Mafotokozedwe Akatundu
Kodi PT-141(Bremelanotide) ndi chiyani?
PT-141, yomwe imadziwikanso kuti bremelanotide,ndi dzina lachidziwitso cha kalasi yatsopano ya ma peptide omwe akuphunziridwa kuti athandize kuthetsa vuto la kugonana (erectile dysfunction, kapena impotence) mwa amuna komanso kuthandizira kusokoneza kugonana (matenda odzutsa kugonana) mwa amayi.141 sichigwira ntchito pa mitsempha ya mitsempha monga mitundu iwiri yapitayi, koma imadziwika ndipo yasonyezedwa kuti ikuthandiza kuonjezera kugonana kwa zinyama zonse zamphongo ndi zazikazi. Komanso, peptide PT 141 tsopano yavomerezedwa ndi FDA kuti athetse vuto la kugonana kwa amayi.Ngati anthu akufuna kugula peptide PT. 141 pa intaneti, magwero ambiri, monga wopanga PT 141 ndi ogulitsa, angapezeke mosavuta.
Kodi PT-141(Bremelanotide) imagwira ntchito bwanji?
PT-141 (Bremelanotide) ndi gulu loyamba la mankhwala ena omwe amadziwika kuti melanocortin agonists for therapeutic pathology.Makina a PT-141 (Bremelanotide) angapereke ubwino wofunikira wa chitetezo ndi mphamvu poyerekeza ndi zomwe zilipo panopa chifukwa zimagwira ntchito. Njira zoyendetsera ntchito m'malo molunjika pa system.Deta yachipatala ikuwonetsa kuti PT-141 (Bremelanotide) imathanso kuchiza odwala osiyanasiyana opanda mphamvu. ochezeka ndi odwala poyerekeza ndi mankhwala obwera monga jakisoni ndi ma pellets a transurethral, ndipo akuwoneka kuti akuyamba kuchitapo kanthu mwachangu.
Bremelanotide PT-141 akuti imagwira ntchito poyambitsa melanocortin receptors mu ubongo, potero imathandizira kukulitsa chilakolako chogonana. otsika kwambiri ngati 1-2 mg, pamene makoswe ambiri achikazi amasonyeza mayankho abwino pa mlingo wokwanira 2-3 mg. Zofunikira za mlingo zinali zapamwamba kwa makoswe aakazi, koma zotsatira zamphamvu zinkawoneka mu makoswe aakazi.
Ndikofunikira kudziwa kuti kachitidwe ka zinthuzo ndi kogwirizana ndi mtundu wake.Zogulitsa zapamwamba zokha zomwe zitha kukhala ndi njira yabwino yochitirapo kanthu. gwero.AASraw, wopanga mbiri komanso wogulitsa PT-141, amapereka mankhwala apamwamba a peptide kwa kafukufuku wodziimira payekha ndi malo otukuka ndi mafakitale.Ngati muli ndi zofunikira zenizeni, kusankha kugulitsa PT-141 kuchokera ku AASraw ndi njira yabwino kwambiri.
Ubwino wogwiritsa ntchito peptide PT-141(Bremelanotide)
PT-141 (Bremelanotide) imapereka zopindulitsa zazikulu pochiza vuto la kugonana mwa amuna ndi akazi. Ikaperekedwa kudzera mu jekeseni, yawonetsa zotsatira zabwino kwambiri pa maphunziro a amayi. low libido, ndi kusowa mphamvu.
Wonjezerani chilakolako chogonana
Mmodzi mwa ubwino waukulu wa PT-141 ndi kuthekera kwake kuonjezera chilakolako chogonana kudzera m'kati mwa dongosolo la mitsempha popanda kusokoneza dongosolo la mitsempha. mbiri.Siziika chiwopsezo chachikulu ku thanzi la munthu.
Pochiza vuto la kugonana, PT-141 yasonyezedwa kuti imalimbikitsa chilakolako chogonana mwa amayi, ndipo zotsatira zake zimakhala zokhalitsa.
