Mafotokozedwe Akatundu
Pregabalin Powder Video-AAsraw
Makhalidwe Oyambirira a Pregabalin Powder
| Name mankhwala: | Pregabalin ufa |
| Nambala ya CAS: | 148553-50-8 |
| Makhalidwe a Maselo: | C8H17NO2 |
| Kulemera kwa maselo: | 159.23 |
| Melt Point: | 194-196 ° C |
| mtundu; | White kapena woyera ufa wa kristalo |
| Kusungirako nyengo: | RT |
Kodi Pregabalin Powder ndi chiyani?
Pregabalin ufa ndi mankhwala a gulu la gabapentin omwe amagwira ntchito poletsa njira zina za calcium. Pregabalin Poyambirira ufa udapangidwa kuti uzichiza khunyu chifukwa kachitidwe kake kamafanana ndi ka gabapentin, komwe kamatha kuletsa kukomoka pogwiritsa ntchito njira za calcium zomwe zimadalira mphamvu yamagetsi m'katikati mwa mitsempha. pakuwongolera ululu. Pregabalin ufa amachepetsa ululu wa neuropathic, diabetesic peripheral neuropathy, ndi zizindikiro zina mwa kukulitsa GABA milingo m'thupi komanso kupondereza kutulutsidwa kwa ma neurotransmitters osangalatsa. Pregabalin ufa ungagwiritsidwenso ntchito pochiza matenda angapo, kuphatikizapo fibromyalgia ndi postherpetic neuralgia. Chotsatira chake, ufa wa pregabalin umagwiritsidwa ntchito kwambiri pochiza mitundu yosiyanasiyana ya ululu ndipo watulukira ngati mankhwala ofunikira pachipatala cha ululu wa neuropathic.
Kodi Pregabalin Imagwira Ntchito Bwanji Pathupi?
Pregabalin limagwirira ntchito ndi lofanana ndi la gabapentin, ndipo lawonetsa zotsatira za anticonvulsant ndi analgesic m'zitsanzo zambiri za nyama, ngakhale njira yeniyeni yochitirapo kanthu sikudziwika. Pregabalin ndi yofanana ndi GABA ya neurotransmitter, komabe simagwira ntchito mofananamo. Mankhwalawa, komabe, amasiyana ndi mankhwala oletsa khunyu. Mkati mwa ndende yogwira mtima, ilibe mphamvu pa GABAA kapena GABAB receptors. Sichimatembenuzidwa kukhala GABA kapena GABA agonist, komanso sichiletsa kutengeka kwa GABA ndi kuwonongeka, komanso sichitapo kanthu pa njira za sodium kapena calcium, komanso kuchepetsa kutulutsidwa kwa glutamate ndi kutengeka.
Komabe, ufa wa Pregabalin ulibe mgwirizano wa glutamic acid, GABA, kapena ma amino acid ena omwe amagwira ntchito, koma amatha kulowetsa GABA ku calcium ion channel 2 ndi subreceptors ndikuletsa dongosolo lapakati la mitsempha. A subunit 2-protein of voltage-dependent calcium channels omwe amalepheretsa calcium ion influx, kutsitsa kutulutsidwa kwa ma neurotransmitters osangalatsa monga glutamate, norepinephrine, ndi substance P komanso kusonkhezera GABAergic neurotransmission. Kuphatikiza apo, pregabalin imatha kukweza kwambiri kuchuluka kwa GABA m'thupi, ndikuwonjezera mlingo wa pregabalin kumatha kukulitsa ntchito ya glutamic acid decarboxylase.
Mbiri Yogwiritsa Ntchito Pregabalin Powder?
M'zaka za m'ma 1950, asayansi adapeza njira ina yolepheretsa neurotransmitter yotchedwa gamma-aminobutyric acid, kapena GABA mwachidule. GABA ndi neurotransmitter yomwe imagwira ntchito pa GABA receptors m'thupi la munthu. Anthu amaganiza kuti GABA yotsika ingayambitse khunyu, komanso kuti GABA ikhoza kugwirizanitsidwa ndi ululu chifukwa cha kulepheretsa kwake. Kupezeka kwa GABA komanso kumveka bwino kwa njira yake yopangira mankhwala kunapangitsa kuti pakhale mankhwala oletsa khunyu, omwe amadziwika bwino kwambiri omwe ndi pregabalin.
Pregabalin ufa ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda osiyanasiyana, kuphatikizapo matenda a shuga a peripheral neuralgia, postherpetic neuralgia, fibromyalgia, ndi ululu wa neuropathic chifukwa cha kuvulala kwa msana kwa akuluakulu, pakati pa ena. Chiyambireni kupezeka kwa pregabalin, chitukuko ndi kugwiritsa ntchito kwake zakhala zikuchitika mosalekeza.
