Mankhwala a Lorcaserin (Belviq) (616202-92-7) hplc≥98% | AASraw
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Lorcaserin ufa

mlingo: SKU: 616202-92-7. Category:

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu mpaka kulemera kwa Lorcaserin (Belviq) powder (616202-92-7), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

 

Mafotokozedwe Akatundu

 

Lorcaserin Chiyambi

Kupanga mankhwala abwino ndi otetezeka kudulidwa mankhwala ndi ntchito yovuta. Mayesero akale adadza ndi zotsatira zina zambiri monga kuwonongeka kwa mtima. Mwamwayi, kafukufuku watsopano akuti lorcaserin kupiritsika kwa piritsi kungakuthandizeni kuchotsa kulemera kwambiri popanda kupereka nsembe ya moyo wanu. Lorcaserin ndi piritsi lopweteka losafuna kudya, lomwe linavomerezedwa ndi FDA ku 2012. Koma kodi lorcaserin ndi chiyani? Chabwino, m'munsimu muli kufotokozera mwatsatanetsatane ka mankhwala, mankhwala ake ndi katundu, ntchito, mlingo, zodzitetezera, ndi zina zambiri.

Dzina la Zamalonda: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Mavidiyo a ufa wa Lorcaserin (Belviq)

 

 


 

I.Lorcaserin (Belviq) ufa Othandiza:

 

Name: Lorcaserin (Belviq) ufa
CAS: 616202-92-7
Maselo chilinganizo:  C11H14ClN
Kulemera kwa Maselo: 195.692
Melt Point: 212 ° C
Kusungirako nyengo: RT
mtundu; Yoyera mpaka wofiira

 


 

Lorcaserin Chiyambi

Kupanga mankhwala abwino ndi otetezeka kudulidwa mankhwala ndi ntchito yovuta. Mayesero akale adadza ndi zotsatira zina zambiri monga kuwonongeka kwa mtima. Mwamwayi, kafukufuku watsopano akuti lorcaserin kupiritsika kwa piritsi kungakuthandizeni kuchotsa kulemera kwambiri popanda kupereka nsembe ya moyo wanu. Lorcaserin ndi piritsi lopweteka losafuna kudya, lomwe linavomerezedwa ndi FDA ku 2012. Koma kodi lorcaserin ndi chiyani? Chabwino, m'munsimu muli kufotokozera mwatsatanetsatane ka mankhwala, mankhwala ake ndi katundu, ntchito, mlingo, zodzitetezera, ndi zina zambiri.

Dzina la Zamalonda: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Pansipa pali chikhalidwe cha lorcaserin mu kusintha kwa 3-D.

Lorcaserin (Belviq) ufa

 

Zida Zamakampani a Lorcaserin (belviq) (CAS 616202-92-7)

M'munsimu muli mwachidule mankhwala a Lorcaserin (belviq); awonetsedwa patebulo pansipa kuti muwone mwachangu.

 

Dzina la Malo Phindu la katundu
Chokhazikika-Chokhazikika Unit Unit 1
Isotope Atomu Namba 0
Chiwerengero Chosavomerezeka Chotsatira Chigwirizano 0
Ndondomeko Yowonjezera Bondere Yowonjezera 0
Nambala yosawerengeka ya Atomu 0
Nambala yosawerengeka ya Atomu yofotokozedwa 1
Kuchuluka kwa Atomu Yambiri 13
Kulipira Kwachibadwa 0
Chimanga ndi Canonicalized N'zoona
XLogP3-AA 2.7
Misa Yeniyeni 195.081 g / mol
Misa ya Monoisotopic 195.081 g / mol
Malo otchedwa Topological Polar Area 12 A ^ 2
Kuvuta 172
Chiwerengero Chogwirizana Chogwirizana 0
Chiwerengero Chovomerezeka cha Hydrogeni 1
Hydrogen Bond Donor Count 1
Kulemera kwa maselo 195.69 g / mol
Okhazikika M'magulu

 

pKa = 9.98 (est)

 

Malongosoledwe osavuta a ufa wa Lorcaserin HCL

Lorcaserin (Belviq) ndi mapiritsi opondereza kudya omwe amapangidwa ndi Arena Pharmaceuticals. Ndi za gulu la mankhwala omwe amatchedwa serotonin receptor agonists. Lapangidwa kuti likuthandizeni kumva kuti mwakhuta mukadya chakudya chochepa. Imaletsa chilakolako poyambitsa 5-HT2C mapuloteni, omwe ali mitundu ya serotonin receptors mu dera la ubongo (hypothalamus) lomwe limayambitsa chilakolako. Pamene akuonetsa kuti thupi lanu likhale lamphumphu, mumadya pang'ono, motero mumatha kuchepa.

