Mafotokozedwe Akatundu
Kodi Melanotan II ndi chiyani?
Melanotan II (yomwe imatchedwanso Melanotan 2,MT2,MT-2,MT-II) ndi mtundu wopangidwa mwaluso wa timadzi ta peptide timapangidwa mwachilengedwe m'thupi lomwe limapangitsa melanogenesis, njira yomwe imapangitsa khungu kukhala lamtundu. Hormone, yomwe nthawi zambiri imadziwika kuti MSH, imagwira ntchito poyambitsa zolandilira za melanocortin kuti zibweretse zotsatira zake.Zowonadi, kudzera mu zolandilira za melanocortin, MSH imakhudzanso kwambiri kagayidwe ka lipid, njala, ndi chilakolako chogonana.Chotsatira chake, kafukufuku wawonetsa kuti Melanotan 2 ili ndi zotulukapo zomwe zimapitilira kuwonjezera kutenthetsa khungu, monga kupondereza njala, kulimbikitsa lipolysis, komanso kukulitsa libido.
Kukula kwa Melanotan 2
Kulengedwa koyambirira kwa peptide yopangidwa ndi Melanotan 2 ikhoza kutchulidwa ku yunivesite ya Arizona. Pakafukufuku womwe cholinga chake chinali kupanga chitetezo ku khansa yapakhungu, cholinga chinayikidwa pakupanga njira yolimbikitsira melanogenesis, kapena kupanga melanin. Poyambirira, ofufuza a University of Arizona anayesa kupereka mwachindunji mahomoni obadwa mwachilengedwe a alpha-MSH kuti apeze zotsatira zomwe akufuna. adatsimikiza kuti MSH yochitika mwachilengedwe inali ndi theka la moyo wautali kuti ikhale yogwiritsidwa ntchito ngati njira yochizira. kukhala ndi theka la moyo wotalikirapo kuti agwiritse ntchito zochizira.
Melanin ndi chiyani?
Melanin ndi khungu la pigment lomwe limapangidwa lomwe limateteza khungu lathu ku kuwala kwa dzuwa ndi kuwonongeka kwa dzuwa. Ikhoza kuonedwa ngati chitetezo cha dzuwa cha thupi lathu. Kutsika kwa melanin kumatanthauza kuti khungu limatha kuwonongeka ndi DNA chifukwa cha dzuwa. ndipo chitetezo chake ku radiation ya UV kumatanthauza kuti anthu omwe ali ndi khungu loyera amakhala ndi chizolowezi chowotcha komanso kuyika pachiwopsezo cha kuwonongeka kwa DNA. Zimatanthauzanso kuti nthawi yochuluka imayikidwa luso lawo lopanga chitani bwino popanda kuwotcha.
Kulandira vitamini D wokwanira kuchokera kudzuwa popanda kukhala pachiwopsezo chokhala ndi melanoma ndi njira yofananira.Kafukufuku wapeza kale kuti kukhala padzuwa kuti tipewe khansa ya melanoma kungayambitse kuchepa kwa vitamini D. Melanotan II imawonjezera kupanga melanin kudzera mu kukondoweza. ma cell a pigment a khungu otchedwa melanocytes.
Kodi Melanotan II amagwira ntchito bwanji?
Melanotan II (MT2) imagwira ntchito polumikizana ndi zolandilira zina m'thupi zomwe zimatchedwa melanocortin receptors.
Kumanga kwa melanocortin receptors
Melanotan II imamanga ndi kuyambitsa zolandilira za melanocortin, makamaka ma MC1R ndi MC4R receptors.
Kulimbikitsa kupanga melanin
Pamene Melanotan II imamangiriza ku melanocortin receptors, imayambitsa zochitika zingapo za biochemical mkati mwa melanocytes.
Kuyambitsa njira za melanin
Melanotan II imayambitsa njira zowonetsera zomwe zimakhudzidwa ndi melanogenesis, njira ya melanin synthesis.
Kuwonjezeka kwa ntchito ya melanocyte
Melanotan II imalimbikitsa kuchulukana ndi ntchito za melanocyte, zomwe zimapangitsa kuti melanin achuluke.Izi zimapangitsa kuti khungu likhale lakuda ndipo limatha kutsanzira zotsatira za kutentha kwachilengedwe.
Zotsatira zachitetezo cha dzuwa
Powonjezera kupanga melanin, Melanotan II imatha kupereka chitetezo ku radiation ya UV.
Ndikofunika kuzindikira kuti mphamvu ndi nthawi ya zotsatira za kutentha kwa Melanotan II zingasiyane pakati pa anthu chifukwa cha zinthu monga majini, mlingo, ndi nthawi zambiri zomwe zimagwiritsidwa ntchito. Njira zodzitetezera ku dzuwa, monga kuvala zodzitetezera ku dzuwa komanso kuchepetsa kutetezedwa kwa UV.
