TB-500

Kodi TB-500 ndi chiyani?

TB500, yomwe imadziwikanso kuti Thymosin Beta-4, ndi peptide yopangidwa yomwe imachokera ku puloteni yopezeka mwachilengedwe yotchedwa thymosin beta-4. Ili ndi mndandanda wa ma amino acid ndipo yakhala ikufufuzidwa ndikungoganizira momwe angagwiritsire ntchito mankhwalawa. .

Thymosin beta-4 imapangidwa mwachibadwa m'thupi la munthu ndipo imagwira ntchito zosiyanasiyana za thupi, kuphatikizapo kuchiritsa mabala, kukonza minofu, ndi kuwongolera kutupa. kuwonongeka kwa minofu.

TB500, the synthetic version of thymosin beta-4, nthawi zambiri imagwiritsidwa ntchito poyesera ndipo yatchuka kwambiri m'madera othamanga ndi omanga thupi chifukwa cha mphamvu yake yopititsa patsogolo kuchira ndi kulimbikitsa machiritso. kuonjezera kukula kwa minofu, kusintha kusinthasintha, ndi kuchepetsa kutupa.

Zambiri za TB 500

Monga tanenera kale, TB-500 ndi mtundu wopangidwa wa Thymosin Beta 4, protein peptide yomwe imapezeka mwachilengedwe m'matupi a nyama ndi anthu. mayesero azachipatala pogwiritsa ntchito TB-500 pamahatchi.

Kafukufuku wa Thymosin mu akavalo anayamba m'zaka za m'ma 1960. Dr.Allan Goldstein anapanga thymosin alpha 1 kuti apititse patsogolo chitetezo cha mthupi ndi thymosin beta 4 kapena TB-500 kuti afulumire machiritso ndi kukonza mabala.

Kumayambiriro kwa zaka za m'ma 2010, mphekesera kuti mtundu wa TB-500 unkagwiritsidwa ntchito kwambiri pa mpikisano wamahatchi ampikisano. mpikisano wotsutsana ndi mahatchi ena.lt inali panthawiyi pamene kuyesa kuyesa TB-500 mu mahatchi othamanga kunayamba kupangidwa mwakhama.

TB-500, Thymosin beta-4, ndi zina zonse zomwe zimachokera kumeneko tsopano zaletsedwa kupikisana pamahatchi ampikisano, komanso mipikisano yonse yamasewera yomwe ili pansi pa Code of the World Anti-Doping Agency(WADA).

Thymosin inayamba kugwiritsidwa ntchito pa anthu mu 1974, pamene kamtsikana kakang'ono kamene kamakhala ndi thymus gland yosagwira ntchito analandira jakisoni wa mankhwalawo. ,ndi kuchira msanga.

Kodi TB-500 (Thymosin Beta-4) imagwira ntchito bwanji?

Njira yeniyeni ya TB500 (Thymosin Beta-4) sichikumveka bwino, ndipo kafukufuku wotsimikizira zotsatira zake zenizeni pa thupi akupitirizabe.

Kulimbikitsa kusamuka kwa ma cell

TB500 imaganiziridwa kuti imapangitsa kuti maselo asamuke, omwe ndi njira yomwe maselo amasamukira ku malo ovulala kapena kuwonongeka.Zingathandize kukopa maselo omwe amakhudzidwa ndi kukonzanso minofu ndi kusinthika kumalo ovutika, monga maselo a tsinde, fibroblasts, ndi endothelial cell. , kuthandizira machiritso ndi kusinthika kwa minofu.

Kusinthasintha kwa kutupa

Mwa kuwongolera mbadwo ndi ntchito za mamolekyu otupa, TB500 ikhoza kukhala ndi zotsatira zotsutsa-kutupa.TB500 yasonyezedwa kuti ichepetse kutulutsidwa kwa ma cytokines oyambitsa kutupa, omwe ndi mankhwala omwe ali ndi gawo lothandizira kuyankha.TB500 ingathandize kukhazikitsa zowonjezereka. malo abwino ochiritsira ndi kukonza minofu pochepetsa kutupa.

Kukondoweza kwa angiogenesis

Angiogenesis ndi mapangidwe a mitsempha yatsopano yamagazi.TB500 yasonyezedwa kuti imapangitsa angiogenesis, zotheka mwa kulimbikitsa endothelial cell proliferation ndi kusamuka, zomwe ndizofunikira pakupanga mitsempha ya magazi. kwa kusinthika kwa minofu.

