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Kufotokozera kwa ufa wa Spermidine

Spermidine ufa ndi chinthu chosangalatsa ndipo chimayambitsanso umuna. Zakudya zambiri zimakhala ndi spermidine, monga bowa, soya, mtedza, makamaka nyongolosi ya tirigu.Spermidine imapezeka muzomera zonse ndi nyama komanso pafupifupi khungu lililonse la thupi lanu. Mu matupi athu, zimatha kubwera kuchokera kuzakudya zomwe timadya - zopangidwa m'matumbo a microbiome kapena zopangidwa m'maselo.Spermidine ufa umagwira gawo lofunikira m'zinthu zamoyo, monga anthu komanso zomera. Imodzi mwazinthu zazikulu kwambiri komanso zazikulu kwambiri za spermidine, zomwe ntchito zina zimayambira, ndikutha kuthana ndi ukalamba ndikulimbikitsa kudzipaka.

Njira Yogwirira Ntchito ya Spermidine

Spermidine ndi aliphatic polyamine. Spermidine synthase (SPDS) imathandizira mapangidwe ake kuchokera ku putrescine. Ndiyomwe imayambitsanso ma polyamines ena, monga spermine ndi kapangidwe kake kake, umuna wotentha.

Spermidine ndi wothandizira kuti akhale ndi moyo wautali pazinyama chifukwa cha njira zosiyanasiyana, ndipo njirazi zikuyamba kumveka. Autophagy ndiyo njira yayikulu pamaselo, koma umboni wazinthu zina wapezeka, kuphatikiza kuchepa kwa kutupa, lipid metabolism, ndikuwongolera kukula kwa maselo, kuchuluka, ndi kufa.

Zopindulitsa za Spermidine Powder

Spermidine ndiyofunikira pakukonzanso kwama cell. Maselo akale akamwalira, ma cell ena amawapatsa mphamvu ndikugwiritsa ntchito mamolekyulu kuti apange ma cell atsopano. Tikamakalamba, kuchuluka kwachilengedwe kwa spermidine mthupi lathu kumachepa, potero kumachepetsa kuthekera kwa maselo kuti adzikonzenso ndikukonzanso.

Spermidine yawonetsedwanso kuti ichepetse chiwopsezo cha mitundu ina ya khansa, ndipo ikamwedwa nthawi yayitali, imatha kutalikitsa moyo. Ndipo zingathandize kuteteza katemera kwa okalamba.

Ndipo spermidine imagwira gawo lofunikira pakusunga nembanemba yama cell ndikuwongolera ma pH and voliyumu yama cell. Kafukufuku adawonetsanso kuti zitha kuchepetsa chiwopsezo cha matenda amtima komanso kusintha kuzindikira. Spermidine imakhala ndi vuto la neuroprotective pa kuwonongeka kwa mitsempha yoyambitsidwa ndi kutupa, ischemia ndi kupsinjika kwa oxidative.

Zotsatira za Spermidine Powder

Chifukwa cha magwiridwe antchito osiyanasiyana, spermidine imathandizira kuti nyama zizikhala ndi moyo wautali, kuphatikiza kuchepa kwamatenda, kagayidwe kake ka lipid, ndikuwongolera kukula kwa maselo, kuchuluka, ndi kufa. Spermidine imatha kuteteza chiwindi cha fibrosis ndi hepatocellular carcinoma zomwe ndizomwe zimayambitsa khansa ya chiwindi. Amagwiritsidwa ntchito mopitilira muyeso womwe, ukamamwedwa, pafupipafupi, umatha kusintha moyo wautali.

Kufotokozera kwa ufa wa Spermidine trihydrochloride

Spermidine trihydrochloride powder imakhalanso ndi polyamine yomwe imaletsa neuronal nitric oxide synthase (nNOS) ndipo imamangiriza ndikuchepetsa DNA. Itha kugwiritsidwa ntchito kuyeretsa mapuloteni omanga a DNA. Kuphatikiza apo, spermidine imalimbikitsa ntchito za T4 polynucleotide kinase. Zimakhudzidwa ndikukula, chitukuko, komanso mayankho kupsinjika kwa mbeu.

