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Orlistat ufa

mlingo: SKU: 96829-58-2. Category:

AASraw ndi akatswiri opanga Orlistat Powder yoyera yomwe ili ndi labu yodziyimira payokha ndi fakitale yayikulu monga chithandizo, zonse zopanga zizichitika motsogozedwa ndi CGMP ndikuwongolera kachitidwe kabwino. Dongosolo loperekera ndi lokhazikika, malonda onse ogulitsa ndi ogulitsa ndi ovomerezeka.Takulandirani kuyitanitsa kuchokera ku AASraw!

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Orlistat Powder kanema-AASraw

 


Orlistat Powder Makhalidwe Oyambira

Name: Orlistat ufa
CAS: 96829-58-2
Maselo chilinganizo: C29H53NO5
Kulemera kwa Maselo: 495.7
Melt Point: 50 ° C
Kusungirako nyengo: 2-8 ° C
mtundu; White powder

 


Kodi Orlistat Powder ndi chiyani?

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito pochiza kunenepa kwambiri kapena odwala olemera kwambiri.Inayamba kupangidwa ndi Roche ndipo inayambika ku United States ku 1999.Ndilo mankhwala okhawo omwe amachepetsa kulemera kwa thupi omwe amavomerezedwa ndi FDA, CFDA ndi EMA Imagwira ntchito poletsa pancreatic ndi gastric lipases, ma enzymes omwe amaphwanya mafuta am'mimba m'matumbo. Izi zimapangitsa kuti mafuta osagayidwa azituluka mu ndowe, zomwe zimapangitsa kuti mafuta azikhala ochepa.

Ku United States, orlistat ndi yovomerezeka pochiza index mass index (BMI,Body Mass Index,unit kg/㎡) kufika kapena kupitirira 30 (US kunenepa kwambiri). ndi zinthu zina zowopsa paumoyo monga kuthamanga kwa magazi kapena shuga.

Kodi Orlistat Powder Imagwira Ntchito Motani?

Orlistat ufa amagwira ntchito poletsa m'mimba ndi pancreatic lipases, omwe ndi michere yomwe imayambitsa kuphwanya triglycerides kukhala mafuta ang'onoang'ono acids omwe amatha kuyamwa ndi thupi.Mwa kuletsa ma enzymes, AASraw orlistat imalepheretsa hydrolysis ya triglycerides m'matumbo, yomwe imatsogolera ku kuchepa kwa kuchuluka kwa mafuta ophatikizidwa muzakudya.

Popeza kuti triglycerides sichiphwanyidwa kukhala mafuta amafuta aulere, amachotsedwa mosasinthika mu ndowe.Njirayi imayambitsa kuchepetsa kudya kwa caloric ndikulimbikitsa kuchepa kwa thupi.Orlistat yasonyezedwa kuti iteteze pafupifupi 30% ya mafuta a zakudya kuti asatengeke.

Kuwonjezera pa kuletsa lipases, orlistat imalepheretsanso thioesterase domain ya mafuta acid synthase (FAS) . -zolinga kapena kusapezeka bwino kwa bioavailability, zitha kulepheretsa ntchito yake ngati antitumor wothandizira.

Ponseponse, kachitidwe ka orlistat kumakhudzanso kuletsa kwa michere yomwe imakhudzidwa ndi chimbudzi chamafuta, zomwe zimapangitsa kuchepetsa kuchuluka kwamafuta am'zakudya komanso kulimbikitsa kuchepa thupi.

Ubwino Wogwiritsa Ntchito Orlistat Powder

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito makamaka pochiza kunenepa kwambiri, makamaka poletsa kuyamwa kwa mafuta kuchokera ku zakudya zaumunthu. zotsatira.

· Kuchiza kwa Kunenepa Kwambiri

Orlistat ufa makamaka umagwiritsidwa ntchito pochiza kunenepa kwambiri pamodzi ndi wothandizira zaumoyo-oyang'anira kuchepetsa-calorie diet.Ntchito yake yaikulu ndikuletsa kuyamwa kwa mafuta okhudzana ndi zakudya pochita ngati lipase inhibitor, motero kuchepetsa kudya kwa caloric.AASraw Orlistat ufa amagwira ntchito Poletsa chapamimba ndi pancreatic lipases, michere yomwe imayambitsa kuphwanya triglycerides m'matumbo. Ntchito ya lipase ikatsekeka, triglycerides kuchokera m'zakudya samapangidwa ndi hydrolyzed kukhala mafuta amafuta aulere, ndipo m'malo mwake amatulutsidwa mosasinthika.

