Mafotokozedwe Akatundu
Kodi PT-141(Bremelanotide) ndi chiyani?
PT-141, yomwe imadziwikanso kuti bremelanotide, ndi dzina lachidziwitso cha gulu latsopano la ma peptides omwe akuphunziridwa kuti athandizire kukonza vuto la kugonana (erectile dysfunction, kapena impotence) mwa amuna komanso kuthandiza kukonza vuto la kugonana (kugonana ndi chilakolako chogonana) mwa amayi. .[6]141 sichigwira ntchito pa mitsempha ya mitsempha monga mankhwala awiri am'mbuyomu, koma imadziwika ndipo yasonyezedwa kuti imathandizira kuonjezera kugonana kwa amuna ndi akazi.[3][8][5] Kuphatikiza apo, peptide PT 141 tsopano yavomerezedwa ndi FDA kuti athetse vuto la kugonana mwa amayi.[8][5] Ngati anthu akufuna kugula peptide PT 141 pa intaneti, magwero ambiri, monga opanga PT 141 ndi ogulitsa, angapezeke mosavuta.
Kodi PT-141(Bremelanotide) imagwira ntchito bwanji?
PT-141 (Bremelanotide) ndi gulu loyamba la mankhwala ena omwe amadziwika kuti melanocortin agonists pachipatala chamankhwala.[1] Njira yochitira PT-141 (Bremelanotide) ikhoza kupereka chitetezo chofunikira komanso ubwino wochita bwino poyerekeza ndi zomwe zilipo panopa. mankhwala chifukwa imagwira ntchito panjira zowongolera m'malo molunjika padongosolo.[3] Zambiri zachipatala zikuwonetsa kuti PT-141 (Bremelanotide) imathanso kuchiza odwala osiyanasiyana omwe alibe mphamvu.[4] Mapangidwe a mphuno a PT-141 (Bremelanotide) omwe akupangidwa ndi abwino ngati chithandizo cham'kamwa, amakhala oleza mtima kwambiri poyerekeza ndi mankhwala osokoneza bongo monga jekeseni ndi ma pellets a transurethral, ndipo akuwoneka kuti akuyamba kuchitapo kanthu mofulumira.[1]
Bremelanotide PT-141 akuti imagwira ntchito poyambitsa melanocortin receptors muubongo, potero imathandizira kukulitsa chilakolako chogonana. Ndi mankhwala opangidwa ndi melanocortin Peptide zomwe zasonyeza kuchita bwino mu maphunziro azachipatala mu makoswe amuna ndi akazi. Makoswe aamuna adawonetsa mayankho a erectile pamlingo wochepera 1-2 mg, pomwe makoswe ambiri achikazi adawonetsa mayankho abwino pamiyeso yoposa 2-3 mg. Zofunikira za mlingo zinali zapamwamba kwa makoswe achikazi, koma zotsatira zamphamvu zinawonedwa mu makoswe achikazi.
Nkofunika kuzindikira kuti limagwirira ntchito ya mankhwala okhudzana ndi khalidwe lake. Zogulitsa zapamwamba zokha zomwe zingakhale ndi njira yabwino yochitirapo kanthu. Kuti mutsimikizire mtundu wa PT-141, ndikofunikira kuupeza kuchokera ku gwero lodalirika.AASraw, wopanga mbiri komanso wogulitsa PT-141, amapereka peptide yapamwamba kwambiri. mankhwala odziimira pawokha kafukufuku ndi chitukuko malo ndi mafakitale.Ngati muli ndi zofunika zenizeni, kusankha yogulitsa PT-141 kuchokera AASraw ndi njira yabwino kwambiri.
Ubwino wogwiritsa ntchito peptide PT-141(Bremelanotide)
PT-141 (Bremelanotide) imapereka zopindulitsa zazikulu pochiza kukanika kugonana mwa amuna ndi akazi. Ikaperekedwa kudzera mu jakisoni, yawonetsa zotsatira zolimbikitsa makamaka mwa maphunziro achikazi. Komabe, zimatsimikiziranso zopindulitsa kwa amuna omwe akukumana ndi zovuta monga erectile dysfunction, low libido, ndi kusowa mphamvu.
