Lorcaserin HCL ufa

Lorcaserin hydrochloride Powder Video-AASraw

Yaiwisi Lorcaserin hydrochloride Powder Basic Characters

Chani is Lorcaserin hydrochloride Powder?

Lorcaserin hydrochloride ndi hydrochloride yomwe imapezeka ndi zochita za lorcaserin ndi imodzi yofanana ndi hydrochloric acid. Amagwiritsidwa ntchito ngati mankhwala oletsa kunenepa kwambiri. Imakhala ndi gawo ngati agonist ya serotonergic komanso yokhumudwitsa chilakolako.

Lorcaserin hydrochloride powder imakhudza zizindikiro za mankhwala mu ubongo zomwe zimayendetsa chilakolako. Mankhwala a Lorcaserin HCL ufa umagwira ntchito pokuthandizani kuti mukhale okhuta ndi zakudya zing'onozing'ono. Lorcaserin hydrochloride powder amagwiritsidwa ntchito pamodzi ndi zakudya ndi masewera olimbitsa thupi kuti athetse kunenepa kwambiri. Lorcaserin hydrochloride powder nthawi zina amagwiritsidwa ntchito pochiza kunenepa kwambiri komwe kungakhale kokhudzana ndi matenda a shuga, cholesterol, kapena kuthamanga kwa magazi.

Kodi Lorcaserin hydrochloride ndi chiyani?

Lorcaserin hydrochloride imagwiritsidwa ntchito pothandizira akuluakulu omwe ali onenepa kwambiri kapena olemera kwambiri komanso omwe ali ndi mavuto azachipatala okhudzana ndi kulemera kuti achepetse thupi komanso kuti asabwererenso kulemera kwake. Lorcaserin iyenera kugwiritsidwa ntchito limodzi ndi chakudya chochepa cha calorie komanso ndondomeko yolimbitsa thupi. Lorcaserin ali m'gulu la mankhwala otchedwa serotonin receptor agonists. Zimagwira ntchito powonjezera kukhuta kotero kuti chakudya chochepa chidyedwe.

Lorcaserin hydrochloride imagwiritsidwa ntchito pamodzi ndi zakudya zochepetsera kalori komanso masewera olimbitsa thupi kuti akuthandizeni kuchepetsa thupi. Amagwiritsidwanso ntchito kwa anthu onenepa kwambiri omwe angakhalenso ndi matenda a shuga, kuthamanga kwa magazi, cholesterol yapamwamba, kapena matenda a mtima.

BUbwino wa Lorcaserin hydrochloride

Lorcaserin hydrochloride ndi mankhwala omwe amaperekedwa pamlomo omwe amalimbikitsa kuwonda. Amagwiritsidwa ntchito ndi zakudya ndi masewera olimbitsa thupi kwa akuluakulu olemera kwambiri omwe ali ndi vuto lachipatala lokhudzana ndi kulemera kwa thupi kapena akuluakulu olemera kwambiri kuti achepetse thupi ndikuzisunga.

Lorcaserin hydrochloride ndi serotonin 2C (5-HT2C) receptor agonist. lorcaserin imaganiziridwa kuti imalimbikitsa 5-HT2C receptors mu hypothalamus, dera la ubongo lomwe limadziwika kuti. amatenga gawo lalikulu pakuwongolera njala ndi kudya. Poyambitsa ma receptor awa, lorcaserin ikhoza kuchepetsa kudya mwa kuchepetsa chilakolako cha kudya ndikupangitsa munthu kukhala wokhuta ngakhale atadya chakudya chochepa kusiyana ndi nthawi zonse.

Lorcaserin hydrochloride ndi serotonin 2C receptor agonist yomwe imasonyezedwa pofuna kuchiza matenda aakulu omwe ali ndi chiwerengero cha thupi (BMI) cha 30 kapena chachikulu (obese) monga kuwonjezera pa zakudya zochepetsetsa za calorie ndi masewera olimbitsa thupi. lorcaserin imavomerezedwanso kuti igwiritsidwe ntchito ndi akuluakulu omwe ali ndi BMI ya 27 kapena wamkulu (olemera kwambiri) komanso omwe ali ndi vuto limodzi lolemera kwambiri monga kuthamanga kwa magazi (kuthamanga kwa magazi), mtundu wa 2 shuga, kapena cholesterol (dyslipidemia).

