Mafotokozedwe Akatundu
Makhalidwe Oyamba a Semaglutide
| Name mankhwala: | Semaglutide |
| Nambala ya CAS: | 910463-68-2 |
| Makhalidwe a Maselo: | C187H291N45O59 |
| Kulemera kwa maselo: | 4113.58g / mol |
| Melt Point: | 34-39 ° C |
| mtundu; | White |
| Kusungirako nyengo: | Sungani pa 8 ° C-20 ° C, tetezani ku chinyezi ndi kuwala |
Kodi Semaglutide ndi chiyani?
Semaglutide ndi glucagon-ngati peptide-1 receptor agonist yomwe imagwiritsidwa ntchito mwa anthu omwe ali ndi matenda a shuga a 2 monga kuwonjezera pa zakudya ndi masewera olimbitsa thupi kuti azitha kuyendetsa bwino glycemic..Semaglutide ndi GLP-1 mimic yokhala ndi 94% sequence homology kwa GLP-1 yamunthu. Imatha kumangirira ku GLP-1 receptor ndikuyambitsa cholandilira kuti chichepetse shuga wamagazi polimbikitsa kupanga insulin ndikuchepetsa katulutsidwe ka glucagon ngati cholandilira cha GLP-1. agonist.Kuphatikiza apo, semaglutide imatha kuchitapo kanthu m'mimba mwa kuchedwa kutulutsa m'mimba kuti ipangitse kudzaza; pa ubongo mwa kupondereza chilakolako; ndi pa circulatory system pokonza intima yowonongeka ndi kukonza endothelial ntchito.
Kodi Semaglutide Imagwira Ntchito Motani?
Semaglutide ufa ndi agonist wa glucagon-ngati peptide-1 receptor.Imakulitsa kupanga kwa insulin, hormone yomwe imachepetsa shuga m'magazi, potengera zotsatira za incretin glucagon-like peptide-1 (GLP-1) . Kuonjezera apo, AASraw semaglutide imatha kuchepetsa kupanga kwa glucagon, hormone yomwe imapangitsa glycogenolysis (kutulutsidwa kwa ma carbs osungidwa m'chiwindi) ndi gluconeogenesis ( kupangidwa kwa glucose watsopano). Imachepetsa kudya mwa kuletsa njala ndi kuchedwetsa kagayidwe kachakudya m'mimba, zomwe zimathandizira kuchepetsa thupi. Imachepetsa chilakolako, chilakolako cha chakudya, komanso kusunga mafuta.
Kafukufuku wa Semaglutide
①Mau oyamba
Semaglutide ndi mankhwala omwe poyamba adapangidwa kuti athetse matenda a shuga.Kamodzi-Weekly Semaglutide mu Achinyamata Omwe Ali ndi Kunenepa Kwambiri-- lofalitsidwa mu New England Journal of Medicine (NEJM) wapeza kuti semaglutide ingathandizenso achinyamata onenepa kwambiri kuchepetsa thupi komanso kulimbikitsa thanzi la mtima.
②Zotsatira zazikulu
- Achinyamata onenepa kwambiri omwe adatenga semaglutide mlungu uliwonse adawona kuwonjezeka kwa 16.1% mu index ya misa ya thupi (BMI) muyeso lazachipatala lapadziko lonse la 3a, poyerekeza ndi kuwonjezeka kwa 0.6% mu gulu la placebo.
- Semaglutide ndi glucagon-ngati peptide 1 (GLP-1) receptor agonist yomwe ingachepetse chilakolako, zakudya, ndi calorie kudya, kuti ikhale yothandiza pakuwonda.
- Chiyeso chachikulu chachipatala chinasonyeza kuti semaglutide ili ndi zotsatira zodabwitsa monga mankhwala ochepetsa thupi, ndipo gulu lochiritsidwa likutaya pafupifupi 15.3 kg.
- Mu June 2021, USFood and Drug Administration (FDA) idavomereza malonda a semaglutide (Semaglutide), mankhwala ochepetsa thupi omwe ali ndi dzina lamalonda la Wegovy.
- Kafukufuku waposachedwa wapeza kuti semaglutide idaposa placebo ponena za kuwonda komanso kusintha kwa ziwopsezo za cardiometabolic mwa achinyamata onenepa kwambiri.
- Pambuyo potenga semaglutide, zinthu zowopsa za mtima monga chiuno chozungulira, magazi a shuga index HbA1c, cholesterol chonse, otsika kwambiri komanso otsika kwambiri a lipoprotein cholesterol, triglycerides, ndi triglycerides bwino.