√ Mu Ogasiti 2003, Pfizer adalemba koyamba fomu yolembetsa ku United States.
√ Mu Disembala 2004, a US FDA pregabalin yovomerezeka ya matenda ashuga peripheral neuralgia ndi postherpetic neuralgia.
√ Mu June 2005, pregabalin idavomerezedwa ngati mankhwala othandizira pochiza kukomoka pang'ono.
√ Mu June 2007, pregabalin idavomerezedwa ndi US FDA ngati mankhwala oyamba ochizira matenda a fibromyalgia.
√ Mu June 2012, a FDA adavomereza pregabalin ngati mankhwala oyamba kuchiza neuralgia chifukwa cha kuvulala kwa msana.
√ Mu Marichi 2019, pregabalin idagwiritsidwa ntchito mwalamulo kuchiza fibromyalgia ku China.
Pakadali pano, pregabalin yavomerezedwa kuti ichiritse ululu wa neuropathic m'maiko opitilira 40 kuphatikiza Europe, Canada, ndi Mexico.
Ngakhale ufa wa pregabalin umapezeka padziko lonse lapansi, ndikofunika kusamala poganizira kugula pregabalin ndikungogula kuchokera kuzinthu zodziwika bwino. Ma pregabalin ambiri amapanga ndi ogulitsa amati amapereka pregabalin ndipamwamba kwambiri, koma si ufa wonse wa pregabalin ndi wowona. Kugula mankhwala kuchokera kwa omwe sanatsimikizidwe kapena m'misika yapaintaneti kungakhale kowopsa ndipo kungayambitse kulandira zinthu zabodza kapena zotsika mtengo.
Ubwino Wogwiritsa Ntchito Pregabalin Powder
Pregabalin ufa ndi mankhwala osinthika omwe amapereka zabwino zambiri kwa anthu omwe ali ndi matenda osiyanasiyana. Zina mwazofala zomwe zingapindule pogwiritsa ntchito ufa wa AASraw pregabalin kuphatikizapo matenda a shuga peripheral neuropathy, postherpetic neuralgia, khunyu, fibromyalgia, ululu wa neuropathic, ndi matenda ovutika maganizo.
· Diabetic Peripheral Neuropathy (DPN)
Diabetic peripheral neuropathy (DPN) ndi chotsatira chofala cha matenda amtundu woyamba komanso amtundu wa 1, zomwe zimakhudza pafupifupi 2-30% ya odwala matenda ashuga. Zizindikiro za mitsempha imeneyi m'manja ndi mapazi ndi ululu, kufooka, ndi kutaya kumverera. Pregabalin ufa ndiye mankhwala oyamba a DPN, opereka mpumulo waukulu komanso kuthana ndi zovuta zina monga nkhawa ndi kusowa tulo. Kafukufuku wochulukirapo akufunika, komabe, kuti mumvetsetse bwino kuti pregabalin ndi chithandizo chamankhwala pa nkhawa ndi vuto la kugona, komanso kupeza anthu omwe angapindule kwambiri ndi mankhwalawa.
· Postherpetic Neuralgia (PHN)
Postherpetic neuralgia (PHN) ndi matenda opweteka kwambiri omwe amatha kuchitika pambuyo pa mliri wa herpes zoster ndipo amafala kwambiri akamakalamba. PHN ikhoza kukhala yovuta kuchiza ndipo nthawi zambiri imafuna kugwiritsa ntchito mankhwala angapo kuti muchepetse ululu. Pregabalin ufa ndi mankhwala atsopano omwe amavomerezedwa ku PHN. Deta imawonetsa mphamvu zochepetsera ululu komanso kusokonezeka kwa kugona komwe kumachitika chifukwa cha PHN mwa odwala omwe akhudzidwa. Ngakhale kuti sipanakhalepo kufananitsa kwachindunji, pregabalin ikuwoneka ngati yofanana ndi gabapentin ndi mankhwala ena oyambirira ochizira PHN.
· Khunyu Wapang'ono
Pregabalin ufa wapatsidwa chilolezo ndikugulitsa mankhwala oletsa khunyu kuti agwiritsidwe ntchito ngati chithandizo chothandizira khunyu. Imagwira pamayendedwe a presynaptic calcium, modulating neurotransmitter kumasulidwa mu CNS. Mayesero atatu opangidwa mwachisawawa, akhungu awiri, oyendetsedwa ndi placebo omwe amalembetsa odwala omwe ali ndi khunyu osasinthika awonetsa mphamvu ya antiepileptic ya pregabalin motsutsana ndi placebo, monga chithandizo chothandizira, ndi 31-51% ya odwala omwe akuwonetsa kuchepa kwa 50% pafupipafupi.