Zomwe zaphatikizidwa m'mayesero azachipatala zikuwonetsa kuti anthu omwe amapatsidwa orlistat kuphatikiza pakusintha kwa moyo wawo, monga zakudya ndi masewera olimbitsa thupi, amataya pafupifupi ma kilogalamu 2-3 (4-7 lb) kuposa omwe samamwa mankhwalawa pakatha chaka chimodzi. Pakati pa 35.5 % ndi 54.8% ya maphunziro adapindula ndi 5% kapena kuchepa kwakukulu kwa thupi, ngakhale kuti sizinthu zonsezi zomwe zinali zonenepa. orlistat inaimitsidwa, chiwerengero chachikulu cha maphunziro chinayambanso kulemera - mpaka 16.4% ya kulemera kumene iwo anataya.

· Kuchepetsa Kuthamanga kwa Magazi

Kuwonjezera pa kuthandizira kuchepetsa thupi, kafukufuku wasonyeza kuti ufa wa orlistat ungathandizenso kuchepetsa kuchepa kwa magazi.Deta yophatikizidwa kuchokera ku mayesero a zachipatala imasonyeza kuti orlistat imachepetsa kuthamanga kwa magazi kwa systolic ndi diastolic ndi pafupifupi 2.5 ndi 1.9 mmHg, motsatira. Njira yochepetsera kuthamanga kwa magazi uku imaganiziridwa kuti ikugwirizana ndi kuchepa kwa thupi komwe kumapezeka pogwiritsa ntchito orlistat, monga kunenepa kwambiri ndizomwe zimadziwika kuti zimayambitsa matenda oopsa. ang'onoang'ono ndipo sayenera kudaliridwa ngati mankhwala okhawo omwe ali ndi matenda oopsa.

· Kupewa Kuyamba kwa Matenda a shuga amtundu wa 2

Orlistat ufa wasonyezedwa kuti uli ndi mphamvu yoletsa kuyambika kwa matenda a shuga a mtundu wa 2, kuphatikizapo kulemera kwake ndi kutsika kwa magazi. Kafukufuku wasonyeza kuti orlistat ikhoza kuchepetsa chiwerengero cha matenda a shuga a mtundu wa 2 mwa anthu omwe ali onenepa kwambiri mofanana ndi momwe moyo umasinthira. sizikumveka bwino, koma zimaganiziridwa kuti zimagwirizana ndi mphamvu ya mankhwalawa yochepetsera kudya kwa caloric mwa kulepheretsa kuyamwa kwa mafuta a zakudya, zomwe zingapangitse kusintha kwa kagayidwe ka shuga ndi insulin sensitivity. kuti mukhale ndi moyo wathanzi, ndipo kugwiritsidwa ntchito kwake kuyenera kuphatikizidwa ndi zakudya zopatsa mphamvu zama calorie komanso masewera olimbitsa thupi kuti zitheke.

Zindikirani:Kuti muwonjezere ubwino wa ufa wa Orlistat, ndizofunika kuti mugule kuchokera kwa wothandizira wodalirika.AASraw amapereka ufa wapamwamba wa Orlistat pamtengo wokwanira, monga katswiri wothandizira ufa wa Orlistat wokhala ndi R & D yodziimira payekha ndi fakitale.Mukagula ufa wa Orlistat kuchokera ku AASraw, mungakhale ndi chidaliro kuti mukupeza chinthu choyera, chapamwamba kwambiri chomwe chimatsatira zofunikira zolimba.

Zotsatira Zake za Orlistat Powder?

Orlistat ufa, monga mankhwala aliwonse, ali ndi zotsatirapo.Ngakhale zimangokhudza m'mimba komanso osati machitidwe a mtima kapena mitsempha yapakati, zotsatira zake sizinganyalanyazidwe.