- Gulu la semaglutide linapambana gulu la placebo pamiyeso yokhudzana ndi kulemera kwa moyo, chifukwa makamaka ndi zitonthozo zapamwamba za thupi.
③Mapeto
Semaglutide yasonyezedwa kuti ndi mankhwala othandiza kuchepetsa thupi, ndipo kafukufuku waposachedwapa wasonyeza kuti angakhalenso opindulitsa kwa achinyamata olemera kwambiri. miyeso ya moyo.
Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997064/
Ubwino Wogwiritsa Ntchito Semaglutide
Semaglutide ndi mankhwala osokoneza bongo omwe amapereka ubwino wambiri kwa anthu omwe ali ndi matenda osiyanasiyana.Zina mwazofala zomwe zingapindule pogwiritsa ntchito AASraw Semaglutide kuphatikizapo Type 2 Diabetes Mellitus, ngozi za caidiovascular, kunenepa kwambiri ndi Alzheimer.
①Kuchepetsa Milingo ya Glucose
Semaglutide ndi GLP-1 receptor agonist yomwe imathandizira kuchepetsa kuchuluka kwa shuga m'magazi mwa anthu omwe ali ndi matenda a shuga a 2 pogwiritsa ntchito njira zingapo.Imathandizira kutulutsa kwa insulini, komwe kumathandizira kusuntha shuga m'magazi kupita ku maselo komwe angagwiritsidwe ntchito mphamvu. Semaglutide imachepetsanso kutulutsa kwa glucagon, yomwe imachepetsa kupanga shuga ndi chiwindi.
M'mayesero azachipatala, semaglutide yawonetsedwa kuti imachepetsa kwambiri milingo ya HbA1c, yomwe ndi chizindikiro cha kuwongolera shuga wamagazi kwa nthawi yayitali. kuyesa, kunachepetsa kuchuluka kwa HbA1c ndi 1% poyerekeza ndi placebo.Semaglutide yasonyezedwanso kuti imathandizira kuchepetsa kusala kudya kwa plasma glucose ndi postprandial glucose excursions.
②Kuchepetsa Chiwopsezo cha Zochitika Zamtima
Semaglutide yasonyezedwa kuti ichepetse chiopsezo cha zochitika zazikulu za mtima (MACE) monga imfa ya mtima, infatal myocardial infarction, ndi sitiroko yoopsa kwa akuluakulu omwe ali ndi matenda a shuga a 2 ndipo adayambitsa matenda a mtima. - Mayesero a 6, omwe adawonetsa kuchepa kwakukulu kwa MACE ndi chithandizo cha semaglutide poyerekeza ndi placebo. Komanso, Semaglutide yasonyezedwa kuti imapangitsa kuti pakhale ngozi zambiri za mtima monga kuthamanga kwa magazi, mbiri ya lipid, ndi zizindikiro za kutupa kwa anthu omwe ali ndi matenda a shuga a 6. mayeso a SUSTAIN-2, semaglutide adalumikizidwa ndi kuchepa kwakukulu kwa kuthamanga kwa magazi kwa systolic komanso kusintha kwa lipid mbiri, kuphatikiza kuchepa kwa cholesterol yonse, LDL cholesterol, ndi triglycerides.
③Kuchepetsa thupi
Semaglutide ndi mphamvu yochepetsera thupi, ngakhale kwa anthu opanda shuga.Semaglutide imagwira ntchito mwa kuchepetsa kudya ndi kudya kwa kalori, zomwe zimapangitsa kuchepa kwa thupi. hypothalamus, yomwe imayang'anira njala ndi kukhuta, ndipo imachepetsa chilakolako chofuna kudya mwa kuwonjezera kumverera kwa kukhuta.Kuonjezera apo, semaglutide imachepetsa kutulutsa m'mimba, zomwe zimatalikitsa kumva kukhuta pambuyo pa chakudya ndi kuchepetsa chilakolako chofuna kudya.
Mayesero azachipatala awonetsa phindu lolemera la semaglutide.Mu pulogalamu ya STEP, yomwe idayesa kugwiritsa ntchito semaglutide pakuwongolera kulemera kwa anthu opanda shuga, semaglutide idalumikizidwa ndi kuchepa kwakukulu kolemera poyerekeza ndi placebo.Omwe adalandira semaglutide kamodzi pa sabata adataya pafupifupi 15% ya kulemera kwa thupi lawo pa masabata 68, pamene omwe adalandira placebo adataya 2.4% yokha.