· Fibromyalgia
Pregabalin ufa akuyembekezeka kuchepetsa ululu wa fibromyalgia mwa kuchepetsa kufalikira kwa nociception kudzera mu calcium channel blockage ndi neurotransmitter kumasulidwa mu njira yowawa yokwera. Pregabalin yawonetsedwanso kuti imachepetsa kuchuluka kwa glutamate ndi glutamine mu posterior insula ya odwala fibromyalgia, kusokoneza kugwirizana kwake kogwira ntchito ku network mode default.
Maphunziro a Occipital nerve stimulation (ONS) pa odwala a fibromyalgia amawonetsa kusasinthika kosinthika kowawa. Pregabalin yasonyezedwa kuti ili ndi zotsatira zotsika zozungulira zowawa mu makoswe ovulala ndi mitsempha; Choncho, pregabalin ndi zotsatira zapakati zingathandize kuti zikhale zogwira mtima pochiza fibromyalgia.
· Zowawa za Neuropathic
Pregabalin ufa ndi wotsutsana ndi njira ya Ca2 + ya voltage-gated yomwe imamangiriza ku subunit ya alpha-2-delta kuti apange zotsatira za analgesic. Imachiritsa bwino zizindikiro za mitundu yambiri ya ululu wa neuropathic ndipo yasintha kukhala mankhwala ochizira oyamba omwe ali ndi chitetezo chokwanira komanso chothandiza. Zatsimikiziridwa mu kafukufuku wamakono mu zinyama zambiri za ululu wa neuropathic kuti zikhale zothandiza pochiza zizindikiro monga allodynia ndi hyperalgesia.
· Generalized Anxiety Disorder (GAD)
Kafukufuku wasonyeza kuti pregabalin imagwira bwino ntchito pochiza matenda ovutika maganizo (GAD). Pakuwunika kovutirapo, mayesero asanu ndi awiri mwa asanu ndi atatu mwa asanu ndi atatu mwa asanu ndi atatu osasinthika komanso owongolera adawonetsa kuchepa kwakukulu kwa Hamilton Anxiety Rating Scale scores ndi pregabalin powder doses kuyambira 150-600 mg. Mu kafukufuku wina wokhudzana ndi odwala a GAD omwe adalandira chithandizo cha pregabalin ufa kwa masabata a 12-24, zochitika za zizindikiro zowonongeka ndi kuyambiranso nkhawa pambuyo posiya zinali zochepa. Pregabalin ufa ukhozanso kukhala njira yabwino yothandizira odwala omwe ali ndi GAD omwe sanayankhe bwino mankhwala oletsa kuvutika maganizo.
Chenjezo: Chifukwa mphamvu yeniyeni ya pregabalin imagwirizana ndi mtundu wa chinthucho, ndikofunikira kugula ufa wapamwamba kwambiri wa pregabalin. Pregabalin yaiwisi ya ufa wogulitsa AASraw opanga ndikupereka pregabalin yaiwisi ya ufa ndi miyezo yokhwima yopangira. Ngati mukufuna, AASraw's pregabalin ufa ndi chisankho chabwino.
Kodi Zotsatira Zotani Zogwiritsa Ntchito Pregabalin Powder?
Zotsatira za ufa wa pregabalin ndizofanana ndi zina zapakati pa mitsempha yodetsa nkhawa. Zotsatira zoyipa zokhudzana ndi kugwiritsa ntchito pregabalin ndi monga:
· Zofala kwambiri (> 10%):
chizungulire
Chisokonezo
· Wamba (1-10%):
kusawona
diplopia
Euphoria
chisokonezo
Kuwonjezeka kwa chilakolako ndi kulemera kotsatira
· Zachilendo (0.1-1%):
Hypoglycemia
Rash
Mitsempha ya minofu
Myalgia
Arthralgia
Supombocytopenia
Impso miyala
Chenjezo: Ngati zotsatira zake sizichepa kapena kutha pang'onopang'ono, pitani kuchipatala mwamsanga. Komanso, chonde onetsetsani kugula mankhwala oyenerera kuchepetsa mavuto.