Kuwonjezera mphamvu
Kuphatikiza pa ntchito yake pothana ndi vuto la kugonana, PT-141 yawonetsa kuthekera kowonjezera mphamvu mwachilengedwe. Zipatala za mahomoni a amuna amagwiritsanso ntchito PT-141 kuthana ndi zizindikiro zokhudzana ndi kuchepa kwa testosterone. amene nthawi zambiri amatopa, kutopa, kapena kusowa mphamvu.
Chitani matenda a khungu.
Kuphatikiza apo, PT-141 idawunikiridwa kuti ili ndi kuthekera kwake pochiza matenda amtundu wa khungu ndipo yakhala ikugwiritsidwa ntchito ngati chotenthetsera chachilengedwe, chopanda dzuwa. Ndikofunikira kudziwa kuti cholinga choyambirira chogwiritsa ntchito PT-141 chimakhalabe chithandizo chazovuta zosiyanasiyana komanso kupititsa patsogolo chilakolako chogonana mwa amuna ndi akazi.
Ndikofunikira kugula PT-141 kuchokera kuzinthu zodziwika bwino; Apo ayi, simungapeze mphamvu yabwino kuchokera ku PT-141.Monga katswiri wa PT-141 wopanga ndi wogulitsa, AASraw ikufuna kupereka PT-141 yoyera padziko lonse lapansi.Ngati muli ndi zosowa, peptide ya AASraw PT-141 ndi yabwino kwa inu.
Zotsatira za peptide PT-141 (Bremelanotide)
Ngakhale kuti PT-141 (Bremelanotide) nthawi zambiri imaloledwa bwino, ndikofunika kudziwa zotsatira zomwe zingachitike. Zina mwazotsatira za PT-141 ndi monga:
nseru:Mseru ndi chimodzi mwazotsatira zomwe zimanenedwa kawirikawiri za PT-141. Zingayambitse kukhumudwa kapena kukhumudwa m'mimba.
mutu:Anthu ena akhoza kudwala mutu monga zotsatira za PT-141.Mitu iyi imakhala yochepa kwambiri ndipo imathetsa paokha.
Jekeseni malo zimachitikira:Popeza PT-141 imayendetsedwa kudzera mu jakisoni, pali kuthekera kokumana ndi zochitika zamalo ojambulira monga kupweteka, kufiira, kapena kutupa pamalo ojambulira.
chizungulire:Chizungulire kapena kupepuka mtima kungachitike ngati zotsatira za PT-141.Ndikofunikira kupewa zochitika zomwe zimafuna kukhala tcheru ngati mukumva chizungulire.
kutopa:Anthu ena amatha kutopa kapena kutopa atamwa PT-141.
Kusokonezeka kwapadera:Ngati PT-141 kutumikiridwa mu mawonekedwe opopera mphuno, m`mphuno kupindika kapena stuffiness akhoza kuchitika ngati mbali zotsatira.
Ndikofunika kuzindikira kuti si aliyense amene angakumane ndi zotsatirazi, ndipo kuopsa kwake ndi kuchuluka kwa zotsatira zake zingakhale zosiyana pakati pa anthu. .Kuwonjezera apo, pogula PT-141, muyenera kusankha mosamala wothandizira PT-141 kuti muwonetsetse kuti katunduyo ndi wabwino.
PT-141 vs Melanotan II (MT-2)
PT-141 (Bremelanotide) ndi Melanotan II (MT-2) ali ndi kusiyana kwina mu zotsatira zawo ndi njira zogwirira ntchito pokhudzana ndi chithandizo cha erectile dysfunction (ED) . zotsatira za ED.
①Njira Zochita
Chithunzi cha PT-141
PT-141 imagwira ntchito kwambiri pakatikati pa mitsempha yapakati poyang'ana ma melanocortin receptors, makamaka melanocortin 4 receptor (MC4R) mu ubongo. ntchito yabwino ya erectile.
Melanotan II
Melanotan II makamaka imagwira ntchito poyang'ana ma receptor a melanocortin, makamaka melanocortin 1 receptor (MC1R). Cholinga chake chachikulu ndikulimbikitsa kupanga melanin pakhungu, zomwe zimapangitsa khungu kukhala mdima. Erectile ntchito sizolunjika kwambiri poyerekeza ndi PT-141.