Kwa anthu omwe ali ndi matenda a shuga a 2, semaglutide imatha kubweretsa zopindulitsa zina zowonda. .Omwe adalandira semaglutide adataya pafupifupi 7 kg, pomwe omwe adalandira placebo adataya 2 kg yokha.
④Kuchiza Matenda a Alzheimer's Symptom
Kafukufuku wambiri wasonyeza kuti semaglutide ili ndi neuroprotective properties motsutsana ndi amyloid-β plaques mu cell line ya neuroblastoma (SH-SY5Y), zomwe zimasonyeza kuti semaglutide ikhoza kuthetsa zizindikiro za matenda a Alzheimer's. Malinga ndi chilengezo cha Novo Nordisk, chizindikiro cha mapiritsi a semaglutide a matenda a Alzheimer's (AD) ali m'chipatala. Mayesero awiri apadziko lonse a Phase III, EVOKE ndi EVOKE kuphatikiza, akuchitika, ndipo odzipereka pafupifupi 3,700 akuyembekezeka kulembedwa. Poyerekeza ndi placebo, yang'anani kuchuluka kwa mapiritsi a semaglutide pazachidziwitso m'maphunziro omwe ali ndi vuto lochepa lachidziwitso (MCI) kapena dementia wofatsa chifukwa cha AD.
Chenjezo:Ndikofunikira kugula semaglutide kuchokera kuzinthu zodalirika, apo ayi, simungapeze mphamvu yabwino ya semaglutide.Monga katswiri wa semaglutide wopanga ndi wogulitsa, AASraw ikufuna kupereka semaglutide yoyera padziko lonse lapansi.Ngati muli ndi zosowa, semaglutide ya AASraw ndi yabwino kusankha bwino zanu.
Zotsatira za Semaglutide?
Semaglutide, monga mankhwala aliwonse, angayambitse zotsatira zake.
①Zotsatira zodziwika bwino ndi izi:
- nseru
- kusanza
- kutsekula
- ululu m'mimba
- Kutaya njala
- kudzimbidwa
- mutu
- kutopa
- chizungulire
②Zotsatira zochepa koma zowopsa kwambiri zingaphatikizepo:
- Pancreatitis
- Hypoglycemia (shuga wotsika wamagazi)
- Kuvulala kwakukulu kwa impso
- Matenda a shuga a retinopathy
- Matenda a Gallbladder
- Zosokonezeka
- Matenda a chithokomiro
Zindikirani: Kutalika kwa zotsatira za semaglutide kungasinthe malinga ndi munthu payekha komanso kuopsa kwa zotsatira zake. nseru, kutsekula m'mimba, kusanza, kudzimbidwa, ndi kupweteka mutu nthawi zambiri zimathetsa mkati mwa masiku angapo mpaka sabata.Ngati mukukumana ndi zotsatira zachilendo kapena zoopsa pamene mutenga semaglutide, pitani kwa dokotala mwamsanga.Kuonjezera apo, kugula semaglutide ndi khalidwe lapamwamba kuchokera kwa ogulitsa odalirika, monga AASraw, ndiyofunikira.
Mlingo ndi Ulamuliro wa Semaglutide for Reference
Mlingo ndi kayendetsedwe ka semaglutide zimatha kusiyanasiyana malinga ndi zomwe zikugwiritsidwa ntchito.Nawa malangizo ena onse:
① Chizindikiro: Type 2 Diabetes Mellitus
· Subcutaneous jakisoni
Mlungu 1-4: 0.25 mg / sabata
Mlungu wa 5 ndi kupitirira: 0.5 mg / sabata
√ Ngati pakufunika, pakatha masabata osachepera 4 pa mlingo wa 0.5-mg, onjezerani 1 mg subcutaneously kamodzi pa sabata.
√ Ngati pakufunika, pakatha masabata osachepera 4 pa mlingo wa 1-mg, onjezerani 2 mg subcutaneously kamodzi pa sabata; musapitirire 2 mg / sabata.
· Oral Tablet
Tsiku 1-30: 3 mg / tsiku
Tsiku 31 ndi mtsogolo: 7 mg / tsiku
√ Ngati pakufunika, patatha masiku osachepera 30 pa mlingo wa 7-mg, onjezerani 14 mg pakamwa kamodzi patsiku.
√ Dziwani:Musamwe mapiritsi awiri a 7-mg kuti mukwaniritse mlingo wa 14-mg
②Chizindikiro:Kuwongolera Kulemera Kwambiri
· Subcutaneous jakisoni
Mlungu 1-4: 0.25 mg / sabata
Mlungu 5-8: 0.5 mg / sabata
Mlungu 9-12: 1 mg / sabata
Mlungu 13-16: 1.7 mg / sabata
Mlungu wa 17 ndi mtsogolo: 2.4 mg / sabata (mlingo wokonza)
√ Yambani ndi mlingo wochepa ndipo pang'onopang'ono onjezerani mlingo wokonza kuti muchepetse vuto la m'mimba.
