Orlistat ufa

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AASraw ili ndi kaphatikizidwe ndi kapangidwe kameneka kuchokera ku gramu mpaka kulemera kwa ufa wa Orlistat (96829-58-2), pansi pa malamulo a CGMP ndi dongosolo loyendetsa khalidwe labwino.

Orlistat ufa ndi mankhwala okhudzana ndi lipstatin, omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda timene timapanga tizilombo toyambitsa matenda. Orlistat ndi mankhwala okonzera kunenepa kwambiri. Komabe, chifukwa cha kuphweka kwake kulimbika, orlistat inasankhidwa pa lipstatin kuti chitukuko ngati mankhwala oletsa kunenepa kwambiri.

Mafotokozedwe Akatundu

Vuto lawotchi la orlistat


Orlistat ufa wofunikira

Name: Orlistat ufa
CAS: 96829-58-2
Makhalidwe a Maselo: C29H53NO5
Kulemera kwa maselo: 495.7
Melt Point: 50 ° C
Kusungirako nyengo: 2-8 ° C
mtundu; White powder


Dzina la Zamalonda: Orlistat

IUPAC Name: [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate

Chiyambi cha Orlistat

Anthu oposa theka la anthu padziko lonse adayesapo polojekiti yolemetsa, monga kudya, kuchita, opaleshoni, kapena mankhwala. Zonsezi zothandizira kulemera kwake ndizothandiza kokha ngati ndinu okhulupirika kwa iwo ndikutsatira malangizo kwa omaliza. Komabe, kusankha kwa opaleshoni kapena mankhwala kungakhale kovulaza pamene simutenga zowonjezereka.

Maonekedwe a mankhwala a Orlistat (kusintha kwa 3-D)

Maonekedwe a mankhwala a Orlistat (kusintha kwa 2-D)

Mitundu ya mankhwala a Orlistat

Dzina la Malo Phindu la katundu
Chokhazikika-Chokhazikika Unit Unit 1
Isotope Atomu Namba 0
Chiwerengero Chosavomerezeka Chotsatira Chigwirizano 0
Ndondomeko Yowonjezera Bondere Yowonjezera 0
Nambala yosawerengeka ya Atomu 0
Nambala yosawerengeka ya Atomu yofotokozedwa 4
Kuchuluka kwa Atomu Yambiri 35
Kulipira Kwachibadwa 0
Chimanga ndi Canonicalized N'zoona
XLogP3-AA 10
Misa Yeniyeni 495.392 g / mol
Misa ya Monoisotopic 495.392 g / mol
Malo otchedwa Topological Polar Area 81.7 A ^ 2
Kuvuta 579
Chiwerengero Chogwirizana Chogwirizana 23
Chiwerengero Chovomerezeka cha Hydrogeni 5
Hydrogen Bond Donor Count 1
Kulemera kwa maselo 495.745 g / mol

Malongosoledwe osavuta a Orlistat ufa

M'modzi mwa kulemera kwa mankhwala kuti mudzapeza mufuna kwanu kuti mupeze mankhwala ogwiritsira ntchito kulemera kwambiri ndi Orlistat. Mu ndondomeko iyi ya Orlistat, mudzapeza zambiri zofunika, kuphatikizapo momwe izo zimagwirira ntchito, komanso momwe ziyenera kugwiritsidwira ntchito, kotero mutha kusankha ngati ndikuyenera kukusankhira.

Kodi Orlistat ndi chiyani?

Orlistat, yomwe imagulitsidwa ngati mankhwala opatsirana pogwiritsira ntchito dzina la malonda Xenical, ndi mankhwala omwe amaletsa kulemera kwa mankhwala omwe amapangidwa kuti athetse vuto lolemera kwambiri monga kunenepa kwambiri, komanso mavuto ena olemera. Zapangidwa ndi GlaxoSmithKline ngati mankhwala osokoneza bongo otchedwa Alli ku United States ndi United Kingdom.

