Orlistat ufa

Orlistat Powder kanema-AASraw

Orlistat Powder Makhalidwe Oyambira

Kodi Orlistat Powder ndi chiyani?

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito pochiza a kunenepa kwambiri kapena odwala onenepa kwambiri. Idapangidwa koyamba ndi Roche ndipo idakhazikitsidwa ku United States mu 1999. Ndilo lokhalo lopanda kunenepa lovomerezeka ndi FDA, CFDA, ndi EMA mdziko lapansi. Amagwira ntchito poletsa pancreatic ndi gastric lipases, ma enzyme omwe amaphwanya mafuta am'mimba m'matumbo. Izi zimapangitsa kuti mafuta osagawika atulutsidwe mu ndowe, zomwe zimapangitsa kuti ma calories ochepa amatengedwa kuchokera kumafuta.

Ku United States, orlistat imavomerezedwa kuti igwiritsidwe ntchito index mass body (BMI, Body Mass Index, unit kg/㎡) kufika kapena kupitirira 30 (US kunenepa kwambiri). Kupatula apo, anthu omwe ali ndi index yayikulu ya thupi pakati pa 27 ndi 30 ndi zinthu zina zowopsa paumoyo monga kuthamanga kwa magazi kapena shuga.

Kodi Orlistat Powder Imagwira Ntchito Motani?

Orlistat ufa amagwira ntchito poletsa chapamimba ndi pancreatic lipases, omwe ndi michere yomwe imayambitsa kuphwanya triglycerides kukhala mafuta ang'onoang'ono acids omwe amatha kutengedwa ndi thupi. Poletsa ma enzymes awa, AASraw orlistat imalepheretsa hydrolysis ya triglycerides m'matumbo, zomwe zimabweretsa kuchepa kwa kuchuluka kwa mafuta omwe amadya.

Popeza kuti ma triglycerides samaphwanyidwa kukhala mafuta amafuta aulere, amachotsedwa mosasinthika mu ndowe. Izi zimapangitsa kuchepetsa kudya kwa caloric ndikulimbikitsa kuwonda. Orlistat yawonetsedwa kuti imalepheretsa pafupifupi 30% yamafuta azakudya kuti asatengeke.

Kuphatikiza pa kuletsa lipases, orlistat imalepheretsanso thioesterase domain ya fatty acid synthase (FAS). Enzyme imeneyi imakhudzidwa ndi kuchuluka kwa maselo a khansa koma osati maselo abwinobwino. Komabe, zotsatira zoyipa ya orlistat, monga kuletsa ma cell ena omwe sali kutsata kapena kusapezeka bwino kwa bioavailability, kumatha kulepheretsa kugwiritsa ntchito kwake ngati antitumor wothandizira.

Ponseponse, njira ya orlistat imaphatikizapo kuletsa kwa michere yomwe imakhudzidwa ndi chimbudzi chamafuta, zomwe zimapangitsa kuchepa kwamafuta am'zakudya komanso kulimbikitsa kuchepa thupi.

Ubwino Wogwiritsa Ntchito Orlistat Powder

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito makamaka pochiza kunenepa kwambiri, makamaka poletsa kuyamwa kwa mafuta m'zakudya zaumunthu. Kuonjezera apo, imatha kuchepetsa kuthamanga kwa magazi modzichepetsa ndipo ikuwoneka kuti imalepheretsa kuyambika kwa matenda a shuga a mtundu wa 2, kaya ndi kuchepa kwa thupi kapena zotsatira zina.

· Kuchiza kwa Kunenepa Kwambiri

Orlistat ufa umagwiritsidwa ntchito makamaka pochiza kunenepa kwambiri molumikizana ndi wothandizira zaumoyo yemwe amayang'aniridwa ndi zakudya zochepetsetsa za kalori. Ntchito yake yaikulu ndikuletsa kuyamwa kwa mafuta a zakudya pochita ngati lipase inhibitor, motero kuchepetsa kudya kwa caloric.AASraw Orlistat ufa amagwira ntchito poletsa chapamimba ndi pancreatic lipases, ma enzyme omwe amaphwanya triglycerides m'matumbo. Ntchito ya lipase ikatsekedwa, ma triglycerides ochokera m'zakudya samapangidwa ndi hydrolyzed kukhala mafuta acids aulere ndipo m'malo mwake amatulutsidwa osasinthika.

