TB-500

Kodi TB-500 ndi chiyani?

TB500, yomwe imadziwikanso kuti Thymosin Beta-4, ndi peptide yopangidwa yomwe imachokera ku puloteni yopezeka mwachilengedwe yotchedwa thymosin beta-4. Zili ndi mndandanda wa ma amino acid ndipo zakhala zikufufuzidwa komanso zongopeka ponena za momwe angachire.

Thymosin beta-4 imapangidwa mwachilengedwe m'thupi la munthu ndipo imagwira ntchito zosiyanasiyana zakuthupi, kuphatikiza kuchiritsa mabala, kukonza minofu, komanso kuwongolera kutupa. Zapezeka m'magulu akuluakulu m'mapulateleti a magazi, kumene amamasulidwa chifukwa cha kuvulala kwa minofu.

TB500, mtundu wa thymosin beta-4, womwe umagwiritsidwa ntchito nthawi zambiri poyesera ndipo watchuka kwambiri m'magulu othamanga ndi omanga thupi chifukwa cha kuthekera kwake kupititsa patsogolo kuchira ndi kulimbikitsa machiritso. Ena amanena kuti TB500 ikhoza kuthandizira kukonzanso minofu, kuonjezera kukula kwa minofu, kusintha kusinthasintha, ndi kuchepetsa kutupa.

Zambiri za TB 500

Monga tanenera kale, TB-500 ndi mtundu wopangidwa wa Thymosin Beta 4, protein peptide yomwe imapezeka mwachilengedwe m'matupi a nyama ndi anthu. Ngakhale kuti TB-500 ilipo pofuna kufufuza, imagwiritsidwa ntchito kwambiri ndi madokotala ambiri omwe amayesa TB-500 pa akavalo.

Kafukufuku wa Thymosin mu akavalo anayamba m'zaka za m'ma 1960. Dr.Allan Goldstein anapanga thymosin alpha 1 kuti apititse patsogolo chitetezo cha mthupi ndi thymosin beta 4 kapena TB-500 kuti afulumire machiritso ndi kukonza mabala.

M'mayambiriro, mtundu wa TB-500 wopangidwa ndi mphekesera unali wogwiritsidwa ntchito kwambiri pa mpikisano wamahatchi opikisana. Pampikisano wamahatchi, kugwiritsa ntchito TB 500 kwachepetsa kwambiri kutupa ndikuletsa kapena kuchepetsa mapangidwe omatira pambuyo pakuwonongeka - kupatsa mahatchi omwe amalandila mpikisano wolimbana ndi akavalo ena. Inali panthawiyi pamene kuyesa kuyesa TB-500 mu mahatchi othamanga kunayamba kupangidwa mwakhama.

TB-500, Thymosin beta-4, ndi zotuluka zake zonse tsopano zaletsedwa kuthamanga pamahatchi ampikisano, komanso mipikisano yonse yamasewera yomwe ili pansi pa Code of the World Anti-Doping Agency(WADA).

Thymosin idagwiritsidwa ntchito koyamba kwa anthu mu 1974 pomwe kamtsikana kakang'ono kokhala ndi chithokomiro chosagwira ntchito adalandira jakisoni wa chinthucho. Kuyambira pamenepo, othamanga ambiri ndi biohackers ayamba kugwiritsa ntchito thymosin pazolinga zomwezo - kukonza, kuchepetsa kutupa, ndi kuchira msanga.

Kodi TB-500 (Thymosin Beta-4) imagwira ntchito bwanji?

Njira yeniyeni ya TB500 (Thymosin Beta-4) sikumveka bwino, ndipo kafukufuku wotsimikizira zotsatira zake zenizeni pa thupi akupitirirabe. Komabe, kutengera zomwe zilipo, nazi zina zomwe zingatheke pa TB500:

Kulimbikitsa kusamuka kwa ma cell

TB500 imaganiziridwa kuti imathandizira kusamuka kwa maselo, yomwe ndi njira yomwe maselo amasamukira kumalo ovulala kapena kuwonongeka. Zingathandize kukopa maselo okhudzidwa ndi kukonza minofu ndi kusinthika kumalo ovutika, monga ma cell stem, fibroblasts, ndi endothelial cell, kuthandizira machiritso ndi kusinthika kwa minofu.

