Lorcaserin (Belviq) ufa

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AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu mpaka kulemera kwa Lorcaserin (Belviq) powder (616202-92-7), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Lorcaserin (Belviq) ufa amagwiritsidwa ntchito pamodzi ndi zakudya ndi machitidwe olimbitsa thupi kuti athetse kunenepa kwambiri. Ndipo nthawi zina amagwiritsidwa ntchito pofuna kuchepetsa kunenepa kwambiri komwe kungakhale kokhudzana ndi shuga, highcholesterol, kapena kupsinjika kwa magazi. Lorcaserin ndi mankhwala omwe amatchedwa 2C receptor agonist. Mankhwalawa amaphatikizapo maselo apadera a hypothalamus omwe amachititsa njala ndipo amagwira ntchito kuti achepetse ntchito mu malo okhumba a ubongo.

Mafotokozedwe Akatundu

Lorcaserin Chiyambi

Kupanga mankhwala abwino ndi otetezeka kudulidwa mankhwala ndi ntchito yovuta. Mayesero akale adadza ndi zotsatira zina zambiri monga kuwonongeka kwa mtima. Mwamwayi, kafukufuku watsopano akuti lorcaserin kupiritsika kwa piritsi kungakuthandizeni kuchotsa kulemera kwambiri popanda kupereka nsembe ya moyo wanu. Lorcaserin ndi piritsi lopweteka losafuna kudya, lomwe linavomerezedwa ndi FDA ku 2012. Koma kodi lorcaserin ndi chiyani? Chabwino, m'munsimu muli kufotokozera mwatsatanetsatane ka mankhwala, mankhwala ake ndi katundu, ntchito, mlingo, zodzitetezera, ndi zina zambiri.

Dzina la Zamalonda: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Vidiyo ya Lorcaserin (Belviq)


I.Lorcaserin (Belviq) ufa Othandiza:

Name: Lorcaserin (Belviq) ufa
CAS: 616202-92-7
Makhalidwe a Maselo: C11H14ClN
Kulemera kwa maselo: 195.692
Melt Point: 212 ° C
Kusungirako nyengo: RT
mtundu; Yoyera mpaka wofiira


Lorcaserin Chiyambi

Kupanga mankhwala abwino ndi otetezeka kudulidwa mankhwala ndi ntchito yovuta. Mayesero akale adadza ndi zotsatira zina zambiri monga kuwonongeka kwa mtima. Mwamwayi, kafukufuku watsopano akuti lorcaserin kupiritsika kwa piritsi kungakuthandizeni kuchotsa kulemera kwambiri popanda kupereka nsembe ya moyo wanu. Lorcaserin ndi piritsi lopweteka losafuna kudya, lomwe linavomerezedwa ndi FDA ku 2012. Koma kodi lorcaserin ndi chiyani? Chabwino, m'munsimu muli kufotokozera mwatsatanetsatane ka mankhwala, mankhwala ake ndi katundu, ntchito, mlingo, zodzitetezera, ndi zina zambiri.

Dzina la Zamalonda: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Pansipa pali chikhalidwe cha lorcaserin mu kusintha kwa 3-D.

Lorcaserin (Belviq) ufa

Mankhwala a Lorcaserin (belviq) (CAS 616202-92-7)

M'munsimu muli mwachidule mankhwala a Lorcaserin (belviq); iwo aperekedwa mu tebulo ili m'munsi kuti awone msanga.

Dzina la Malo Phindu la katundu
Chokhazikika-Chokhazikika Unit Unit 1
Isotope Atomu Namba 0
Chiwerengero Chosavomerezeka Chotsatira Chigwirizano 0
Ndondomeko Yowonjezera Bondere Yowonjezera 0
Nambala yosawerengeka ya Atomu 0
Nambala yosawerengeka ya Atomu yofotokozedwa 1
Kuchuluka kwa Atomu Yambiri 13
Kulipira Kwachibadwa 0
Chimanga ndi Canonicalized N'zoona
XLogP3-AA 2.7
Misa Yeniyeni 195.081 g / mol
Misa ya Monoisotopic 195.081 g / mol
Malo otchedwa Topological Polar Area 12 A ^ 2
Kuvuta 172
Chiwerengero Chogwirizana Chogwirizana 0
Chiwerengero Chovomerezeka cha Hydrogeni 1
Hydrogen Bond Donor Count 1
Kulemera kwa maselo 195.69 g / mol
Okhazikika M'magulu

pKa = 9.98 (est)

Malongosoledwe osavuta a ufa wa Lorcaserin HCL

Lorcaserin (Belviq) ndi mapiritsi oletsa kudya omwe amadziwika ndi Arena Pharmaceuticals. Zili m'gulu la mankhwala omwe amatchedwa serotonin receptor agonists. Zapangidwira kukuthandizani kuti mukhale okhuta mutadya chakudya chochepa. Zimathetsa chilakolako choyambitsa 5-HT2C mapuloteni, omwe ali mitundu ya serotonin receptors mu dera la ubongo (hypothalamus) lomwe limayambitsa chilakolako. Pamene akuonetsa kuti thupi lanu likhale lamphumphu, mumadya pang'ono, motero mumatha kuchepa.