Maonekedwe a Orlistat amapezeka m'mayiko angapo. Kuchokera ku 2000, yapangidwa ngati mankhwala a S3 over-the-counter ku Australia. Chivomerezo cha Orlistat ngati mankhwala osokoneza bongo chinali nkhani yotsutsana ku United States. Ankawotsutsa mobwerezabwereza kuntchito ndi chitetezo cha gulu la ogulitsa ogulitsa omwe amadziwika ngati Boma la Anthu.

Zochita za Orlistat ngati lipase inhibitor, zomwe zimatanthawuza kuti zimateteza mafuta ku chakudya, motero kuchepetsa kuchuluka kwa makilogalamu omwe mumatenga. Mofanana ndi mankhwala ena ambiri olemera, Orlistat amagwiritsidwa ntchito kuti agwiritsidwe ntchito pamodzi ndi zochitika zina zokhudzana ndi moyo monga zolimbitsa thupi komanso zakudya. Maphunziro a zachipatala amasonyeza kuti anthu omwe amamatira pamagulu amenewa amakhala ndi mwayi wopeza awiri kapena atatu kilogalamu kuposa zomwe siziphatikizapo mankhwala mu mphamvu yawo yolemera.

Chimodzi mwa zinthu zofunika kwambiri za Orlistat ndikuti sikuti zimangokuthandizani kuti muchepetse thupi koma mumachepetsanso kuchepetsa kuthamanga kwa magazi. Kuonjezerapo, mankhwala osokoneza bongo amakhulupirira kuti amalephera kuyambira mtundu wa 2 shuga mwa anthu omwe ali ochepa kwambiri momwe moyo umasinthira.

Ngakhale pali zothandizira zambiri kuti mukhale osangalala, palinso zotsatira zina za Orlistat kuti muzimvetsera. Kawiri kawiri kawiri kawiri kawiri kawiri kawiri kawiri kwa mapiritsi olemerawa ndi steatorrhea. Izi ndi matenda a m'mimba omwe amadziwika ndi mafuta, otayirira. Zizindikiro, mwansanga, zimachepa ndi nthawi.

Njira yochezera

Orlistat ndi mphamvu yamatumbo ya Lipase Inhibitor. Mankhwalawa ndi inhibitor yogwira ntchito yogwiritsidwa ntchito yogwiritsira ntchito m'mimba. Mankhwalawa amapanga mgwirizano wolimba ndi malo otetezeka a serine pancreatic ndi chapastases lipases, motero amalepheretsa zochita zawo komanso kuteteza mafuta ku zakudya kuchokera ku hydrolyzed ndi absorption. (NCI04).

Mu mawu ophweka, Orlistat amathandiza kuchepetsa kulemera kwa kuchepetsa kuperewera kwa pancreatic ndi chapastas lipases, zomwe ndizofunikira mimba m'matumbo omwe amachititsa triglycerides. Pamene lipases imatsekedwa, hydrolyzation ya triglycerides kuchokera zakudya zanu kukhala odziwika mafuta mafuta amaletsedwa.

Mapiritsi odyera amatengedwa pamlomo ndipo kamodzi amatengedwa; malo amtundu wa lipase amachitika mkati mwa thirakiti la GI. Mankhwala ochepa chabe amalowa m'thupi, ndipo mankhwala ambiri amachotsedwa kudzera m'zipweya zam'madzi.

Kafukufuku wam'mbuyo apeza kuti Orlistat ndi yowonongeka ndi mavitamini omwe amaphatikizapo kufalitsidwa kwa maselo oopsa a khansa. Komabe, zotsatira zoyipa za mankhwala (monga kulepheretsa maselo ena osayang'aniridwa kapena osauka) zimalepheretsa kugwiritsa ntchito ngati wothandizira wothandizira. Mu kafukufuku wina, ofufuza anapeza njira yowonongeka ya mankhwala kuti apeze zatsopano zamagulu za mankhwala, kuphatikizapo zolepheretsa.

