Mafotokozedwe Akatundu
1. J147 Powder kanema-AASraw
2. J147 Powder Makhalidwe Oyambira
| Name: | J 147 ufa |
| CAS: | 1146963-51-0 |
| Maselo chilinganizo: | C18H17F3N2O2 |
| Kulemera kwa Maselo: | 350.3349896 |
| Melt Point: | 177-178 ° C |
| Kusungirako nyengo: | 4 ° C |
| mtundu; | Yeretsani kapena yang'anireni ufa wonyezimira |
Kodi J147 Powder ndi chiyani?
J147 Powder ndi mankhwala opangidwa ndi curcumin, omwe ndi chigawo cha curry spice turmeric. J147 Powder kwenikweni ndi Curcumin ndi Cyclohexyl-Bisphenol A (CBA) yochokera ku neurogenic ndi neuroprotective.
J147 Powder yasonyezedwa kuti ikuwongolera kwambiri kuwonongeka kwa chidziwitso kwa odwala okalamba a Alzheimer's. Zotsatirazi zimachokera ku zinyama zakukalamba zomwe zimafulumira. J147 Powder ndi mankhwala opangidwa pakamwa a neurotrophic omwe amasintha kuwonongeka kwa chidziwitso.
Curcumin ndi polyphenol yomwe imapezeka mu turmeric ndi ginger.
Curcumin ili ndi zopindulitsa zingapo zomwe zasonyezedwa pochiza matenda osiyanasiyana, komabe pali zolepheretsa zoonekeratu chifukwa cha mphamvu yake yofooka yodutsa Magazi-Brain Barrier (BB).
J147 Powder imatha kuwoloka BBB mu ubongo (yamphamvu) ndikupangitsa kupanga maselo a neuronal stem.
J147 Powder, mosiyana ndi mankhwala amakono a Alzheimer's Disease, si acetylcholinesterase inhibitor kapena phosphodiesterase inhibitor, koma imapangitsa kuzindikira ndi chithandizo chanthawi yochepa.
Nootropic iyi ikuyamba kutchuka ngati chithandizo cha matenda a Alzheimer's. J-147 Powder yakopanso chidwi cha ogwiritsa ntchito athanzi chifukwa cha kuthekera kwake pakukulitsa kukumbukira, kukulitsa luso la kuphunzira, komanso thanzi laubongo lonse. Wogwiritsa ntchito yemwe amayang'ana kugula J147 Powder, ayenera kugula ndi wopanga choyambirira, kuti muthe kupeza fakitale J-147 mtengo wa ufa kuti musunge ndalama.
Kodi J-147 imagwira ntchito bwanji?
Zomwe J-147 zimakhudzira maselo sizinali zodziwika mpaka Salk Institute neurobiologists adathetsa chithunzithunzi mu 2018. J-147 imagwira ntchito pomanga ku ATP synthase. Puloteni iyi ya mitochondrial imayang'anira ukalamba posintha kupanga mphamvu zama cell. Kukhalapo kwa J-147 Powder m'thupi la munthu kumapewa kuopsa kwa zaka zomwe zimachitika chifukwa cha mitochondria yosagwira ntchito komanso kuchulukitsa kwa ATP.
Njira yogwiritsira ntchito J-147 Powder idzawonjezeranso milingo ya ma neurotransmitters osiyanasiyana monga NGF ndi BDNF. Kuphatikiza apo, imachepetsa milingo ya beta-amyloid, yomwe nthawi zonse imakhala yokwera mwa odwala a Alzheimer's ndi dementia. Zotsatira za J-147 zimaphatikizapo kuchepetsa kufalikira kwa matenda a Alzheimer's, kuchepetsa kukumbukira kukumbukira, komanso kukulitsa kupangidwa kwa ma neuronal cell.
Maphunziro angapo ndi J-147 Powder achitika mu mbewa. Kuyesedwa kwa anthu kunachitika mu 2020, komabe, zotsatira zonse sizinagawidwebe.
ubwino of J147 ufa
①Imawonjezera Ntchito ya Mitochondrial Ndipo Utali wamoyo
J147 Powder ndi yothandiza kwambiri pochepetsa kupsinjika kwa okosijeni komanso kukulitsa magwiridwe antchito a mitochondrial.