Zomwe zaphatikizidwa m'mayesero azachipatala zikuwonetsa kuti anthu omwe amapatsidwa orlistat kuphatikiza pakusintha kwa moyo wawo, monga zakudya ndi masewera olimbitsa thupi, amataya pafupifupi ma kilogalamu 2-3 (4-7 lb) kuposa omwe samamwa mankhwalawa pakatha chaka. Pakati pa 35.5% ndi 54.8% ya maphunziro adapeza 5% kapena kuchepa kwakukulu kwa thupi, ngakhale kuti sizinthu zonsezi zomwe zinali mafuta. Pakati pa 16.4% ndi 24.8% adapeza kuchepa kwa 10% kwamafuta amthupi. Ndizofunikira kudziwa kuti orlistat itayimitsidwa, anthu ambiri adayambiranso kulemera - mpaka 35% ya kulemera komwe adataya.

· Kuchepetsa Kuthamanga kwa Magazi

Kuphatikiza pa kuthandizira kuchepetsa thupi, kafukufuku wasonyeza kuti ufa wa orlistat ungapangitsenso kuchepetsa kuchepa kwa magazi. Deta yophatikizidwa kuchokera ku mayeso azachipatala ikuwonetsa kuti orlistat imachepetsa kuthamanga kwa magazi kwa systolic ndi diastolic ndi avareji ya 2.5 ndi 1.9 mmHg, motsatana. Njira yochepetsera kuthamanga kwa magazi uku imaganiziridwa kuti ikugwirizana ndi kuchepa kwa thupi komwe kumachitika pogwiritsa ntchito orlistat, chifukwa kunenepa kwambiri ndizomwe zimadziwika kuti zimayambitsa matenda oopsa. Komabe, ndikofunikira kuzindikira kuti kuchepa kwa kuthamanga kwa magazi komwe kumachitika chifukwa chogwiritsa ntchito orlistat ndikocheperako ndipo sikuyenera kudaliridwa ngati njira yokhayo yochizira matenda oopsa. Anthu omwe ali ndi vuto la kuthamanga kwa magazi ayenera kupitiriza kutsatira malangizo a dokotala wawo ndikugwiritsa ntchito mankhwala monga momwe akufunira.

· Kupewa Kuyamba kwa Matenda a shuga amtundu wa 2

Orlistat ufa wasonyezedwa kuti uli ndi chitetezo pachiyambi cha matenda a shuga a mtundu wa 2, kuwonjezera pa kuchepa thupi komanso kuchepetsa kuthamanga kwa magazi. Izi mwina ndichifukwa choti kunenepa kwambiri ndiye chiwopsezo chachikulu chokhala ndi matenda amtundu wa 2, ndipo Orlistat imatha kuthandiza kuchepetsa thupi mwa anthu onenepa kwambiri. Kafukufuku wasonyeza kuti orlistat imatha kuchepetsa kuchuluka kwa matenda a shuga a 2 mwa anthu omwe ali onenepa kwambiri molingana ndi momwe kusintha kwa moyo kumathandizira. Njira yeniyeni yomwe orlistat imalepheretsa kuyambika kwa matenda a shuga a 2 sikudziwika bwino, koma akuganiza kuti akugwirizana ndi mphamvu ya mankhwalawa yochepetsera kudya kwa caloric poletsa kuyamwa kwamafuta azakudya, zomwe zingapangitse kusintha kwa shuga ndi insulin. kumva. Ndikofunika kuzindikira kuti orlistat siilowa m'malo mwa moyo wathanzi, ndipo kugwiritsidwa ntchito kwake kuyenera kuphatikizidwa nthawi zonse ndi zakudya zochepetsetsa za calorie ndi masewera olimbitsa thupi kuti zitheke.

Zindikirani: Kuti muwonjezere ubwino wa ufa wa Orlistat, ndikofunika kuti mugule kuchokera kwa wothandizira wodalirika.AASraw amapereka ufa wapamwamba wa Orlistat pamtengo wokwanira, monga katswiri wothandizira ufa wa Orlistat ndi malo odziimira a R & D ndi fakitale. Mukamagula ufa wa Orlistat kuchokera ku AASraw, mutha kukhala otsimikiza kuti mukupeza choyera, chapamwamba kwambiri. mankhwala amene amatsatira mokhwimitsa khalidwe zofunikira.

Zotsatira Zake za Orlistat Powder?

Orlistat ufa, monga mankhwala aliwonse, ali ndi kuthekera zotsatira zoyipazi. Ngakhale kumangokhudza m'mimba thirakiti osati mtima kapena chapakati mantha kachitidwe, ndi zotsatira zoyipazi sangathe kunyalanyazidwa.

