OL 135

AASraw ili ndi kaphatikizidwe ndi kupanga kupanga kuchokera ku gramu kupita kwa akuluakulu a OL 135 (681135-77-3), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

OL135 ndi CNS wodwalayo, wolimba kwambiri komanso wosankha chokhazikika cha FAAH. Amasonyeza analgesic pharmacology mu zinyama zosiyanasiyana zosiyana popanda kuwonongeka kwa magalimoto zomwe zimagwiridwa ndi CB1 agonism. Zimapangitsa ntchito ya analgesic ndi hypothermic ya anandamide.

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Mafotokozedwe Akatundu

OL 135 kanema


I.OL 135 Anthu oyambirira:

Name: OL 135
CAS: 4642-95-9
Makhalidwe a Maselo: C18H20O2
Kulemera kwa maselo: 258.36
Melt Point: 138-141 ℃
Kusungirako nyengo: Kutentha kwa Chipinda
mtundu; Mphuno yonyezimira kapena yonyezimira ya Crystalline


II. Zambiri Pa OL 135 Aliyense ayenera kudziwa:

1.Name:

OL 135

2.Kodi ndikugwira ntchito pa OL 135 ?:

OL-135 idasungidwa pa -80 ° C mu mawonekedwe a ufa, mpaka pafupifupi 60 min asanayesedwe kachitidwe. Mankhwala atatu anali okonzedwa (0, 5.6, 10.0 mg / kg) ndi galimoto yokhala ndi 1: 1: 18 ethanol, cremophor, ndi saline. Kugwiritsa ntchito mankhwala osokoneza bongo kunachitika maminiti a 30 musanaphunzire (Yesani 1) kapena mwamsanga (mkati mwa 5 min) mutaphunzira (Yesani 2) kudzera mu jekeseni la intraperitoneal (IP).

Kukonzekera kunkachitika m'zipinda zinayi zoyambirira kumagwiritsa ntchito mapulogalamu awo a "Freezing" omwe amagwiritsa ntchito njira zomwe zatulutsidwa kale, ndikumvetsetsa kuti zigwiritsidwe ntchito pazokulu. Mwachidule, tsiku loyamba (maphunziro) anapatsidwa malo asanu ndikutsatiridwa ndi ma 10 awiri a 10-s 67-db 4-kHz tone ndi mantha a 2-0.3-mA. Pa tsiku lachiwiri (kuyesedwa kwachidziwitso) maphunziro adasamutsira ku chipinda chimodzimodzi monga tsiku lomwe lakhalapo kwa maminiti asanu pamene nthawi yozizira inayesedwa. Pa tsiku lachitatu (maphunziro oyesedwa) amayendetsedwa m'chipinda chatsopano chokhala ndi chikhalidwe chosiyana. Kusungunula kunayesedwa pa nthawi ya mphindi zisanu ndikutsatiridwa ndi 10 mafotokozedwe a chidziwitso choyendetsera panthawi yomwe kuzizira kunayesedwa. Nthawi zonse, kuzizira kumatanthauzidwa ngati kusowa kwa kayendedwe ka khola pansi pa malo osungirako 0.5s. Chigawocho chinatsimikiziridwa mu maphunziro oyendetsa ndege ndi wofufuzira adaphunzitsidwa kuti adziwe kuyankha kozizira. Mawerengero ozizira kwambiri amawerengedwa poyerekeza ndi nthawi yomwe ili pansi pa kayendetsedwe ka kayendetsedwe ka nthawi yonse ya chochitikacho, kuphatikizapo kuwonetsa ma toni onse a 10.

Pofuna kuonetsetsa kuti zotsatira za mankhwalawa ndizoopsa komanso osati zowonongeka, timayesetsanso kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda, monga mtengo wapatali komanso mtengo wapatali. Pakati pa njira imodzi njira ZOYENERA za mlingo wa mankhwala pazikuluzikulu ndi zozizwitsa zowopsya zimapezekanso kusiyana kwakukulu.

3.Chiani chimakhudza OL 135?

FAAH Inhibitor OL-135 imasokoneza kugula, koma osati kuphatikiza, kwa chikhalidwe cha mantha
 Kuchita mantha ndi chiopsezo komanso kusokonezeka komwenso kumakhalabe kosakhudzidwa.
Kodi, ma detawa amasonyeza mbali yeniyeni yothetsera mavuto omwe amachititsa kuti matendawa asapangidwe.