Belviq, yemwe dzina lake ndi (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hydrohydrate, amatanthauza kutengedwa pamlomo. Kulemera kwa maselo ndi 241.16 g / mol, ndipo mphamvu yake ndi C11H15Cl2N • 0.5H2O. Malemba ake ndi awa:

Lorcaserin (Belviq) ufa

Mankhwala a Lorcaserin hydrochloride hemihydrate m'madzi ndi apamwamba kuposa 400 mg / mL. Pulogalamu ya Belviq imakhala ndi mamililo a 10.4 a crystalline lorcaserin hydrochloride hemihydrate (woyera mpaka woyera-wofiira wochuluka), womwe uli wofanana ndi 10.0 milligrams yamadzi a lorcaserin hydrochloride. Palinso zinthu zina, kuphatikizapo magnesium stearate NF, talc USP, FD & C Blue #2 aluminium lake, titanium dioxide USP, polyethylene glycol NF, polyvinyl mowa USP, colloidal silicon dioxide NF, sosiyiti ya sosiyoni ya NF, croscarmellose sodium NF, ya microcrystalline cellulose ndi hydroxypropyl cellulose NF.

Zochita za Lorcaserin

Malinga ndi njira zoyenera kutsata zogwiritsira ntchito Food and Drug Administration (2007), Lorcaserin ikhoza kuthandizira akuluakulu kuti athandizidwe kwambiri. Mankhwalawa amavomereza kuti akamachita zinthu zolimbitsa thupi komanso zakudya zochepa. Zingathandize kwambiri ndi kulemera kolemera, makamaka ndi anthu omwe ali olemera kwambiri (osachepera 27 kg / m2), kapena obese (BMI ya osachepera30 kg / m2). Mankhwalawa angathandizenso anthu omwe ali ndi vuto limodzi kapena zolemera, monga mtundu wa 2 shuga, dyslipidemia, kapena matenda oopsa.

Lorcaserin ndi pulogalamu yachangu yomwe imagwira ntchito ngati 5-HT2C receptor agonist mu hypothalamus ndi chochita chisankho cha fifteen times affinity kwa 5-HT2C zolandira kuposa 5-HT2A ndi kuwombera nthawi 100 yowonjezera ntchito yosankha kwa 5-HT2C zolandila kuposa 5-HT2B.

Zopatsa 5-HT2C zili pafupi ndi ubongo wa munthu ndipo zimapezeka mu thalamus, hypothalamus, cortex, hippocampus, plexus ya choroid, cerebellum, ndi amygdala. Zokakamiza za 5-HT2C receptors mu hypothalamus zimayambitsa kupanga POMC (proopiomelanocortin) ndipo motero zimalimbikitsa kuchepetsa kulemera kwa chidziwitso. Mtsutso uwu umathandizidwa ndi mayesero ovomerezeka ochizira komanso maphunziro ena ofufuza. Ngakhale kuti nthawi zambiri amaganiza kuti othandizira a 5-HT2C amathandiza kuthetsa chilakolako chofuna kudya, kutsekemera kwapopinine, ndi maganizo, njira yeniyeni yothetsera chilakolako cha kudya siidziwika.

Mlandire EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

Kugwiritsa ntchito ufa wa Lorcaserin HCL

Ngati tilingalira zowona zenizeni za Lorcaserin kunja uko, ndiye kuti mwina ndilo piritsi labwino kwambiri la kulemera pamsika lero. Anthu ena olemera kwambiri, mwachitsanzo, omwe ali ndi matenda okhudzana ndi kulemera kapena omwe ali olemera akhoza kupindula kwambiri ndi mankhwalawa.

Pogwiritsidwa ntchito mogwirizana ndi pulogalamu yovomerezeka ya dokotala, ndondomeko ya zakudya zowonongeka, komanso kusintha kwa moyo, Lorcaserin ikhoza kuthandiza munthu kuchita zochuluka kuposa kungowonjezera kulemera kwake - kungathandize kuchepetsa mavuto ambiri azaumoyo omwe amadza chifukwa cha kunenepa kwambiri, kuphatikizapo kuthamanga kwa magazi, matenda a shuga, matenda a mtima, ndi imfa yoyambirira.