√ Ngati mukulephera kulekerera mlingo pakukwera, ganizirani kuchedwetsa kukwera kwa mlingo kwa masabata anai.
√ Ngati simungathe kulekerera mlingo wokonza wa 2.4 mg kamodzi pa sabata, ukhoza kuchepa kwakanthawi mpaka 1.7 mg kamodzi pa sabata kwa milungu inayi; pambuyo pa masabata a 4, onjezerani kukonzanso 4 mg kamodzi pa sabata; kusiya ngati sikuloledwa pambuyo kuyesera kachiwiri.
√ Zindikirani: Mlingo ndi kayendetsedwe ka semaglutide zingasinthe malinga ndi zomwe zikugwiritsidwa ntchito. Tsatirani malangizo operekedwa ndi dokotala kapena monga momwe akusonyezera pa chizindikiro cha mankhwala.
Kodi mungagule kuti Semaglutide?
Semaglutide, mankhwala omwe amafunidwa kwambiri pochiza matenda a shuga a mtundu wa 2, yakhala yotchuka kwambiri pakati pa odwala omwe akufunafuna njira zothetsera vutoli. nsanja za digito zimapatsa makasitomala mwayi wofananiza mitengo, kuwerenga ndemanga, ndikupeza njira zambiri zomwe angasankhe kuti zigwirizane ndi zosowa zawo. Pochita kafukufuku wozama ndikusankha wogulitsa wodalirika komanso wovomerezeka, anthu akhoza kugula molimba mtima semaglutide pa intaneti ndikuyendetsa bwino matenda awo a shuga mosavuta.
AASraw Cholinga chopanga abd kupereka mankhwala ophatikizika ndi mankhwala opangira mankhwala (APIs), ndi wodalirika wopereka semaglutide wapamwamba kwambiri ndi zinthu zina zokhudzana nazo. Pogula pa AASraw, anthu omwe akufunafuna semaglutide akhoza kusangalala ndi zogula zabwino, zotetezeka, komanso zodalirika, pamene akupindula ndi chidziwitso chawo chochuluka ndi luso lawo pamunda.
Semaglutide Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yosanthula chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo..Mwachitsanzo, NMR ikhoza kusanthula mochulukira zosakaniza zomwe zili ndi zinthu zodziwika bwino. Pazinthu zosadziwika, NMR ikhoza kugwiritsidwa ntchito kuti ifanane ndi malaibulale osawoneka bwino kapena kuyerekeza kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR ingagwiritsidwe ntchito kudziwa momwe ma molekyulu amayendera. mu yankho komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.
Semaglutide- COA
Semaglutide (910463-68-2) -COA
Kodi mungagule bwanji Semaglutide kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Tsamba:
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[2] Wilding JPH,Batterham RL,Davies M,Van Gaal LF,Kandler K,Konakli K,Lingvay I,McGowan BM,Oral TK,Rosenstock J,Wadden TA,Wharton S,Yokote K,Kushner RF; CHOCHITA 1 Gulu Lophunzira.Kulemera kwa thupi ndi zotsatira za cardiometabolic pambuyo pochotsa semaglutide: The STEP 1 yowonjezera mayesero.Diabetes Obes Metab.2022 Aug;24(8):1553-1564.
[3] Garvey WT,Batterham RL,Bhatta M,Buscemi S,Christensen LN,Frias JP,Jódar E,Kandler K,Rigas G,Wadden TA,Wharton S; CHOCHITA 5 Gulu Lophunzira. Zotsatira za zaka ziwiri za semaglutide kwa akuluakulu omwe ali ndi kunenepa kwambiri kapena kunenepa kwambiri: mayesero a STEP 5. Nat Med.2022 Oct; 28 (10): 2083-2091.
[4] Knudsen LB, Lau J.Kupeza ndi Kukula kwa Liraglutide ndi Semaglutide.Front Endocrinol (Lausanne).2019 Apr 12; 10:155.
[5] Mahapatra MK,Karuppasamy M,Sahoo BM.Therapeutic Potential of Semaglutide,a Newer GLP-1 Receptor Agonist, mu Kuchepetsa Kunenepa Kwambiri,Non-Alcoholic Steatohepatitis ndi Neurodegenerative Disease: A Narrative Review.Pharm Res.2022 Jun;39(6) ): 1233-1248.