Belviq, yemwe dzina lake ndi (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hydrohydrate, amatanthauza kutengedwa pamlomo. Kulemera kwa maselo ndi 241.16 g / mol, ndipo mphamvu yake ndi C11H15Cl2N • 0.5H2O. Malemba ake ndi awa:

 

Lorcaserin (Belviq) ufa

 

Kusungunuka kwa Lorcaserin hydrochloride hemihydrate m'madzi ndipamwamba kuposa 400 mg / mL. Piritsi la Belviq lili ndi mamiligalamu 10.4 a crystalline lorcaserin hydrochloride hemihydrate (yoyera mpaka ufa woyera), wofanana ndi 10.0 milligrams anhydrous lorcaserin hydrochloride. Mulinso zosakaniza zina, kuphatikiza magnesium stearate NF, talc USP, FD & C Blue # 2 aluminium nyanja, titaniyamu dioxide USP, polyethylene glycol NF, polyvinyl mowa USP, colloidal silicon dioxide NF, croscarmellose sodium NF, silicified microcrystalline cellulose ndi hydroxypropyl cellulose NF.

 

Zochita za Lorcaserin

Malinga ndi njira zoyenera kutsata zogwiritsira ntchito Food and Drug Administration (2007), Lorcaserin ikhoza kuthandizira akuluakulu kuti athandizidwe kwambiri. Mankhwalawa amavomereza kuti akamachita zinthu zolimbitsa thupi komanso zakudya zochepa. Zingathandize kwambiri ndi kulemera kolemera, makamaka ndi anthu omwe ali olemera kwambiri (osachepera 27 kg / m2), kapena obese (BMI ya osachepera30 kg / m2). Mankhwalawa angathandizenso anthu omwe ali ndi vuto limodzi kapena zolemera, monga mtundu wa 2 shuga, dyslipidemia, kapena matenda oopsa.

Lorcaserin ndi pulogalamu yachangu yomwe imagwira ntchito ngati 5-HT2C receptor agonist mu hypothalamus ndi chochita chisankho cha fifteen times affinity kwa 5-HT2C  zolandira kuposa 5-HT2A  ndi kuwombera nthawi 100 yowonjezera ntchito yosankha kwa 5-HT2C zolandila kuposa 5-HT2B.

Ma 5-HT2C receptors amapezeka pafupifupi muubongo wamunthu ndipo amapezeka mu thalamus, hypothalamus, cortex, hippocampus, choroid plexus, cerebellum, ndi amygdala. Kukondoweza kwa ma 5-HT2C receptors mu hypothalamus kumayambitsa kupanga kwa POMC (proopiomelanocortin) motero kumalimbikitsa kuchepetsa kunenepa kudzera mukukhuta. Kutsutsana uku kumathandizidwa ndi mayeso azachipatala ovomerezeka ndi maphunziro ena ofufuza. Ngakhale zimaganiziridwa kuti ma 5-HT2C receptors amathandizira pakukhazikitsa chilakolako chofuna kudya, kutulutsa kwa endocrine, ndi momwe zimakhalira, magwiridwe antchito enieni a lamulo la kudya sakudziwika.

 

Mlandire EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

 

Kugwiritsa ntchito ufa wa Lorcaserin HCL

Ngati tilingalira zowona zenizeni za Lorcaserin kunja uko, ndiye kuti mwina ndilo piritsi labwino kwambiri la kulemera pamsika lero. Anthu ena olemera kwambiri, mwachitsanzo, omwe ali ndi matenda okhudzana ndi kulemera kapena omwe ali olemera akhoza kupindula kwambiri ndi mankhwalawa.

