Mafotokozedwe Akatundu
Lorcaserin hydrochloride Powder Video-AASraw
Yaiwisi Lorcaserin hydrochloride Powder Basic Characters
| Name: | Lorcaserin hydrochloride ufa |
| CAS: | 1431697-94-7 |
| Maselo chilinganizo: | C11H15Cl2N |
| Kulemera kwa Maselo: | 232.1525 |
| Melt Point: | 212 ° C |
| Kusungirako nyengo: | -20 ℃ |
| mtundu; | White powder |
Chani is Lorcaserin hydrochloride Powder?
Lorcaserin hydrochloride ndi hydrochloride yomwe imapezeka ndi zochita za lorcaserin ndi imodzi yofanana ndi hydrochloric acid. Amagwiritsidwa ntchito ngati mankhwala oletsa kunenepa kwambiri. Imakhala ndi gawo ngati agonist ya serotonergic komanso yokhumudwitsa chilakolako.
Lorcaserin hydrochloride powder imakhudza zizindikiro za mankhwala mu ubongo zomwe zimayendetsa chilakolako. Lorcaserin HCL ufa umagwira ntchito pokuthandizani kuti mukhale odzaza ndi zakudya zing'onozing'ono.Lorcaserin hydrochloride powder amagwiritsidwa ntchito pamodzi ndi zakudya ndi masewera olimbitsa thupi kuti athetse kunenepa kwambiri.Lorcaserin hydrochloride powder nthawi zina amagwiritsidwa ntchito pochiza kunenepa kwambiri komwe kungakhale kokhudzana ndi matenda a shuga, high cholesterol, kapena kuthamanga kwa magazi. .
Kodi Lorcaserin hydrochloride ndi chiyani?
Lorcaserin hydrochloride imagwiritsidwa ntchito pothandizira anthu akuluakulu omwe ali olemera kwambiri kapena omwe ali olemera kwambiri komanso omwe ali ndi mavuto azachipatala okhudzana ndi kulemera kuti achepetse thupi komanso kuti asabwererenso kulemera kwake. Lorcaserin iyenera kugwiritsidwa ntchito pamodzi ndi kuchepetsa zakudya za calorie komanso ndondomeko yolimbitsa thupi. Lorcaserin ali m'gulu la mankhwala otchedwa serotonin receptor agonists. Zimagwira ntchito powonjezera kukhuta kotero kuti chakudya chochepa chidyedwe.
Lorcaserin hydrochloride imagwiritsidwa ntchito pamodzi ndi zakudya zochepetsera kalori komanso masewera olimbitsa thupi kuti akuthandizeni kuchepetsa thupi. Amagwiritsidwanso ntchito kwa anthu onenepa kwambiri omwe angakhalenso ndi matenda a shuga, kuthamanga kwa magazi, cholesterol yapamwamba, kapena matenda a mtima.
The Ubwino wa Lorcaserin hydrochloride
Lorcaserin hydrochloride ndi mankhwala omwe amaperekedwa pamlomo omwe amalimbikitsa kuwonda. Amagwiritsidwa ntchito ndi zakudya ndi masewera olimbitsa thupi kwa akuluakulu olemera kwambiri omwe ali ndi vuto lachipatala lokhudzana ndi kulemera kwa thupi kapena akuluakulu olemera kwambiri kuti achepetse thupi ndikuzisunga.
Lorcaserin hydrochloride ndi serotonin 2C (5-HT2C) receptor agonist. lorcaserin amaganiziridwa kuti amasankha 5-HT2C receptors mu hypothalamus, dera la ubongo lomwe limadziwika kuti limagwira ntchito yaikulu pakuwongolera njala ndi kudya. Poyambitsa ma receptor awa, lorcaserin ikhoza kuchepetsa kudya mwa kuchepetsa chilakolako cha kudya ndikupangitsa munthu kukhala wokhuta ngakhale atadya chakudya chochepa kusiyana ndi nthawi zonse.
Lorcaserin hydrochloride ndi serotonin 2C receptor agonist yomwe imasonyezedwa pofuna kuchiza matenda aakulu omwe ali ndi chiwerengero cha thupi (BMI) cha 30 kapena chachikulu (obese) monga kuwonjezera pa zakudya zochepetsetsa za calorie ndi masewera olimbitsa thupi. lorcaserin imavomerezedwanso kuti igwiritsidwe ntchito ndi akuluakulu omwe ali ndi BMI ya 27 kapena wamkulu (olemera kwambiri) komanso omwe ali ndi vuto limodzi lolemera kwambiri monga kuthamanga kwa magazi (kuthamanga kwa magazi), mtundu wa 2 shuga, kapena cholesterol (dyslipidemia).