Malingana ndi Center for Control Disease Control, kutayika kwa 5 kwa 10 peresenti ya kulemera kwathunthu kwa thupi kungawononge ubwino wa thanzi monga kusintha kwa magazi, shuga ya magazi, ndi kuthamanga kwa magazi.

Mlingo wa Lorcaserin HCL ufa

Akulu amayenera kutenga mapiritsi awiri patsiku. Choncho muyenera kutenga mapiritsi a 60 mwezi uliwonse. Malingana ndi FDA, munthu ayenera kugwiritsa ntchito mankhwalawa m'moyo wake wonse kuti akhalebe wathanzi.

Ndikofunika kuzindikira kuti zotsatira zabwino ziyenera kuchitika patapita masabata a 12. Ngati simungataye osachepera 5 peresenti ya zolemera zanu zapakati pa nthawi yanu, mumalangizidwa kuti musayambe kugwiritsa ntchito mapiritsi. Ngakhale mukupitiriza kugwiritsa ntchito, sizowonjezereka kuti mutha kukwaniritsa ndikuthandizira kuchipatala chofunikira kwambiri.

Malangizo a Lorcaserin HCL

Ndibwino kukumbukira kuti katswiri wanu wa zaumoyo wapereka mankhwalawa chifukwa awona kuti ubwino umene mumapeza ndi wapamwamba kusiyana ndi kuopsa kwa zotsatira zake. Anthu ambiri omwe amamwa mankhwalawa samasonyeza zotsatira zoyipa.

Musanayambe kutenga lorcaserin, mulole mankhwala kapena dokotala wanu adziwe ngati muli ndi mankhwala osokoneza bongo; kapena ngati muli ndi chifuwa chilichonse. Lorcaserin ili ndi zinthu zopanda mphamvu zomwe zingayambitse mavuto kapena zina. Funsani wamankhwala wanu kuti akupatseni inu zambiri.

Musanayambe kumwa mankhwalawa, dziwani mankhwala anu a zachipatala kapena dokotala za mbiri yanu yachipatala, makamaka matenda a impso, matenda a shuga, matenda a chiwindi, matenda a mtima (kuphatikizapo mtima wamtima, matenda a mtima, valve mtima, vuto la mtima) zomwe zingapangitse ngozi zovuta zomwe zimachitika pakati pa amuna (kuphatikizapo mbolo yofooka, matenda a Peyronie, matenda ambiri a myeloma, malaya a magazi, matenda a m'magazi).

Piritsi lokhazika mtima pansi limeneli lingakupangitseni kuchepetsa kuganiza kwanu kapena chizungulire. Chigololo kapena mowa zingayambitse mavutowa. Musagwiritse ntchito makina, kuyendetsa galimoto, kapena kuchita chirichonse chimene chimafuna kukhala tcheru mpaka mutatha kuchichita mosamala. Pewani zakumwa zoledzeretsa ndi kuyankhula ndi dokotala ngati mukugwiritsa ntchito chamba.

Ngati mukufuna kuti muchitidwe opaleshoni, ndibwino kuti muwauze dokotala wanu wa mano kapena mankhwala omwe mumagwiritsa ntchito (kuphatikizapo mankhwala osagwiritsidwa ntchito, mankhwala osokoneza bongo, ndi mankhwala osokoneza bongo).

Ngati mukudwala matenda a shuga, mapiritsi olemerawa angakhudze shuga lanu la magazi. Onetsetsani kuti muyang'ane msinkhu wanu wa shuga pafupipafupi monga momwe mwalangizira ndikugawana zotsatira zanu ndi dokotala. Dokotala wanu adziwe ngati muli ndi zizindikiro zochepa za shuga. Wothandizira zaumoyo wanu angafunike kusintha ndondomeko yanu ya masewera olimbitsa thupi, zakudya kapena matenda a shuga.

Mankhwalawa sayenera kutengedwa panthawi ya mimba chifukwa akhoza kuvulaza mwana wosabadwa. Funsani dokotala wanu za kugwiritsa ntchito njira zodalirika zowononga. Ngati muli ndi pakati kapena mukutenga mimba, funsani zaumoyo wanu mwamsanga.

