JW 642

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AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita ku dongosolo la JW 642 (1416133-89-5), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Mafotokozedwe Akatundu

JW 642 kanema


JW 642 Anthu oyambirira

Name: JW 642
CAS: 1416133-89-5
Makhalidwe a Maselo: C21H20F6N2O3
Kulemera kwa maselo: 462.4
Melt Point:
Kusungirako nyengo: pa -XUMUM ° C Zaka 20 Powder
mtundu; White olimba


Pulogalamu ya JW 642

Mayina

Maina a Mankhwala:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Mafanowo:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

JW 642 (1416133-89-5) Kagwiritsidwe

Mu njira za ma laboratory, kuti tizisungirako nthawi yaitali, timati kuti JW 642be amasungidwa pa -20 ℃. Iyenera kukhala yolimba kwa chaka chimodzi.
JW 642 imaperekedwa ngati yankho mu methyl acetate. Kusintha zokhudzana ndi zosungunulira, zimangokhala mchere wotchedwa methyl acetate pansi pa madzi ofanana ndi nayitrogeni ndipo nthawi yomweyo kuwonjezera zosungunulira. Mavitamini monga asethanol, DMSO, ndi dimethyl formamide atsukidwa ndi mpweya wa inert angagwiritsidwe ntchito. Kutha kwa JW 642 muzitsulozi kumayandikira 13,5, ndi 11mg / ml, motsatira.
JW 642 imakhala yosungunuka pang'ono pamabotolo amadzimadzi. Kuti mukhale otetezeka kwambiri m'madzi amadzimadzimadzi, njira yowonongeka ya JW 642yi iyenera kuchepetsedweratu ndi chimbudzi chodziwika bwino. JW 642 imatha kusungunuka pafupifupi 0.3 mg / ml mu 1: 2 yankho la ethanol: PBS (pH 7.2) pogwiritsa ntchito njirayi. Sitikulimbikitsanso kusunga yankho lamadzimadzi kwa tsiku limodzi.

Kodi mlingo wa JW 642 ndi wotani?

DMSO ku 100 mM
Ethanol ku 100 mM
Malangizo Okhazikika ndi Okhazikika: Zina mwa njira zowonjezera zingakhale zovuta kuzipeza ndipo zimatha kukulimbikitsani ndi kuthamanga, kutentha kapena kutentha (mu 45-60 ° C madzi osamba). Zomwe zimakhudzana ndi kugulitsidwa kwa mankhwala, makamaka njira yothetsera, sizinayambe zakhala zikudziwika ndipo nthawi zambiri tikhoza kupereka chitsogozo chachikulu. Zomwe timayamikira ndizo: SOLIDS: Zomwe zimasungidwa zimatchulidwa pa cholembera ndipo mankhwalawa amakhala osindikizidwa mwamphamvu, mankhwalawa akhoza kusungidwa mpaka miyezi ya 6 kuyambira tsiku limene alandira. SOLUTIONS: Timapereka njira zothetsera malonda, zomwe zakhala zitakonzedwa kale, zimasungidwa muzithunzi zolimba kwambiri -20 ° C kapena pansi ndi kugwiritsidwa ntchito mkati mwa mwezi wa 1.Zonse zomwe zingatheke kuti zithetsedwe ziyenera kupangidwa ndikugwiritsidwa ntchito tsiku lomwelo.

Momwe JW 642 amagwirira ntchito

JW 642 ndi monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Zojambula> 1000-fold selectivity kwa MAGL pa mafuta acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) ndi serine hydrolase amene amayambitsa hydrolysis ya 2-AG kwa arachidonic asidi ndi glycerol, motero kuthetsa chilengedwe chake. Zotsatira za poizoni zingayambane monga pansipa: Methyl Acetate - Deta Deta Data: Mlomo LD50 (makoswe):> 5,000 mg / kg; Mlomo LD50 (kalulu): 3,705 mg / kg; Khungu LD50 (kalulu):> 5,000 mg / kg; Kutsegula m'mimba TCLO (anthu): 15,000 mg / m3; Methyl Acetate - Irritation Data: Khungu (kalulu): 500 mg (24h) yofatsa; Eyes (kalulu): 100 mg (24h) yochepa.

JW 642 (1416133-89-5) chenjezo

I. Kukhazikika ndi kuchitapo kanthu

5.1 Reactivity

Khola pansi pa zoyendetsera zoyendetsa kapena zosungirako.