Wonjezerani chilakolako chogonana
Chimodzi mwazabwino zazikulu za PT-141 ndikutha kukulitsa chilakolako chogonana kudzera mu dongosolo lapakati lamanjenje popanda kuwononga dongosolo la mitsempha. Poyerekeza ndi mankhwala ena okhudzana ndi kugonana, AASraw PT-141 imaonedwa kuti ndi yamphamvu kwambiri pamene ikukhalabe ndi chitetezo chabwino. Siziika chiwopsezo chachikulu ku thanzi la munthu.[3][8]
Pochiza vuto la kugonana, PT-141 yawonetsedwa kuti imakulitsa chilakolako cha kugonana mwa amayi, ndipo zotsatira zake zimakhala zokhalitsa. Anthu ena amapeza zabwinozo mpaka maola 72 akutsatira jakisoni wa PT-141.
Kuwonjezera mphamvu
Kuphatikiza pa ntchito yake pothana ndi vuto la kugonana, PT-141 yawonetsa kuthekera kowonjezera mphamvu mwachilengedwe. Zachimuna timadzi Zipatala zimagwiritsanso ntchito PT-141 kuti athetse zizindikiro zokhudzana ndi testosterone yochepa. Kuphatikiza kwa peptide kwa PT-141 kumatha kukhala kopindulitsa kwa anthu omwe nthawi zambiri amatopa, kutopa, kapena kusowa mphamvu.[7][3]
Chitani matenda a khungu.
Kuphatikiza apo, PT-141 idawunikiridwa kuti ili ndi kuthekera kwake pochiza matenda amtundu wa khungu ndipo yakhala ikugwiritsidwa ntchito ngati mankhwala achilengedwe, osatentha ndi dzuwa. Komabe, kukhudzika kwa PT-141 kupangitsa chidwi chogonana mwa ogwiritsa ntchito kwachepetsa kugwiritsa ntchito kwake pazinthu zowotcha. Ndikofunika kuzindikira kuti cholinga choyambirira chogwiritsira ntchito PT-141 chikadali chithandizo chazovuta zosiyanasiyana komanso kupititsa patsogolo chilakolako chogonana mwa amuna ndi akazi.
Ndikofunikira kugula PT-141 kuchokera kuzinthu zodziwika bwino; apo ayi, simungathe kuchita bwino kwambiri kuchokera ku PT-141. Monga katswiri wopanga ndi ogulitsa PT-141, AASraw ikufuna kupereka PT-141 yoyera padziko lonse lapansi. Ngati muli ndi zosowa, Peptide ya AASraw PT-141 ndi chisankho chabwino kwa inu.
Zotsatira za peptide PT-141 (Bremelanotide)
Ngakhale PT-141 (Bremelanotide) nthawi zambiri imaloledwa bwino, ndikofunikira kudziwa zotsatira zoyipa zomwe zikhoza kuchitika. Zina mwazotsatira za PT-141 ndi monga:
nseru: Mseru ndi chimodzi mwa zomwe zimanenedwa mofala zotsatira zoyipazi wa PT-141.Zitha kuyambitsa kukhumudwa kapena kukhumudwa m'mimba.
mutu: Anthu ena amatha kudwala mutu ngati a zotsatira zoyipa wa PT-141.Mitu iyi imakhala yochepa kwambiri ndipo imathetsa paokha.
Jekeseni malo zimachitikira: Popeza PT-141 imayendetsedwa kudzera mu jakisoni, pali kuthekera kokumana ndi zochitika za malo a jakisoni monga kupweteka, kufiira, kapena kutupa pamalo opangira jakisoni.
chizungulire: Chizungulire kapena kupepuka mtima kumatha kuchitika ngati a zotsatira zoyipa ya PT-141.Ndikofunikira kupewa zochitika zomwe zimafuna kukhala tcheru ngati mukumva chizungulire.
kutopa: Anthu ena amatha kutopa kapena kutopa atamwa PT-141.