Zotsatira zofala

Zakudya zokhala ndi mafuta ochepa kapena mafuta ochepa

• Flatulence
• Kupweteka m'mimba
• Kufulumira kwa ndowe
• Kuchuluka kwa chopondapo
• Fecal incontinence
• Oily spotting
• Kuwonjezeka kwa m'mimba flatus
• Zakudya zamafuta (zamafuta).
• Steatorrhea

Pamene mafuta omwe ali muzakudya akuwonjezeka, chiwerengero cha zochitika chimawonjezeka moyenerera. Odwala ambiri amatha kusintha atamwa mankhwala kwakanthawi.

pachimake m`mimba zimachitikira

• Kupweteka kwa m'mimba / kusapeza bwino
• Chimbudzi chamadzi
• Zithunzi zofewa
• Kupweteka kwa rectum / kusapeza bwino,
• Kusapeza bwino kwa mano
• Kusapeza bwino chingamu

Zindikirani: Ndikoyenera kudziwa kuti mtundu wa orlistat ufa umagwirizana kwambiri ndi zotsatirapo, ndi ufa wapamwamba wa orlistat ukhoza kuchepetsa chiopsezo cha zotsatirapo. Kugula kuchokera kwa wogulitsa ufa waiwisi wotchuka monga AASraw kungathandize kuchepetsa chiopsezo cha zotsatira zoyipazi mogwira mtima.AASraw imapereka ufa wapamwamba wa Orlistat wopangidwa pansi pa malamulo okhwima a GMP kuonetsetsa chiyero ndi potency. Komabe, ndikofunikira nthawi zonse kukaonana ndi dokotala musanayambe mankhwala atsopano kapena zowonjezera.

Mlingo ndi Kuwongolera kwa Orlistat Powder for Reference

Orlistat ufa ndi mankhwala omwe amagwiritsidwa ntchito poyang'anira kulemera kwa thupi ndi kuchepetsa kulemera pamene amagwiritsidwa ntchito pamodzi ndi zakudya zochepetsetsa za calorie. Mlingo wovomerezeka ndi kayendetsedwe ka ufa wa Orlistat ndi awa.

Mlingo

Mlingo woyenera wa ufa wa Orlistat ndi 120 mg wotengedwa pakamwa 3 pa tsiku ndi chakudya chachikulu chilichonse chomwe chili ndi mafuta. Mlingo watsiku ndi tsiku sayenera kupitirira 360 mg.

Administration

Orlistat ufa uyenera kutengedwa pamlomo panthawi, kapena mpaka ola limodzi pambuyo pa chakudya chachikulu chilichonse chomwe chili ndi mafuta. Ngati chakudya chikuphonya kapena mulibe mafuta, mlingo wa ufa wa Orlistat ukhoza kudumpha. Odwala ayenera kulangizidwa kuti atenge multivitamin yomwe ili ndi mavitamini osungunuka mafuta osachepera maola awiri musanayambe kapena mutatha kumwa ufa wa Orlistat.

Kusintha kwa Mlingo

Palibe kusintha kwa mlingo kofunikira kwa odwala omwe ali ndi vuto la aimpso kapena chiwindi. Komabe, odwala omwe ali ndi matenda a shuga angafunikire kusintha mlingo wa mankhwala awo a shuga, ndipo kuwongolera glycemic kuyenera kuyang'aniridwa mosamala.

CHENJEZO

Ndikofunika kuzindikira kuti ufa wa Orlistat sayenera kugwiritsidwa ntchito panthawi yomwe ali ndi pakati kapena omwe ali ndi matenda aakulu a malabsorption syndrome, cholestasis, kapena hypersensitivity kwa chinthu chogwira ntchito kapena mankhwala aliwonse othandizira. Odwala omwe ali ndi matenda a shuga angafunikire kusintha mankhwala awo a shuga ndikuyang'anira mosamala glycemic control.

zolemba

Zambiri za mlingo ndi kayendetsedwe ka ufa wa Orlistat ndizongodziwa zokhazokha ndipo siziyenera kugwiritsidwa ntchito m'malo mwa uphungu wachipatala. Nthawi zonse funsani ndi wothandizira zaumoyo musanayambe mankhwala aliwonse kapena zowonjezera, kuphatikizapo ufa wa Orlistat. The Mlingo ndi kayendetsedwe ka ufa wa Orlistat ziyenera kutsimikiziridwa malinga ndi mbiri yakale yachipatala, mankhwala omwe alipo panopa, ndi zina zofunika. Komanso, kugula Orlistat ufa ndi khalidwe lapamwamba kuchokera kwa ogulitsa ufa wa Orlistat wodalirika kapena wogulitsa ndizofunika kwambiri.