Kupanga collagen

TB500 yapangidwa kuti iwonjezere kupanga kolajeni, yomwe ingathandize kukonzanso minofu ndi machiritso a mabala.TB500 ingathandize kulimbikitsa ndi kukonza minyewa yowonongeka powonjezera kaphatikizidwe ka collagen.

Ubwino wa TB-500

TB-500 ndi mtundu wopangidwa wa peptide yomwe imapezeka mwachilengedwe m'thupi la munthu. maubwino ena omwe aperekedwa:

Kukonza minofu ndi kusinthika

TB-500 yaperekedwa kuti ilimbikitse kukonzanso kwa minofu ndi kusinthika. Ikhoza kulimbikitsa kukula kwa mitsempha yatsopano ya magazi (angiogenesis) ndikulimbikitsa kupanga minofu yatsopano, kuphatikizapo minofu, tendons, ligaments, ndi khungu. Izi zingakhale zothandiza makamaka kwa anthu pawokha. kuchira kuvulala, chifukwa kukhoza kufulumizitsa machiritso ndikusintha thanzi la minofu yonse.

Kuchira msanga kwa kuvulala

TB-500 ingathandize kuthamangitsa machiritso a mitundu yosiyanasiyana ya kuvulala, monga kupweteka kwa minofu, sprains, ndi misozi ya ligament.Izi zanenedwa kuti zimachepetsa nthawi yochira yofunikira pambuyo povulazidwa mwa kulimbikitsa kusamuka kwa ma cell ndi kufalikira pamalo ovulala. Izi zingayambitse machiritso mofulumira komanso kubwerera mwamsanga kuntchito zolimbitsa thupi.

Kuchepetsa Kutupa

TB-500 imawonetsa anti-inflammatory properties, zomwe zingathandize kuchepetsa kutupa m'thupi. Ikhoza kulepheretsa kupanga mamolekyu oletsa kutupa ndikulimbikitsa kutulutsidwa kwa zinthu zotsutsana ndi kutupa, motero kuchepetsa kutupa ndi ululu wogwirizana nawo. anthu omwe ali ndi matenda otupa monga nyamakazi, tendonitis, kapena bursitis.

Thanzi lolumikizana komanso lolumikizana

Pothandizira kukonza minofu ndi kuchepetsa kutupa, TB-500 ikhoza kuthandizira kupititsa patsogolo thanzi labwino la minofu ndi kugwirizanitsa.

Kukula kwa minofu ndikuchira

Ngakhale kuti TB-500 yokha sizinthu zomanga minofu yolunjika, ikhoza kuthandizira kuti minofu ikule ndi kuchira. kukonza ndi kukula, kupititsa patsogolo kupirira kwa minofu, ndi kuchepetsa kupweteka kwa minofu.

Kukula tsitsi kumakula

Pali umboni wina wosonyeza kuti TB-500 ikhoza kukhala ndi zotsatira zabwino pakukula kwa tsitsi. Imakhulupirira kuti imalimbikitsa kukula kwa mitsempha ya magazi ndi kuperekera zakudya kumagulu a tsitsi, zomwe zingathe kulimbikitsa kukula kwa tsitsi ndi makulidwe. momaliza.

Thanzi Labwino

TB-500 yaphunziridwa chifukwa cha ubwino wake mu thanzi la mtima. Ikhoza kulimbikitsa kukula kwa mitsempha yatsopano ya magazi, kupititsa patsogolo magazi, komanso kupititsa patsogolo ntchito ya mtima. matenda a mitsempha.

Chani mitundu ya TB-500 ilipo?

Peptide yaiwisi ufa mawonekedwe

TB500 yaiwisi ufa ndi zopangira kupanga lyophilized ufa TB500 mu vial.Sili okonzeka kuti anthu ntchito.

Kukonzanso

TB-500 (Thymosin Beta-4) imapezeka mu mawonekedwe a lyophilized ufa wa reconstitution. Izi lyophilized ufa amaperekedwa mu mbale kapena vial kits. madzi, kupanga njira yothetsera jakisoni.

Ndikofunika kudziwa kuti TB-500 ndi peptide yopangira, ndipo sipezeka mumitundu ina monga mapiritsi amkamwa kapena mafuta opaka. akatswiri.

Mukamagula TB-500, ndikofunikira kuwonetsetsa kuti mukuyipeza kuchokera kwa ogulitsa odalirika komanso odalirika kuti muwonetsetse kuti zinthu zili bwino komanso zodalirika.AASRAW ndi wopanga ma peptide odalirika kuti akhulupirire. mtengo.