Pa mlingo wokwanira wa mankhwala a 120 mg 3 pa tsiku tsiku lisanayambe kudya, mapiritsi a weight loss amateteza kuzungulira 30 peresenti ya mafuta okhutira kuti asamalowe m'thupi. Kutenga mlingo waukulu sikupereka zotsatira zowonjezera.

Gwiritsani ntchitoOrlistatpowder

Orlistat amagwiritsidwa ntchito ngati mankhwala oletsa kulemera. Ndi kusankha kwabwino kwa anthu omwe ali olemera kwambiri kapena olemera kwambiri. Pirisi yolemetsa imeneyi imalimbikitsidwa kuti igwiritsidwe ntchito ndi anthu omwe ali ndi matenda okhudzana ndi kulemera. Amalonjeza kuthandiza anthu osati kungowononga kulemera, komabe kumathandizanso kuti asapeze kulemera kwawo. Pochita zimenezi, zimathandiza kuchepetsa chiopsezo cha kuthamanga kwa magazi, shuga, matenda a mtima, ndi zina zambiri zoopsa zomwe zimakhudzana ndi kunenepa kwambiri.

Kuchuluka kwa kulemera kwake mutatha kutenga Orlistat kumasiyanasiyana kuchokera kwa munthu mmodzi. Ochita kafukufuku amene akuyesa mayesero a chipatala kwa chaka chimodzi adapeza kuti pakati pa 35.5 peresenti ndi 54.8 peresenti ya maphunziro omwe anakwanitsa kupeza kuchepa kwakukulu kwa 5 mu thupi lonse, ngakhale kuti sikuti onse otaika anali olemera. Pafupifupi 16.4% -24.8 ya maphunziro omwe amatha kukwaniritsa mwina kuchepa kwa 10 kwa mafuta a thupi. Nkhanizo zitasiya kumwa Orlistat, chiwerengero chawo chinawonjezeredwa kufika pa 35 peresenti ya kulemera kumene iwo anatha kutaya.

Mlingo wa Orlistat

Orlistat imabwera ngati mawonekedwe otchedwa turquoise, hard-gelatin capsules omwe ali ndi mapepala a ufa ndipo amayeza 120-mg. Mlingo woyenera tsiku ndi tsiku ndi makapisozi atatu pa tsiku. Musagwiritse mapiritsi onse atatu, koma mmalo mwake mutenge piritsi lililonse ndi chakudya chachikulu chomwe chili ndi mafuta, mwachitsanzo, kamodzi kadzutsa chakudya, chakudya chamadzulo, ndi chimodzi cha chakudya chamadzulo. Mukhoza kumwa mapiritsi onse ndi chakudya kapena ola limodzi mutatha kudya. Ngati chakudya nthawi zambiri sichipezeka, kapena ngati chakudya chanu chilibe mafuta, mlingo wa Orlistat umatha. Mlingo pamwamba pa mlingo wa tsiku lovomerezeka sunapezedwe kupereka phindu lina lililonse.

Orlistat imakhala yogwira mtima kwambiri pophatikizapo njira zina zowonongeka monga kutsata zakudya zopatsa thanzi, zochepetsera zakudya zamakono komanso machitidwe olimbitsa thupi. Mukulangizidwa kuti mutenge piritsi lolemera ndi chakudya chomwe chili ndi mafuta a 30 peresenti. Zotsatira za mankhwala zikuwonetsedwa mwamsanga maola a 24-48 atatha kumwa mlingo.

Orlistat yapezeka kuti ikuthandiza kuchepetsa kuyamwa kwa mavitamini ena osungunuka ndi beta-carotene. Choncho, anthu omwe amamwa mapiritsi akulangizidwa kuti azitenga limodzi ndi mavitamini ambiri omwe ali ndi mavitamini osungunula mafuta kuti athetse chakudya chokwanira. Ndikoyenera kuti vitamini yowonjezeretsa ikhale yotenga maola awiri osanayambe kapena atatha Orlistat.