②Yang'anani kwambiri pa Erectile Dysfunction
Chithunzi cha PT-141
PT-141 yaphunziridwa mwachindunji ndikupangidwira kuti athetse vuto la kugonana, kuphatikizapo kusokonezeka kwa erectile, mwa amuna ndi akazi.
Melanotan II
Ngakhale kuti Melanotan II yadziwika kuti imakhala ndi zotsatirapo pa kugonana ndi libido, cholinga chake chachikulu sichinayang'ane pochiza vuto la erectile.
③Umboni Wachipatala
Chithunzi cha PT-141
PT-141 yakhala ikukumana ndi mayesero a zachipatala makamaka kuyesa mphamvu yake pochiza vuto la erectile.
Melanotan II
Melanotan II ili ndi umboni wochepa wachipatala wochirikiza mphamvu yake pochiza erectile dysfunction.Zambiri zomwe zilipo pa zotsatira zake pa ntchito yogonana zimachokera ku malipoti osadziwika m'malo mwa maphunziro okhwima a zachipatala.
Mwachidule, PT-141 yakhala ikuphunziridwa mozama ndikupangidwira chithandizo cha erectile dysfunction ndi kugonana kwa amuna ndi akazi. dzanja, Melanotan II imayang'ana kwambiri pakhungu ndipo ili ndi umboni wocheperako wothandiza pothana ndi vuto la erectile.
Kodi Mungagule Kuti PT-141(Bremelanotide)?
Pankhani ya PT-141 (Bremelanotide), ndikofunikira kuika patsogolo chitetezo ndi kudalirika poganizira zogula kuchokera kwa ogulitsa pa intaneti.Magwero odalirika komanso odalirika ayenera kufufuzidwa kuti atsimikizire ubwino ndi mphamvu ya mankhwala pa ntchito zomwe akufuna. za mbiri ya ogulitsa ndizofunikira, monganso kutsatira kwawo miyezo yoyendetsera bwino komanso kupereka zolembedwa zofunika monga Certificate of Analysis.
Ngati mukufunafuna gwero lodalirika logula PT-141, AASraw ikhoza kukhala njira yabwino.AASraw ndi kampani yomwe imapereka ma peptides osiyanasiyana, kuphatikizapo PT-141.Zogulitsa zawo zimagwiritsidwa ntchito ndi ma laboratories ndi mabungwe ofufuza za chitukuko ndi kupanga zinthu zosiyanasiyana zaumoyo.
PT-141 Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji PT-141 kuchokera ku AASraw?
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
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[2] Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. J Sex Med.141 Jul; PMID: 2006.
[3] Ückert S,Bannowsky A,Albrecht K,Kuczyk MA (November 2014)."Melanocortin receptor agonists pochiza vuto la kugonana kwa amuna ndi akazi:zimachokera ku kafukufuku wofunikira komanso maphunziro achipatala". 23): 11–1477.doi:83/10.1517.PMID 13543784.2014.934805.
[4] Pfaus J, Giuliano F, Gelez H. "Bremelanotide: mwachidule za zotsatira za CNS zowonongeka pa kugonana kwa akazi." J Sex Med.2007 Nov.PMID: 17958619.
[5] Mintzes B, Tiefer L, Cosgrove L.”Bremelanotide ndi flibanserin chifukwa cha chilakolako chochepa chogonana mwa akazi: zolakwika za malamulo oyendetsera ntchito.
[6] Molinoff PB,Shadiack AM,Earle D,Diamond LE,Quon CY."PT-141:a melanocortin agonist pochiza vuto la kugonana"Ann NY Acad Sci.2003 Jun.PMID:12851303.
[7] Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. kuyankha kwa Viagra."Int J Impot Res.141 Apr.PMID:2004.
[8] Diamond LE, Earle DC, Garcia WD, Spana C.” Kugwiritsiridwa ntchito kwa Mlingo wochepa wa intranasal PT-141, melanocortin receptor agonist, ndi sildenafil kwa amuna omwe ali ndi vuto la erectile kumabweretsa kuyankha kwamphamvu kwa erectile." Urology. 2005 Apr;PMID:15833522.