Mwachitsanzo, J147 Powder imawonjezera ntchito ya mitochondrial mwa kukonza ma ATP (kuletsa ATP synthase, makamaka ATP5A).
J147 Powder imatha kuchepetsa ma metabolites owopsa omwe amatsogolera ku excitotoxicity poletsa ATP synthase.
Pa mlingo wa biochemical, izi zimalimbikitsa achinyamata / wathanzi mitochondria (posintha njira ya AMPK / mTOR).
② Amaletsa Matenda a Alzheimer
J147 Powder amachiritsa kuwonongeka kwa chidziwitso mu mtundu wa mbewa wa matenda a Alzheimer's (AD).
J147 Powder imatha kulimbikitsa kagayidwe ka Amyloid-Beta (A) ndikuchepetsa milingo muubongo mwa kuchepetsa -Secretase protein protein (BACE).
J147 Powder imatha kuteteza BBB permeability homeostasis ndikuwongolera magwiridwe antchito amtundu wa nyama za matenda a Alzheimer's.
J147 Powder imathanso kukweza kwambiri ma Docosahexaenoic Acid (DHA) muubongo.
Zingathandize kubwezeretsa ma Glutamate mu ubongo (omwe amapangidwa kuchokera ku TCA yapakatikati -ketoglutarate).
③Zimasintha Chikumbutso
Imawongolera kuzindikira mu mbewa za matenda a Alzheimer's komanso mitundu yanyama yazaka zabwinobwino.
Ufa wa J147 ukhoza kubwezeretsanso kuwonongeka kwachidziwitso ngakhale mu zinyama zokalamba kwambiri.
J-147 ingathandizenso kukumbukira malo ndi Kutha Kwanthawi yayitali (LTP).
④Kukula kwa Ubongo
J 147 Powder imatha kupititsa patsogolo komanso kulimbikitsa mapulasitiki a synaptic muubongo.
J 147 Powder imalimbikitsa synaptic plasticity mwa kusunga Synaptophysin expression (protein ya synaptic vesicle yomwe imachepetsedwa mu ukalamba ndi AD ndipo imatengedwa kuti ndi biomarker ya synapse imfa).
J-147 Powder imalimbikitsa kukula kwa ubongo mwa kulimbikitsa miyeso ya Nerve Growth Factor (NGF) ndi Brain-Derived Neurotrophic Factor (BDNF) (BDNF).
⑤Kuteteza Neurons
J 147 Powder sichifuna BDNF kukhala neuroprotective.
J 147 Powder imatetezanso ma neuroni ku kusowa kwa glutathione (GSH).
J-147 Powder imateteza ubongo ku kusowa kwa glucose.
Mu ubongo wa AD, 5-Lipoxygenase (5-LOX) imapanga maselo ambiri oteteza chitetezo cha mthupi kuti ayankhe kutupa, ndipo Heme Oxygenase 1 (HO-1) imakhala ngati pro-oxidant osati antioxidant.
Curcumin yochokera ku J147 Powder imatha kuchepetsa milingo ya HO-1 komanso kuletsa 5-LOX.
⑥Akhoza Kupititsa patsogolo Matenda a Shuga
M'zitsanzo za nyama, J147 Powder yawonetsa kuchepa kwa Glucose wamagazi ndi HbA1c powonjezera AMPK.
Ngakhale sizofunikira, J147 Powder imathanso kupititsa patsogolo ntchito ya maselo otsalira a beta mu shuga.
⑦Amalimbana ndi Zowawa Ndi Neuropathy
J-147 Powder idatsimikiziridwa kuti ndi yothandiza pochiza Diabetic Neuropathy pachitsanzo cha nyama chokhala ndi matenda amtundu woyamba.
Zitha kuthandizira kuchepetsa kusokonezeka kwa mitsempha yamagalimoto chifukwa cha matenda a shuga, kumva kwa zotumphukira, komanso kuwawa.
⑧ Mutha Kukulitsa Nkhawa
J147 Powder imatha kuchepetsa nkhawa.