Peptide TB-500 reconstitution kalozera

Mlingo wa TB500

Poganizira kuchepa kwa kafukufuku wofalitsidwa mpaka pano pa TB-500, palibe malingaliro okhazikitsidwa paza kafukufuku.

Komabe, m'maphunziro asayansi ndi azachipatala mpaka pano, kuchuluka kwa TB-500 komwe kumadziwika kuti ndi 2-5 mg.TB-500 nthawi zambiri kumaperekedwa kudzera mwa subcutaneous (pansi pa khungu) kapena jakisoni wa intramuscular, amaperekedwa kawiri pa sabata. nthawi ya masabata 4 mpaka 8, kutengera mtundu wa kafukufukuyu. Madokotala ena amakonda mlingo woyambira wokulirapo kwa masabata 1 mpaka 2, kutsatiridwa ndi mlingo wokonzekera wofanana ndi theka la mlingo woyambirira kwa masabata awiri mpaka 2 pambuyo pake.

Momwe mungagwiritsire ntchito TB-500?

Choyamba, konzani njira ya TB-500 posakaniza ufa wa lyophilized ndi madzi a bacteriostatic kapena madzi osabala. Mukasakaniza, jambulani voliyumu yoyenera ndikuyibaya pamalo omwe mukufuna mutatsuka malo ojambulira ndi mowa.

Anthu ambiri amakonda njira ya intramuscular poika singano pafupi ndi malo ovulala, pamene njira yodutsa mtsempha imaphatikizapo kupeza mtsempha woyenera wa jekeseni.

Mukatha jekeseni, kusisita pang'onopang'ono kumaloko kumalimbikitsa kugawa kwa peptide moyenera.Ndikofunikira kukaonana ndi katswiri wazachipatala kuti mupeze chitsogozo chaumwini ndikuwonetsetsa kuti TB-500 ikugwiritsidwa ntchito moyenera komanso moyenera.

Kuphatikiza apo, kusungidwa koyenera ndi kusamalira peptide ndikofunikira kuti ikhalebe yogwira mtima.

Zomwe zaperekedwa pano ndi zongodziwitsa chabe ndipo siziyenera kutengedwa ngati upangiri wachipatala. Ndi dokotala wodziwa bwino yemwe angakupatseni malangizo olondola komanso ogwirizana ndi zomwe mukukumana nazo. Ndikofunika kuika patsogolo thanzi lanu ndi chitetezo chanu pofunsana ndi dokotala musanagwiritse ntchito mankhwala kapena chithandizo chilichonse.

Ndani ayenera kugwiritsa ntchito TB-500?

Kupereka kwa TB500 ndi kwakukulu.N'zosavuta kupeza chifukwa pali TB500 yambiri yogulitsidwa pa intaneti.Kugwiritsa ntchito TB-500 (Thymosin Beta-4) kuyenera kutsimikiziridwa payekha payekha komanso motsogoleredwa ndi katswiri wa zaumoyo. Amagwiritsidwa ntchito kwambiri pazinthu zotsatirazi:

Othamanga ndi Okonda Zolimbitsa Thupi: Peptide yofufuza ya TB-500 ingagwiritsidwe ntchito ndi othamanga ndi anthu omwe akuchita masewera olimbitsa thupi kuti athandize kuchira kwa minofu, kulimbikitsa kukonza minofu, komanso kupititsa patsogolo ntchito.

Kuchira Kuvulala: Aliyense amene ali ndi vuto la minofu angagwiritse ntchito Tb-500.Peptide TB-500 nthawi zambiri amagwiritsidwa ntchito ndi anthu omwe akuchira kuvulala kwa minofu, monga kupweteka kwa minofu, misozi ya ligament, kapena tendonitis.Zingathandize kulimbikitsa machiritso, kusinthika kwa minofu, ndi kuchepetsa kutupa m'madera ovulala.

Zovuta Zotupa Zotupa: Anthu omwe ali ndi matenda otupa kwambiri monga nyamakazi, tendonitis, kapena bursitis angaganizire kugwiritsa ntchito TB-500 moyang'aniridwa ndi achipatala.

Mankhwala Obwezeretsa: TB-500 ikufufuzidwa kuti igwiritsidwe ntchito mu mankhwala obwezeretsanso. Ikhoza kukhala ndi phindu pa machiritso a mabala, kukonza minofu, ndi angiogenesis (kukula kwa mitsempha ya magazi), kuti ikhale yogwirizana ndi matenda osiyanasiyana.

TB-500 chitetezo ndi zotsatira zake

Ngakhale kuti TB-500 sinaphunzire mokwanira za chitetezo cha anthu, zomwe zilipo panopa zikusonyeza kuti ndi zotetezeka komanso zolekerera zikagwiritsidwa ntchito moyenera.