Kusinthasintha kwa kutupa

Mwa kuwongolera mbadwo ndi ntchito za mamolekyu otupa, TB500 ikhoza kukhala ndi zotsatira zotsutsa-kutupa.TB500 yasonyezedwa kuti ichepetse kutulutsidwa kwa ma cytokines oyambitsa kutupa, omwe ndi mankhwala omwe ali ndi gawo lothandizira kuyankha.TB500 ingathandize kukhazikitsa zowonjezereka. malo abwino ochiritsira ndi kukonza minofu pochepetsa kutupa.

Kukondoweza kwa angiogenesis

Angiogenesis ndi mapangidwe a mitsempha yatsopano ya magazi.TB500 yasonyezedwa kuti imathandizira angiogenesis, zomwe zingatheke mwa kulimbikitsa kufalikira kwa maselo a endothelial ndi kusamuka, zomwe ndizofunikira pakupanga mitsempha ya magazi. Mapangidwe a mitsempha ya magazi amatha kupititsa magazi kumalo ovulala, kupereka zakudya ndi mpweya wofunikira kuti minofu ipangidwenso.

Kupanga collagen

TB500 yaperekedwa kuti iwonjezere mapangidwe a collagen, omwe angathandize kukonzanso minofu ndi machiritso a mabala.TB500 ingathandize kulimbikitsa ndi kukonza minyewa yowonongeka mwa kukulitsa kaphatikizidwe ka collagen.

Ubwino wa TB-500

TB-500 ndi mtundu wopangidwa wa peptide yopezeka mwachilengedwe m'thupi la munthu. Yapeza kutchuka mu masewera ndi midzi yomanga thupi chifukwa cha ubwino wake. Ngakhale kuli kofunika kuzindikira kuti kafukufuku wa TB-500 akadalipo, apa pali ena zopindulitsa zomwe zalembedwa:

Kukonza minofu ndi kusinthika

TB-500 yaperekedwa kuti ilimbikitse kukonza ndi kusinthika kwa minofu. Ikhoza kulimbikitsa kukula kwa mitsempha yatsopano ya magazi (angiogenesis) ndikulimbikitsa kupanga minofu yatsopano, kuphatikizapo minofu, tendon, ligaments, ndi khungu. Izi zitha kukhala zothandiza makamaka kwa anthu omwe akuchira kuvulala, chifukwa zitha kufulumizitsa machiritso ndikuwongolera thanzi la minofu yonse.

Kuchira msanga kwa kuvulala

TB-500 ikhoza kuthandizira kuchiritsa kwa mitundu yosiyanasiyana ya kuvulala, monga minyewa ya minofu, ma sprains, ndi misozi ya ligament. Zanenedwa kuti zimachepetsa nthawi yochira yofunikira pambuyo povulazidwa polimbikitsa kusamuka kwa ma cell ndi kufalikira pamalo ovulala. Izi zingayambitse machiritso mofulumira komanso kubwerera mwamsanga kuntchito zolimbitsa thupi.

Kuchepetsa Kutupa

TB-500 imawonetsa anti-inflammatory properties, zomwe zingathandize kuchepetsa kutupa m'thupi. Ikhoza kulepheretsa Kupanga za mamolekyu oletsa kutupa ndikulimbikitsa kutulutsa zinthu zotsutsana ndi kutupa, motero kuchepetsa kutupa ndi ululu wogwirizana nawo. Izi zitha kukhala zopindulitsa kwa anthu omwe ali ndi zotupa zosatha monga nyamakazi, tendonitis, kapena bursitis.

Thanzi lolumikizana komanso lolumikizana

Pothandizira kukonza minofu ndikuchepetsa kutupa, TB-500 ikhoza kuthandizira kukonza thanzi la minofu yolumikizana komanso yolumikizana. Ikhoza kupititsa patsogolo umphumphu ndi kusungunuka kwa tendons, ligaments, ndi cartilage, zomwe zimapangitsa kuti mgwirizano ukhale wabwino, kusinthasintha kwakukulu, ndi kuchepetsa chiopsezo cha kuvulala.

Kukula kwa minofu ndikuchira

Ngakhale kuti TB-500 palokha sizinthu zomanga minofu mwachindunji, zikhoza kuthandizira kuti minofu ikule ndi kuchira. Mwa kulimbikitsa kukonzanso minofu ndi kuchepetsa kutupa, kungathandize kuchira pambuyo pochita masewera olimbitsa thupi kwambiri kapena kuvulala. Izi zingayambitse kukonzanso minofu ndi kukula mofulumira, kupirira bwino kwa minofu, ndi kuchepetsa kupweteka kwa minofu.