Pakadali pano, sakudziwika ngati mankhwalawa amapita mkaka wa m'mawere. Pofuna kuteteza kuti mwana akakhale ndi chiopsezo, kuyamwa pamene akugwiritsa ntchito mankhwalawa sikuvomerezedwa. Onetsetsani kuti muwafunse dokotala musanayambe kuyamwa.

Fufuzani Mapepala Odziwiritsira Ntchito mosamala ngati alipo kwa dokotala musanayambe kugwiritsa ntchito lorcaserin ndipo nthawi iliyonse mukamaliza. Ngati muli ndi funso lililonse, funsani azimayi anu kapena adokotala.

Pewirani mapiritsiwa okhutira ndi chakudya kapena osadya monga mwadokotala wanu, kawiri kawiri. Gwiritsani ntchito mankhwalawa nthawi zonse kuti mupindule kwambiri. Pofuna kukuthandizani kukumbukira, imwani mapiritsi nthawi imodzimodzi tsiku lililonse.

Lorcaserin ndi chizolowezi chopanga mankhwala. Musati muwonjezere mlingo kapena mutenge mapiritsiwa mobwerezabwereza kuposa momwe mukulamulidwa. Chikhalidwe chimene muli nacho sichitha kusintha msanga, ndipo chiopsezo cha zotsatirapo chikhoza kuwonjezeka.

Kugwiritsa ntchito mankhwala osokoneza bongo kungachitike pamene mankhwala ena amagwiritsidwa ntchito pamodzi ndi lorcaserin mapiritsi. Uzani dokotala wanu za mankhwala onse omwe mumagwiritsa ntchito pakalipano, ndi mankhwala ena omwe mumayambitsa kapena kuleka kugwiritsa ntchito.

Lipilisi ya Lorcaserin sivomerezedwa kuti igwiritsidwe ntchito ndi anthu aang'ono kuposa zaka 18.

Ndingatenge bwanji ufa wa Lorcaserin HCL?

Musayese, kuswa, kapena kuphwanya pulogalamu yotulutsidwa. Ingoyimmeza iyo yonse.

Mankhwala a Lorcaserin ndi ochepa chabe omwe amaphatikizapo masewero olimbitsa thupi, omwe amayenera kuwonetsetsa masewero olimbitsa thupi, kudya zakudya, komanso nthawi zonse kuyesa shuga lanu la magazi. Tsatirani mankhwala anu, zakudya zopatsa thanzi, komanso nthawi zonse zomwe mumakonda kuchita.

Sungani mankhwalawa kutentha kutentha kunja kwa kutentha ndi chinyezi.

Sungani mbiri ya mankhwala omwe amagwiritsidwa ntchito mu mabotolo onse. Pulogalamu ya Lorcaserin yolimbitsa thupi ndi mankhwala osokoneza bongo, ndipo nthawi zonse muyenera kudziwa ngati wina akugwiritsa ntchito mankhwala anu popanda mankhwala kapena mankhwala osayenera.

Musamagwire nawo mankhwala a lorcaserin ndi wina aliyense. Sungani mankhwala pamalo omwe palibe wina angapeze.

Kodi chimachitika ndi chiyani mukaphonya mlingo wa Lorcaserin?

Pangani mlingo womwe umasowa mwamsanga mukukumbukira. Muyenera kudumpha mlingo wophonyezedwa ngati nthawi ya mlingo wotsatirayi ili pafupi. Musatenge mlingo wambiri kuti mupange mlingo wosowa.

Kodi chimachitika ndi chiyani mutagonjetsa Lorcaserin?

Fufuzani thandizo lachipatala mwamsanga kapena funsani chithandizo cha poizoni ku 1-800-222-1222.

Kodi ndiyenera kupewa chiyani nditatenga lorcaserin?

Musati mutenge zina zowonjezerapo kapena mankhwala olemera-owonongeka popanda malangizo a dokotala wanu. Komanso musamamwe mankhwala ozizira kapena okhudzidwa mukatenga mapiritsi a lorcaserin.

Ndi mankhwala ena ati omwe angakhudze lorcaserin?

Mankhwala otsatirawa angakhudze momwe lorcaserin amagwirira ntchito:

  • "Triptan" yomwe imakhala mankhwala a mutu wa migraine-monga Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, ndi ena.
  • Cabergoline;
  • linezolid;
  • mtundu uliwonse wa antidepressant
  • lithium;
  • Wort John;
  • Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, ndi ena;
  • tramadol;
  • tryptophan (amadziwika kuti L-tryptophan);
  • chifuwa kapena mankhwala ozizira omwe ali ndi dextromethorphan; kapena
  • mankhwala ochizira matenda, matenda kapena matenda ovutika maganizo.