• kutopa
• mutu
• nseru
• chizungulire
• Masomphenya a Blurry
• Kusintha kwa kugunda kwa mtima
• Kupweteka pa malo a jakisoni

Komabe, chifukwa pali kuchepa kwa chidziwitso chokhudza kugwiritsidwa ntchito kwakanthawi kochepa kapena kwanthawi yayitali m'maphunziro a anthu, ofufuza akulimbikitsidwa kusamala popereka TB-500.

• Kusintha kwa kuthamanga kwa magazi
• Kusintha kwa chilakolako
• Ululu pa malo a jekeseni

Zotsatira zoyipa zimachepa paokha ndipo zimagwirizana ndi kugwiritsa ntchito mankhwala a peptide otsika.Zoterezi, zogulidwa kwa ogulitsa osaloledwa, zitha kulembedwa molakwika kapena kukhala ndi zowononga zowononga.Pamene opanga ma peptide ambiri amagulitsa ma peptide, timalimbikitsa AASRAW ogulitsa.

Malingana ngati mukuchita zonse molondola pogwiritsa ntchito TB-500 (mwachitsanzo, kugwiritsa ntchito njira zoyenera za jakisoni, kusunga ndi kukonzanso peptide, kuwerengera mlingo woyenera, kupeza mankhwala a TB-500 okha, ndi zina zotero), ndizokayikitsa kuti mungatero. kuthana ndi mavuto awa.

Koma ndizothekadi - kumbukirani, kusapezeka kwa zotsatira zoyipa m'maphunziro ochepa azachipatala omwe adasindikizidwa mpaka pano sizitanthauza kuti sizikhalapo mukamagwiritsa ntchito TB-500.

Kodi mungagule kuti TB-500 pa intaneti?

Mutha kupeza ogulitsa ambiri a TB-500 pa intaneti. Mawebusayitiwa atha kugulitsa mwalamulo ma peptides pazolinga zofufuza. Kuti mutsimikizire chitetezo cha TB-500, akuti ma peptides onse agulidwe kuchokera kwa opanga omwe amakwaniritsa izi:

(1) Ma peptides ayenera kusankhidwa kuti agwiritsidwe ntchito pofufuza.

(2) Wogulitsa sayenera kutsimikizira zachipatala kapena zonena za zotsatira za kayendetsedwe ka peptide.

(3) Zogulitsa za Peptide ziyenera kubwera ndi ziphaso zovomerezeka zowunikira (CoAs).

TB-500 Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.

Kodi mungagule bwanji TB-500 kuchokera ku AASraw?

❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.

❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.

❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).

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❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD.” Doping control analysis of TB-500, a synthetic version of a active region thymosin β₄, in equine mkodzo ndi plasma by madzi chromatography-mass spectrometry."J Chromatogr A. 2012 Nov 23; 1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.PMID: 23084823

[2] Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P.”Kaphatikizidwe ndi mawonekedwe a N-terminal acetylated 17-23 fragment ya thymosin beta 4 yodziwika mu TB-500, mankhwala omwe akuganiziridwa kuti ali ndi mphamvu zogwiritsa ntchito mankhwala osokoneza bongo. "Mankhwala Oyesera Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7.PMID: 22962027

[3] Mapaipi GT, Yang J. "Cardioprotection ndi Thymosin Beta 4." Vitam Horm. 2016; 102:209-26. doi: 10.1016/bs.vh.2016.04.004. Epub 2016 May 31.PMID: 27450736

[4] Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D.” Thymosin beta-4 ikuwonetsa njira zatsopano zopangira njira zochiritsira zochiritsira zoletsa kukalamba. ”Int Immunopharmacol. 2023 Marichi; 116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27.PMID: 36709593

[5] Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC." Thymosin beta 4 regulation of actin mu sepsis." Katswiri Opin Biol Ther. 2018 Jul; 18 (chakudya1): 193-197. doi: 10.1080/14712598.2018.1448381. Epub 2018 Mar 6.PMID: 29508629

[6] Jing J, Tian T, Wang Y, Xu X, Shan Y.”Kuwunika kochulukira kwa ma peptide ang'onoang'ono ndi alkaline pre-activated solid phase m'zigawo limodzi ndi liquid chromatography-high resolution mass spectrometry muulamuliro wa doping." J Chromatogr A. 2022 Aug 2; 1676:463272. doi: 10.1016/j.chroma.2022.463272. Epub 2022 Jun 22.PMID: 35802965

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