Mlingo ndi Kuwongolera kwa Pregabalin Powder for Reference
Nayi tchati cha mlingo woyenera wa pregabalin ufa pazachipatala zosiyanasiyana:
| Mkhalidwe Wachipatala | Mlingo ndi Utsogoleri |
| Diabetesic peripheral neuropathy | Kuyambira: 50 mg, 3 nthawi / tsiku Kutalika: 100 mg, 3 nthawi / tsiku |
| Postherpetic neuralgia | Kuyambira: 75-150mg,2 times/day;50-100mg,3 times/day Kutalika: 200mg, 3 nthawi / tsiku; 300mg, 2 nthawi / tsiku |
| Khunyu pang'ono | Mlingo woyambira: 50mg, 3 nthawi / tsiku; 75mg, 2 nthawi / tsiku Mlingo wambiri: 600mg / tsiku |
| Fibromyalgia | Mlingo woyambira: 75 mg, 2 nthawi / tsiku Mlingo wambiri: 450mg / tsiku |
| Kupweteka kwa mtima | Mlingo woyambira: 75 mg, 2 nthawi / tsiku Mlingo wambiri: 300 mg, 2 nthawi / tsiku |
| Generalized nkhawa matenda | Mlingo woyambira: 75 mg, 2 nthawi / tsiku Mlingo wambiri: 300mg / tsiku |
Chenjerani: Ndikofunikira kuzindikira kuti mlingo uwu ndi malangizo anthawi zonse ndipo ukhoza kusiyanasiyana malinga ndi momwe munthu amakhalira, monga msinkhu, kulemera kwake, ndi mbiri yachipatala. Kuonjezera apo, mlingo ungafunike kusinthidwa pakapita nthawi kutengera momwe munthuyo angayankhire mankhwala ndi zotsatira zina zomwe angakhale nazo. Ndikofunika kukaonana ndi wothandizira zaumoyo kuti mudziwe mlingo woyenera wa matenda alionse.
Kodi mungagule kuti Pregabalin Powder?
Pregabalin imapezeka pa intaneti komanso pa intaneti, koma muyenera kusankha omwe akukusamalirani mosamala kuti muwonetsetse kuti mukupeza ufa wa pregabalin. Posankha wogulitsa pregabalin ufa, pali zinthu zingapo zofunika kuziganizira. Choyamba, ndikofunikira kuwonetsetsa kuti wogulitsa ndi wodalirika komanso wodalirika. Yang'anani ogulitsa ali ndi mbiri yopereka zinthu zapamwamba komanso ntchito yodalirika yamakasitomala. Kuphatikiza apo, mungafune kuganizira zinthu monga kuchuluka kwa madongosolo ocheperako, nthawi yobweretsera, ndi njira zolipira. Pomaliza, ndi lingaliro labwino kuwerenga ndemanga ndikupempha malingaliro kuchokera kwa makasitomala ena kuti mudziwe mbiri ya ogulitsa komanso kuchuluka kwa kukhutitsidwa kwamakasitomala. Poganizira izi, mukhoza kusankha pregabalin ufa wopereka ufa womwe umakwaniritsa zosowa zanu ndikupereka mankhwala ndi mautumiki apamwamba.
AASraw ndi amodzi mwa opanga odziwika bwino komanso ogulitsa ufa wa pregabalin, omwe adadzipereka kuti apereke ufa wapamwamba kwambiri, wa pregabalin kwa makasitomala padziko lonse lapansi. Kupatula apo, AASraw ili ndi gulu la akatswiri odziwa zambiri kuti atsimikizire kuti zogulitsa zathu zonse zimakwaniritsa miyezo yapamwamba kwambiri komanso yoyera. Komanso, AASraw amagwiritsa ntchito zipangizo zamakono ndi zipangizo zopangira ufa wa pregabalin womwe ulibe zonyansa ndi zowonongeka. Potsirizira pake, AASraw ili ndi ndondomeko yoyendetsera khalidwe labwino kuti iwonetsetse kuti mtanda uliwonse wa pregabalin ufa umayesedwa bwino kuti ukhale woyera ndi potency.
Raw Pregabalin Powder Testing Report- HNMR
Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira..
Pregabalin Powder (148553-50-8) -COA
Pregabalin Powder (148553-50-8) -COA
Kodi mungagule bwanji Pregabalin Powder kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Reference
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[2] MJ Field, RJ Oles, L. Singh. Pregabalin ikhoza kuyimira gulu lakale la othandizira anxiolytic okhala ndi zochitika zambiri. Br J Pharmacol, 132 (2001), tsamba 1-4
[3] Hong JS, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. (Marichi 2022). "Gabapentin ndi pregabalin mu matenda a bipolar, nkhawa, ndi kusowa tulo: kuwunika mwadongosolo, kusanthula meta, ndi zomveka". Molecular Psychiatry. 27 (3): 1339–1349.
[4] Freynhagen R, Baron R, Kawaguchi Y, Malik RA, Martire DL, Parsons B, et al. (Januware 2021). "Pregabalin ya ululu wa neuropathic m'malo osamalira odwala kwambiri: malingaliro a dosing ndi titration". Mankhwala Omaliza Maphunziro. Malingaliro a kampani Informa UK Limited 133 (1): 1–9.
[5] Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N (February 2019). "Machiritso a Pharmacological for Generalized Anxiety Disorder: Kuwunika Mwadongosolo ndi Kuwunika kwa Meta" (PDF). Lancet. 393 (10173): 768-777.