Odwala omwe amalandira chithandizo cha cyclosporin, akulangizidwa kuti apereke cyclosporine osachepera maola 3 atatenga Orlistat. Kwa omwe amalandira mankhwala a levothyroxine, akulimbikitsidwa kupereka mankhwala a levothyroxine osachepera maola 4 atatenga Orlistat. Amene amatenga awiri Orlistat ndi levothyroxine ayenera kusamalidwa mosamala chifukwa cha kusintha kwa chithokomiro.

OrlistatPrecautions

Poyamba, mndandanda wa orlistat unatengedwera mwatsatanetsatane ndi dokotala kapena wamankhwala. Komabe, mu 2007, boma la United States la Food and Drug Administration linaligwiritsa ntchito pa msika wodutsa, choncho, kuwapangitsa kukhalapo kwa aliyense.

Onani zotsatira zowonongeka

Musanayambe kumwa mankhwalawa, ndibwino kuti mulankhule ndi dokotala wanu za momwe mungayankhire. Orlistat ili ndi zosakaniza zopanda ntchito, zomwe sizikukukondani, zomwe zingayambitse mavuto aakulu komanso zotsatira zake. Zina mwa izo ndi monga cellulose, microcrystalline, gelatin, silika, ndi sodium wowuma glycolate.

Taganizirani mbiri yanu ya zamankhwala

Muyenera kugawana ndi wamalonda kapena dokotala wanu za matenda alionse omwe mungakhale nawo. Ichi ndi chifukwa chakuti orlistat imatsutsana ndi zovuta ndi mavuto, makamaka omwe amagwirizana ndi chimbudzi.

Ngati mukuvutika ndi zifukwa zili m'munsizi, ndibwino kuti mudziwe zambiri kuchokera kwa katswiri.

Malabsorption syndrome

Izi ndizosavomerezeka chifukwa cha kuchepa kwa zakudya zopatsa thanzi pamtundu wa GIT. Muyenera kuzindikira kuti orlistat yokha imagwira ntchito poletsa kuyamwa kwa mafuta. Choncho, izi zidzakhala zovuta kwambiri kwa aliyense amene amamwa mankhwala, komabe akudwala malabsorption syndrome.

Matenda a chiwindi kapena cholestasis

Ichi ndi chikhalidwe chomwe chimalepheretsa bile kutuluka pachiwindi. Pali zambiri malipoti zomwe zimagwirizanitsa orlistat ku kuvulala kwa chiwindi, ngakhale zimachitika nthawi zambiri kapena pansi pa mlingo waukulu.

Matenda a Gallbladder

Izi zikuphatikizapo cholecystectomy ndi syndromes.

Zinthu zina zaumoyo zomwe muyenera kufunsa kwa mabizinesi anu zimaphatikizapo matenda opatsirana kachilombo ka HIV, matenda a chithokomiro, mawere a impso, kugwidwa, kapena kupanikizika. Mukamadwala kapena kugwedezeka, orlistat ikhoza kuthetsa kusalabadira mankhwala opatsirana pogwiritsa ntchito mankhwalawa.

Kudya matenda

Zina mwa matendawa ndi bulimia ndi anorexia. Ndiponso, palibe chifukwa choyenera kutenga orlistat ngati suli olemera kwambiri.

Mankhwala ena

Ndi bwino kudziwitsa dokotala wanu ngati muli ndi mankhwala ena makamaka omwe angathe kuchepetsa chitetezo cha mthupi. Kugwiritsa ntchito mankhwala osokoneza bongo kungasokoneze pharmacokinetics, zomwe zimapangitsa kuwonjezeka kapena kuchepa kwa onsewa. Mwachitsanzo, orlistat nthawi zonse imasokoneza njira ya mankhwala omwe amaperekedwa kuti akonzeke.

Ngati muli pa cyclosporine, dokotala wanu adzakuuzani kuti mupewe orlistat. Komabe, mungathe kumangogwiritsa ntchito malamulo okhaokha. Kuti mukhale otetezeka, muyenera kumatenga maola awiri musanayambe mankhwala osokoneza bongo kapena maola awiri kenako.