Kukula tsitsi kumakula

Pali umboni wina wosonyeza kuti TB-500 ikhoza kukhala ndi zotsatira zabwino pakukula kwa tsitsi. Amakhulupirira kuti amalimbikitsa kukula kwa mitsempha yamagazi ndikupereka michere ku ma follicles atsitsi, zomwe zimatha kulimbikitsa kukula kwa tsitsi ndi makulidwe. Komabe, kufufuza kwina kuli zofunikira kukhazikitsa phindu ili momaliza.

Thanzi Labwino

TB-500 yaphunziridwa chifukwa cha ubwino wake paumoyo wamtima. Ikhoza kulimbikitsa kukula kwa mitsempha yatsopano ya magazi, kuyendetsa magazi bwino, ndi kupititsa patsogolo ntchito ya mtima. Zotsatirazi zitha kukhala zopindulitsa kwa anthu omwe ali ndi matenda amtima, monga matenda amtima kapena zotumphukira mitsempha yamagazi.

Chani mitundu ya TB-500 ilipo?

Peptide yaiwisi ufa mawonekedwe

TB500 yaiwisi ufa ndi zopangira kupanga lyophilized ufa TB500 mu Mbale. Sili wokonzeka kuti anthu azigwiritsa ntchito. Zofufuza zokha.

Kukonzanso

TB-500 (Thymosin Beta-4) imapezeka mu mawonekedwe a lyophilized ufa wokonzanso. Izi lyophilized ufa amaperekedwa mu Mbale kapena vial zida. The lyophilized ufa ndiye wosakanizidwa ndi diluent yoyenera, monga madzi a bacteriostatic kapena madzi osabala, kuti apange yankho la jakisoni.

Ndikofunika kudziwa kuti TB-500 ndi peptide yopangira, ndipo sipezeka mumitundu ina monga mapiritsi amkamwa kapena zonona. Njira yoyamba yoperekera mankhwalawa ndi jekeseni, intramuscularly, intravenously, kapena subcutaneously, malinga ndi momwe katswiri wa zaumoyo amasonyezera.

Mukamagula TB-500, ndikofunikira kuwonetsetsa kuti mukuyipeza kuchokera kwa ogulitsa odziwika komanso odalirika kuti mutsimikizire khalidwe ndi kukhulupirika kwa mankhwala.AASRAW ndi wopanga ma peptide odalirika kukhulupirira. Pamaoda ogulitsa peptide, mupeza mtengo wopikisana kwambiri.

Peptide TB-500 reconstitution kalozera

Mlingo wa TB500

Poganizira kuchepa kwa kafukufuku wofalitsidwa mpaka pano pa TB-500, palibe zokhazikitsidwa malangizo a mlingo wofufuza zolinga.

Komabe, m'maphunziro asayansi ndi azachipatala mpaka pano, kuchuluka kwa TB-500 komwe kumadziwika kuti ndi 2-5 mg.TB-500 nthawi zambiri kumaperekedwa kudzera pa subcutaneous (pansi pa khungu) kapena jakisoni wa intramuscular, omwe amaperekedwa kawiri pa sabata. nthawi ya masabata 4 mpaka 8, kutengera mtundu wa kafukufukuyo. Madokotala ena amakonda mlingo woyambira wokulirapo kwa masabata 1 mpaka 2, ndikutsatiridwa ndi mlingo wokonzekera wofanana ndi theka la mlingo woyambirira kwa masabata awiri mpaka 2 pambuyo pake.

Momwe mungagwiritsire ntchito TB-500?

Choyamba, konzani njira ya TB-500 posakaniza mawonekedwe a lyophilized ufa ndi madzi a bacteriostatic kapena madzi osabala. Mukasakaniza, jambulani voliyumu yoyenera ndikuyibaya pamalo omwe mukufuna mutatsuka malo ojambulira ndi mowa.

Anthu ambiri amakonda njira ya intramuscular poika singano pafupi ndi malo ovulala, pamene njira yolowera m'mitsempha imaphatikizapo kupeza mtsempha woyenera jekeseni. Kapenanso, njira ya subcutaneous imaphatikizapo kukankhira singano pamalo ovulala.