Kuyanjana kwa Orlistat ndi Mankhwala Ena

• Orlistat ikhoza kuchepetsa kuyamwa kwa mavitamini A, D, ndi E. Choncho, ngati mukutenga zokonzekera zomwe zili ndi mavitamini A, D, ndi E (monga makonzedwe a multivitamin), muyenera kumwa mavitamini 2 maola mutatha kutenga orlistat.
• Odwala omwe ali ndi matenda amtundu wa 2 angafunikire kuchepetsa mlingo wamankhwala amkamwa a hypoglycemic (monga sulfonylureas).
• Kugwiritsa ntchito limodzi kwa orlistat ndi cyclosporine kungayambitse kuchepa kwa plasma yomaliza.
• Orlistat ikagwiritsidwa ntchito limodzi ndi amiodarone, imatha kuchepetsa kuyamwa kwake ndikuchepetsa mphamvu yakuchiritsa.
• Ngati agwiritsidwa ntchito ndi mankhwala ena panthawi imodzimodzi, kuyanjana kwa mankhwala kungatheke, chonde funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Kodi mungagule kuti Orlistat Powder?

Kupeza wodalirika komanso wodziwika bwino wa ufa wa Orlistat ndikofunikira kwa iwo omwe ali m'makampani azachipatala kapena azachipatala omwe amafunikira mankhwalawa pazinthu zawo kapena odwala. Ndikofunika kusankha wogulitsa yemwe angapereke ufa wapamwamba wa Orlistat womwe umakwaniritsa zofunikira ndi malamulo. Woperekayo ayeneranso kukhala ndi mbiri yabwino pankhani ya kuwongolera, kulongedza, kutumiza, ndi ntchito zamakasitomala. Posankha wogulitsa wodalirika, makasitomala angatsimikizire kuti amalandira mankhwala otetezeka komanso ogwira mtima pa zosowa zawo.

AASraw ndi wothandizira wokhazikika wa mankhwala opangira mankhwala, kuphatikizapo ufa wa Orlistat. Amakhala ndi dongosolo lokhazikika lowongolera kuti awonetsetse kuti katundu wawo ndi wapamwamba kwambiri komanso amakwaniritsa zofunikira. Amaperekanso makasitomala chiphaso cha kusanthula kwa gulu lililonse la ufa wa Orlistat omwe amagulitsa, kuti mukhale otsimikiza za chiyero ndi khalidwe la mankhwala. Kuphatikiza apo, AASraw imapereka mitengo yampikisano ndi kutumiza kodalirika, zomwe ndizofunikira kuziganizira posankha wogulitsa. Zonse, AASraw ndi wodalirika wogulitsa ufa wa Orlistat womwe umapereka zinthu zapamwamba kwambiri, mitengo yampikisano, komanso kutumiza kodalirika.

Orlistat Powder Lipoti Loyesa-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Orlistat ufa (96829-58-2) -COA

Orlistat ufa (96829-58-2) -COA

Mungagule bwanji Ufa wa Orlistat kuchokera ku AASraw?

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❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).

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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Xiongcai Feng
Dipatimenti ya Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
2. Jovana V. Jovankić
Yunivesite ya Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000, Kragujevac, Serbia
3. Sandhya R. Bassin MD
Icahn School of Medicine ku Mount Sinai, dipatimenti ya Endocrine, Diabetes, and Bone Disease
4. Vian Ahmed Wasta Esmail
Dipatimenti ya Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Siebenhofer A,Winterholer S,Jeitler K,Horvath K,Berghold A,Krenn C,Semlitsch T (Januware 2021). "Zotsatira za nthawi yayitali za mankhwala ochepetsa thupi mwa anthu omwe ali ndi matenda oopsa". Cochrane Database of Systematic Reviews. 1 (1): CD007654.

[2] Mancini MC,Halpern A (April 2006). "Pharmacological chithandizo cha kunenepa kwambiri". Arquivos Brasileiros de Endocrinologia ndi Metabologia. 50 (2):377–389.

[3] Heck AM,Yanovski JA,Calis KA (March 2000). "Orlistat, lipase inhibitor yatsopano yothandizira kunenepa kwambiri". Pharmacotherapy. 20 (3):270–279.

[4] Garcia SB, Barros LT, Turatti A, Martinello F, Modiano P, Ribeiro-Silva A, et al. (August 2006).” Mankhwala oletsa kunenepa kwambiri a Orlistat amalumikizidwa ndi kuwonjezeka kwa zolembera za colonic preneoplastic mu makoswe omwe amapangidwa ndi mankhwala a carcinogen. ”. Makalata a Cancer. 240 (2):221–224.

[5] "FDA Ivomereza Orlistat Kuti Igwiritsidwe Ntchito Pang'onopang'ono" (Press release).USFood and Drug Administration (FDA).7 February 2007.Archived from choyambirira pa 13 May 2009.Idabwezedwanso pa 7 February 2007.

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