Pogwiritsidwa ntchito mogwirizana ndi pulogalamu yovomerezeka ya dokotala, ndondomeko ya zakudya zowonongeka, komanso kusintha kwa moyo, Lorcaserin ikhoza kuthandiza munthu kuchita zochuluka kuposa kungowonjezera kulemera kwake - kungathandize kuchepetsa mavuto ambiri azaumoyo omwe amadza chifukwa cha kunenepa kwambiri, kuphatikizapo kuthamanga kwa magazi, matenda a shuga, matenda a mtima, ndi imfa yoyambirira.

Malingana ndi Center for Control Disease Control, kutayika kwa 5 kwa 10 peresenti ya kulemera kwathunthu kwa thupi kungawononge ubwino wa thanzi monga kusintha kwa magazi, shuga ya magazi, ndi kuthamanga kwa magazi.

 

 Mlingo wa Lorcaserin HCL ufa

Akulu amayenera kutenga mapiritsi awiri patsiku. Choncho muyenera kutenga mapiritsi a 60 mwezi uliwonse. Malingana ndi FDA, munthu ayenera kugwiritsa ntchito mankhwalawa m'moyo wake wonse kuti akhalebe wathanzi.

Ndikofunika kuzindikira kuti zotsatira zabwino ziyenera kuchitika patapita masabata a 12. Ngati simungataye osachepera 5 peresenti ya zolemera zanu zapakati pa nthawi yanu, mumalangizidwa kuti musayambe kugwiritsa ntchito mapiritsi. Ngakhale mukupitiriza kugwiritsa ntchito, sizowonjezereka kuti mutha kukwaniritsa ndikuthandizira kuchipatala chofunikira kwambiri.

 

Malangizo a Lorcaserin HCL

Ndibwino kukumbukira kuti katswiri wanu wazachipatala wakupatsani mankhwalawa chifukwa awona kuti mwayi womwe mumapeza ndiwokwera kuposa kuwopsa kwa zotsatirapo zake. Anthu ambiri omwe amamwa mankhwalawa samakhala ndi zovuta zina.

Musanatenge lorcaserin, dziwitsani wamankhwala kapena dokotala wanu ngati mukudwala mankhwalawa; kapena ngati muli ndi chifuwa china. Lorcaserin ili ndi zinthu zopanda ntchito zomwe zingayambitse zovuta zina kapena zina. Funsani wamankhwala wanu kuti akupatseni zambiri.

Musanamwe mankhwalawa, dziwitsani wamankhwala kapena dokotala za mbiri ya zamankhwala, makamaka mavuto a impso, matenda ashuga, vuto la chiwindi, matenda amtima (kuphatikiza chotchinga mtima, matenda a valavu yamtima, kugunda kwamtima pang'ono, kulephera kwa mtima) mavuto omwe angapangitse ngozi zopweteka / zopweteka kwa amuna (kuphatikizapo mbolo yolemala, matenda a Peyronie, multipleeloma, sickle cell anemia, leukemia).

Piritsi loletsa kudya lingakupangitseni kuchepetsa kuganiza kwanu kapena chizungulire. Chamba kapena mowa zitha kukulitsa izi. Musagwiritse ntchito makina, kuyendetsa, kapena kuchita chilichonse chomwe chimafunikira kukhala tcheru mpaka mutha kuchita mosamala. Chepetsani zakumwa zoledzeretsa ndipo lankhulani ndi dokotala ngati mukusuta chamba.

Ngati mukuyenera kuchitidwa opaleshoni, ndi kwanzeru kuti muuze dokotala wanu wamano kapena zamankhwala zonse zomwe mumamwa (kuphatikiza mankhwala osalemba, mankhwala azitsamba, ndi mankhwala akuchipatala).

Ngati mukukhala ndi matenda ashuga, mapiritsi ochepetsa mavutowa angakhudze shuga. Onetsetsani kuti mumayang'ana kuchuluka kwa shuga wamagazi pafupipafupi monga mwalangizidwa ndikugawana zotsatira zanu ndi adotolo. Adziwitseni adotolo ngati muli ndi shuga wochepa m'magazi. Wothandizira zaumoyo wanu angafunike kuti musinthe pulogalamu yanu yochita masewera olimbitsa thupi, zakudya kapena matenda ashuga.