J147 Powder inatha kuchepetsa nkhawa panthawi ya mayesero a maze mu zinyama za AD.
J147 Ufa dose ndi stack
Kafukufuku wosiyanasiyana wagwiritsa ntchito mitundu yosiyanasiyana ya mbewa, koma imodzi mwamafukufuku owunikiridwa bwino idapatsa mbewa 10 mg / kg yolemera thupi patsiku. Kafukufuku wina adagwiritsa ntchito Mlingo wa 1, 3 kapena 9 mg / kg, ndipo adapeza zotsatira zodalira mankhwala, ndimiyeso yayikulu ikugwira ntchito bwino.
Komabe, kumasulira izi pamlingo wamunthu kumafunikira kusintha kwa thupi. Malinga ndi njira yogwiritsira ntchito yomwe imagwiritsidwa ntchito kwambiri, mlingo wofanana ndi umunthu uyenera kufanana ndi muyeso wama mbewa wogawidwa ndi 12.3-kapena .81 mg pa kg ya kulemera thupi patsiku.
Zina mwazabwino zake zimawonekera mukangoyamba kugwiritsa ntchito. Ngakhale ndi chithandizo chanthawi yochepa, J-147 imapangitsa kuti pakhale zotsatira zofulumira ngati makoswe pamasiku a 3 popanda kukhazikitsa kulekerera kwa mankhwala kapena kuwonjezeka kwa kuzindikira. Pali zambiri za J147 Powder zogulitsidwa pa intaneti, ndikofunikira kugula zinthu zenizeni komanso zapamwamba. Mutha kugula J147 Powder Wholesale ndi ogulitsa AASRAW.
J147 sinakhale yotchuka pakati pa anthu athanzi kwa nthawi yayitali kuti tivomereze molimba mtima ma stacks aliwonse. Osati ma nootropics onse omwe angakhale 'kusakaniza ndi kugwirizanitsa' mosamala.
J147 ufa humani tma rials and user ezokumana nazo
Phunziro loyamba laumunthu la J147 Powder lalembedwa ndipo likuyembekezeka kutha mu 2020. Zikuwoneka kuti zakhala zikuyesedwa ngati gawo la 1 pa anthu athanzi a 64, ndi cholinga chachikulu chowunika chitetezo ndi pharmacokinetics (hafu ya moyo, mbali). zotsatira, minyewa ya minofu) ya J147 Powder, osati yothandiza pochiza vuto lililonse.
Ngakhale kuti zotsatira za kafukufukuyu sizinafotokozedwe poyera, tikudziwa kuti zinkawoneka kuti zatha popanda mavuto aakulu.
Ngakhale J147 Powder ndi mankhwala ofufuza ndipo akhala akukambidwa m'madera angapo a nootropics, sipanakhalepo malipoti ambiri ogwiritsira ntchito omwe aperekedwa mpaka pano, ndipo anthu ambiri akuyembekezera kuwona maphunziro ena asanagwiritse ntchito. Malingana ndi ogwiritsa ntchito a Powder a J-147, N'zosavuta kugula ufa wa J147 pa intaneti, kupeza wothandizira wa Powder wa J147 wodalirika adzathera nthawi zina. Wothandizira AASRAW amapereka ufa wapamwamba wa J-147 Powder. Ngati mupanga zowonjezera za J-147, mutha kugula zambiri za J147 Powder kuti musangalale ndi mtengo wabwino.
Anthu ambiri akuwoneka kuti sakuwona zotsatira zowoneka mwazochita zochepa za ogwiritsa ntchito zomwe zanenedwa. Ngakhale ogwiritsa ntchito amakhala achichepere komanso athanzi ndipo nthawi yogwiritsira ntchito imakhala yochepa kwambiri kuposa maphunziro, curcumin yochokera ku J147 Powder sangakhale ndi zotsatira zazikulu za nootropic pa achinyamata athanzi.