Mndandanda umene uli pamwambawu siwukwanira. Mankhwala ena angakhudze lorcaserin, ndipo sizingatheke kuyanjanitsa mankhwala.

BBC Reports On Safety and Efficiency ya Lorcaserin HCL (CAS 616202-92-7)

Pali nkhani zambiri za BBC za Lorcaserin zokhudzana ndi zowonongeka komanso mankhwala a chitetezo. Malingana ndi BBC, kafukufuku waposachedwapa, wofalitsidwa mu New England Journal of Medicine, amasonyeza kuti anthu ogwiritsira ntchito lorcaserin kudya mapiritsi opondereza amatha pafupifupi pafupifupi 8.8lb (4kg) pa nthawi ya zaka zitatu ndi theka. Zotsatira za phunziroli zatsimikizira kuti lorcaserin mosakayikira ndi imodzi mwa mapiritsi olemera kwambiri othandizira kuperewera.

Lipotili limanenanso kuti mankhwalawa chifukwa amagwira ntchito poletsa chilakolako chosafuna kudya, musaike ogwiritsa ntchito pa chiopsezo chachikulu cha mtima. Kuphunzira kofalitsidwa kunayambitsa odwala 12,000 olemera kwambiri kapena odwala kunenepa kwambiri ku USA pa miyezi 40.

Pambuyo pa zaka zitatu ndi theka, akuluakulu omwe amatenga lorcaserin anali oposa katatu kusiyana ndi osachepera asanu kapena khumi peresenti ya thupi lawo kusiyana ndi omwe akulandira malowa, motero Dr. Erin Bohula.

Mayesero opangidwa pamtima wa valve sanasonyeze kusiyana kulikonse poyerekeza ndi valves ya mtima a iwo omwe amatenga placebo. Podziwa kuti ichi chakhala chodetsa nkhaŵa makamaka pokhudzana ndi mapiritsi ena ochepa, lorcaserin ikhoza kukhala piritsi labwino kwambiri.

Akuluakulu omwe amatenga mankhwala anali pangozi yochepa ya mtundu wa 2 shuga. Piritsi imadula £ 155-225 ($ 220-290) pamwezi mlingo ku US. Lorcaserin imapereka njira yabwino kwambiri yowonjezerapo kuchepetsa kuchepetsa kulemera kwa thupi monga opaleshoni ya opaleshoni ya gulu pakati pa ena.

Lipoti lina la BBC linapereka kafukufuku wofufuza ndi akatswiri a pa yunivesite ya Aberdeen a Rowett Institute omwe anafufuza kafukufuku. Asayansi ananena kuti kafukufuku wawo wokhudzana ndi chilakolako chawatsogolera ku gawo lina la ubongo.

Iwo anazindikira kuti mwa kutsogolera maselo enieniwo ndi mankhwala omwe amatha kuchepetsa kudya. Popeza lorcaserin amagwira ntchito mwa njirayi, zotsatira za phunziroli sizinatsegula zitseko za mankhwala atsopano monga lorcaserin koma zimalimbikitsanso zomwe akatswiri amakhulupirira zokhudzana ndi lorcaserin-chitetezo chake ndi mphamvu yake.

zolemba

  1. Weissman NJ, Sanchez M, Koch GG, et al. Kafukufuku wa zojambula za mtima wa valvular wamtima wowonjezera ndi lorcaserin kuchokera ku kusanthula mayesero a 3 a 3. Circ Mafilimu Ojambula 2013; 6: 560-7
  2. Halford JC: Mankhwala olemera kwambiri mu chitukuko chachipatala. Mankhwala Opin Investig Mankhwala. 2006 Apr; 7 (4): 312-8.
  3. Thomsen WJ, Grottick AJ, Menzaghi F, et al. Lorcaserin, buku lopangidwa ndi anthu 5-hydroxytryptamine2C agonist: mu vitro ndi mu vivo mankhwala apadera. J Pharmacol Exp Ther 2008; 325: 577-87
  4. Smith BM, Smith JM, Tsai JH, ndi al. Kupeza ndi kugwirizanitsa ntchito ndi Lorcaserin, serotonin 5-HT2C receptor agonist pofuna kuchiza kunenepa kwambiri. J Med Chem 2008; 51: 305-13
  5. BBC News, "A Gulu laling'ono la kagulu ka ubongo lingapangitse kunenepa kwambiri malinga ndi akatswiri a ku Aberdeen. "


Zambiri mwatsatanetsatane zamagetsi,kulandila apa.


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1 review kwa Lorcaserin (Belviq) ufa

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