Melanotan II (MT2) yowotcha peptide imapindula
Melanotan II (MT2) ili ndi zinthu zingapo zapadera zomwe zimaisiyanitsa ndi njira zina zofufutira komanso zopaka utoto wa khungu. Nazi zina zodziwika bwino:
Kuchulukitsa kupanga melanin
Melanotan II idapangidwa kuti ilimbikitse kupanga melanin, pigment yomwe imayambitsa khungu, tsitsi, ndi mtundu wamaso.
Kutha kuchepetsedwa kukhala padzuwa (Melanotan II pakuwotcha)
Chimodzi mwazabwino kwambiri za Melanotan II ndi kuthekera kwake kuchepetsa kuchuluka kwa dzuwa lomwe likufunika kuti likwaniritse tani. kuwonongeka kwa khungu.
Melanotan II amalola iwo omwe samatenthedwa komanso amawotcha nthawi zonse padzuwa kuti apeze tan.Synthetic melanotropin peptide supplements amapereka mwayi wosintha moyo kwa odwala omwe ali ndi matenda a dzuwa / osinthika olandirira.Kutentha kwachilengedwe komwe kumayamba pakapita nthawi ndiye chitetezo champhamvu kwambiri cha khansa. kuti khungu loyera lingathe lero kukwaniritsa.Melanotan inalengedwa ndi cholinga chochepetsera chiwerengero cha khansa ndipo mwinamwake kukhala wothandizira wotentha wopanda dzuwa.
Ochita masewera olimbitsa thupi ndi okonda masewera olimbitsa thupi amagwiritsa ntchito Melanotan 2 pofuna kufulumira kutentha thupi, kuwonjezeka kwa libido ndi kuchepetsa chilakolako. Melanotan II ikupitilizabe kukhala peptide yotentha kwambiri yogulitsidwa pa intaneti.Chonde onetsetsani kuti mwagula MT2 kuchokera kwa wopanga ma peptide weniweni chifukwa chopangidwa molakwika chingakhale ndi zoopsa zina.
Mapulogalamu azachipatala omwe angathe
Kuphatikiza pa kupukuta khungu, Melanotan II imasonyeza kudalirika pazochitika zina zachipatala. Mwachitsanzo, ikhoza kugwiritsidwa ntchito ngati chithandizo kwa anthu omwe ali ndi vitiligo, matenda a pakhungu omwe amadziwika ndi zigamba za khungu. kuyang'anira erythropoietic protoporphyria (EPP), matenda osowa cholowa omwe amachititsa chidwi kwambiri ndi kuwala kwa dzuwa.
Adanenedwa kukulitsa libido
Chinthu chochititsa chidwi chomwe chimagwirizanitsidwa ndi Melanotan 2 ndi zotsatira zake zomwe zimatchulidwa pa libido ndi ntchito yogonana.Ogwiritsa ntchito ena awonetsa kuwonjezeka kwa kugonana ndi chilakolako monga zotsatira zogwiritsira ntchito peptide iyi. dziwani ndi ogwiritsa ntchito onse.
Melanotan II kuchepetsa thupi
Ngakhale kuti sichinali cholinga chake chachikulu, kafukufuku wina wasonyeza kuti Melanotan II ikhoza kuthandizira kuchepetsa chilakolako ndi kuchepa kwa thupi.
Mtundu womwe ulipo wa Melanotan II (MT2) pamsika
Pali zambiri za Melanotan II zogulitsidwa pa intaneti, kupezeka kwa MT2 ndi kwakukulu.MT2 ili ndi mawonekedwe opopera a M'mphuno, majekeseni osakanikirana a Melanotan 2, mapiritsi, oral melanotan2 ndi Melanotan II. Komabe, peptide Melanotan II (MT2) imapezeka makamaka mumsika mu mawonekedwe a lyophilized ufa wokonzanso ndi kulamulira kotsatira.Nazi mitundu yambiri ya Melanotan II yomwe ilipo:
Fomu la Powor
Melanotan II amagulitsidwa ngati ufa wa lyophilized, womwe ndi mawonekedwe owuma a peptide. Nthawi zambiri amabwera m'mabotolo kapena ziwiya zazing'ono.Wopereka Melanoan 2 AASRAW samangopereka peptide yaiwisi ya ufa, komanso ufa wa lyophilized mu mbale.
Kukonzanso
Musanagwiritse ntchito, ufa uyenera kukonzedwanso ndi chosungunulira choyenera, madzi omwe amakhala osabala kapena bacteriostatic water.Reconstitution malangizo akhoza kusiyana malingana ndi mankhwala enieni ndi MT2 wopanga, kotero ndikofunika kutsatira mosamala malangizo operekedwawo.
Kupweteka
Pamene ufawo umakonzedwanso, Melanotan II nthawi zambiri amaperekedwa kudzera mu jekeseni wa subcutaneous.Singano yaying'ono imagwiritsidwa ntchito kulowetsa yankho pansi pa khungu, makamaka m'matumbo a m'mimba kapena ntchafu.M'malo mogula jekeseni m'dziko lanu, ndi sungani ndalama kuti agule lyophilized ufa wa Melanotan 2 kuti adzipangire okha jekeseni wa MT2. Gulani Melanotan 2 wholesale adzalandira mtengo wabwino.