Mukatha jekeseni, kusisita pang'onopang'ono malowa kumatha kulimbikitsa kugawa kwa peptide moyenera. Ndikofunikira kukaonana ndi katswiri wazachipatala kuti akutsogolereni payekha ndikuwonetsetsa kuti TB-500 ikugwiritsidwa ntchito moyenera komanso moyenera.

Kuphatikiza apo, kusungidwa koyenera ndi kusamalira peptide ndikofunikira kuti zisungidwe bwino.

The zambiri za mlingo ndi kayendetsedwe kake zomwe zaperekedwa pano ndi zongodziwitsa chabe ndipo siziyenera kuwonedwa ngati upangiri wachipatala. Ndi dokotala wodziwa bwino yemwe angakupatseni malangizo olondola komanso ogwirizana ndi zomwe mumakonda. Ndikofunika kuika patsogolo thanzi lanu ndi chitetezo chanu pofunsana ndi dokotala musanagwiritse ntchito mankhwala kapena chithandizo chilichonse.

Ndani ayenera kugwiritsa ntchito TB-500?

Kupereka kwa TB500 ndikwambiri. Ndiosavuta kupeza chifukwa pali ma TB500 ambiri kugulitsa pa intaneti. Kugwiritsa ntchito TB-500 (Thymosin Beta-4) kuyenera kutsimikiziridwa payekha payekha komanso motsogozedwa ndi katswiri wazachipatala. Amagwiritsidwa ntchito kwambiri pazinthu zotsatirazi:

Othamanga ndi Okonda Zolimbitsa Thupi: TB-500 peptide yofufuza ingagwiritsidwe ntchito ndi othamanga ndi anthu omwe akuchita masewera olimbitsa thupi kuti athandizire kuchira kwa minofu, kulimbikitsa kukonza minofu, ndi wokonzeka kuwonjezera ntchito. Ikhoza kuthandizira kuchira kuvulala ndi kuchepetsa kutupa komwe kumakhudzana ndi maphunziro.

Kuchira Kuvulala: Aliyense amene ali ndi kuvulala kokhudzana ndi minofu angagwiritse ntchito Tb-500.Peptide TB-500 nthawi zambiri amagwiritsidwa ntchito ndi anthu omwe akuchira kuvulala kwa minofu, monga kupweteka kwa minofu, misozi ya ligament, kapena tendonitis. Zingathandize kulimbikitsa machiritso, ndi kusinthika kwa minofu, ndi kuchepetsa kutupa m'madera ovulala.

Zovuta Zotupa Zotupa: Anthu omwe ali ndi matenda otupa kwambiri monga nyamakazi, tendonitis, kapena bursitis angaganizire kugwiritsa ntchito TB-500 moyang'aniridwa ndi achipatala. Zaphunziridwa chifukwa cha zotsutsana ndi zotupa komanso zomwe zingathe kuchepetsa zizindikiro zokhudzana ndi izi.

Mankhwala Obwezeretsa: TB-500 ikufufuzidwa kuti igwiritsidwe ntchito pamankhwala obwezeretsanso. Zitha kukhala ndi zopindulitsa pakuchiritsa mabala, kukonza minofu, ndi angiogenesis (kukula kwa chotengera chamagazi), zomwe zimapangitsa kuti zikhale zofunikira pazachipatala zosiyanasiyana.

TB-500 chitetezo ndi zotsatira zake

Ngakhale kuti TB-500 sinaphunzire mokwanira za chitetezo cha anthu, zomwe zilipo panopa zikusonyeza kuti ndi zotetezeka komanso zolekerera zikagwiritsidwa ntchito moyenera. Zotsatira zoyipa sizichitika kawirikawiri, zimadutsa, komanso zimakhala zochepa. Izi ndi zitsanzo:

• kutopa
• mutu
• nseru
• chizungulire
• Masomphenya a Blurry
• Kusintha kwa kugunda kwa mtima
• Kupweteka pa malo a jakisoni

Komabe, chifukwa pali kuchepa kwa chidziwitso chokhudza kugwiritsidwa ntchito kwakanthawi kochepa kapena kwanthawi yayitali m'nkhani za anthu, ofufuza akulimbikitsidwa kusamala popereka TB-500.