Lorcaserin hydrochloride amagwiritsidwa ntchito ngati mankhwala oletsa kunenepa kwambiri

Kunenepa kwambiri ndichinthu chofunikira kwambiri pazaumoyo chomwe chimafunikira njira zotetezeka komanso zothandiza kuthana ndi mliri wa kunenepa kwambiri. Lorcaserin ndi serotonergic agonist yodziwika bwino kwa 5HT- 2C receptor yovomerezeka kuti azisamalira kunenepa kwambiri kwa odwala omwe ali ndi BMI ≥ 30 kg / m (2) kapena BMI ≥ 27 kg / m (2) ndi comorbidities zokhudzana ndi kunenepa kwambiri.

Lorcaserin ndi wapadera kwambiri wosankha serotonergic agonist wopangidwa kuti achepetse zoopsa zomwe zimagwirizanitsidwa ndi othandizira akale m'kalasili. Mlingo wochizira umalekerera bwino ndipo umatulutsa wocheperako koma wothandiza kwambiri kuwonda ndi kusintha kwakukulu mu magawo a cardiometabolic. Kuchita bwino kwamankhwala kuyenera kuyesedwa pamasabata a 12 (≥ 5% kuwonda) kuti adziwe omwe angayankhe. amapeza kuonda kwakukulu komanso phindu la metabolic kuchokera ku chithandizo chanthawi yayitali. Zotsatira za kuyesa kwa zotsatira za mtima (CAMELLIA TIMI 61) zidzatsimikizira ntchito ya lorcaserin popewera matenda a shuga mwa anthu olemera kwambiri / onenepa kwambiri komanso kugwiritsidwa ntchito kwa anthu omwe ali ndi chiopsezo chachikulu cha odwala omwe ali ndi matenda a mtima kapena matenda ambiri a mtima. .

Kumene angagule Lorcaserin hydrochloride Ufa?

Lorcaserin imagwiritsidwa ntchito pothandizira anthu akuluakulu omwe ali olemera kwambiri kapena omwe ali olemera kwambiri komanso omwe ali ndi mavuto azachipatala okhudzana ndi kulemera kuti achepetse thupi komanso kuti asabwererenso kulemera kwake. Lorcaserin iyenera kugwiritsidwa ntchito limodzi ndi chakudya chochepa cha calorie komanso ndondomeko yolimbitsa thupi. Lorcaserin ali m'gulu la mankhwala otchedwa serotonin receptor agonists. Zimagwira ntchito powonjezera kukhuta kotero kuti chakudya chochepa chidyedwe.

Raw Lorcaserin hydrochloride Powder Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Lorcaserin hydrochloride (1431697-94-7) -COA

Lorcaserin hydrochloride (1431697-94-7) -COA

Mungagule bwanji Lorcaserin hydrochloride Ufa wochokera ku AASraw?

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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Stefan Wagner
Rowett Institute, University of Aberdeen, Aberdeen, UK
Stefan Wagner ndi Daniel I. Brierley anathandizira mofananamo pantchitoyi.
2. Qihua Zhu
Jiangsu Key Laboratory of Kapangidwe ka Mankhwala ndi Kukhathamiritsa
Dipatimenti ya Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China
3. Thiago F. Ribeiro
Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, PO Box 131, Goiânia, GO 74690-900, Brazil
4. Dattatraya V. Wani
Department of Pharmaceutical Chemistry, Maulana Azad Education Trust's YB Chavan College of Pharmacy, Aurangabad, Maharashtra, India
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito izi mankhwala pa chifukwa chilichonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Reference

[1] piritsi la Belviq (lorcaserin hydrochloride) [Eisai, Inc]”. DailyMed. Eisai, Inc. Ogasiti 2012. Adasungidwa kuchokera koyambirira pa 21 Okutobala 2013. Adabwezedwanso pa 21 Okutobala 2013.

[2] "FDA ikupempha kuchotsedwa kwa mankhwala ochepetsa thupi Belviq, Belviq XR (lorcaserin) pamsika". US Food and Drug Administration (FDA). 14 Januware 2020. Adabwezedwanso pa Epulo 1, 2020.

[3] "FDA Mwachidule: FDA Imapempha Kuchotsa Mwaufulu kwa Mankhwala Ochepetsa Kunenepa Pambuyo pa Kuyesedwa Kwachipatala Kumasonyeza Kuwonjezeka kwa Khansa". FDA. 13 February 2020.

[4] "Mapiritsi a Belviq XR (lorcaserin hydrochloride) otulutsidwa nthawi yayitali". US Food and Drug Administration (FDA). 26 October 2016. Idabwezedwanso pa 14 Januware 2020.

[5] "Phukusi Lovomereza Mankhwala: Belviq (lorcaserin hydrochloride) Mapiritsi NDA #022529". US Food and Drug Administration (FDA). 7 Ogasiti 2012. Adabwezeretsedwanso pa Januware 14, 2020.

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