Lorcaserin hydrochloride amagwiritsidwa ntchito ngati mankhwala oletsa kunenepa kwambiri
Kunenepa kwambiri ndichinthu chofunikira kwambiri pazaumoyo chomwe chimafunikira njira zotetezeka komanso zothandiza kuthana ndi mliri wa kunenepa kwambiri. Lorcaserin ndi serotonergic agonist yodziwika bwino kwa 5HT- 2C receptor yovomerezeka kuti azisamalira kunenepa kwambiri kwa odwala omwe ali ndi BMI ≥ 30 kg / m (2) kapena BMI ≥ 27 kg / m (2) ndi comorbidities zokhudzana ndi kunenepa kwambiri.
Lorcaserin ndi wapadera kwambiri wosankha serotonergic agonist wopangidwa kuti achepetse zoopsa zomwe zimagwirizanitsidwa ndi othandizira akale m'kalasili. Mlingo wochizira umalekerera bwino ndipo umatulutsa kuonda pang'ono koma kothandiza kwambiri ndikuwongolera kwambiri magawo a cardiometabolic. Kuchita bwino kwamankhwala kuyenera kuyesedwa pamasabata a 12 (≥ 5% kuwonda) kuti adziwe omwe adzalandira kulemera kwakukulu ndi kupindula kwa metabolic kuchokera ku chithandizo chanthawi yayitali. Zotsatira za kuyesa kwa zotsatira za mtima (CAMELLIA TIMI 61) zidzatsimikizira ntchito ya lorcaserin popewera matenda a shuga mwa anthu olemera kwambiri / onenepa kwambiri komanso kugwiritsidwa ntchito kwake kwa anthu omwe ali ndi chiopsezo chachikulu cha odwala omwe ali ndi matenda a mtima kapena matenda ambiri a mtima.
Kumene angagule Lorcaserin hydrochloride Ufa?
Lorcaserin imagwiritsidwa ntchito pothandizira anthu akuluakulu omwe ali olemera kwambiri kapena omwe ali olemera kwambiri komanso omwe ali ndi mavuto azachipatala okhudzana ndi kulemera kuti achepetse thupi komanso kuti asabwererenso kulemera kwake. Lorcaserin iyenera kugwiritsidwa ntchito pamodzi ndi kuchepetsa zakudya za calorie komanso ndondomeko yolimbitsa thupi. Lorcaserin ali m'gulu la mankhwala otchedwa serotonin receptor agonists. Zimagwira ntchito powonjezera kukhuta kotero kuti chakudya chochepa chidyedwe.
Raw Lorcaserin hydrochloride Powder Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Lorcaserin hydrochloride (1431697-94-7) -COA
Lorcaserin hydrochloride (1431697-94-7) -COA
Mungagule bwanji Lorcaserin hydrochloride Ufa wochokera ku AASraw?
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Reference
[1] piritsi la Belviq (lorcaserin hydrochloride) [Eisai, Inc]”. DailyMed. Eisai, Inc. Ogasiti 2012. Adasungidwa kuchokera koyambirira pa 21 Okutobala 2013. Adabwezedwanso pa 21 Okutobala 2013.
[2] "FDA ikupempha kuchotsedwa kwa mankhwala ochepetsa thupi Belviq, Belviq XR (lorcaserin) pamsika". US Food and Drug Administration (FDA). 14 Januware 2020. Adabwezedwanso pa Epulo 1, 2020.
[3] "FDA Mwachidule: FDA Imapempha Kuchotsa Mwaufulu kwa Mankhwala Ochepetsa Kunenepa Pambuyo pa Kuyesedwa Kwachipatala Kumasonyeza Kuwonjezeka kwa Khansa". FDA. 13 February 2020.
[4] "Mapiritsi a Belviq XR (lorcaserin hydrochloride) otulutsidwa nthawi yayitali". US Food and Drug Administration (FDA). 26 October 2016. Idabwezedwanso pa 14 Januware 2020.
[5] "Phukusi Lovomereza Mankhwala: Belviq (lorcaserin hydrochloride) Mapiritsi NDA #022529". US Food and Drug Administration (FDA). 7 Ogasiti 2012. Adabwezeretsedwanso pa Januware 14, 2020.