• Kusintha kwa kuthamanga kwa magazi
• Kusintha kwa chilakolako
• Ululu pa malo a jekeseni

Zotsatira zoyipa zimachepa zokha ndipo zimayenderana ndi kugwiritsa ntchito mankhwala a peptide otsika. Zogulitsa zotere, zogulidwa kwa ogulitsa osaloledwa, zitha kukhala zolembedwa molakwika kapena kukhala ndi zoyipa zoyipa. Ngakhale opanga ma peptide ambiri amagulitsa ma peptide, timalimbikitsa Othandizira AASRAW.

Malingana ngati mukuchita zonse moyenera pogwiritsa ntchito TB-500 (monga jekeseni yoyenera, moyenera kusunga ndi kukonzanso peptide, kuwerengera mlingo woyenera, kupeza mankhwala a TB-500 okha, ndi zina zotero), ndizokayikitsa kwambiri kuti mutha kuthana ndi mavutowa.

Koma ndizothekadi - kumbukirani, kusowa kwamphamvu zotsatira zoyipazi m'maphunziro ochepa azachipatala omwe adasindikizidwa mpaka pano sizitanthauza kuti sizikhalapo mukamagwiritsa ntchito TB-500.

Kodi mungagule kuti TB-500 pa intaneti?

Mutha kupeza ambiri ogulitsa TB-500 pa intaneti. Mawebusayitiwa atha kungogulitsa mwalamulo ma peptides pazolinga zofufuza. Kuonetsetsa chitetezo cha TB-500, akuti ma peptides onse agulidwe kwa opanga omwe amakwaniritsa mfundo zodalirika izi:

(1) Ma peptides ayenera kusankhidwa kuti agwiritsidwe ntchito pofufuza.

(2) Wogulitsa sayenera kutsimikizira zachipatala kapena zonena za zotsatira za kayendetsedwe ka peptide.

(3) Zogulitsa za Peptide ziyenera kubwera ndi ziphaso zovomerezeka za kusanthula (CoAs).

TB-500 Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Kodi mungagule bwanji TB-500 kuchokera ku AASraw?

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Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Ildiko Bock-Marquette
Dipatimenti ya Biochemistry ndi Medical Chemistry, University of Pecs, Medical School, Pecs H-7624, Hungary
2. Gabriel Sosne
Dipatimenti ya Ophthalmology, Visual & Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, USA
3. Othman Othman
School of Life Sciences, Division of Physiology, Pharmacology & Neuroscience, University of Nottingham Medical School, Queens Medical Center, United Kingdom
4. Harmanpreet Kaur
Dipatimenti ya Chemistry ndi Biochemistry, University of Windsor, Windsor, Ontario, Canada
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD.” Doping control analysis of TB-500, a synthetic version of a active region thymosin β₄, in equine mkodzo ndi plasma by madzi chromatography-mass spectrometry."J Chromatogr A. 2012 Nov 23; 1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.PMID: 23084823

[2] Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P.”Kaphatikizidwe ndi mawonekedwe a N-terminal acetylated 17-23 fragment ya thymosin beta 4 yodziwika mu TB-500, mankhwala omwe akuganiziridwa kuti ali ndi mphamvu zogwiritsa ntchito mankhwala osokoneza bongo. "Mankhwala Oyesera Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7.PMID: 22962027

[3] Mapaipi GT, Yang J. "Cardioprotection ndi Thymosin Beta 4." Vitam Horm. 2016; 102:209-26. doi: 10.1016/bs.vh.2016.04.004. Epub 2016 May 31.PMID: 27450736

[4] Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D.” Thymosin beta-4 ikuwonetsa njira zatsopano zopangira njira zochiritsira zochiritsira zoletsa kukalamba. ”Int Immunopharmacol. 2023 Marichi; 116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27.PMID: 36709593

[5] Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC." Thymosin beta 4 regulation of actin mu sepsis." Katswiri Opin Biol Ther. 2018 Jul; 18 (chakudya1): 193-197. doi: 10.1080/14712598.2018.1448381. Epub 2018 Mar 6.PMID: 29508629

[6] Jing J, Tian T, Wang Y, Xu X, Shan Y.”Kuwunika kochulukira kwa ma peptide ang'onoang'ono ndi alkaline pre-activated solid phase m'zigawo limodzi ndi liquid chromatography-high resolution mass spectrometry mu zowongolera zopatsa mphamvu." J Chromatogr A. 2022 Aug 2; 1676:463272. doi: 10.1016/j.chroma.2022.463272. Epub 2022 Jun 22.PMID: 35802965

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