Mankhwalawa sayenera kumwedwa ali ndi pakati chifukwa atha kuvulaza mwana wosabadwa. Funsani dokotala wanu za momwe mungagwiritsire ntchito njira zodalirika zolerera. Ngati muli ndi pakati kapena muli ndi pakati, uzani katswiri wanu nthawi yomweyo.

Pakadali pano, sizikudziwika ngati mankhwalawa amapitilira mkaka wa m'mawere. Pofuna kupewa chiopsezo kwa khanda, kuyamwitsa mukamagwiritsa ntchito mankhwalawa sikuvomerezeka. Onetsetsani kuti mwaonana ndi dokotala musanayamwe.

Werengani Tsamba Labwino Logwiritsa Ntchito Mosamala ngati lingapezeke kwa dokotala musanayambe kugwiritsa ntchito lorcaserin ndipo nthawi iliyonse mukadzaza. Ngati mungakhale ndi funso lililonse, funsani wamankhwala kapena dokotala wanu.

Tengani mapiritsi opondereza pakamwa pakamwa kapena osadya monga mwadongosolo lanu, nthawi zambiri kawiri patsiku. Gwiritsani ntchito mankhwalawa pafupipafupi kuti mupindule kwambiri. Kukuthandizani kukumbukira, imwani mapiritsi nthawi yofanana tsiku lililonse.

Lorcaserin ndi chizolowezi chopanga mankhwala. Musati muwonjezere mlingo kapena mutenge mapiritsiwa mobwerezabwereza kuposa momwe mukulamulidwa. Chikhalidwe chimene muli nacho sichitha kusintha msanga, ndipo chiopsezo cha zotsatirapo chikhoza kuwonjezeka.

Kugwiritsa ntchito mankhwala osokoneza bongo kungachitike pamene mankhwala ena amagwiritsidwa ntchito pamodzi ndi lorcaserin mapiritsi. Uzani dokotala wanu za mankhwala onse omwe mumagwiritsa ntchito pakalipano, ndi mankhwala ena omwe mumayambitsa kapena kuleka kugwiritsa ntchito.

Lipilisi ya Lorcaserin sivomerezedwa kuti igwiritsidwe ntchito ndi anthu aang'ono kuposa zaka 18.

 

Ndingatenge bwanji ufa wa Lorcaserin HCL?

Musayese, kuswa, kapena kuphwanya pulogalamu yotulutsidwa. Ingoyimmeza iyo yonse.

Mankhwala a Lorcaserin ndi ochepa chabe omwe amaphatikizapo masewero olimbitsa thupi, omwe amayenera kuwonetsetsa masewero olimbitsa thupi, kudya zakudya, komanso nthawi zonse kuyesa shuga lanu la magazi. Tsatirani mankhwala anu, zakudya zopatsa thanzi, komanso nthawi zonse zomwe mumakonda kuchita.

Sungani mankhwalawa kutentha kutentha kunja kwa kutentha ndi chinyezi.

Sungani mbiri ya mankhwala omwe amagwiritsidwa ntchito mu mabotolo onse. Pulogalamu ya Lorcaserin yolimbitsa thupi ndi mankhwala osokoneza bongo, ndipo nthawi zonse muyenera kudziwa ngati wina akugwiritsa ntchito mankhwala anu popanda mankhwala kapena mankhwala osayenera.

Musamagwire nawo mankhwala a lorcaserin ndi wina aliyense. Sungani mankhwala pamalo omwe palibe wina angapeze.

 

Kodi chimachitika ndi chiyani mukaphonya mlingo wa Lorcaserin?

Pangani mlingo womwe umasowa mwamsanga mukukumbukira. Muyenera kudumpha mlingo wophonyezedwa ngati nthawi ya mlingo wotsatirayi ili pafupi. Musatenge mlingo wambiri kuti mupange mlingo wosowa.

 

Kodi chimachitika ndi chiyani mutagonjetsa Lorcaserin?

Fufuzani thandizo lachipatala mwamsanga kapena funsani chithandizo cha poizoni ku 1-800-222-1222.