Kusokonezeka kwapadera: Ngati PT-141 imalowetsedwa mu mawonekedwe opopera a m'mphuno, kutsekeka kwa mphuno kapena kuyanika kumatha kuchitika ngati zotsatira zoyipa.
Ndikofunika kuzindikira kuti si onse omwe angakumane ndi izi zotsatira zoyipazi, komanso kuopsa kwake komanso kuchuluka kwa zotsatirapo zake zimatha kusiyana pakati pa anthu. Ngati mukukumana ndi zovuta kapena kulimbikira zotsatira zoyipazi, tikulimbikitsidwa kuti mufunsane ndi katswiri wazachipatala kuti akupatseni malangizo ena. Kuphatikiza apo, pogula PT-141, muyenera kusankha mosamala PT-141 kuti mutsimikizire mtundu wa chinthucho. Panthawi imodzimodziyo, iyenera kugwiritsidwa ntchito motsogoleredwa ndi akatswiri kuti apewe zotsatirapo zoipa.[2] [7][3]
PT-141 vs Melanotan II (MT-2)
PT-141 (Bremelanotide) ndi Melanotan II (MT-2) ali ndi kusiyana kwina pazotsatira zawo ndi njira zogwirira ntchito pankhani ya chithandizo cha erectile dysfunction (ED). Nayi kufananitsa pakati pa PT-141 ndi MT-2 pazotsatira zawo pa ED.
①Njira Zochita
Chithunzi cha PT-141
PT-141 imagwira ntchito kwambiri pakatikati pa mitsempha yapakati poyang'ana melanocortin receptors, makamaka melanocortin 4 receptor (MC4R) mu ubongo. Amathandizira kutulutsidwa kwa nitric oxide, yomwe imathandiza kupumula minofu yosalala mu mbolo ndikuwonjezera magazi, zomwe zimapangitsa kuti erectile igwire bwino.
Melanotan II
Melanotan II imagwira ntchito poyang'ana ma melanocortin receptors, makamaka melanocortin 1 receptor (MC1R). Cholinga chake chachikulu ndikulimbikitsa kupanga melanin pakhungu, zomwe zimapangitsa khungu kukhala mdima. Ngakhale zingakhale ndi zotsatirapo pa ntchito yogonana, zotsatira zake pa ntchito ya erectile ndizochepa kwambiri poyerekeza ndi PT-141.
②Yang'anani kwambiri pa Erectile Dysfunction
Chithunzi cha PT-141
PT-141 idaphunziridwa mwachindunji ndikupangidwira chithandizo chazovuta zakugonana, kuphatikiza kusagwira bwino ntchito kwa erectile, mu zonse ziwiri. amuna ndi akazi. Mayesero azachipatala awonetsa zotsatira zabwino pakuwongolera magwiridwe antchito a erectile ndi chilakolako chogonana.
Melanotan II
Pomwe Melanotan II adanenedwa kuti ali ndi ena zotsatira pa ntchito yogonana ndi libido, cholinga chake chachikulu sichimangoyang'ana pochiza vuto la erectile. Amagwiritsidwa ntchito makamaka pakuwotcha ndipo ali ndi umboni wocheperako wochirikiza kugwiritsidwa ntchito kwake pochiza ED.
③Umboni Wachipatala
Chithunzi cha PT-141
PT-141 yakumana ndi mayesero azachipatala makamaka akuwunika momwe imagwirira ntchito pochiza vuto la erectile. Mayeserowa awonetsa zotsatira zabwino, zomwe zikuwonetsa kuthekera kwake ngati njira yothandizira ED.
Melanotan II
Melanotan II ili ndi umboni wochepa wachipatala wotsimikizira kuti umagwira ntchito bwino pochiza vuto la erectile. Zambiri zomwe zilipo pazotsatira zake pakuchita zogonana zimachokera ku malipoti osadziwika m'malo mwa maphunziro okhwima azachipatala.