Kuonjezerapo, muyenera kutchula mankhwala onse osamalidwa komanso osagwiritsidwa ntchito, zakudya zowonjezera zakudya, mavitamini, anticoagulants, kapena mankhwala omwe mungakhale nawo.

Azimayi oyembekezera ndi akuyamwitsa

Mankhwala othandizira kulemera kwake si a amayi oyembekezera, omwe akukonzekera kutenga pakati, kapena akuyamwitsa mums. Mankhwalawa sangawonongeke ndipo amatha kuvulaza mwanayo.

Ngakhale kuti sizinafike poyera ngati olemba ma CD amatha kupita ku mawere, mungachite bwino kupewa ndikumva kuti muli otetezeka, kusiyana ndi chisoni.

Odwala matenda a shuga

Orlistat ndi zomwe munthu aliyense yemwe ali ndi shuga ayenera kusintha ndi kuyendetsa shuga wa magazi ndikupangitsa kuti azikhala osasamala. Komabe, muyenera kuyang'anitsitsa magawo a shuga nthawi zonse ndikupita kwa dokotala mobwerezabwereza. Kuchita zimenezi kumakuthandizani kudziwa momwe mungasinthire mankhwala a shuga, zakudya zoyenera, komanso pulogalamu yochita masewera olimbitsa thupi.

Zotsatira za Orlistat

Monga mankhwala ambiri, orlistat ili ndi zotsatira zake. Mbali yoyamba yotsatira imakhala ikuwonetsedwa nthawi zonse mu zizolowezi zamatumbo. Komabe, izi zikhoza kuonekeratu pamasabata angapo oyambirira kutenga mankhwala olemetsa.

Kwa anthu ena, zizindikiro zimatha kugonjetsa ena; Ikhoza kupitilira nthawi yonse yolemba orlistat. Panthawiyi, ndibwino kudziwitsa dokotala wanu. Mukamayesetsa kuti mukhale ndi zakudya zochepa kwambiri, zimakhala zovuta kuti muchepetse.

Nazi zotsatira zina zofala;

Steatorrhea

Ngakhale zopanda phindu, steatorrhea ndi kukhalapo kwa mafuta ndi mafuta owonjezera mu mpando. Popeza kuti orlistat imaletsa lipases, sipadzakhalanso zotsatira za mafuta ochepa. Zotsatira zake, zinyama ziwoneka ngati wochuluka komanso wochuluka.

Pofuna kuthetsa zotsatirazi, munthu ayenera kupewa zakudya zamtundu wambiri komanso mafuta ambiri. Malinga ndi ndondomeko ya FDA, ndalamazo zikhale mkati mwa 0.53 ounces ndipo zisapitirire 30%.

Flatulence

Kawirikawiri, mpweya umatuluka ndi mafuta ena. Mudzafunika kufufuza zovala zanu kapena zovala zanu zapaka mafuta.

  • Fecal incontinence

Zosasunthika, zosafunika, komanso nthawi zambiri zamasamba

  • Kukhumudwa ndi ululu m'mimba
  • Kusamba kwabwino kwa msambo
  • Maseŵera otsika kwambiri a shuga

Izi ndizofala pakati pa anthu omwe ali ndi matenda a shuga a mtundu wachiwiri.

  • Kuvulala kwakukulu kwa chiwindi

Zochitika zoterozo sizodziwika koma zimapezeka ngati muli ndi vuto lina la chiwindi, kapena mutenga mlingo waukulu. Mu 2010, FDA ikuphatikizapo chenjezo la chitetezo pa malemba a orlistat, omwe amasonyeza chiopsezo cha kuvulazidwa kwa chiwindi.

Komabe, zotsatirazi ndizitsutsanabe ndi zina phunziro nkhani lofalitsidwa pa British Medical Journal linasonyeza mosiyana.

Zina mwa zizindikiro zochenjeza za matenda a chiwindi ndizo kusanza, kupweteka kwa m'mimba, khungu la chikasu, ndi mkodzo wakuda.