Titha kungolingalira mozama momwe J147 Powder ingakhalire yothandiza ngati palibe kafukufuku waumunthu kapena zolemba zodziwika bwino. Mwachidziwitso, chilichonse chomwe chimawonjezera mphamvu ya neuronal metabolism chiyenera kukhala ndi zotsatira za nootropic, komabe chidziwitso chanu sichingakhale chochepa ndi kugwiritsa ntchito mphamvu. Zingadalire momwe zakudya zimalowera mwachangu ndikutuluka muubongo wanu kapena momwe malingaliro anu amalumikizirana bwino.
Curcumin yochokera ku J147 Powder imapanganso zinthu zambiri za neurotrophic, zomwe zikutanthauza kuti zitha kuthandiza ubongo wanu kupanga ma synapses ambiri ndi ma cell aubongo. Koma kumbukirani kuti pakhoza kukhala kuchuluka kwa ma synapses ndi ma cell aubongo.
Pakalipano palibe chifukwa chokhulupirira kuti J147 Powder idzakhala ndi mphamvu yaikulu ya nootropic kwa achinyamata, akuluakulu athanzi. Kwa iwo omwe ali ndi dementia, ndizothandiza kwambiri. Mwa anthu okalamba pang'ono omwe amadziwa kuti matenda a dementia amayamba m'banja mwawo, zingakhale zothandiza ngati nootropic chifukwa akhoza kuyimitsa kapena kusokoneza chidziwitso chisanayambike kukhala dementia. Mulimonse momwe zingakhalire, pakapita nthawi kuti titsimikizire.
J-147 Ufa risk ndi spano ezimayambitsa
J147 Powder yayesedwa kuchipatala ndipo yapezeka kuti ndi yotetezeka kuti igwiritsidwe ntchito kwa nthawi yayitali ndi ma laboratory odziimira okha. Idapambana mayeso a toxicological m'maphunziro a nyama omwe bungwe la Food and Drug Administration (FDA) limafunikira, ndipo palibe zoyipa zomwe zidalembedwa mwa anthu zikamwedwa pamlingo wovomerezeka (zokambidwa pambuyo pake).
Kodi kugula J-147 Powder?
Zovomerezeka za nootropic izi zikukambidwabe, komabe sizidzakulepheretsani kugula zinthu zovomerezeka. Kupatula apo, mayeso azachipatala a J-147 Alzheimer's ayamba kale. Mutha kugula ufawo m'masitolo apaintaneti popeza mutha kufananiza mitengo ya Powder ya J-147 kuchokera kwa ogulitsa ambiri. Komabe, muyenera kuyang'ana mozungulira kuti mupeze wopanga wodalirika yemwe ali ndi mayeso odziyimira pawokha a labotale.
Ngati mukufuna J-147 Powder yogulitsa, fufuzani ndi fakitale yathu. Timapereka mitundu yambiri ya nootropics pansi pa ulamuliro wolimba kwambiri. Kutengera cholinga chanu cha psychonautic, mutha kugula zambiri kapena payekhapayekha. Zindikirani kuti, mtengo wa J-147 Powder ndi wochezeka pokhapokha mutagula kuchuluka.
J147 Powder Lipoti Loyesa-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
J-147 Ufa(1146963-51-0)-COA
Mungagule bwanji J147 Powder kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. "Kutsegula kwa monoaminergic system kumathandizira kuti antidepressant- ndi anxiolytic-like zotsatira za J147. Behav Brain Res. 2021 Aug 6; 411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 May 21. PMID: 34023306
[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. "Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Kupyolera mu 5-HT1A-Mediated cAMP Signaling. "Front Neurosci. 2020 Jul 8; 14:701. doi: 10.3389/fnins.2020.00701. eCollection 2020.PMID: 32733195
[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 Imachepetsa Kutaya Kwambiri kwa tPA-Induced Brain Hemorrhage mu Acute Experimental Stroke in Rats."Front Neurol. 2022 Marichi 2; 13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561
[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "Mu Silico Repurposing ya J147 ya Neonatal Encephalopathy Chithandizo: Kufufuza Njira Zamagetsi za Mutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251
[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. "Zotsatira za antidepressant-monga za buku la curcumin derivative J147: Kuphatikizidwa kwa 5-HT1A cholandilira. Neuropharmacology. 2018 Jun; 135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566