Mwachidule, PT-141 yaphunziridwa mozama ndikupangidwira pochiza kusagwira bwino kwa erectile komanso kusokonezeka kwa kugonana mwa amuna ndi akazi. Njira yake yochitira zinthu imayang'ana mwachindunji dongosolo la mitsempha yapakati ndipo yawonetsa zotsatira zodalirika m'mayesero achipatala. Kumbali ina, Melanotan II imayang'ana kwambiri pakhungu ndipo ili ndi umboni wocheperako wothandiza pochiza vuto la erectile.
Kodi Mungagule Kuti PT-141(Bremelanotide)?
Zikafika pa PT-141 (Bremelanotide), ndikofunikira kuika patsogolo chitetezo ndi kudalirika poganizira zogula kuchokera kwa ogulitsa pa intaneti. Magwero odalirika komanso odalirika akuyenera kufufuzidwa kuti awonetsetse kuti mankhwalawa ndi abwino komanso ogwira ntchito pazaumoyo zomwe akufuna. Kutsimikizira mbiri ya ogulitsa ndikofunikira, monganso kutsatira kwawo miyezo yoyendetsera bwino komanso kupereka zolembedwa zofunika monga Certificate of Analysis.[1][3]
Ngati mukufunafuna gwero lodalirika la kugula PT-141, AASraw ikhoza kukhala njira yabwino.AASraw ndi kampani yomwe imapereka ma peptides osiyanasiyana, kuphatikizapo PT-141. Zogulitsa zawo zimagwiritsidwa ntchito ndi ma laboratories ndi mabungwe ofufuza popanga ndi kupanga zinthu zosiyanasiyana zaumoyo.
PT-141 Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji PT-141 kuchokera ku AASraw?
❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani m'maola 12.
❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.
❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. Anita H. Clayton MD
Dipatimenti ya Psychiatry ndi Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia
2. François Giuliano MD, PhD
Chipatala cha Raymond Poincaré-Dipatimenti ya Physical Medicine ndi Rehabilitation, Garches, France
3. Mohammad Reza Safarinejad
Urology and Nephrology Research Center, Chipatala cha Shaheed Modarress, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
4. Raymond C. Rosen PhD
Dipatimenti ya Psychiatry, University of Medicine ndi Dentistry ya New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1].Simon JA,Kingsberg SA"Chitetezo Chanthawi Yaitali ndi Kuchita Bwino kwa Bremelanotide kwa Hypoactive Sexual Desire Disorder."Obstet Gynecol.2019 Nov.PMID:31599847.
[2] Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. J Sex Med.141 Jul; PMID: 2006.
[3] Ückert S,Bannowsky A,Albrecht K,Kuczyk MA (November 2014)."Melanocortin receptor agonists pochiza vuto la kugonana kwa amuna ndi akazi:zimachokera ku kafukufuku wofunikira komanso maphunziro achipatala". 23): 11–1477.doi:83/10.1517.PMID 13543784.2014.934805.
[4] Pfaus J, Giuliano F, Gelez H. "Bremelanotide: mwachidule za zotsatira za CNS zowonongeka pa kugonana kwa akazi." J Sex Med.2007 Nov.PMID: 17958619.
[5] Mintzes B,Tiefer L,Cosgrove L.”Bremelanotide ndi flibanserin chifukwa cha chikhumbo chochepa chogonana mwa akazi:kunama kwa malamulo oyendetsera dziko."Drug Ther Bull.2021 Dec;PMID:34642243.
[6] Molinoff PB,Shadiack AM,Earle D,Diamond LE,Quon CY."PT-141:a melanocortin agonist pochiza vuto la kugonana"Ann NY Acad Sci.2003 Jun.PMID:12851303.
[7] Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. kuyankha kwa Viagra."Int J Impot Res.141 Apr.PMID:2004.
[8] Diamond LE, Earle DC, Garcia WD, Spana C.” Kugwiritsiridwa ntchito kwa Mlingo wochepa wa intranasal PT-141, melanocortin receptor agonist, ndi sildenafil kwa amuna omwe ali ndi vuto la erectile kumabweretsa kuyankha kwamphamvu kwa erectile." Urology. 2005 Apr;PMID:15833522.