Spermidine trihydrochloride Njira Yogwirira Ntchito

Spermidine trihydrochloride ndi polyamine yachilengedwe yopangidwa kuchokera ku putrescine ndi decarboxylated S-adenosylmethionine (dcSAM) yolembedwa ndi spermidine synthase, ndi buku lodziyimira palokha ndipo limasokoneza N-methyl-d-aspartate (NMDA).

Amamangirira kumalo osungunuka a polyamine a NMDA receptor ndipo amadziwika kuti ndi agonist potengera kuthekera kwake kopititsa patsogolo kumangiriza kwa [3H] -MK801.

Kugwiritsa ntchito ufa wa Spermidine trihydrochloride

Spermidine trihydrochloride yakhala ikugwiritsidwa ntchito pakusintha kwa ma infrared spectroscopy (FTIR) komanso muyeso wa zeta.

Spermidine hydrochloride imapezeka mwachilengedwe komanso yofunikira pakukula kwa minofu; Nthawi zambiri amagwiritsidwa ntchito ngati chida chofufuzira zamankhwala am'mimba; Spermidine hydrochloride ndi polyamine, C7H22Cl3N3, yomwe imapezeka mu ribosomes ndi ziwalo zamoyo ndikukhala ndimagwiritsidwe osiyanasiyana azinthu.

Zotsatira za Spermidine trihydrochloride Powder

Spermidine trihydrochloride powder ndi Inhibits neuronal nitric oxide synthase (nNOS). Amamanga ndi kugwetsera DNA; Spermidine trihydrochloride powder itha kugwiritsidwa ntchito poyeretsa DNA yomanga proteinine komanso timulates T4 polynucleotide kinase.

Kodi Mungagule Bwanji Bulk Spermidine Powder?

AASraw ndiopanga komanso amagulitsa mafuta ambiri a spermidine powder ogulitsa. Ngati mukufuna kugula ufa wa spermidine wambiri, chonde tumizani kufunsa kwa ife mwachindunji.Pamwamba kwambiri ya speridine ufa wokhala ndi mtengo wokwera kwambiri woperekedwa ndi ife!

Tsamba:

[1] American Heritage Dictionary Yotulutsidwa 2014-11-18.
[2] Minois, Nadège (28 Januware 2014). "Maziko A" Zotsutsa-Kukalamba "Zotsatira za Spermidine ndi Mitundu Yina Yachilengedwe - Kuwunika Kwapang'ono". Gerontology. 60 (4): 319–326. onetsani: 10.1159 / 000356748. PMID 24481223. (Adasankhidwa)
[3] Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018). "Spermidine mu thanzi ndi matenda". Sayansi. 359 (6374): eaan2788. onetsani: 10.1126 / science.aan2788. PMID 29371440.
[4] [4] Ramot, Yuval; Tiede, Stephan; Bíró, Tamás; Abu Bakar, Mohd Hilmi; Sugawara, Koji; Philpott, Michael P .; Harrison, Wesile; Pietilä, Marko; Paus, Ralf (27 Julayi 2011). "Spermidine Imalimbikitsa Kukula Kwa Tsitsi La Anthu Ndipo Ndi Novel Modulator ya Human Epithelial Stem Cell Functions". MALO OYAMBA. 6 (7): e22564. onetsani: 10.1371 / journal.pone.0022564. Ndi ISSN 1932-6203. PMC 3144892. PMID 21818338 (Adasankhidwa)
[5] Munir et al (1993) Polyamines amatsata zotsatira za neurotoxic za NMDA mu vivo. Resin Ubongo. 616 163 PMID: 8358608.
[6] Williams et al (1989) Zotsatira zama polyamines pakumanga kwa [3H] -MK801 kupita ku N-MthD.-aspartate receptor: umboni wazamankhwala wakupezeka kwa tsamba lodziwika la polyamine. Mol. Pharmacol. 36 375 PMID: 2554112

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