4.Inanso malangizo:

Mafuta ochepetsetsa a amide hydrolase (FAAH) omwe amachititsa kuti mankhwalawa asapangidwe kwambiri OL135 amatsitsimutsa mitsempha yotchedwa ratings (SNL) ndi mafilimu ochepetsa kutentha (MTI). Kuwonongeka kwa mavitamini owononga kwambiri a asidi amide hydrolase (FAAH) kumapangitsa kuwonetsa kosalekeza ndipo kungachititse zotsatira zofanana popanda zotsatirapo. Kafukufuku wamakono akufufuzira zotsatira za mlingo wochepa (5.6 mg / kg) kapena mlingo wa pakati (10.0 mg / kg) Mlingo wa OL-135 (FAAH inhibitor) pa kugula ndi kukhazikitsa chikhalidwe cha mantha, omwe ndi Common chiwonetsero chopweteka kwambiri. Mayendedwe onse a OL-135 akuwonongeka mwatsatanetsatane koma opanda mantha omveka. Impact reactivity sakhudzidwa. Chifukwa cha zowonjezera maulendo oyendetsa maulendo omwe amayenera kufotokozedwa ndi nkhaniyi, koma osati zolemba, mantha, ma datawa amasonyeza kuti mapeto ake amatha kusonyeza kuti kunja kwa amygdala kungakhale kofunika kwa chikumbukiro choopsa. Mankhwala aakulu a anandamide ubongo (350 pmol g (-1) minofu) ndi 60 pmol g (-1) zothandizidwa ndi magalimoto zimapezeka mu ubongo wa makoswe opatsidwa OL135 (20 mg kg (-1)) ip. Mphindi 15 isanafike jekeseni ya intraperitoneal ya 20 mg / kg (-1). Mankhwala osokoneza bongo. Ubongo wa 3 FAAH inatetezedwa ku makoswe osasinthika ndi makoswe OL135 (2-60 mg kg (-1) ip) Mphindi 30 isanayambe kulamuliridwa ndi FAAH inhibitor (URB597: 0.3 mg kg (-1) osayimilira). Mlingo wa chitetezo cha enzyme ndi wofanana ndi OL 135 mu ubongo womwewo. Pambuyo pa 30 min pambuyo poyambira, 4OL135 (100 mg kg (-1) ip) inachepetsanso mphamvu ya MTI (MPE) yomwe imapangidwa ndi ma FI (+ / +) mbewa (yoyeretsedwa ndi Frey filaments). 50%, koma palibe zotsatira mu FAAH (- / -) mbewa. 5 OL135 yomwe inayendetsedwa ip inachititsa kuti mayendedwe amtundu wa ED (50) pakati pa 6 ndi 9 mg kg (-1) ayambe kugwiritsidwa ntchito pazithunzi za MTI ndi SNL. Magulu a plasma a ED (50) m'magulu awiriwa anali 0.7 microM (240 ng ml (-1)). Pulogalamu ya kondomu SNL, kugwirizanitsa kwa CB-XMUMX mg (-2) pulogalamu ya CB (144528) yothandizira odwala SR5 (1 mg kg--20) ip) ndi 135 mg / kg OL135 yotsekedwa ndi OL 1 yomwe inachititsa kuti zipangizo zamagetsi zisawonongeke. Komabe, CB (141716) ) mdani SR5A (141716 mg / kg (ip)) analibe ntchito. Pogwiritsa ntchito makoswe a MTI, kuphatikizapo adani awiri, SR144528A kapena SR5 (onse opatsidwa 1 mg kg (-135) intraperitoneally) kapena kuphatikiza ndi OL 20 (30 mg / kg), adatsekedwa pambuyo pa miyezi ya 8 ya kusintha kwa chiwerengero cha makina opangira mawonekedwe. 1 M'njira yamakono MTI ndi chitsanzo cha SNL, naloxone (1 mg kg (-30), 135 min jekeseni ya m'thupi pambuyo pa OL15) ikhoza kusinthira analgesia (135% ya gawo lolamulira mu MTI chitsanzo, ndi zero SNL). OL XNUMX amapereka.

5. OL 135:

10grams yayamba.
Funso labwino kwambiri (mkati mwa 1kg) lingatumizedwe mu maola a 12 mutatha kulipira.
Kuti mukhale wamkulu (mkati mwa 1kg) mukhoza kutumizidwa mu tsiku la ntchito 3 mutatha kulipira.

6. OL 135 Maphikidwe:

Kuti mufunse Wotumikira Wathu Woimira Wathu (CSR) kuti mudziwe zambiri, kuti muwone.

7. OL 135 Marketing:

Kuti aperekedwe m'tsogolomu.


III. OL 135 HNMR

Ndife aprepitant ufa wophimba, ufa wa Aprepitant wogulitsidwa, ufa wochuluka wa Aprepitant (170729-80-3) hplc =98% | Ikani ma Reagents a R & D


IV. Kodi mungagule bwanji OL 135 kuchokera ku AASRAW?

1.Kutiwuza ife ndi imelo yathu kafukufuku, kapena skype pa intanetiwoimira makasitomala (CSR).
2.Zotipatseni ife afunsidwa zambiri ndi adiresi yanu.
3.Our CSR idzakupatsani inu ndondomeko, nthawi yobwezera, nambala yotsatira, njira yobweretsera ndi tsiku lofika kufika (ETA).
4.Payment yachitidwa ndipo katunduyo adzatumizidwa mu maola a 12 (Kukonzekera mkati mwa 10kg).
5.Goods inalandira ndi kupereka ndemanga.


Tangoganizirani zomwe mumakonda kwambiri blog:

Mmene mungagwiritsire ntchito Clenbuterol kuti muwonongeke Kodi ufa wa nandrolone umagwiritsidwa ntchito bwanji / nandrolone phindu?


Zambiri mwatsatanetsatane zamagetsi,kulandila apa.


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