Zotsatira zofala

Zakudya zokhala ndi mafuta ochepa kapena mafuta ochepa

  • Flatulence
  • Kupweteka m'mimba
  • Kufulumira kwa ndowe
  • Kuchuluka kwa chopondapo
  • Fecal incontinence
  • Oily spotting
  • Kuwonjezeka kwa m'mimba flatus
  • Zakudya zamafuta (zamafuta).
  • Steatorrhea

Pamene mafuta omwe ali m'zakudya akuwonjezeka, chiwerengero cha chiwerengero chimawonjezeka moyenerera.Odwala ambiri amatha kusintha atamwa mankhwala kwa nthawi ndithu.

pachimake m`mimba zimachitikira

  • Kupweteka kwa m'mimba / kusapeza bwino
  • Chimbudzi chamadzi
  • Zithunzi zofewa
  • Kupweteka kwa rectum / kusapeza bwino,
  • Kusapeza bwino kwa mano
  • Kusapeza bwino chingamu

Zindikirani:Ndikoyenera kudziwa kuti ubwino wa ufa wa orlistat umagwirizana kwambiri ndi zotsatira zake, ndipo ufa wapamwamba wa orlistat ukhoza kuchepetsa chiopsezo cha zotsatirapo. mogwira mtima.AASraw imapereka ufa wapamwamba wa Orlistat wopangidwa pansi pa malamulo okhwima a GMP kuonetsetsa chiyero ndi potency.Komabe, ndikofunikira nthawi zonse kukaonana ndi katswiri wa zaumoyo musanayambe mankhwala atsopano kapena mankhwala owonjezera.

Mlingo ndi Kuwongolera kwa Orlistat Powder for Reference

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito poyang'anira kulemera kwa thupi ndi kuchepetsa kulemera kwa thupi pamene amagwiritsidwa ntchito pamodzi ndi zakudya zochepetsetsa za kalori.

Mlingo

Mlingo woyenera wa ufa wa Orlistat ndi 120 mg wotengedwa pamlomo katatu pa tsiku ndi chakudya chachikulu chilichonse chomwe chili ndi mafuta.Mlingo wa tsiku ndi tsiku sayenera kupitirira 3 mg.

Administration

Orlistat ufa uyenera kutengedwa pamlomo panthawi, kapena mpaka ola limodzi pambuyo pake, chakudya chachikulu chilichonse chomwe chili ndi mafuta.Ngati chakudya chikusowa kapena mulibe mafuta, mlingo wa ufa wa Orlistat ukhoza kunyalanyazidwa.Odwala ayenera kulangizidwa kuti atenge multivitamin yomwe ili ndi mavitamini ambiri. mavitamini osungunuka mafuta osachepera maola awiri musanayambe kapena mutatha kumwa ufa wa Orlistat.

Kusintha kwa Mlingo

Palibe kusintha kwa mlingo komwe kumafunikira kwa odwala aimpso kapena chiwindi.

CHENJEZO

Ndikofunika kuzindikira kuti ufa wa Orlistat sayenera kugwiritsidwa ntchito panthawi yomwe ali ndi pakati kapena omwe ali ndi matenda aakulu a malabsorption syndrome, cholestasis, kapena hypersensitivity kwa chinthu chogwira ntchito kapena mankhwala aliwonse othandizira. pafupi.

zolemba

Mlingo ndi maulamuliro operekedwa za ufa wa Orlistat ndizongodziwa zambiri ndipo sayenera kugwiritsidwa ntchito m'malo mwa upangiri wachipatala wa akatswiri.Nthawi zonse funsani ndi wothandizira zaumoyo musanayambe mankhwala aliwonse kapena zowonjezera, kuphatikizapo Orlistat powder.Mlingo ndi kayendetsedwe ka Orlistat ufa uyenera kutsimikiziridwa malinga ndi mbiri yakale yachipatala, mankhwala omwe alipo panopa, ndi zinthu zina zoyenera. Komanso, kugula ufa wa orlistat ndi khalidwe lapamwamba kuchokera kwa ogulitsa odalirika a Orlistat powder kapena ogulitsa n'kofunika kwambiri.