Ndikofunikira kuwonetsetsa kuti chinthucho ndi chovomerezeka pogula Melanotan II, chifukwa mitundu yabodza kapena yopangidwa molakwika imatha kubweretsa zoopsa zina.
Zotsatira za Melanotan II
Melanotan II peptide yoperekedwa pang'onopang'ono imanenedwa kuti ndi yotetezeka komanso yothandiza pa mlingo wovomerezeka.
nseru
Kupweteka m'mimba
utachepa chilakolako
Kukudula
Khungu lakuda
Kukoka kwa mbolo modzidzimutsa
Kusintha mu mawonekedwe a mole
Pazovuta kwambiri, pali zoopsa zomwe zingatheke chifukwa cha zotsatira zoyipa izi, kuphatikizapo:
Mtundu waukulu wa khansa yapakhungu (melanoma)
Kupanga ma moles atsopano ndi atypical melanocytic naevi
Rhabdomyolysis (kuwonongeka kwa maselo a minofu komwe kungathe kupha)
Encephalopathy syndrome
Kulephera kugonana
Ndikofunikiranso kumvetsetsa kuti ngati singano zimagawidwa kapena osayeretsedwa bwino musanagwiritse ntchito, pamakhala chiopsezo choyipitsidwa. Monga jekeseni iliyonse, kufiira ndi kuwawa pamalo opangira jekeseni ndizotheka. Gulani peptide melanotan II yokhala ndi chiyero cha 98% kapena apamwamba.
Sitikulimbikitsidwa kugwiritsa ntchito jekeseni wa PT-141 nthawi imodzi ndi PDE5 inhibitor mwa amuna chifukwa cha chiopsezo cha priapism.
Mankhwalawa sayenera kugwiritsidwa ntchito ngati muli ndi pakati kapena mukuyamwitsa.Palibe umboni wokwanira wosonyeza kuti ndi otetezeka bwanji kwa anthu omwe ali m'gululi.Monga mankhwala ena aliwonse, nthawi zonse muyenera kukaonana ndi katswiri wa zachipatala musanayambe mankhwala owonjezera. makamaka ngati mukugwiritsa ntchito mankhwala ena aliwonse.Pakali pano, palibe kuyanjana kwamankhwala komwe kumadziwika, koma ndikwabwino kusamala kuposa kupepesa.
Ofufuza omwe ali ndi chidwi chofufuza zotsatira za Melanotan 2 angakhale ndi chidwi chofuna kudziwa komwe angagule mankhwala ofufuzawa pa intaneti.Mwatsoka, kupeza wovomerezeka wa peptides wa kafukufuku wa kafukufuku kungakhale kovuta.AASRAW ndi wodalirika wopanga peptide kuti akhulupirire.
Lipoti Loyesa la Melanotan II-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji Melanotan II kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Gilhooley E, Daly S, McKenna D. "Melanotan II Zokumana nazo za Ogwiritsa Ntchito: Kafukufuku Woyenerera Wamabwalo Okambilana Paintaneti." Dermatology. 2021;237(6):995-999. doi: 10.1159/000514492. Epub 2021 Aug 31.PMID: 34464955
[2] Peters B, Hadimeri H, Wahlberg R, Afghahi H.”Melanotan II: chomwe chingakhale chifukwa cha infarction yaimpso: kuwunikanso zolemba ndi lipoti lamilandu. "CEN Case Rep. 2020 May; 9(2): 159-161. doi: 10.1007/s13730-020-00447-z. Epub 2020 Jan 18.PMID: 31953620
[3] Tomassi S, Dimmito MP, Cai M, D'Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S."CLIPSing Melanotan-II to Discover Ma hMCR Agonists Ogwira Ntchito Angapo." J Med Chem. 2022 Marichi 10; 65 (5): 4007-4017. doi: 10.1021/acs.jmedchem.1c01848. Epub 2022 Feb 21.PMID: 35188390
[4] Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J. ”Melanotan-II: Kufufuza zotsatira za inducer ndi otsogolera pakupanga mbolo mu makoswe opangidwa ndi anesthetized.” Neuroscience. 2006;138(1):293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19.PMID: 16360286
[5] Hjuler KF, Lorentzen HF." Melanoma yokhudzana ndi kugwiritsa ntchito melanotan-II." Dermatology. 2014;228(1):34-6. doi: 10.1159/000356389. Epub 2013 Dec 18.PMID: 24355990
[6] Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.” Melanotan II imayambitsa hypothermia mu mbewa poyambitsa ma mast cell komanso kukondoweza kwa histamine 1. "Am J Physiol Endocrinol Metab. 2018 Sep 1; 315(3):E357-E366. doi: 10.1152/ajpendo.00024.2018. Epub 2018 May 29.PMID: 29812984
Pezani mawu a Bulk
