J-147 ukhoza kuteteza komanso kusinthiratu kukumbukira kukumbukira ndi matenda a Alzheimer mu mbewa zomwe zili ndi mtundu wobadwa nawo Alzheimer's, yomwe imagwiritsidwa ntchito kwambiri mbewa. Komabe, mtundu uwu wamatenda umangokhala pafupifupi 1 peresenti ya matenda a Alzheimer's. Kwa ena onse, ukalamba ndiye vuto lalikulu, atero a Schubert. Gululi linkafuna kudziwa zomwe zimachitika chifukwa cha mbewa zomwe zimakula msanga ndikukumana ndi matenda amisala omwe amafanana kwambiri ndi matenda okhudzana ndi ukalamba.

 

J 147 Pakuda Kwambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

 

Mawotchi Awotchi a J 147

Kuti aperekedwe m'tsogolomu.

 


 

Momwe mungagulire J 147 ufa kuchokera ku AASRAW

 

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