Zosokonezeka

Ndizosavuta kuti munthu atenge kachilombo koyambitsa matenda. Kwa anthu ena, mankhwala osokonezeka omwe amapezeka mu mankhwalawa angayambitse kunyowa, kuyabwa, kuthamanga, kutupa thupi, kupuma kovuta, kapena chizungulire.

Zovuta zina zochepa zomwe zimakhalapo zimaphatikizapo kuda nkhawa, kupwetekedwa mutu, kupweteka, kupweteka kwapadera, kutopa, kusafuna kudya, ndi ziphuphu. Ngati muli ndi zizindikiro zovuta, muyenera kudziwitsa dokotala mwamsanga kapena kuwuzani Fomu ya Lipoti la FDA.

Chigamulo chomaliza pa ufa wa Orlistat

Ngakhale kuti orlistat imakhala ndi zotsatira zochepa, ndi mankhwala abwino kwambiri othandizira mankhwala omwe angapereke zotsatira mkati mwa masabata awiri. Chinsinsi chopindula ndi mankhwalawa chikutsatira malangizo, kumvetsetsa zowonetsetsa, ndikuwunika zakudya zanu.

Pamene mukulemba, ndikofunika kutsatira ndondomeko yoyenera ya zakudya, kudya mafuta ochepa, otsika kwambiri, ndi kuchita masewera olimbitsa thupi nthawi zonse. Zakudya zabwino ziyenera kuphatikizapo zipatso, masamba, ndi mbewu zambiri. Kuonjezerapo, muyenera kuwonjezera zakudya zanu ndi mankhwala othandizira multivitamin kuyambira pamene orlistat imatseka kuyamwa kwa mavitamini othawa mafuta.

Mukakayikira, mungathe kuonana ndi wamisiri wanu kapena dokotala kuti mudziwe zambiri. Mwinanso, mungathe kulankhulana ndi US Food and Drug Administration kuti mufunse mafunso kapena kuika zotsatira zoopsa zowopsa, zomwe sizinalembedwe.


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COA

COA 96829-58-2 Nature Orlistat AASRAW

HNMR

Mafuta a orlistat (96829-58-2) hplc≥98% | Kuthana ndi ufa wothira mafuta

AASraw amapereka chiyero cha 99% Orlistat ufa wochuluka kwa opanga thupi kapena mabala apansi pantchito yogwiritsira ntchito.

Maphikidwe

Mafotokozedwe ndi zolemba zamagulu

Anti-Obesity ufa: Cetilistat ufa vs Orlistat ufa

Chilichonse chomwe muyenera kudziwa pa Orlistat ufa chifukwa cha kutayika kwa mafuta

Mafuta a Orlistat a pakhomo kuti awonongeke-Chodabwitsa mafuta otaya mankhwala muyenera kudziwa !!!

zolemba

Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Kukambirana za orlistat zochepa zowonongeka, lipase inhibitor, mwa anthu odzipereka wathanzi". J Clin Pharmacol. 35 (11): 1103-8

  1. Garcia SB, Barros LT, Turatti A, et al. Wothandizira wodwala kunenepa kwambiri kapena Orlistat amagwirizanitsidwa ndi kuwonjezeka mu zizindikiro zamakono zowonongeka m'thupi mwa makoswe otengedwa ndi khansa ya mankhwala. Khansa Lett. 2006; 240: 221-4.
  2. FDA ikuvomereza alli (orlistat 60 mg capsules) Over-The-Counter "(PDF) (Press release). PRNewswire. 7 February 2007
  3. Mittendorfer B, Ostlund RE, Jr, Patterson BW, et al. Orlistat imaletsa cholesterol chopatsa thanzi. Obes Res. 2001; 9: 599-604
  4. Peng-Yu, Yang; Chimpho; Mun Hong, Ngai; J.Lear, Martin; R.Wenk, Markus; S.Qin, Yao (2010). "Kugwiritsa ntchito pulogalamu ya proteome yomwe ingakhale ndi ma makina a mankhwala a Orlistat-a FDA ovomerezeka ndi anti-tumor". Journal of the American Chemical Society. 132 (2): 656-66.

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