 

Kodi ndiyenera kupewa chiyani nditatenga lorcaserin?

Musati mutenge zina zowonjezerapo kapena mankhwala olemera-owonongeka popanda malangizo a dokotala wanu. Komanso musamamwe mankhwala ozizira kapena okhudzidwa mukatenga mapiritsi a lorcaserin.

 

Ndi mankhwala ena ati omwe angakhudze lorcaserin?

Mankhwala otsatirawa angakhudze momwe lorcaserin imagwirira ntchito:

  • "Triptan" yomwe ndi mankhwala opweteka mutu wa migraine - monga Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, ndi ena.
  • Cabergoline;
  • linezolid;
  • mtundu uliwonse wa antidepressant
  • lithium;
  • Wort wa John;
  • mankhwala osokoneza bongo a erectile- Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, ndi ena;
  • tramadol;
  • tryptophan (amadziwika kuti L-tryptophan);
  • chifuwa kapena mankhwala ozizira omwe amakhala ndi dextromethorphan; kapena
  • mankhwala ochizira matenda amisala, malingaliro kapena matenda amisala.

Mndandanda umene uli pamwambawu siwukwanira. Mankhwala ena angakhudze lorcaserin, ndipo sizingatheke kuyanjanitsa mankhwala.

 

Malipoti a BBC On Chitetezo ndi Kuchita Bwino kwa Lorcaserin HCL (CAS 616202-92-7)

Pali nkhani zambiri za BBC za Lorcaserin zokhudzana ndi zowonongeka komanso mankhwala a chitetezo. Malingana ndi BBC, kafukufuku waposachedwapa, wofalitsidwa mu New England Journal of Medicine, amasonyeza kuti anthu ogwiritsira ntchito lorcaserin kudya mapiritsi opondereza amatha pafupifupi pafupifupi 8.8lb (4kg) pa nthawi ya zaka zitatu ndi theka. Zotsatira za phunziroli zatsimikizira kuti lorcaserin mosakayikira ndi imodzi mwa mapiritsi olemera kwambiri othandizira kuperewera.

Lipotili limanenanso kuti mankhwalawa chifukwa amagwira ntchito poletsa chilakolako chosafuna kudya, musaike ogwiritsa ntchito pa chiopsezo chachikulu cha mtima. Kuphunzira kofalitsidwa kunayambitsa odwala 12,000 olemera kwambiri kapena odwala kunenepa kwambiri ku USA pa miyezi 40.

Pambuyo pa zaka zitatu ndi theka, akuluakulu omwe amatenga lorcaserin anali oposa katatu kusiyana ndi osachepera asanu kapena khumi peresenti ya thupi lawo kusiyana ndi omwe akulandira malowa, motero Dr. Erin Bohula.

Mayesero opangidwa pamtima wa valve sanasonyeze kusiyana kulikonse poyerekeza ndi valves ya mtima a iwo omwe amatenga placebo. Podziwa kuti ichi chakhala chodetsa nkhaŵa makamaka pokhudzana ndi mapiritsi ena ochepa, lorcaserin ikhoza kukhala piritsi labwino kwambiri.

Akuluakulu omwe amamwa mankhwala anali pachiwopsezo chochepa cha matenda ashuga amtundu wa 2. Piritsi imawononga $ 155-225 ($ 220-290) pamwezi ku US. Lorcaserin imapereka njira yabwino kwambiri yothandizira kuchepetsa kuchepa kwa thupi monga opaleshoni ya m'mimba mwa ena.

Lipoti lina la BBC lidawonetsa kafukufuku wofufuza ku University of Aberdeen ku Rowett Institute omwe adachita kafukufuku wokhudza njala. Asayansiwo adati kafukufuku wawo wokhudza kudya adawatsogolera gawo lina laubongo.

Iwo anazindikira kuti mwa kutsogolera maselo enieniwo ndi mankhwala omwe amatha kuchepetsa kudya. Popeza lorcaserin amagwira ntchito mwa njirayi, zotsatira za phunziroli sizinatsegula zitseko za mankhwala atsopano monga lorcaserin koma zimalimbikitsanso zomwe akatswiri amakhulupirira zokhudzana ndi lorcaserin-chitetezo chake ndi mphamvu yake.