5.2 chikhalire cha mankhwala

Khola pansi pa zinthu zosungirako zoyenera.

5.3 Zovuta zowonongeka

Zoopsa zowopsa sizidzachitika pazochitika zoyendetsa bwino kapena zosungirako. Kuwonongeka kumachitika pokhapokha pazochitika kapena zida zomwe zili pansipa.

5.4 Zinthu zoteteza kutentha, chinyezi.
Zida 5.5 zosiyana

Makhalidwe amphamvu / alkalis, olimbikitsa / ochepetsa mphamvu.

5.6 Zamagalimoto zowonongeka

Kutentha kumatulutsa utsi woopsa. Palibe chidziwitso chodziwitsidwa.

II.Kusunga ndi kusungirako

Zosamala za 5.1 kuti zithetse bwino

Gwiritsani ntchito malo opangira mankhwala, ndi mpweya woperekedwa ndi dongosolo lodziimira. Pewani kupuma, kukhudzana ndi maso, khungu komanso
zovala. Pewani mapangidwe a fumbi ndi mafinya. Gwiritsani ntchito m'dera lopuma mpweya wabwino. Khalani kutali ndi magwero a kutaya. Pewani
kuwonetsa kwa nthawi yaitali kapena mobwerezabwereza.

Zolinga za 5.2 zosungira zosungira, kuphatikizapo zosagwirizana.

Sungani pamalo ozizira, abwino podutsa mpweya. Pewani kuwala kwa dzuwa. Sungani chidebe chotsekedwa mwamphamvu kufikira mutakonzekera kuti mugwiritse ntchito.
Zosungidwa kutentha yosungirako: Sungani pa -20 ° C

Kutsatsa kwapadera kwa 5.3

Gwiritsani ntchito malo opangira mazira a ma laboratory komwe kuli kotheka.

JW 642 (1416133-89-5) Mphala wambiri

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti muyambe kukonzekera mukhoza kutumizidwa mu masiku a ntchito 3 mutatha kulipira.

JW 642 ufa (1416133-89-5) Marketing

Kuti aperekedwe m'tsogolomu.

Kodi JW 642 Ali ndi Zotsatira Zonse?

Zinthu zakuthupi zingakhale zokwiyitsa kwambiri mu membrane ndi tsamba lopuma; Zingakhale zovulaza ndi kutsekemera, kumeza, kapena kuyamwa khungu; Zingayambitse kugona; Zingapangitse kuti khungu kapena kupuma kukhumudwitse. Kuwonetsedwa kobwerezabwereza kungayambitse khungu kapena kupunthwa.
Kuwongolera kutetezedwa / chitetezo chaumwini

Zosintha za 9.1

Zomwe zili ndi magawo ogwira ntchito
Sili ndi zinthu zomwe zili ndi malire okhudzidwa ndi ntchito.

Kulamulira kwa 9.2

Zida zoyenera zamagetsi
Gwiritsani ntchito malo otentha komwe kuli koyenera. Onetsetsani kuti njira zonse zamakono zomwe zafotokozedwa pansi pa gawo la 7 la SDS zilipo.
Onetsetsani kuti labotayi ili ndi malo otetezeka komanso malo osambira.
Zida zoteteza

Kutetezedwa kwa diso / nkhope
Gwiritsani ntchito magalasi oyenera oteteza.
Chitetezo cha khungu
Gwiritsani ntchito magolovesi osagwiritsidwa ntchito (zofunikira zochepa zogwiritsa ntchito BS EN 374: 2003). Maguluvesi ayenera kukhala
kuyang'aniridwa musanagwiritse ntchito. Sambani ndi kuuma manja mosamala mutatha kuchitapo kanthu.
Thupi la chitetezo
Valani zovala zoyenera zoteteza.
Chitetezo cha kupuma
Ngati kuunika kwa chiopsezo kukuwonetseratu koyenera, gwiritsani ntchito mpweya wabwino.

pakati pa ena


Mungagule bwanji JW 642 powder (1416133-89-5) kuchokera kuASASRAW

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


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COA

COA 1416133-89-5 JW 642 AASRAW

HNMR

Maphikidwe

Maphikidwe Owopsa a JW 642:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

Mafotokozedwe ndi zolemba zamagulu

MAGL inhibitor ndi FAAH Inhibitor: JW-642 & OL-135 & PF-750

Reviews

Palibe ndemanga komabe.

Yambani kuwonetsa "JW 642"