Kuyanjana kwa Orlistat ndi Mankhwala Ena

  • Orlistat ikhoza kuchepetsa kuyamwa kwa mavitamini A, D ndi E. Choncho, ngati mukutenga zokonzekera zomwe zili ndi mavitamini A, D ndi E (monga makonzedwe a multivitamin), muyenera kumwa mavitamini 2 maola mutatenga orlistat.
  • Odwala omwe ali ndi matenda amtundu wa 2 angafunikire kuchepetsa mlingo wamankhwala amkamwa a hypoglycemic (monga sulfonylureas).
  • Kugwiritsa ntchito limodzi kwa orlistat ndi cyclosporine kungayambitse kuchepa kwa plasma yomaliza.
  • Orlistat ikagwiritsidwa ntchito limodzi ndi amiodarone, imatha kuchepetsa kuyamwa kwake ndikuchepetsa machiritso.
  • Ngati agwiritsidwa ntchito ndi mankhwala ena nthawi yomweyo, kuyanjana kwamankhwala kumatha kuchitika, chonde funsani dokotala kapena wazamankhwala kuti mumve zambiri.

Kodi mungagule kuti Orlistat Powder?

Kupeza mankhwala odalirika komanso odalirika a ufa wa Orlistat n'kofunika kwambiri kwa iwo omwe ali m'makampani ogulitsa mankhwala kapena azachipatala omwe amafunikira mankhwalawa chifukwa cha mankhwala kapena odwala. .Wopereka katunduyo ayeneranso kukhala ndi mbiri yabwino poyang'anira khalidwe, kulongedza katundu, kutumiza, ndi utumiki wa makasitomala.Posankha wogulitsa wodalirika, makasitomala angatsimikizire kuti amalandira mankhwala otetezeka komanso ogwira mtima pa zosowa zawo.

AASraw ndi wothandizira wokhazikika wa mankhwala opangira mankhwala, kuphatikizapo ufa wa Orlistat.Amakhala ndi dongosolo lokhazikika lowongolera khalidwe kuti atsimikizire kuti katundu wawo ndi wapamwamba kwambiri komanso amakwaniritsa zofunikira.Amaperekanso makasitomala chiphaso cha kusanthula kwa aliyense gulu la ufa wa Orlistat omwe amagulitsa, kotero mutha kukhala otsimikiza za chiyero ndi khalidwe la mankhwala.Kuonjezera apo, AASraw imapereka mitengo yamtengo wapatali komanso yodalirika yobweretsera, zomwe ndizofunikira kuziganizira posankha wogulitsa. ufa wa Orlistat womwe umapereka zinthu zapamwamba kwambiri, mitengo yampikisano, komanso kutumiza kodalirika.

Orlistat Powder Lipoti Loyesa-HNMR

Orlistat HNMR

Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.

Orlistat ufa (96829-58-2) -COA

Orlistat ufa (96829-58-2) -COA

Mungagule bwanji Ufa wa Orlistat kuchokera ku AASraw?

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❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).

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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Siebenhofer A,Winterholer S,Jeitler K,Horvath K,Berghold A,Krenn C,Semlitsch T (Januware 2021). "Zotsatira za nthawi yayitali za mankhwala ochepetsa thupi mwa anthu omwe ali ndi matenda oopsa". Cochrane Database of Systematic Reviews. 1 (1): CD007654.

[2] Mancini MC,Halpern A (April 2006). "Pharmacological chithandizo cha kunenepa kwambiri". Arquivos Brasileiros de Endocrinologia ndi Metabologia. 50 (2):377–389.

[3] Heck AM,Yanovski JA,Calis KA (March 2000). "Orlistat, lipase inhibitor yatsopano yothandizira kunenepa kwambiri". Pharmacotherapy. 20 (3):270–279.

[4] Garcia SB, Barros LT, Turatti A, Martinello F, Modiano P, Ribeiro-Silva A, et al. (August 2006).” Mankhwala oletsa kunenepa kwambiri a Orlistat amalumikizidwa ndi kuwonjezeka kwa zolembera za colonic preneoplastic mu makoswe omwe amapangidwa ndi mankhwala a carcinogen. ”. Makalata a Cancer. 240 (2):221–224.

[5] "FDA Ivomereza Orlistat Kuti Igwiritsidwe Ntchito Pang'onopang'ono" (Press release).USFood and Drug Administration (FDA).7 February 2007.Archived from choyambirira pa 13 May 2009.Idabwezedwanso pa 7 February 2007.


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